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2021 Vol. 18, No. 36 Published: 2021-12-25

	4	Evaluation of the development of medical science and technology in the century after the founding of the Communist Party of China from the perspective of bibliometrics#br#
		LI Ling YANG Yuan YUAN Ziyan QIN Yi GAO Dongping
		Objective To evaluate the development of medical science and technology in the century after the founding of the Communist Party of China (CPC) from the perspective of bibliometrics. Methods The scientific research papers and medical research papers published by Chinese scholars from 1921 to 2020 included in science citation index database were searched, the research scale, academic achievements, and academic influence of medical science and technology in China were analyzed quantitatively, Excel 2010 was used to analyze the included literature. Results Over the century since the founding of the CPC, the total number of medical research papers published in China had reached 1 556 900, ranking fourth in the world. In the past decade, the total citation frequency of scientific research papers had exceeded 14 million times, ranking third in the world. The citation influence value of discipline standardization increased to 1.46. The number of highly cited papers reached 2154, ranking the second in the world. The number of papers published by Chinese scholars in international top medical journals has increased rapidly. The number of Chinese international cooperation documents accounted for 22.33%. Conclusion After one hundred years of development, the output scale and quality of medical research papers in China have been significantly improved, and international cooperation has been strengthened.
		2021 Vol. 18 (36): 4-7,39 [Abstract] ( 148 ) HTML (1 KB) PDF (882 KB) ( 225 )

	8	Effect of lncRNA TUG1 on colorectal cancer cell metastasis and epithelial mesenchymal transformation through miR-145/KIAA1199 axis#br#
		LI Haiqiang LI Yan SHEN Xuning JIANG Honggang
		Objective To investigate the effect of LncRNA TUG1 on colorectal cancer cell metastasis and epithelial mesenchymal transformation (EMT) through microRNA-145 (miR-145)/KIAA1199 axis. Methods A total of 30 patients with colorectal cancer who were pathologically confirmed and did not receive preoperative chemoradiotherapy were collected from the First Hospital of Jiaxing, Zhejiang Province from August 2020 to February 2021. Differential expressions of lncRNA TUG1, miR-145, and KIAA1199 in Colo320, HCT116, and NCM460 cells, cancer and paracancerous tissues were detected by RT-qPCR; the effect target and correlation of LncRNA TUG1 and miR-145 were analyzed; the effects of lncRNA TUG1 on Colo320 cell development and KIAA1199 expression via miR-145 were detected; the effects of TUG1 or KIAA1199 down-regulation on Colo320 cell proliferation, invasion, and EMT were detected. Results The expression levels of lncRNA TUG1 and KIAA1199 in cancer tissues were higher than those in paracancerous tissues, and the expression level of miR-145 was lower than that in paracancerous tissues (P < 0.01). The expression levels of LncRNA TUG1 and KIAA1199 in HCT116 and Colo320 cells were higher than those in NCM460 cell, and the expression level of miR-145 was lower than that in NCM460 cell (P < 0.01). The cell viability (24, 48, 72 h) and invasion number of TUG1 down-regulated group were lower than those of down-regulated control group (P < 0.05); the expression levels of N-cadherin, Vimentin, and Snail in TUG1 down-regulated group were lower than those in down-regulated control group, while the expression of E-cadherin was higher than that in down-regulated control group (P < 0.01). The lucifase activity of LncRNA TUG1 wildtype+miR-145 mimics group was lower than that of LncRNA TUG1 wildtype+ mimics control group (P < 0.01); there was no significant difference in lucifase activity between LncRNA TUG1 mutant+ mimic group and LncRNA TUG1 mutant+miR-145 mimic group (P > 0.05). The number of cell invasion and cell viability (24, 48, 72 h) in TUG1 overexpression+miR-145 mimics group were higher than those in overexpression control+miR-145 mimics group (P < 0.05); the expression levels of N-cadherin, Vimentin, and Snail in TUG1 overexpression+miR-145 mimics group were higher than those in overexpression control+miR-145 mimics group, while the expression level of E-cadherin was lower than that in overexpression control+miR-145 mimics group (P < 0.01). The cell viability (24, 48, 72 h) and invasion number of KIAA1199 down-regulated group were lower than those of down-regulated control group (P < 0.05); the expression levels of N-cadherin, Vimentin, and Snail in KIAA1199 down-regulated group were lower than those in down-regulated control group, while the expression level of E-cadherin was higher than that in down-regulated control group (P < 0.01). Conclusion LncRNA TUG1 promotes KIAA1199 expression through miR-145 and accelerates the proliferation, invasion, and EMT of Colo320 cell.
		2021 Vol. 18 (36): 8-13 [Abstract] ( 148 ) HTML (1 KB) PDF (1079 KB) ( 95 )

	14	Effects of ginsenoside Rg1 on viability and vascular differentiation of human umbilical blood mesenchymal stem cells#br#
		ZHOU Qimiao1 PENG Ajian2 ZHANG Xi3 ZHU Furong1 TAN Meixin2 WANG Xiaoqin2 PENG Jiarui2 XIONG Wu1
		Objective To investigate the effects of ginsenoside Rg1 (GS-Rg1) on the activity and endothelial differentiation of human umbilical cord blood mesenchymal stem cell (MSC) in vitro. Methods Human umbilical blood was collected from normal cesarean placenta under aseptic conditions, and mononuclear cells were isolated by density gradient centrifugation. When the cells were fusiform, osteogenesis, chondrogenesis, and adipogenic differentiation were identified. The identified human umbilical blood MSCs were treated with 0, 5, 10, 20, 40, and 80 mg/L GS-Rg1, respectively, to determine the optimal concentration of GS-Rg1 to promote the proliferation of human umbilical blood MSCs. Then human umbilical blood MSCs were divided into experimental group and control group. The experimental group was treated with optimal concentration of GS-Rg1, and the control group was treated with equal volume of phosphate buffer. CCK-8 method was used to study the cell activity of the two groups, and Matrigel experiment was used to study in vitro angiogenesis of the two groups. Meanwhile, the expression of platelet-endothelial cell adhesion molecule-1 (CD31) and von Willebrand factor (vWF) were detected by immunofluorescence. Results Microscopically, the morphology of the cells was uniform, showing a long spindle fibroblast-like morphology, which was typical of MSCs. The staining results of osteogenic, chondrogenic, and adipogenic differentiation showed a large number of deep staining parts, indicating that they were MSCs. When GS-Rg1 concentration was 40 and 80 mg/L, the MSCs optical density value was higher than that when GS-Rg1 concentration were 0, 5, 10, and 20 mg/L, the differences were statistically significant (P ＜ 0.05). When GS-Rg1 concentration was 80 mg/L, there was no significant difference in the optical density of MSCs when GS-Rg1 concentration was 40 mg/L (P ＞ 0.05). The cell activity, lumen length, and fluorescence intensity of CD31 and vWF in experimental group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). Conclusion GS-Rg1 has the potential to promote the proliferation of human umbilical blood MSCs in vitro and induce their differentiation into endothelial cells and angiogenesis in vitro.
		2021 Vol. 18 (36): 14-18 [Abstract] ( 373 ) HTML (1 KB) PDF (948 KB) ( 49 )

	19	Effect of electroacupuncture on the expression of NADPH oxidase in the substantia nigra of Parkinson disease mice induced by LPS#br#
		KANG Kaiwen1 YIN Faming2 WANG Yuan3 YUAN Wei3 LU Gang3 BAI Qiuju1 WANG Qiang3
		Objective To investigate the effect of electroacupuncture on the expression of p47phox and p22phox of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in the substania nigra of lipopolysaccharide (LPS) induced Parkinson disease (PD) mice, and to explore the mechanism of electroacupuncture in improving PD. Methods Forty male C57BL/6 mice with clean grade of 22-25 g were divided into blank group, model group, Levodopa group, and electroacupuncture group by random number table method, with ten mice in each group. Except blank group, the other groups were given 10 μl (1 g/L, dissolved in the 0.9% sodium chloride solution) LPS by nasal drip to make PD model. The blank group was given the same amount of the 0.9% sodium chloride solution. Levodopa group was intraperitoneally injected with 0.2 ml Levodopa Injection (10 mg/kg). Electroacupuncture group acupuncture “yìntáng” “yíngxiāng” point (2 Hz/100 Hz, 1 mA, 20 min). Blank group and model group were captured in the same degree. After the intervention, the mice were subjected to behavioral testing, and the expression of p47phox and p22phox in substantia nigra cells was detected by immunohistochemical method. Results Compared with blank group, the total number of arm advances and accuracy in model group was decreased significantly (P ＜ 0.01). Compared with model group, the total number of arm entry and accuracy of electroacupuncture group was increased (P ＜ 0.05). Compared with blank group, the number of p47phox and p22phox protein positive cells in model group was increased significantly (P ＜ 0.01). Compared with model group, the number of p47phox and p22phox protein positive cells in the substantia nigra in electroacupuncture group was decreased (P ＜ 0.05). Conclusion “Xiu Sanzhen” can inhibit oxidative stress, improve motor symptoms and delay PD process in PD mice, which may be related to the inhibition of NADPH oxidase.
		2021 Vol. 18 (36): 19-22 [Abstract] ( 168 ) HTML (1 KB) PDF (742 KB) ( 33 )

