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2021 Vol. 18, No. 4
Published: 2021-02-05
 
 
4 Data mining and bioinformatics analysis of expression profile chip for embryonic and mature mice liver
LYU Xing1 YANG Shuhong2
Objective To depth analysis of liver differential expression genes in embryonic and mature mice. Methods Download gene expression profile data numbered GSE65063 from the National Center for Biotechnology Information (NCBI) GEO database, microchips were extracted at 14 embryonic days and 56 postnatal days. Online analysis tool GEO2R was used to complete differentially expressed genes (DEGs) screening. DAVID was used to analyze the gene ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway enrichment of DEGs, STRING was used to analyze the interaction between proteins encoded by DEGs, visualization with Cytoscape software. MCODE loaded in Cytoscape software was used to build functional modules, CytoHubba was used to screen the hub genes and analyze them to construct PPI network map. Results A total of 2969 DEGs were screened in mature liver compared with embryonic liver, of which 1620 were up-regulated and 1349 were down-regulated. Upregulated DEGs were mainly concentrated in metabolism-related biological processes, organelle components and metabolic pathways, while down-regulated DEGs were mainly concentrated in cell cycle, DNA repair and other cell proliferation-related organelles, biological processes and signaling pathways. Modular analysis showed that the top gene modules were all down-regulated genes, which were mainly enriched in signaling pathways related to cell cycle and cell senescence. Module two was mainly related to complement system, cholesterol metabolism and PARP signaling pathway. Module third was mainly related to retinol metabolism steroid and somatic hormone synthesis. A total of 16 hub genes were screened out, among which 14 were down-regulated and two were up-regulated. Conclusion There are significant differences in gene expression profiles between matare and embryonic liver maturation and embryonic stage. Liver development and maturation are regulated by specific gene groups in different time and space. Metabolism-related genes are dominant in mature liver, while cell proliferation and division related genes are mainly concentrated in embryonic liver. The screened hub genes, especially the down-regulated genes, may be used as early diagnostic and prognostic indicators for liver abnormalities such as liver cancer, which is of great clinical significance.
2021 Vol. 18 (4): 4-8,28 [Abstract] ( 219 ) HTML (1 KB)  PDF (1349 KB)  ( 57 )
9 Effects of Selenium-enriched Danggui Yinyanghuo Recipe on SOD, MDA and serum sex hormone in rat testis
LI Jintao1 LI Shijun2 SONG Zhangxin2 XIANG Kui2 ZHAO Hua2 CUI Yingdong2 TIAN Zhaohui3
Objective To study the effects of different doses of Selenium-enriched Danggui Yinyanghuo Recipe on superoxide dismutase (SOD), malondialdehyde (MDA) and serum sex hormones (follicle stimulating hormone [FSH], luteinizing hormone [LH] and testosterone [T]) in rats testis. Methods Ten male SD rats were randomly selected as the normal group (gavage physiological saline), and the remaining rats were divided into four groups according to random number table method: model control group (gavage adenine), Selenium-enriched Danggui Yinyanghuo Recipe high dose group (gavage adenine + 15 days later, gavage 20.92 g/[kg·d] selenium-enriched traditional Chinese medicine), middle dose group (gavage adenine + 15 days later, gavage 10.46 g/[kg·d] selenium-enriched traditional Chinese medicine), low dose group (gavage adenine + 15 days later, gavage 5.23 g/[kg·d] selenium-enriched traditional Chinese medicine). The experiment lasted for 45 days with 12 rats in each group. The general state, SOD and MDA of testis, serum sex hormone and testicular morphology of rats were detected and compared in each group. Results Observation of general state: from the fourth day of modeling, the model control group and the Selenium-enriched Danggui Yinyanghuo Recipe groups showed clinical manifestations of reduced diet, decreased body weight and increased urine volume. After the implementation of drug intervention, the diet and body weight of the low, medium and high dose groups of Selenium-enriched Danggui Yinyanghuo Recipe gradually increased, and the urine volume and other clinical manifestations gradually tended to be normal. Compared with normal group, SOD decreased and MDA increased in testicular homogenate of model control group, with high statistical significance (all P < 0.01). Compared with the model control group, SOD in the Selenium-enriched Danggui Yinyanghuo Recipe high dose and medium dose groups increased to varying degrees, with high statistical significance (all P < 0.01). However, there was no significant difference between Selenium-enriched Danggui Yinyanghuo Recipe low dose group and model control group (P ＞ 0.05). Compared with the model control group, MDA in the high, medium and low dose groups of Selenium-enriched Danggui Yinyanghuo Recipe was decreased to different degrees, with high statistical significance (all P ＜ 0.01). Compared with normal group, serum FSH and LH were increased in model control group, while serum T was decreased, with high statistical significance (all P ＜ 0.01). Compared with model control group, serum FSH and LH were decreased and serum T was increased in the high and medium dose groups of Selenium-enriched Danggui Yinyanghuo Recipe, with high statistical significance (all P ＜ 0.01). Histopathology of testis showed obvious testicular injury in model control group, and improvement in low, medium and high dose groups of Selenium-enriched Danggui Yinyanghuo Recipe. Conclusion Selenium-enriched Danggui Yinyanghuo Recipe can improve the levels of SOD, MDA and serum sex hormones in the testis of rats after adenine modeling, and has a certain therapeutic effect on the testis injury caused by adenine.
