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Professor Liu Ying’s differentiation and treatment experience of Sj?觟gren syndrome based on “theory of latent toxin”#br# |
LUO Yawen1 LIU Ying2 |
1.School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250000, China;
2.Department of Rheumatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250000, China |
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Abstract Sj?觟gren syndrome is a common clinical rheumatic immune disease, which can lead to multi-system damage in addition to exocrine gland damage, seriously affecting patientsem damacal and mental health and quality of life. Modern medicine shows no specific therapeutic drugs for this disease, while Chinese medicine provides a reliable cure. This disease, which comes under the category of “zaobi” in Chinese medicine, characterized by pathologically insidious and severe onset, and clinically prolonged course, increasingly severer condition, and not responding to treatment, matches “latent toxin” in the pathogenic characteristics. Based on years of clinical experience, Professor Liu Ying concludes that the key pathogenic factor of this disease is “hidden toxicity due to vital qi deficiency”, and proposes the treatment method of “clearing dryness to relieve toxins, resolving stasis to remove toxins, and nourishing yin to benefit qi”. This method focuses on “regulation of body and spirit together” and the combination of regulation and nourishment in the treatment. In the meantime, removing toxins and reinforcing vital qi have their own emphasis in different stages of the disease. All of these combine to reflect the concept of “people-oriented” in Chinese medicine. This paper is intended to elaborate the treatment experience of the “theory of latent toxin” on Sj?觟gren syndrome in order to broaden our mind on the treatment of this disease.
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[1] 中华医学会风湿病学分会.干燥综合征诊断及治疗指南[J].中华风湿病学杂志,2010,14(11):766-768.
[2] 王梦洁,徐子琦,刘英.原发性干燥综合征的中西医治疗新进展[J].现代中西医结合杂志,2021,30(4):443-448.
[3] 周仲瑛.“伏毒”新识[J].世界中医药,2007,2(2):73-75.
[4] 刘清平,李楠,林昌松,等.从伏毒论治类风湿关节炎[J].中华中医药杂志,2016,31(4):1168-1170.
[5] 任瑞星,谭祖教,吴磊,等.从“伏邪”论治系统性红斑狼疮[J].中国现代医生,2020,58(13):133-135,139.
[6] Tincani A,Andreoli L,Cavazzana I,et al. Novel aspects of Sj?觟gren’s syndrome in 2012 [J]. BMC Med,2013,11(1):93.
[7] 黄丽玉,郭阳.原发性干燥综合征合并神经系统病变研究进展[J].中国现代神经疾病杂志,2019,19(1):54-59.
[8] 《凯利风湿病学》(第8版,中文版)出版[J].中华风湿病学杂志,2010,14(12):818.
[9] 姜淼,张海波,丁樱.雷公藤多苷药理作用及临床应用研究进展[J].中华中医药学刊,2021,39(3):59-63.
[10] 于得泓,战艺,石红.雷公藤多甙片联合甲氨喋呤治疗对类风湿关节炎患者红细胞沉降率、C反应蛋白及类风湿因子的影响[J].中国医药科学,2019,9(16):90-92,157.
[11] 胡旭君,宋欣伟.雷公藤多苷联合甲氨蝶呤对干燥综合征NOD小鼠治疗作用及TNF-α、IL-1β、AQP-5的表达[J].中华中医药杂志,2014,29(7):2362-2366.
[12] 吴国琳,王庆,卢雯雯,等.基于对NOD小鼠颌下腺RORγt、Foxp3及其mRNA调节探讨白芍总苷治疗干燥综合征的作用机制[J].天然产物研究与开发,2021, 33(3):462-467.
[13] 王丹,薛鸾,胡建东,等.血瘀证在原发性干燥综合征中的临床特点分析[J].中华中医药学刊,2013,31(5):1108-1110.
[14] 姜兆荣,高明利,任冬萌.从虚、毒、瘀辨治干燥综合征[J].中华中医药学刊,2011,29(6):1418-1419.
[15] 刘逊,刘睿,赵呈雷,等.穿山甲高温砂炒炮制增效机制研究[J].中草药,2019,50(7):1603-1609.
[16] 姜珊,王少平,代龙,等.土鳖虫活性肽组分对急性血瘀模型大鼠血液流变学、血脂四项指标及血液因子含量的影响[J].食品与机械,2020,36(1):175-180.
[17] 陈少鹏,韩雅莉,郭桅,等.少棘蜈蚣纤溶活性蛋白的抗血栓作用[J].中国药理学通报,2007,23(8):1088-1092.
[18] 王常瞵,丛竹凤,刘国飞,等.水蛭不同炮制品对急性血瘀模型大鼠血液流变学及凝血指标的影响[J].中国药房,2020,31(16):1984-1988.
[19] 孙红艳,陈慕芝,吕安坤,等.原发性干燥综合征中医体质及证型分布特点研究[J].世界科学技术-中医药现代化,2016,18(12):2148-2153.
[20] 石涛棠.医原[M].徐州:江苏科学技术出版社,1983.
[21] Lin X,Liu J,Chung W,et al. Polysaccharides of Dendrobium officinale induce aquaporin 5 translocation by activating M3 muscarinic receptors [J]. Planta Med,2015, 81(2):130-137.
[22] 鄢圣英,沈卉.张锡纯临床应用黄芪经验[J].时珍国医国药,2006,17(11):2360-2361.
[23] 李时珍.本草纲目:第二册[M].校点本.北京:人民卫生出版社,1977.
[24] 魏强华,聂紫雯.黄芪注射液对NOD小鼠CD4+CD25+CD127(-/low)调节性T细胞的影响[J].免疫学杂志,2010,26(4):316-319.
[25] 陈忆莲,吴国琳.中医药改善干燥综合征焦虑抑郁状态及生活质量的研究现状[J].中华中医药杂志,2019,34(12):5808-5811.
[26] 诸葛叶婷,侯秀娟,刘小平,等.中医治疗干燥综合征焦虑抑郁初探[J].环球中医药,2017,10(9):1106-1108.
[27] 王景,于洋,张海丽,等.中医医联体家庭医生团队慢性病管理模式的探讨[J].中国医院管理,2020,40(7):94-96. |
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