	23	Effect of miR-189 on bone formation and its mechanism#br#
		LIU Xingyu1 WANG Jie2 SHI Fei3
		Objective To explore the effect and mechanism of miR-189 on bone formation. Methods Thirty-two female C57BL/6J mice were divided into four groups by random number table method: sham operation group, castration group, control group, and inhibitor group, with eight mice in each group. Ovarian castration was used to construct a mouse model of osteoporosis. The content of miR-189 in femur was detected by RT-qPCR. After injection of miR-189 negative control sequence (control group) or inhibitor (inhibitor group) into tail vein of emasculated mice, bone formation was detected by micro CT and calcein staining. MC3T3-E1 was transfected with miR-189 negative control sequence, mimics (mimics group) or inhibitors. Western blot was used to detect osteogenic indexes. Results Compared with sham operation group, miR-189 expression of femur in castration group was higher (P ＜ 0.05). Compared with control group, miR-189 of femur in inhibitor group was decreased (P ＜ 0.05), and the bone loss caused by castration was partially alleviated (P ＜ 0.05). Compared with control group, miR-189 was increased in mimics group (P ＜ 0.05), miR-189 was decreased in inhibitor group (P ＜ 0.05), compared with the control group, the osteogenic indexes in the mimics group were decreased (P ＜ 0.05), and the osteoblast index in inhibitor group increased (P ＜ 0.05). Conclusion The femur of emasculated mice is highly expressed with miR-189, which inhibits bone formation by inhibiting osteoblast function.
		2021 Vol. 18 (36): 23-27 [Abstract] ( 99 ) HTML (1 KB) PDF (1130 KB) ( 103 )

	28	Research hotspot and trend of polycystic ovary syndrome treated by traditional Chinese medicine based on visualized analysis#br#
		YU Fangning1,2 XIE Dandan2 WANG Wei1 LI Jinglei2 ZHAO Siyu2 LI Tuo2 GENG Nan3 SHEN Qian2
		Objective To quantitative and visual analysis of literatures related to the treatment of polycystic ovary syndrome (PCOS) with traditional Chinese medicine, and to explore the research hotspots and development trends in this field and to provide reference for subsequent studies. Methods The CNKI database was searched to obtain relevant literatures on the treatment of PCOS with traditional Chinese medicine published by Chinese scholars from construction to September 2020. Statistical softwares such as CiteSpace 5.5 and SATI3.2 were used to perform quantitative analysis and visual analysis on the publication years, journal sources, authors, institutions and key words of the literatures. Results A total of 890 articles were obtained, and the publication time span was from January 1984 to September 2020; the number of articles published in the field of Chinese medicine treatment of PCOS gradually increased after 2007 and reached its peak in 2017; important scholars in this field include Wu Xiaoke, Hou Lihui, Tan Yong, etc. The institution with the largest amount of publications was Heilongjiang University of Chinese Medicine. The main research hotspots were infertility, irregular menstruation, obesity, and insulin resistance. Non-drug treatments were gradually receiving attention, and clinical efficacy observations and reviews occupy a major position; the distribution of journals was relatively scattered, and the industry influence was low. Conclusion Through the method of metrology, it visually shows the time distribution, author institution, cooperation network, research status, research hotspots and development trend of the literature in the field of traditional Chinese medicine treatment of PCOS, which provide reference for the further research and development directions of traditional Chinese medicine treatment of PCOS.
		2021 Vol. 18 (36): 28-33 [Abstract] ( 129 ) HTML (1 KB) PDF (1556 KB) ( 143 )

	34	Molecular mechanism exploration of Semen Euryales-Fructus Rosae Laevigatae in the treatment of diabetic nephropathy based on network pharmacology#br#
		LI Xiaoran1 WANG Xueying2 ZHANG Hua1 WANG Shidong1 ZHENG Xiaoyan1
		Objective To investigate the molecular mechanism of Semen Euryales-Fructus Rosae Laevigatae in the treatment of diabetic nephropathy (DN) based on network pharmacology. Methods The drug ingredients and targets were investigated by traditional Chinese medicine systems pharmacology database and analysis platform, encyclopaedia of traditional Chinese medicine, and Swiss Target Prediction databases, and the GeneCards and OMIM databases were searched for targets related to DN. The protein-protein interaction network and drug-target network were constructed by STRING platform and Cytoscape software, and network topology analysis and core target screening were completed. The enrichment analyses of gene ontology and Kyoto Encyclopedia of Genes and Genomes were completed by R software, and the core pathways and targets were obtained. Finally, the molecular docking of core ingredient targets was completed by VINA software. Results Two active ingredients of Semen Euryales, and seven active ingredients of Fructus Rosae Laevigatae were obtained, including quercetin, kaempferol, gondoic acid, and other core active ingredients. The 20 core targets including mitogen activated protein kinase (MAPK) 1, and transcription factor-AP1 (Jun), MAPK3 were screened. Gene ontology enrichment analysis showed that the targets were mainly concentrated in the cell membrane region, which played various biological functions including cell signal transduction and nuclear transcription, and completed multiple regulatory response to lipopolysaccharide and oxidative stress. Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that the main enrichment pathways were the AGE-RAGE, MAPK, PI3k-Akt, NF-κB, and other signaling pathways. The results of molecular docking showed that quercetin and kaempferol had good affinity with core targets, such as MAPK1, transcription factor-AP1 (Jun) and so on. Conclusion This study applies the network pharmacology method to elucidate the possible mechanism of Semen Euryales-Fructus Rosae Laevigatae pairs in the treatment of DN, including multiple pathways and targets to regulate the complex inflammatory response and oxidative stress, which provides clues and basis for further experimental and clinical pharmacological studies.
		2021 Vol. 18 (36): 34-39 [Abstract] ( 347 ) HTML (1 KB) PDF (2006 KB) ( 92 )

	40	Research progress on the regulatory mechanism of myocardial regeneration after myocardial infarction#br#
		MA Yifu1,2 LIU Tingting1,2 SUN Fangling1,2 TIAN Xin1,2 WANG Yufeng1,2 ZHENG Ruifang3 XING Jianguo3 WANG Wen1,2,3,4▲
		After myocardial infarction, the tissue is ischemic and hypoxic, and a large number of myocardial cells in the infarction area are necrotic, and the damaged tissue is replaced by fibrotic cells, forming scar tissue. Remodeling of the ventricular wall in the non-infarcted area leads to a decrease in the ability of the heart muscle to contract, ultimately leading to heart failure. According to the latest report of the World Health Organization, myocardial infarction and other cardiovascular diseases are the leading causes of death worldwide. In recent years, the problem of younger patients with myocardial infarction has become increasingly prominent, and the overall mortality is on the rise. Myocardial regeneration is a process in which the original myocardial cells proliferate a little after myocardial infarction to alleviate the injury caused by myocardial infarction. Studies have shown that myocardial regeneration after myocardial infarction can be promoted by promoting the self-replication of myocardial cells. In this paper, the current research progress on endogenous repair of myocardial infarction is summarized, and microRNA and cytokines are discussed to induce myocardial cells to re-enter the cell cycle and realize the proliferation of myocardial cells through some specific signaling pathways. In order to find a new way to treat myocardial infarction, this paper reviews the existing regulation mechanism of myocardial regeneration.
		2021 Vol. 18 (36): 40-44 [Abstract] ( 142 ) HTML (1 KB) PDF (564 KB) ( 100 )

	45	Research progress of neural stem cell transplantation for neuroprotective and regenerative therapy of ischemic stroke#br#
		SHEN Youjin1 QI Xiaokun2 ZHOU Zonghua1 HE Jianwen1
		Ischemic stroke is a disease with high incidence and disability rate. Intravenous thrombolysis and mechanical thrombectomy are two most effective therapies for acute ischemic stroke. However, due to the limitations of therapy time window and surgical techniques, there are many patients who cannot fully or largely recover after the treatment of ischemic stroke. Neural stem cell transplantation provides a new method for the treatment of ischemic stroke. By promoting neurogenesis, angiogenesis, synaptic remodeling, cell replacement, and other mechanisms, neural stem cells play a good effect in the treatment of ischemic stroke. Although there are some problems such as insufficient source of neural stem cell, the optimal transplantation dose and route of administration, unclear time window, and tumorigenicity, neural stem cell transplantation is still a promising therapeutic method.
		2021 Vol. 18 (36): 45-49 [Abstract] ( 152 ) HTML (1 KB) PDF (559 KB) ( 186 )