2021 Vol. 18 (4): 9-13,32 [Abstract] ( 195 ) HTML (1 KB)  PDF (929 KB)  ( 29 )
14 Predictive value of bovine corneal opacification and permeability test in combination with histopathology in eye irritation of cosmetic products
XIE Zhen CHEN Shuhuai LIU Lu HE Licheng ZHU Shemin KUANG Rong
Objective To establish a method for evaluating cosmetic eye irritation with bovine corneal opacity and permeability (BCOP) combined with corneal epithelial histological score. Methods BCOP method was used for nine commercial body wash and dye hair cosmetics eye irritation test, at the same time to make HE dyeing from corneal histology slice, the histopathological changes of the cornea and histopathological changes of epithelial score (H) were observed, on the basis of the BCOP test results, corneal epithelium histological grading and Draize test results, prediction model was established. Results The non-irritating substance was that IVIS≤3 and H=0; the slightly irritating substance was that IVIS≤6 and H≤1; and the light irritating substance was that 6<IVIS< 25, and the corneal stroma and endothelium were not abnormal. Conclusion BCOP method combined with histopathological assessment of corneal epithelial injury can improve its predictability and is suitable for the evaluation of cosmetic eye irritation.
2021 Vol. 18 (4): 14-17 [Abstract] ( 94 ) HTML (1 KB)  PDF (770 KB)  ( 44 )
18 Study on screening medicine pair ratio and semi-bionic extraction technology of Jujube Kernel-Schisandra
RAN Jianxin1 HU Denghui2 WANG Xiaojie3
Objective To screen the optimal ratio of Jujube Kernel-Schisandra rnedcine pair on sedative and hypnotic effect, and the semi-bionic extraction technology of the ratio of the drug pair was optimized. Methods Fifty mice were randomly divided into blank group, positive drug group, Jujube Kernel-Schisandra (15 g∶6 g group, 12 g∶6 g group and 6 g∶6 g group), each group was 10 mice. The blank group was given distilled water and the positive drug group was given 0.13% Estazol Lun water solution, while the drug administration group was given suspension with corresponding ratio. Mice were induced to sleep by intraperitoneal injection of different doses of Sodium Pentobarbital, and the sleep status, sleep latency and sleep duration of mice in each group were recorded. The content changes of γ-aminobutyric acid (GABA), glutamate(Glu), glutamine(Gln), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brain tissue fluid of mice in each group were determined to screen the optimal ratio; the comprehensive scores of GABA and 5-HT were uesd as the response values, the best technology for screening semi-bionic extraction by Box-Behnken response surface method. Results Compared with blank group, sleep latency and sleep duration of mice in positive drug group, 15 g:6 g group and 6 g:6 g group were significantly shortened and prolonged (P < 0.05 or P < 0.01). Compared with positive drug group, sleep latency of 12 g:6 g group was significantly prolonged (P < 0.05); Compared with 15 g:6 g group, sleep latency in 12 g:6 g group was significantly prolonged (P < 0.05). Compared with blank group, the contents of GABA in brain of mice in positive drug group and 15 g:6 g group were increased and Glu and Gln in positive drug group and 15 g:6 g group were decreased (P < 0.05 or P < 0.01). Compared with positive drug group, the contents of GABA in 12 g:6 g group and 6 g:6 g group were decreased, while Glu and Gln contents were increased (P < 0.05). Compared with 15 g:6 g group, the contents of GABA in 12 g:6 g group were decreased, while the contents of Gln in 6 g:6 g group were increased (P < 0.05). Compared with blank group, the contents of 5-HT in positive drug group, 15 g:6 g group, 12 g:6 g group and 6 g:6 g group were increased (P < 0.05 or P < 0.01). Compared with positive drug group, the contents of 5-HT in 12 g:6 g group were decreased (P < 0.05). Compared with 15 g:6 g group, the contents of 5-HT in 12 g:6 g group were decreased (P < 0.05). Compared with blank group, the contents of 5-HIAA in positive drug group were decreased (P < 0.05). Compared with positive drug group, the contents of 5-HIAA in 15 g:6 g group, 12 g:6 g group and 6 g:6 g group were increased (P < 0.05 or P < 0.01). The optimal technology of semi-bionic extraction was that the amount of artificial gastric juice was 9.5 times and the time was 2.5 h for the first time. The dosage of artificial intestinal fluid was 6.0 times and the time was 3.6 h for the second time. Conclusion The optimum ratio of 15 g:6 g (corresponding to the daily dose of human body) for sedative and hypnotic effect of Jujube Kernel-Schisandra is obtained. The semi-bionic extraction technology is reliable and operable under the optimal ratio condition.
