脓毒症心肌功能障碍关键基因的筛选及生物信息学分析

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Abstract Objective To screen the key genes of sepsis-induced myocardial dysfunction (SIMD), and analyze the main biological processes. Methods Data sets of sepsis patients and SIMD mouse models were analyzed differentially by R software, genes related to SIMD were extracted, biological analysis, correlation analysis, and protein-protein interaction network analysis were carried out. Results There were 318 and 143 differential genes in sepsis patients and animal models respectively, including 84 SIMD genes, 54 down-regulated genes and 30 up-regulated genes. Sepsis and SIMD differential genes had similar biological functions in gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. ANXA3, S100A8, LCN2, LTF, and KLHL2 were the key genes of SIMD; LTF, LCN2, and SOCS3 were the key proteins of SIMD. Conclusion Many key genes, such as LCN2, LTF, ANXA3, S100A8, KLHL2, and SOCS3 may involve in the pathophysiological process of SIMD, it is significant to further study the clinical diagnosis, prognosis, and treatment of SIMD.

Key words： Sepsis Sepsis-induced myocardial dysfunction Bioinformatics Gene expression omnibus Key gene

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	JIANG Wanwei YANG Guohui

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JIANG Wanwei YANG Guohui. Screening of key genes and bioinformatics analysis of sepsis-induced myocardial dysfunction#br#[J]. 中国医药导报, 2022, 19(3): 24-28,33.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I3/24

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