	50	Research progress of traditional Chinese and Western medicine on acquired immune deficiency syndrome incomplete immune reconstitution#br#
		KE Jingwen1 XIAO Mingzhong2 LIN Lianmei1 LIU Jianzhong2
		Acquired immune deficiency syndrome (AIDS) is a major public health problem worldwide. Some patients have a series of complications due to incomplete immune reconstitution, which accelerates the disease process and seriously affects their quality of life. In recent years, domestic and foreign scholars have carried out a large number of studies in the field of incomplete immune reconstitution of AIDS. This paper reviews AIDS incomplete immune reconstitution pathogenesis and treatment progress from modern medical and traditional medical perspectives by reviewing relevant studies in recent years. It is found that Western medicine focuses on the decline of the number of CD4+T lymphocytes and adopts individualized treatment for different causes, while traditional Chinese medicine concentrates on the vital qi exhaustion of five zang viscera and chooses different strengthening programs. Both Western medicine and traditional Chinese medicine have unique advantages. However, the combination of traditional Chinese and Western medicine has more advantages in effect and safety, but lacks more powerful evidence-based medical evidence, which is worth further digging, in order to form a complete and standardized treatment system.
		2021 Vol. 18 (36): 50-53 [Abstract] ( 137 ) HTML (1 KB) PDF (592 KB) ( 36 )

	54	Research pregross on traditional Chinese medicine diagnosis and treatment of abdominal pressure and abdominal compartment syndrome#br#
		YANG Siwen1 LI Sinai1,2 SONG Maifen1
		Abdominal pressure is one of the most common clinical symptoms. Abdominal compartment syndrome is the severe case of abdominal pressure, which can induce multiple organ failure and lead to death. At present, most of the modern medical treatment methods are invasive treatment, which is painful to some extent, and at the same time, there are increased risks of infection and visceral edema. Therefore, it is necessary to explore less invasive, safer, and more effective treatment methods. There are a variety of methods and fewer side effects in traditional Chinese medicine treatments of abdominal pressure and abdominal compartment syndrome. Several related studies have shown that it’s more safely and effectively in improving the clinical symptoms, reducing abdominal pressure, and shortening the length of hospital stays. This paper reviews the literatures on the treatment of abdominal pressure and abdominal compartment syndrome with traditional Chinese medicine to provide help for its clinical intervention.
		2021 Vol. 18 (36): 54-56,64 [Abstract] ( 177 ) HTML (1 KB) PDF (599 KB) ( 124 )

	57	Research progress of miR-135a / FOXO1 / PINK1 regulatory axis in liver fibrosis and mitochondrial autophagy#br#
		PANG Qiulin1 WANG Zhenchang2
		Hepatic fibrosis is a common pathological stage of all chronic liver diseases and a necessary process for the development of liver cirrhosis. Its causes are complex, lack of effective treatments, and its incidence is increasing year by year, it is a reversible damage-repair process. Therefore, how to block and reverse liver fibrosis is the key to treatment. Autophagy is closely related to liver fibrosis, and the role of mitochondrial autophagy in liver fibrosis has received increasing attention from many researchers. This article discusses the regulatory relationship between liver fibrosis and the miR-135a / FOXO1 / PINK1 regulatory axis of mitochondrial autophagy, and aims to provide scientific reference and new ideas for the treatment of liver fibrosis and the research of new anti-liver fibrosis drugs.
		2021 Vol. 18 (36): 57-60 [Abstract] ( 169 ) HTML (1 KB) PDF (551 KB) ( 72 )

	61	Research progress in surgical treatment of femoral neck fracture in youth
		MA Xianming1 HUANG Wenliang1 ZHANG Yong2 DENG Jiang1
		Femoral neck fractures in youth is mostly caused by high-energy injury, and there are various surgical treatments, such as traditional hollow compression screws, dynamic hip screws, percutaneous compression plates, and femoral neck compression locking bone plates, multiple hollow screws / Pauwels screws combined with fibular allograft, Smith & Nephew Conquest system, and Aesculap Targon system. However, no internal fixation method has been identified as the gold standard for the treatment of femoral neck fractures in youth. Therefore, this article reviews the commonly used treatment methods and the latest research of femoral neck fractures in youth, in order to provide a theoretical reference for the clinical treatment of femoral neck fracture in youth.
		2021 Vol. 18 (36): 61-64 [Abstract] ( 155 ) HTML (1 KB) PDF (555 KB) ( 151 )

	65	Correlation between empowering leadership behavior and elder neglect in nursing staff#br#
		ZHANG Liping DU Yage LIU Jie DOU Haoying ZHANG Chunmei
		Objective To investigate the status of empowering leadership behavior and elder neglect of nursing staff, and to analyze the correlation between them. Methods From July to September 2020, senior care workers in 50 senior care institutions in Henan, Hebei and Shandong Provinces were selected as the research objects. The general information questionnaire, the leadership empowerment behavior scale and the elderly care worker negligence assessment scale were used to investigate them. Results A total of 449 questionnaires were issued and 412 valid questionnaires were returned, with an effective recovery rate of 91.76%. The total score of empowerment behavior authorized by senior care worker leaders was (47.83±7.54) points, while the total score of negligence was (72.89±8.79) points. The total score of leadership empowerment behavior was positively correlated with the total score of negligence (r = 0.511, P ＜ 0.01). The hierarchical regression analysis showed that regular training after entry, wages, and monthly rest time were the main influencing factors of neglect (P ＜ 0.05); leadership empowerment behavior was the influencing factors of neglect (P ＜ 0.05), independently explaining 15.50% of its variation. Conclusion Managers of elderly care institutions should strengthen the authorization and empowerment of elderly care workers and improve the quality of their services for the elderly to prevent neglect of care.
		2021 Vol. 18 (36): 65-68,80 [Abstract] ( 234 ) HTML (1 KB) PDF (723 KB) ( 39 )

	69	Analysis of the current situation and influencing factors of knowledge, attitude, and practice of living will in elderly patients with liver cancer#br#
		GUO Yun WU Jindao WANG Hongxia
		Objective To understand the current situation of knowledge, attitude, and practice of elderly liver cancer patients’s living will and to analyze its influencing factors to provide a theoretical basis for improving the quality of life of elderly liver cancer patients. Methods A questionnaire survey of 270 elderly liver cancer patients the First Affiliated Hospital of Nanjing Medical University was conducted from January to December 2020 by using convenience sampling method, and multiple linear regression was used to analyze the influencing factors of elderly liver cancer patients’ living will. Results In this study, a total of 270 questionnaires were distributed, and 245 valid questionnaires were returned. The effective response rate was 90.74%. There were statistically significant differences in the knowledge, attitude, and practice scores of elderly liver cancer patients with different pensions, medical insurance, religious beliefs, family status, children’s communication frequency, and self-evaluated health status (P ＜ 0.05). Elderly patients with liver cancer had a total score of knowledge, attitude, and practice of(78.52±7.41) points, and a total score of death anxiety (7.50±2.03) points. The total score of living will was negatively correlated with death anxiety (r = -0.13, P ＜ 0.05). The results of multiple linear regression showed that the pensions, medical insurance, religious beliefs, frequency of communication with children, self-assessed health status, and death anxiety were independent influencing factors of the living will of elderly liver cancer patients (P ＜ 0.05), which can explain 21.7% of the total variation. Conclusion Elderly patients with liver cancer have a low level of knowledge, attitude, and practice. Improving the social security system, strengthening parent-child communication between the elderly and easing death anxiety is conducive to the implementation of living will.
		2021 Vol. 18 (36): 69-72 [Abstract] ( 231 ) HTML (1 KB) PDF (447 KB) ( 106 )

	73	Clinical effect of Conbercept injection combined with 532 nm laser panretinal photocoagulation in the treatment of diabetic retinopathy#br#
		XU Jing SHEN Yifei▲
		Objective To explore the effect of Conbercept Injection combined with 532 nm laser panretinal photocoagulation in the treatment of diabetic retinopathy (DR) and its influence on fundus microcirculation. Methods Eighty-two patients (96 eyes) with DR admitted to the Ninth People’s Hospital of Suzhou City from March 2017 to March 2020 were selected and they were divided into observation group (41 cases, 50 eyes) and control group (41 cases, 46 eyes) according to the random number table method. The control group was treated with 532 nm laser panretinal photocoagulation, and the observation group was treated with Conbercept Injection on the basis of the control group. Retinal fovea thickness (CMT), best corrected visual acuity (BCVA), intraocular pressure, clinical efficacy, and fundus microcirculation were compared between the two groups. Results There were no significant differences in CMT, BCVA, and intraocular pressure between the two groups before treatment (P ＞ 0.05); six months after treatment, CMT in both groups was decreased, and the observation group was lower than that of the control group (P ＜ 0.05), BCVA was increased, and the observation group was higher than that of the control group (P ＜ 0.05). There was no statistical significance in intraocular pressure between the two groups (P ＞ 0.05). Six months after treatment, there was a significant difference in clinical effects between the two groups (P ＜ 0.05). There were no statistically significant differences in plasma viscosity (PV), erythrocyte aggregation index (EAI), erythrocyte deformation index (EDI), erythrocyte sedimentation rate (ESR), and hematocrit (Hct) between the two groups before treatment (P ＞ 0.05); six months after treatment, PV, EAI, EDI, ESR, and Hct in both groups were decreased (P ＜ 0.05), and which in the observation group were lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion The treatment of DR patients with conbercept injection combined with 532 nm laser panretinal photocoagulation can reduce CMT, improve vision, and has a definite effect, and it can improve the fundus microcirculation.
		2021 Vol. 18 (36): 73-76 [Abstract] ( 100 ) HTML (1 KB) PDF (422 KB) ( 32 )