2021 Vol. 18 (4): 18-23 [Abstract] ( 116 ) HTML (1 KB)  PDF (957 KB)  ( 55 )
24 Correlation analysis of bacterial diversity and pathological characteristics of patients with Barrett’s esophagus
KALARE·Ahemati HE Xiaolei HALIDA·Xiaerfuhazi ZHANG Zhiqiang GAO Hongliang
Objective To analyze the correlation between the bacterial diversity and pathological characteristics of patients with Barrett’s esophagus (BE). Methods A total of 141 BE patients who were diagnosed and treated in the Department of Gastroenterology the First Affiliated Hospital of Xinjiang Medical University from January 2016 to December 2019 were included in the study (BE group), and a total of 138 persons with normal physical examination during the same period were selected as control. The differences in esophageal flora composition between the two groups were compared. According to the pathological examination results of BE, patients were divided into cardia gland type (53 cases), fundus gland type (59 cases) and special intestinal metaplasia type (29 cases). The clinical data such as age and gender, and flora diversity of patients with different types were compared. Spearman model was used to analyze the correlation between patients’ dysplasia and flora diversity. Results The abundances of Streptococcus, Fusobacterium, Haemophilus, and Staphylococcus in the BE group were lower than those in the control group (P < 0.05); while in the BE group, the abundance of Campylobacter, Veronococcus and Pasteurella, the abundance of Bacillus, Prevotella and Neisseria were higher than those of the control group (P ＜ 0.05). Comparison of the degree of dysplasia in patients with different types, and the differences was statistically significant (P ＜ 0.05). There were no statistically significant differences in age, gender and columnar epithelium length of patients with different types (P ＞ 0.05). The Chao1, Ace, and Shannon indexes of severe group were significantly higher than those of mild and moderate group, and the differences were statistically significant (P ＜ 0.05), while those in moderate group were higher than those in mild group (P ＜ 0.05); the Simpson index in severe group was significantly lower than that of mild and moderate group, while moderate group was lower than mild group, and the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that Chao1, Ace and Shannon indexes were positively correlated with the degree of dysplasia in patients (r = 0.622, 0.593, 0.588, P ＜ 0.05), while the Simpson index was negatively correlated with the degree of dysplasia in patients (r = -0.582, P ＜ 0.01). Conclusion The esophageal flora of patients with BE esophagus changes, and the diversity of the flora is related to the pathological characteristics of patients with BE esophagus, which may be related to the poor prognosis of patients.
