阻塞性睡眠呼吸暂停低通气综合征对老年2型糖尿病患者糖尿病肾病进程的影响

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Abstract Objective To investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on the progression of diabetic nephropathy in elderly type 2 diabetes mellitus (T2DM) patients. Methods A total of 145 T2DM patients admitted to Huaian First People’s Hospital Affiliated to Nanjing Medical University from February 2018 to March 2020 were selected as the study subjects. T2DM patients with nephropathy were statisticsed and they were divided into diabetic nephropathy group and simple diabetes group according to the status of T2DM patients with nephropathy. The clinical data of two groups were compared. The factors affecting the occurrence of T2DM nephropathy were analyzed by logistic multifactor regression. Results In this study, the incidence of diabetic nephropathy in 145 T2DM patients was 26.21%. The course of diabetes, standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursions, mean absolute value of daytime blood glucose (MODD), urinary albumin, serum creatinine (Scr), and apnea hypoventilation index (AHI) in diabetic nephropathy group were higher than those in simple diabetic group (P ＜ 0.05). The estimated glomerular filtration rate (eGFR) and night minimum pulse oxygen saturation (LSPO2) were lower than those in the simple diabetic group (P ＜ 0.05). Logistic multivariate analysis showed that MODD, eGFR, AHI, and LSPO2 were all influencing factors of diabetic nephropathy in elderly T2DM patients (OR = 1.992, 0.826, 4.204, 0.753, P ＜ 0.05). Conclusion SDBG, MODD, AHI and LSPO2 are all influencing factors affecting the occurrence of diabetic nephropathy in elderly patients with T2DM. OSAHS can promote the progress of diabetic nephropathy in elderly patients with T2DM.

Key words： Obstructive sleep apnea hypopnea syndrome Elderly Type 2 diabetes mellitus Diabetic nephropathy

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	TANG Shan ZHANG Ridong YUAN Qi MAO Li▲

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TANG Shan ZHANG Ridong YUAN Qi MAO Li▲. Effect of obstructive sleep apnea hypopnea syndrome on the course of diabetic nephropathy in elderly type 2 diabetic patients#br#[J]. 中国医药导报, 2021, 18(36): 77-80.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I36/77

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