	77	Effect of obstructive sleep apnea hypopnea syndrome on the course of diabetic nephropathy in elderly type 2 diabetic patients#br#
		TANG Shan ZHANG Ridong YUAN Qi MAO Li▲
		Objective To investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on the progression of diabetic nephropathy in elderly type 2 diabetes mellitus (T2DM) patients. Methods A total of 145 T2DM patients admitted to Huaian First People’s Hospital Affiliated to Nanjing Medical University from February 2018 to March 2020 were selected as the study subjects. T2DM patients with nephropathy were statisticsed and they were divided into diabetic nephropathy group and simple diabetes group according to the status of T2DM patients with nephropathy. The clinical data of two groups were compared. The factors affecting the occurrence of T2DM nephropathy were analyzed by logistic multifactor regression. Results In this study, the incidence of diabetic nephropathy in 145 T2DM patients was 26.21%. The course of diabetes, standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursions, mean absolute value of daytime blood glucose (MODD), urinary albumin, serum creatinine (Scr), and apnea hypoventilation index (AHI) in diabetic nephropathy group were higher than those in simple diabetic group (P ＜ 0.05). The estimated glomerular filtration rate (eGFR) and night minimum pulse oxygen saturation (LSPO2) were lower than those in the simple diabetic group (P ＜ 0.05). Logistic multivariate analysis showed that MODD, eGFR, AHI, and LSPO2 were all influencing factors of diabetic nephropathy in elderly T2DM patients (OR = 1.992, 0.826, 4.204, 0.753, P ＜ 0.05). Conclusion SDBG, MODD, AHI and LSPO2 are all influencing factors affecting the occurrence of diabetic nephropathy in elderly patients with T2DM. OSAHS can promote the progress of diabetic nephropathy in elderly patients with T2DM.
		2021 Vol. 18 (36): 77-80 [Abstract] ( 345 ) HTML (1 KB) PDF (453 KB) ( 34 )

	81	Bioinformatics analysis of differential miRNAs in ectopic endometrial tissues#br#
		MA Lanfang1 CAO Lili1 WU Zhangying2 WANG Juntao1
		Objective To explore the molecular regulation mechanism of microRNA (miRNA) and its target gene regulatory network in endometriosis (endometriosis) based on bioinformatics analysis, and provide new ideas for the study of pathogenesis and therapeutic targets. Methods Data set GSE105765 on miRNA expression in ectopic endometrial and situ endometrial tissues was downloaded from the public gene chip database GEO, R language software was used to analyze the differentially expressed miRNA and screen out the top six miRNA with differentially expressed miRNA, target genes were predicted by online databases TargetScan, miRWalk, and miRDB, respectively, and the intersection of target genes predicted by the three databases was obtained. DAVID online website was used to conduct gene enrichment analysis for the intersection target genes obtained by GO and KEGG, so as to determine the biological function or pathway that the target genes mainly affect. Protein-protein interaction (PPI) network analysis was performed on the target genes screened by STRING database and Cytoscape software. Results A total of 85 miRNAs with difference expression in ectopic endometrial and situ endometrial tissues were screened out, among which the top six were miR-202-5p, miR-514a-3p, miR-615-3p, miR-202-3p, miR-509-3p, and miR-509-3-5p; there were 43, 194, 2, 598, 209, 556 target gene intersections predicted by three databases; GO and KEGG enrichment analysis showed that the intersection target genes of six miRNAs were closely related to axon transport and glucose metabolism; through PPI network and module analysis, RAC1, EP300, EGFR, and CTNNB1 were screened as the core sites of protein interaction. Conclusion Using bioinformatics found that, compared with in situ endometrial tissues, miRNAs are differentially expressed in ectopic endometrial tissues, and target genes are involved in the regulation of axonal transport and glucose metabolism, providing new evidence for the pathogenesis and therapeutic target of endometriosis.
		2021 Vol. 18 (36): 81-84,90 [Abstract] ( 131 ) HTML (1 KB) PDF (636 KB) ( 52 )

	85	Meta analysis of negative pressure wound therapy in maternal obesity#br#
		HE Huilin1 HE Fang1 HUANG Huaping2▲
		Objective To investigate the effect of negative pressure wound therapy (NPWT) in maternal obesity, and providing the best evidence to clinical practice. Methods PubMed, EMBase, the Cochrane Central Register of Controlled Trials, ClinicalTrial.gov, CNKI, and WanFang data were systematically searched from create database to December, 2020 to identify relevant randomized controlled trials. Two authors independently read and extracted data from the selected studies. Review Manager 5.3 was applied to analyze the collected data; TSA 0.9 was used to evaluate the reliability of the study results. Results A total of nine articles were included. Meta analysis results showed that, there was no significant difference in surgical site infection rate between two groups (RR = 0.85, 95%CI: 0.66-1.08, P = 0.18); the incidence of site complications including site infection in NPWT group was lower than that in conventional dressing group (RR = 0.81, 95%CI: 0.68-0.97, P = 0.02); the incidence of site complications except site infection in NPWT group was lower than that in conventional dressing group (RR = 0.75, 95%CI: 0.66-0.86, P < 0.0001); there was no statistically significant difference in the readmission rate between two groups (RR = 1.19, 95%CI: 0.62-2.27, P = 0.60). Conclusion NPWT can effectively reduce postoperative site complication rate in maternal obesity, but it cannot reduce surgical site infection rate and readmission rate.
		2021 Vol. 18 (36): 85-90 [Abstract] ( 224 ) HTML (1 KB) PDF (1292 KB) ( 53 )

	91	Analysis of current situation of stigma and social avoidance and distress in school age children with developmental dysplasia of the hip#br#
		FU Huan TIAN Xiaojuan XIA Wudie
		Objective To observe the current situation of stigma in school age children with developmental dysplasia of the hip (DDH), and to analyze the relationship between stigma and social avoidance and distress of children. Methods A total of 120 school age children with DDH treated in West China Hospital of Sichuan University from January 2020 to January 2021 were selected，the stigma scale for school age children with DDH made by hospital was used to evaluate the stigma of all the children, and the baseline data questionnaire was designed to record the relevant data of school age children, the stigma scale score for school age children with DDH of different data characteristics were compared, and the influencing factors that may affect the stigma of school age children with DDH were analyzed. Results The stigma scale score of 120 school age children with DDH were (62.12±8.07) points. School age children with unilateral DDH had higher stigma scale score than school age children with bilateral DDH, school age children with high level social avoidance and distress (SAD) score had higher stigma scale scores than school age children with low level SAD score, and the differences were statistically significant (P < 0.05). Multiple linear regression analysis showed that unilateral incidence and high level SAD score were the risk factors for high stigma (P < 0.05). Conclusion The medium and high level of stigma in school age children with DDH may be related to high level social avoidance and distress.
		2021 Vol. 18 (36): 91-94 [Abstract] ( 91 ) HTML (1 KB) PDF (499 KB) ( 57 )

