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| Research progress of miR-135a / FOXO1 / PINK1 regulatory axis in liver fibrosis and mitochondrial autophagy#br# |
| PANG Qiulin1 WANG Zhenchang2 |
1.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530000, China;
2.Department of Spleen, Stomach and Liver Diseases, Guangxi International Zhuang Medical Hospital, Guangxi Zhuang Autonomous Region, Nanning 530000, China |
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Abstract Hepatic fibrosis is a common pathological stage of all chronic liver diseases and a necessary process for the development of liver cirrhosis. Its causes are complex, lack of effective treatments, and its incidence is increasing year by year, it is a reversible damage-repair process. Therefore, how to block and reverse liver fibrosis is the key to treatment. Autophagy is closely related to liver fibrosis, and the role of mitochondrial autophagy in liver fibrosis has received increasing attention from many researchers. This article discusses the regulatory relationship between liver fibrosis and the miR-135a / FOXO1 / PINK1 regulatory axis of mitochondrial autophagy, and aims to provide scientific reference and new ideas for the treatment of liver fibrosis and the research of new anti-liver fibrosis drugs.
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