	95	Influential factors of postoperative recurrence of chronic sinusitis with nasal polyp and the diagnostic value of peripheral blood eosinophil combined with CD4+/CD8+#br#
		WANG Ling LU Yingying
		Objective To investigate the influential factors of postoperative recurrence of chronic sinusitis with nasal polyp and the diagnostic value of peripheral blood eosinophil (EOS) combined with CD4+/CD8+. Methods A total of 142 patients with chronic sinusitis and nasal polyp who underwent transnasal endoscopic surgery in Wuxi People’s Hospital of Jiangsu Province from January 2018 to March 2020 were selected as the research subjects. According to their recurrence, patients were divided into recurrence group (84 cases) and non-recurrence group (58 cases). Clinical data and biochemical indicators of patients were collected, and logistic regression model was used to analyze the factors influencing postoperative recurrence. The diagnostic value of peripheral blood EOS combined with CD4+/CD8+ detection for postoperative recurrence of chronic sinusitis with nasal polyp was analyzed by receiver operator characteristic curve and the area under the curve (AUC). Results The Lund-Kennedy score, neutrophil count, neutrophil to lymphocyte ratio (NLR), and percentage of EOS in peripheral blood in the recurrence group were higher than those in the non-recurrence group, and CD4+/CD8+ was lower than that in the non-recurrence group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high NLR and high percentage of EOS in peripheral blood were independent risk factors for postoperative recurrence of chronic sinusitis with nasal polyp (OR ＞ 1, P ＜ 0.05), and high CD4+/CD8+ was protective factor for postoperative recurrence of chronic sinusitis with nasal polyp (OR ＜ 1, P ＜ 0.05). Both the percentage of EOS and CD4+/CD8+ in peripheral blood and their combination had diagnostic value for postoperative recurrence of chronic sinusitis with nasal polyp (AUC > 0.5, P ＜ 0.05), and AUC of the combined diagnosis was larger than that of the single diagnosis (P ＜ 0.05). Conclusion The percentage of EOS and CD4+/CD8+ in peripheral blood are the influential factors of postoperative recurrence of chronic sinusitis with nasal polyp, which have higher diagnostic value.
		2021 Vol. 18 (36): 95-98 [Abstract] ( 153 ) HTML (1 KB) PDF (535 KB) ( 137 )

	99	Clinical effect of fire needle in the treatment of patients with facial telangiectasia#br#
		ZHENG Fang1 ZHU Lulu2 LI Meihong2 YANG Zheng1
		Objective To observe the clinical effect of fire needle in the treatment of patients with facial telangiectasia (FT). Methods A total of 44 patients with FT admitted to the First Department of Acupuncture and Dermatology of Dermatology in Shaanxi Provincial Hospital of Chinese Medicine from October 2019 to June 2021 were selected as the observation subjects, and they were divided into the fire needle group and the control group according to the random number table method, with 22 patients in each group. In the fire needle group, the facial telangiectasia was punctured with fire needle, and in the control group, the facial telangiectasia was irradiated with intense pulse light. The treatment course of both groups was one month. The facical situation, facial aesthetic zoning score, and facial capillary morphology score were compared between the two groups before and after treatment. The clinical effect two groups were compared after treatment and followed up for three months. Results After treatment, the area and number of telangiectasia were reduced, and the skin condition was improved. After treatment, the facial aesthetic zoning score and facial capillary morphology score of the two groups were lower than before, with statistically significant differences (P ＜ 0.05), but there was no statistically significant difference between the two groups (P ＞ 0.05). There was no statistically significant difference between the two groups after 3-month follow-up and after treatment (P ＞ 0.05), and there was no statistically significant difference between the two groups (P ＞ 0.05). Conclusion The therapeutic effect of fire needle in the treatment of facial telangiectasia is positive, the therapeutic effect is similar to that of intense pulse light irradiation, and the long-term effect is stable, which can be promoted in clinical practice.
		2021 Vol. 18 (36): 99-102 [Abstract] ( 83 ) HTML (1 KB) PDF (635 KB) ( 128 )

	103	Validation of microbial limit test method of Jiawei Xiaoduyin Granules#br#
		LIU Yu1 WU Wuwei1 FU Shujie2 JIANG Yana2 WANG Guoqian3 PAN Yu1 CHEN Lu1
		Objective To establish a microbial limit test method for Jiawei Xiaoduyin Granules. Methods According to the standard of Pharmacopoeia of the People’s Republic of China, the total number of aerobic bacteria was determined by dilution method (1∶20), and the total number of mold, yeast and control bacteria (Escherichia coli) were detected by conventional method. Results The recovery ratio of aerobic bacteria was 0.98-1.03. The total number of mold and yeast was determined, and the recovery ratio was 1.22-1.24. For Escherichia coli, no positive bacteria were detected in test samples and control group. Conclusion The established method can be used as a test method for microbe limit of Jiawei Xiaoduyin Granules.
		2021 Vol. 18 (36): 103-106 [Abstract] ( 85 ) HTML (1 KB) PDF (399 KB) ( 114 )

	107	Superiority comparison of single-pill combination and traditional antihypertensive strategies#br#
		WANG Ruxian DAI Qingyuan▲
		Hypertension is a chronic disease with a high degree of morbidity, and a major risk factor for cardiovascular and cerebrovascular diseases. The treatment and management of hypertension have always been problems in China and even in the world. Countries around the world also have been searching for treatment methods to rapidly decrease blood pressure and maintain long-term stable blood pressure, from traditional antihypertensive strategies such as monotherapy, ladder treatment, free combination treatment to single-pill combination (SPC), which has emerged in recent years. SPC is composed of two or more drugs with different antihypertensive mechanism, which is the optimization and extension of combination treatment. The superior hypotensive ability of SPC has been widely verified in clinical trials, SPC has a stronger hypotensive effect, a higher compliance rate of blood pressure and an earlier time of compliance than the three traditional antihypertensive strategies mentioned above, it has a better application prospect in the treatment and management of hypertension.
		2021 Vol. 18 (36): 107-110 [Abstract] ( 141 ) HTML (1 KB) PDF (327 KB) ( 192 )

	111	Gao Yimin’s experience in treating gastric intestinal metaplasia#br#
		WANG Wenjuan1 GAO Qi2
		Professor Gao Yimin is good at treating gastric intestinal metaplasia. He believes that the causes of gastric intestinal metaplasia are both external and internal. “Disharmony between spleen and stomach, deficiency of vital qi and accumulation of toxic substance” is the basic pathogenesis. For gastric intestinal metaplasia, early intervention of traditional Chinese medicine should be carried out according to the principle of “preventive treatment of disease” in traditional Chinese medicine to prevent its progress. The treatment needs the combination of disease differentiation and syndrome differentiation. In the treatment of chronic gastritis based on syndrome differentiation, the basic prescription is his experienced prescription Jianpi Hewei Yin, which should be modified according to the symptoms of patients. In the treatment of gastric intestinal metaplasia based on disease differentiation, Yupingfeng San plus Citri Reticulatae Pericarpium, Glycyrrhizae Radix et Rhizoma, Chelidonii Herba and Rabdosiae Rubescentis Herba are the fixed prescription, which should be used consistently. In the process of treatment, we should pay attention to the principle of strengthening vital qi to eliminate pathogenic factor, and adjust the medication at any time according to the specific situation of patients’ vital qi and pathogenic qi.
		2021 Vol. 18 (36): 111-114 [Abstract] ( 144 ) HTML (1 KB) PDF (652 KB) ( 237 )

	115	Discussion on Yanghuo Sanqi Fang in the treatment of impotence based on the principles and rules for medication of “brain-heart-kidney-essence chamber” axis#br#
		WANG Hao ZHAO Feng ZHAO Ming DU Guanchao YAN Bin GAO Qinghe REN Kai ZHANG Jiwei
		The cause of impotence is related to yang deficiency, presence endogenous weakness, and cold, and blood stasis stagnating collaterals. The syndrome of kidney deficiency and blood stasis can be shown. On the basis of principles and rules for medication involved in “brain-heart-kidney-essence chamber” axis, Yanghuo Sanqi Fang treats this disease with its features of treating the whole and the part at the same time to achieve the purposes of tonifying yang in kidney and then being beneficial to the yang of whole body, and making the blood be smooth, so that it can be good for the entire body’s blood flowing. It also has advantages like supplementing without stagnation, warm but not dry, and so on. Thus, this paper discusses Chinese medicine mechanism of impotence in kidney deficiency and blood stasis, eliciting the important meaning about “brain-heart-kidney-essence chamber” axis’s principles and rules for medication. And then, based on the axis, we analyze the specific meaning and experience of Yanghuo Sanqi Fang and give an example for clinical references.
		2021 Vol. 18 (36): 115-118 [Abstract] ( 120 ) HTML (1 KB) PDF (652 KB) ( 60 )

	119	Clinical observation of sublingual vessel in patients with gastric cancer#br#
		WANG Yanan1 YUAN Li2 JIANG Nan1 WANG Li1 XU Zhiyuan2 RUAN Hua3 CHENG Xiangdong2▲ DONG Changwu1▲
		Objective To investigate the characteristics of sublingual vessel in patients with gastric cancer and to analyze the correlation between sublingual vessel and gastric cancer diagnosis. Methods This study collected 81 patients with chronic non-atrophic gastritis and 111 patients with chronic atrophic gastritis who visited Yuhang District Traditional Chinese Medicine Hospital of Hangzhou City, Zhejiang Province from January 2020 to January 2021, and 204 patients with gastric cancer who visited Zhejiang Cancer Hospital during the same period. The information of three groups of sublingual vessel was observed and recorded, including length, thickness, shape, color, petechia, and ecchymosis. The degree of sublingual vessel stasis was quantitatively analyzed based on artificial intelligence tongue diagnosis and identification system. Results There was significant difference in the grading level of sublingual vessel among the three groups (P ＜ 0.05). The gastric cancer group had higher grades of sublingual vessel than chronic non-atrophic gastritis group and chronic atrophic gastritis group, the difference was statistically significant (P ＜ 0.05). There was no significant difference in sublingual vessel grading between chronic atrophic gastritis group and chronic non-atrophic gastritis group (P ＞ 0.05). The grade of sublingual vessel in early gastric cancer patients was better than that in advanced gastric cancer patients, and the difference was statistically significant (P ＜ 0.05). Conclusion The classification of sublingual vessel can be used as a reference index for clinical diagnosis of gastric cancer, suggesting that there is a relationship between sublingual vessel and the occurrence and development of gastric cancer.
		2021 Vol. 18 (36): 119-122 [Abstract] ( 106 ) HTML (1 KB) PDF (681 KB) ( 43 )

	123	Prevention and treatment effect of high-risk human papilloma virus infection with the concept of preventive treatment of disease#br#
		GAO Chaoyi1 YAO Meiyu2
		The infection rate of high-risk human papilloma virus is increasing year by year, and its occult and recurrent nature increases the incidence of cervical cancer, which needs to be focused on prevention and treatment. Therefore, the concept of “preventive treatment of disease” of traditional Chinese medicine is applied to this disease. According to the characteristics of the pathogenesis of the disease as the basis of vital qi deficiency, with dampness, stasis, and toxin pathogen as the targets, intervention is carried out in three stages: preventing before disease onset, preventing disease from exacerbating and preventing recurrence of the disease. Focus on intervention when it does not occur, from adjusting life, changing the way; get rid of inducement (dampness, stasis, toxin), prevent recurrence of the disease; clear constitution, slow and adjust the three aspects to prevent it from germination, at the same time pay attention to the prevention of the disease from exacerbating and the prevention of the recurrence of the disease, reach vital qi excessiveness and pathogen removal, reduce the incidence of cervical cancer, in order to enrich and improve the clinical treatment ideas.
		2021 Vol. 18 (36): 123-126 [Abstract] ( 97 ) HTML (1 KB) PDF (686 KB) ( 31 )

	127	Clinical effect of self-made Lifei Huayu Prescription in the teatment of bronchial asthma patients#br#
		ZHU Licheng1 WU Chuanzhong2▲ ZHU Wenjuan3 SHANG Yunfei1
		Objective To study the clinical effect of self-made Lifei Huayu Prescription on bronchial asthma patients. Methods A total of 80 patients with bronchial asthma admitted to the Third People’s Hospital of Nantong City from January 2018 to April 2020 were selected and divided into two groups by odd and even grouping method, with 40 patients in each group. The control group was given basic treatment, and the observation group was given self-made Lifei Huayu Prescription on the basis of the control group. Both groups were given continuous treatment for two weeks. The efficacy of the two groups was compared. Asthma control test table (ACT) score and the serum levels of immunoglobulin (Ig), cyclic adenosine monophosphate (cAMP), interleukin (IL)-10, and IL-33 in both groups were observed. Results The total effective rate of observation group was higher than control group, and the difference was statistically significant (P ＜ 0.05). There were no significant differences in ACT score, serum IgG, IgA, IgM, cAMP, IL-10, and IL-33 levels between the two groups before treatment (P ＞ 0.05). After treatment, ACT score, Ig, cAMP, and IL-10 levels were increased compared with before treatment, while IL-33 level was decreased compared with before treatment in the two groups. After treatment, ACT score, Ig, cAMP, and IL-10 levels in the observation group were higher than those in the control group, while IL-33 level was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Self-made Lifei Huayu Prescription can improve the immune function of bronchial asthma patients, regulate the levels of cAMP, IL-10, and IL-33, and effectively control asthma.
		2021 Vol. 18 (36): 127-130 [Abstract] ( 151 ) HTML (1 KB) PDF (650 KB) ( 42 )

	131	Clinical effect of ultra-micro acupotomy in the treatment of chronic lumbar muscle strain#br#
		PENG Haoxuan1 ZONG Chenzhong1 YU Chuan2 WANG Qingfu1
		Objective To study the clinical effect of ultra-micro acupotomology in the treatment of chronic lumbar muscle strain. Methods A total of 112 patients with lumbar muscle strain who were treated in the Department of Muscle Injury, Beijing University of Chinese Medicine Third Affiliated Hospital from September 2018 to December 2020 were selected and they were divided into control group and treatment group according to random number table method, with 56 cases in each group. The control group received acupuncture therapy, and the treatment group received ultra-micro acupotomology therapy. The control group was treated with acupuncture and the treatment group was treated with ultramicro acupotomy. The course of treatment for both groups was two weeks. Visual analogue scale (VAS) score, lumbar functional status score, lumbar motion, musculoskeletal ultrasound area of low echo area and total clinical response rate were compared between the two groups before and after treatment. Results After treatment, VAS score, lumbar motion score, and lumbar function state score of the two groups were lower than before treatment, and the area of low echo area was smaller than before treatment, and VAS score, lumbar motion score, and lumbar function state score of the treatment group were lower than those of the control group, and the area of low echo area was smaller than the control group, the differences were statistically significant (P ＜ 0.05). The total clinical effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Ultra-micro acupotomology in the treatment of chronic lumbar muscle strain can effectively relieve the symptoms of low back pain in patients with chronic lumbar muscle strain, improve the lumbar function and range of activity, with good safety.
		2021 Vol. 18 (36): 131-134,149 [Abstract] ( 139 ) HTML (1 KB) PDF (891 KB) ( 174 )

	135	Clinical effect of acupotomy mirror in the treatment of primary periarthritis of shoulder joint#br#
		XIE Lei HUANG Aiping XUE Chunchun GU Zhen WEN Xinlin KONG Shuyi WANG Kaiqiang
		Objective To observe the clinical effict of acupotomy mirror in the treatment of primary periarthritis of Shoulder point. Methods A total of 90 patients with primary periarthritis of shoulder joint admitted to the Department of Pain, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine from June 2019 to December 2020 were selected. They were divided into acupotomy mirror group and acupotomy group by random number table method, with 45 cases in each group. Visual analogue scale (VAS) score, Constant-Murley score of shoulder joint function before and after 14 d of treatment, and clinical efficacy after 14 d of treatment in the two groups were observed. Results Before treatment, there were no significant differences in VAS score and Constant-Murley score between the two groups (P ＞ 0.05). After 14 d of treatment, VAS score of the two groups was lower than before treatment, and Constant-Murley score was significantly higher than before treatment, VAS score of the acupotomy mirror group was lower than that of the acupotomy group, and Constant-Murley score was higher than that of the acupotomy group, the differences were highly statistically significant (P ＜ 0.01). The clinical efficacy of acupotomy mirror group was better than that of acupotomy group, the difference was highly statistically significant (P ＜ 0.01). Conclusion The acupotomy mirror in the treatment of primary periarthritis of shoulder joint can play a good clinical effect. Compared with the acupotomy group, the minimally invasive acupotomoscopy can better relieve pain and improve function, and is conducive to the rehabilitation of patients.
		2021 Vol. 18 (36): 135-138 [Abstract] ( 107 ) HTML (1 KB) PDF (486 KB) ( 42 )

	139	Application of the whole-process respiratory management program in patients with chronic sinusitis complicated with asthma undergoing endoscopic sinus surgery#br#
		YANG Guang1 REN Xiaobo1▲ LI Xiuya1 WANG Changqing1 ZHANG Yuan2
		Objective To investigate the effect of whole-process respiratory care management program in endoscopic sinus surgery for patients with chronic sinusitis complicated with asthma. Methods A total of 116 patients with chronic sinusitis complicated with asthma who underwent endoscopic sinus surgery in the Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University from January to December 2018 were selected as the study subjects by convenience sampling method. According to random number table method, they were divided into control group and observation group, with 58 cases in each group. The control group received routine endoscopic sinus perioperative nursing, and the observation group received whole-process respiratory management program nursing, the incidence of perioperative asthma and the score of perceived control of asthma were compared between the two groups. Results After intervention, the incidence of postoperative asthma in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). The total scores of perceived control of asthma in both groups were higher than those before intervention, and the total score of perceived control of asthma in observation group was higher than that in control group, the differences were statistically significant (P ＜ 0.05). The scores of locus of control, self-efficacy, and learned helplessness in the two groups were higher than those before intervention, and the observation group was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The application of whole-process respiratory management program can effectively reduce the incidence of asthma in patients with chronic sinusitis complicated with asthma after endoscopic sinus surgery, and improve the perception control of patients with asthma, which is worthy of clinical application.
		2021 Vol. 18 (36): 139-142 [Abstract] ( 126 ) HTML (1 KB) PDF (593 KB) ( 23 )

	143	Correlation between emotional intelligence and conflict handling pattern in nursing undergraduates#br#
		PAN Feng SHEN Jie
		Objective To explore the correlation between emotional intelligence and conflict handling pattern of nursing undergraduates. Methods A total of 94 nursing undergraduates who had clinical practice in Beijing Jishuitan Hospital from October 2018 to December 2020 were investigated by general information questionnaire, emotional intelligence scale and conflict management mode scale. Results The total score of emotional intelligence scale was (127.11±14.33) points, and the score of perceived emotion was the lowest (3.82±0.56) points; the highest score of emotion expression was (4.13±0.44) points. Collaboration was the most frequently used conflict resolution mode for nursing undergraduates, with a score of (4.34±0.63) points; the least used conflict processing mode was dominance, with a score of (3.21±0.63) points. Emotional intelligence was positively correlated with collaboration, obedience, dominance, and avoidance (r = 0.635, 0.558, 0.280, 0.503, P ＜ 0.05). Perceiving, expressing, understanding and controlling emotions dimensions were positively correlated with cooperation mode (r = 0.303, 0.275, 0.335, 0.421, P ＜ 0.05). Linear regression analysis showed that emotional intelligence was the influencing factor of conflict handling pattern (P < 0.05). Conclusion The emotional intelligence level of nursing undergraduates is related to their conflict handling patterns, improving the emotional intelligence level of nursing undergraduates is helpful to the selection of effective conflict handling pattern.
		2021 Vol. 18 (36): 143-145,161 [Abstract] ( 171 ) HTML (1 KB) PDF (639 KB) ( 132 )

	146	Application of cluster nursing in prevention of lower extremity deep vein thrombosis in operating room#br#
		WANG Jingjing YAN Li▲ ZHANG Jianmei
		Objective To explore the application effect of cluster nursing in preventing lower extremity deep vein thrombosis in operating room. Methods A total of 84 patients who received surgical treatment in the operating room of Huaian First People’s Hospital of Jiangsu Province from November 2019 to October 2020 were selected, and they were divided into experimental group and control group according to random number table method, with 42 cases in each group. The control group received routine nursing, on the basis of the control group, preoperative, intraoperative and postoperative nursing were performed in the experimental group by the bundle nursing group of deep vein thrombosis in the lower extremity. The incidence of deep vein thrombosis in lower extremity, various coagulation related indexes and lower extremity pain were evaluated one week after operation. Results After intervention, the incidence of thrombosis in the experimental group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). After intervention, the coagulation function indexes of the control group were compared with those before intervention, and the differences were not statistically significant (P ＞ 0.05). Plasma D-dimer in experimental group was lower than that befor intervention, and the experimental group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). Lower limb pain in experimental group was significantly better than that in control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of cluster nursing in the prevention of lower extremity deep vein thrombosis in operating room has remarkable effect and high clinical value.
		2021 Vol. 18 (36): 146-149 [Abstract] ( 145 ) HTML (1 KB) PDF (625 KB) ( 47 )

	150	Effect of individualized extended health management on postoperative rehabilitation of elderly patients with degenerative knee arthritis#br#
		XU Fuli1 GAO Liyun1▲ GU Yanling1 ZHOU Ying1 CAO Lumei2 WU Zhongling1 QU Yuanyuan1
		Objective To investigate the application effect of individualized extended health management on elderly patients with degenerative knee arthritis (DKA) after discharge from hospital. Methods A total of 108 cases of elderly patients with DKA admitted to Nantong Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were enrolled and divided into corventional group (54 cases, implemented routine health management measures after discharge) and study group (54 cases, implemented individualized extended health management measures after discharge) by random number table method, self-management behavior score, the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index scale and quality of life were compared after three months of management. Results Three months after discharge, the self-management behavior score of the study group was higher than that at discharge, and the study group was higher than that of the conventional group, and the differences were statistically significant (P ＜ 0.05). The WOMAC scores in both groups were lower than those at discharge, and the study group was lower than the conventional group, and the differences were statistically significant (P ＜ 0.05). Quality of life score and total score of both groups were higher than those at discharge, and study group was higher than conventional group, and the differences were statistically significant (P ＜ 0.05). Conclusion Individualized extended health management can improve the self-management behavior habits of elderly DKA patients, improve the degree of knee pain, stiffness, and dysfunction, and enhance the quality of life after discharging.
		2021 Vol. 18 (36): 150-153 [Abstract] ( 185 ) HTML (1 KB) PDF (625 KB) ( 75 )

	154	Improvement effect of task-oriented functional training on limb function in stroke patients with hemiplegia#br#
		SANG Ni1 ZHANG Xuan2 ZHU Ling1 MENG Qin3▲
		Objective To investigate the effect of task-oriented functional training on limb function improvement in stroke patients with hemiplegia. Methods A total of 300 stroke patients with hemiplegia admitted to the Department of Geriatric Neurology, Jiangsu Provincial People’s Hospital from November 2017 to November 2020 were selected, according to different nursing methods, the patients were divided into control group and experimental group, with 150 cases in each group. Routine functional training was used in the control group, task-oriented functional training was used in the experimental group, tinetti gait analysis (TGA) and functional ambulation category scale (FAC) were used to assess the improvement of limb function, the self-care ability of patients in daily life was evaluated by the self-care ability scale. Results The training efficiency of experimental group was higher than that of control group, and the difference was statistically significant (P ＜ 0.05); after nursing, TGA and FAC scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The daily self-care ability in experimental group was better than that in control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Task-oriented functional training can improve the training effect of stroke patients with hemiplegia, accelerate the recovery of limb motor function of stroke patients, and improve the daily self-care ability of stroke patients with hemiplegia.
		2021 Vol. 18 (36): 154-157 [Abstract] ( 169 ) HTML (1 KB) PDF (622 KB) ( 62 )

	158	Study on correlation among attitude towards the influencing factors of nurse-patient relationship and communication satisfaction of nursing intern students#br#
		CAO Hong1 CHEN-ZHUO Yuanyuan2 DEN Deqin1 HAN Xingping1 ZHENG Silin3 XIAO Yingqi4▲
		Objective To investigate the cognitive status, communication satisfaction status and their correlation of factors affecting nurse-patient relationship among nursing students in clinical practice, and to provide reference for nursing education and training reform. Methods From January to December 2019, 517 practicing nursing students in Luzhou Grade three general hospital were surveyed by convenience sampling method using the questionnaire of nurses’ recognition of factors affecting nurse-patient relationship and interpersonal communication satisfaction scale. Results The overall cognition of nursing students on factors affecting the nurse-patient relationship was (4.48±0.38) points. The total communication satisfaction of nursing students was (3.35±0.39) points. The total cognitive score of nursing students on factors affecting nurse-patient relationship was positively correlated with communication satisfaction (P ＜ 0.01), the communication satisfaction of nursing students was positively correlated with nurse dimension and patient dimension of factors affecting nurse-patient relationship (P ＜ 0.05). Conclusion With the increase of cognitive score of factors affecting nurse-patient relationship, the communication satisfaction score of nursing students was higher. It is necessary to explore the education and training of nurse-patient relationship, nurse-patient communication, humanistic cultivation and organizational culture of nursing students, strengthen their cognition of factors affecting nurse-patient relationship and improve their interpersonal communication ability.
		2021 Vol. 18 (36): 158-161 [Abstract] ( 112 ) HTML (1 KB) PDF (625 KB) ( 110 )

	162	A case of subcutaneous panniculitis-like T-Cell lymphoma#br#
		MEI Aihua1 LIU Han1 LIU Jinsong1 ZHU Hong1 WU Lun2 DONG Yaqi1
		Subcutaneous panniculitis like T-cell lymphoma is a rare cutaneous malignant lymphoma. In order to improve the understanding of subcutaneous panniculitis like T-lymphoma, a case of subcutaneous panniculitis like T-cell lymphoma was analyzed and the literatures were reviewed in this paper. Combined with the clinicopathological features and immunohistochemical results, to explore the clinical characteristics and treatment, the results showed that subcutaneous panniculitis like T-cell lymphoma had strong invasiveness, rapid disease progression, dangerous natural course and poor prognosis.
		2021 Vol. 18 (36): 162-164,173 [Abstract] ( 117 ) HTML (1 KB) PDF (981 KB) ( 75 )

	165	Status of stroke home-based rehabilitation in developed countries and its enlightenment to China#br#
		JI Longfei1 DENG Wenjie1 HUANG Quyun2 LIU Guojun2 HUANG Qingxiu2 ZHANG Lifang1▲
		Stroke home-based rehabilitation refers to the disability services which served by medical or third-party institutions in the patients’ family. With starting earlier, it has been perfect in hospital continuing services, home health care institutions and case management in developed countries. China has urgent demand but low degree of implementation, shortage of human resources, and imperfect medical insurance policy. By referring to the experience of developed countries, China could gradually transfer continuing services to patients’ families with the transition of community, increase medical insurance payment, and standardize case management. This paper analyzes the current situation of home-based rehabilitation of stroke in developed countries and its enlightenment to China, as well as the current situation and deficiencies in China and aimed to provide reference in the field of home-based stroke rehabilitation for the improvement in China.
		2021 Vol. 18 (36): 165-168，182 [Abstract] ( 185 ) HTML (1 KB) PDF (743 KB) ( 116 )

	169	Research on the current situation and countermeasures of the Party construction work for postgraduates of clinical medicine degree in the new era#br#
		CAO Zhuolin1,2 LIU Renjing2 LIU Ning3
		As an important part of the Party construction, the Party construction of medical postgraduates plays an important role in the new journey of socialist construction and the reform of medical and health undertakings in China. Article expounds the strengthening the Party construction work of medical students for realizing the needs of national development, strengthening the position of education in colleges and universities, and strengthening the personal ideal and faith, analyzing the existing problems in the Party construction of clinical medical master degree students, such as students’ weak ideology, unreasonable branch setting, unclear party member status and so on. Combined with the professional characteristics and training mode, the paper puts forward the Party construction strategy of strengthening the branch construction as the core, taking the counselors and tutors as the starting point, and constructing the co-management and co-education of the university and hospital, so as to lay a foundation for improving the quality of the Party construction work and the level of ideological and political education of medical students.
		2021 Vol. 18 (36): 169-173 [Abstract] ( 114 ) HTML (1 KB) PDF (673 KB) ( 139 )

	174	Development status and comparison of traditional medical education, legislation, and medical and health systems in China, Japan, and South Korea#br#
		SHI Xueqin AN Hong ZHAO Zhupei ZHU Tingyu LIU Meihan LIU Jianfeng
		The traditional medicine of China, Japan, and South Korea has a solid foundation and relatively good overall development, but each has its own characteristics in education, legislation, and medical and health systems. In education, China, Japan, and South Korea are paying more and more attention to traditional medicine, but China embodies the characteristics of “equal importance to both Chinese and Western medicine”; Japanese traditional medicine is a supplementary education based on Western medicine; South Korea focuses on the study of Kampo medicine to construct an education and training system based on the core of traditional medicine. In terms of legislation, traditional medicine in China, Japan, and South Korea is recognized by official laws. China emphasizes “equal emphasis on Chinese and Western medicine” and supports the development of traditional medicine; Japan focuses on the laws of Chinese medicine, and South Korea continues to regulate traditional medicine. In the medical and health system, the traditional medicine of China, Japan, and South Korea has a high degree of participation, Chinese traditional medicine doctors have certain Western medicine prescription rights, and traditional medicine has the widest treatment population; South Korean doctors and Western medicine are seriously separated. However, the scope of diagnosis and treatment by Korean doctors is wide; Japan focuses on the participation of Kampo medicine. Comparing the development status of traditional medicine in China, Japan, and South Korea, we can learn from the advantages of the development of traditional medicine in Japan and South Korea to make up for the shortcomings in the development of traditional medicine in China, so as to better demonstrate the advantages of traditional medicine in China and improve its service capabilities.
		2021 Vol. 18 (36): 174-177,188 [Abstract] ( 97 ) HTML (1 KB) PDF (685 KB) ( 105 )

	178	Discussion on “1239” mode of traditional Chinese medicine intervention strategy based on social psychological service demand#br#
		WU Shengwei XU Yan ZOU Chubing XIAO Aixiang DING Guoan YU Lin
		With the rapid development of social economy, the problem of people’s psychological disorder is gradually emerging. In order to deal with this situation, at the level of social governance, China puts forward a kind of social practice-social psychology service system with Chinese characteristics. At present, the theoretical and applied research of social psychological service in China is still in the primary stage, and lack of complete and applicable presentation of localization research results. As the treasure of Chinese civilization, traditional Chinese medicine has unique advantages in the prevention and treatment of mental and psychological problems, and it is necessary and feasible to actively explore the role in social psychosocial service. This is the first time for us to put forward the three-level service mode of “1239” mental diseases preventive treatment in social psychological service, which can prevent the occurrence and development of mental diseases from the level of integrated Chinese and Western medicine. This paper explores a social psychological service system suitable for the national conditions of China, and then improves the mental health quality of people, which provides a certain reference value for the construction of the social psychological service mode of integrated Chinese and Western medicine.
		2021 Vol. 18 (36): 178-182 [Abstract] ( 91 ) HTML (1 KB) PDF (820 KB) ( 54 )

	183	Research on the knowledge base construction of pneumonia with dyspneic cough of children#br#
		WAN Runzhi1 SUN Liping2 WANG Yanbo1 LI Yaxin3
		Traditional Chinese medicine pediatric textbooks, pediatric pneumonia related diagnosis, treatment guidelines, specifications, and expert consensus are regarded as the knowledge category, this paper uses the ontology construction tool Protégé to construct the classes and categories, the relationship between classes and categories, and the class instances of pneumonia with dyspneic cough of children, then complete the consistency test and realize the reasoning function of ontology. This paper uses the data-driven document base of Java programming language to realize the visualization of ontology knowledge base, construct the ontology knowledge base of pneumonia with dyspneic cough of children, realize knowledge search, knowledge sharing, and knowledge reasoning, lay the foundation for the construction of follow-up pediatric disease diagnosis and treatment knowledge base and simulate expert diagnosis and treatment system, as well as provide the reference to the learning of clinicians and clinical medical students.
		2021 Vol. 18 (36): 183-188 [Abstract] ( 89 ) HTML (1 KB) PDF (1758 KB) ( 54 )

	189	Characteristics of application of traditional Chinese medicine health science and technology projects in Hebei Province in the new period#br#
		LIU Yuhua YANG Zhenru ZHANG Xiuju ZHAO Xiaodong ZHAI Junxia
		Objective To analyze the characteristics of application of traditional Chinese medicine (TCM) health science and technology projects in Hebei Province in the new period. Methods The database of TCM project approval and novelty search projects completed by Medical Information Institute of Hebei Province from January 2017 to December 2020 was constructed by Excel 2013 software. The number of project approval and novelty search projects of TCM was obtained, the number of project approval and novelty search projects in private and military hospitals, in different levels of units, in different areas, in different discipline directions, and in different discipline specialties were counted. Results From 2017 to 2019, the project approval and novelty search projects of TCM showed an increasing trend year by year, while it had a certain decreased in 2020; the annual application proportion of novelty search applied by private hospitals was less than 10%, and applied by military hospitals was less than 3%; the annual application proportion of provincial and prefecture-level hospitals was about 30%, and about 20% of county-level hospitals applied for novelty search every year, the proportion of novelty search applied by other organizations was less in varying degrees; the annual application proportion of Shijiazhuang was more than 54%, except for Xiong’an New Area (which did not apply for new inspections in 2017 and 2018), other regions had applied for different numbers of novelty search, while the application proportion of novelty search applied for Xiong’an New Area had increased in 2019 and 2020; the novelty search proportion in TCM was more than 50% every year, while the proportion of novelty search in Chinese materia medica, and integrated traditional Chinese and Western medicine was increasing year by year; each year, the proportion of novelty search in disease treatment was the most, more than 50%, secondly, the novelty search of rehabilitation medicine, disease prevention was less than that of rehabilitation medicine, and the novelty search of other disciplines decreased to varying degrees. Conclusion In the new period, the number of application projects of TCM declared in this province has increased significantly, the discipline direction is reasonable, the organization distribution and area distribution are imbalance, but they all show the trends of mitigation, the discipline distribution is uneven, focus on disease treatment, and the role of disease prevention is not enhanced.
		2021 Vol. 18 (36): 189-192 [Abstract] ( 89 ) HTML (1 KB) PDF (667 KB) ( 106 )

	193	Practice and thinking of the integrated assessment of brain-neck vascular ultrasound to promote the construction of stroke center#br#
		YANG Jing1 SONG Linzi1 HUA Yang2▲
		The integrated assessment of brain-neck vascular ultrasound is an important method for early screening and diagnosis and treatment evaluation of high-risk population of stroke, and it is also one of the appropriate techniques for stroke prevention and treatment. The integrated assessment technology of brain-neck vascular ultrasound should be promoted vigorously, which expands the clinical application scope of carotid ultrasound and transcranial Doppler ultrasound, enhances their clinical application value, helps in-depth development of pre-hospital screening, in-hospital precision assessment, and post-hospital follow-up work for high-risk group, especially, escorts the clinical carotid artery stenosis and revascularization surgery for stroke patients, improves the quality of surgery and prognosis of patients, and promotes the construction of stroke centers.
		2021 Vol. 18 (36): 193-196 [Abstract] ( 150 ) HTML (1 KB) PDF (663 KB) ( 145 )

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