2021 Vol. 18 (4): 24-28 [Abstract] ( 256 ) HTML (1 KB)  PDF (889 KB)  ( 41 )
29 Predictive value of serum miR-10a and IL-33 levels in patients with severe acute pancreatitis complicated with acute kidney injury
HUANG Xian ZHANG Lijuan WANG Ping
Objective To analyze the predictive value of serum microRNA-10a (miR-10a) and interleukin-33 (IL-33) levels in patients with severe acute pancreatitis (SAP) complicated by acute kidney injury (AKI). Methods A total of 163 SAP patients from January 2016 to December 2019 in Chengdu Fifth People’s Hospital Affiliated to Chengdu University of Traditional Chinese Medicine were selected and divided into AKI group (48 cases) and non AKI group (115 cases) according to whether AKI was complicated. The serum miR-10a, IL-33 and general clinical data between the two groups were compared. The influencing factors of AKI in SAP patients were discussed, and the predictive value of miR-10a and IL-33 on AKI in SAP patients were analyzed. Results The serum levels of miR-10a, IL-33, Ranson score, high-sensitivity C-reactive protein (hs-CRP), procalcitonin, and neutrophil gelatinase-associated lipocalin in the AKI group were significantly higher than those in the non-AKI group, and the differences were statistically significant (P ＜ 0.05). Logistic multivariate regression analysis showed that miR-10a (OR = 1.764), IL-33 (OR = 1.863), Ranson score (OR = 1.631), hs-CRP (OR = 1.547) were all risk factors for SAP patients with AKI (P ＜ 0.05). The area under the ROC curve (AUC) predicted by miR-10a and IL-33 for SAP patients with AKI were 0.828 and 0.807, respectively. The combined predicted AUC of the two was 0.893, which was higher than miR-10a and IL-33, and the differences were statistically significant. (P ＜ 0.05). Conclusion Serum levels of miR-10a and IL-33 are significantly increased in SAP patients with AKI, and they have good predictive value for AKI. Combined detection can provide help for the early identification of AKI.
2021 Vol. 18 (4): 29-32 [Abstract] ( 254 ) HTML (1 KB)  PDF (706 KB)  ( 62 )
33 Research progress on the function of lysine-specific demethylase 1
QIN Xuke1 WU Yingguang2 ZHONG Guangqing2 GUO Ji2 WANG Lei1 DU Yang1 CHEN Zhiyuan1 LIU Xiuheng1
Histone lysine-specific demethylase 1 （LSD1） can catalyze the demethylation of mono-or di-methyl-lysine 4 or 9 of histone H3 for regulating gene expression. Through its demethylation function, LSD1 is involved in a variety of cellular activities in human body, such as cell proliferation, epithelial-mesenchymal transition, autophagy, etc. More and more studies have shown that its abnormal expression is associated with the occurrence, development and poor prognosis of a variety of cancers and other diseases, and LSD1 is a key regulatory factor. As a result, a number of drugs targeting LSD1 are being studied in clinical trials. Howerer, most of these inhibitors are based on blocking their demethylase activity. Recent studies show that LSD1 is also involved in a series of protein-protein interactions that are independent of its demethylation function. This greatly expands the scope of its biological function and provides new strategies and directions for the design of LSD1 inhibitors. Based on the current literatures, this paper summarize the research progress of function of LSD1 and discuss its application prospect.
2021 Vol. 18 (4): 33-36 [Abstract] ( 188 ) HTML (1 KB)  PDF (500 KB)  ( 40 )
37 Research progress on Drebrin in the development of dendritic spines and the formation of cognitive function
XIE Mei XU Ping
Drebrin is a cerebrum development regulation protein, mainly express in the cerebrum and concentrat in the dendritic spines of neurons, which plays a key role in most excitatory synapses. The structural of neuronal dendritic spines are driven by actin dynamics. Drebrin is an actin-binding protein that can interact with cellular actin to regulate its actin skeleton and participate in the formation of dendritic spines, synaptic plasticity changes, cell communication and other neuronal activities. The level of Drebrin drops significantly in some cognitive dysfunction diseases and shows cognitive dysfunction. This article intends to review and analyze the research progress of Drebrin in the development of dendritic spines and the formation of cognitive function.
2021 Vol. 18 (4): 37-40 [Abstract] ( 241 ) HTML (1 KB)  PDF (496 KB)  ( 84 )
41 Research progress of treatment of myocardial fibrosis based on TGF-β1/Smads pathway
FU Weiwu1 OUYANG Yarong1 HUANG Caiyi1 HUANG Jingwei1 WU Cong1 QIN Xiaojun1 WANG Qinggao2
Myocardial fibrosis is a pathological manifestation of heart tissue and structure destroyed by various diseases throughout the body, which can lead to heart failure. Therefore, inhibiting myocardial fibrosis is of great significance for improving heart structure and protecting heart function. Although there are many signal pathways that affect myocardial fibrosis, the transforming growth factor (TGF)-β1/Smads signaling pathway is a classic pathway that affects myocardial fibrosis. In recent years, various studies on its inhibition of myocardial fibrosis have been very extensive. This article combines the latest related documents published at home and abroad in recent years to explain the latest developments of TGF-β1/Smads signaling pathway in the treatment of myocardial fibrosis in Chinese and Western medicine, in order to provide new ideas and directions.
2021 Vol. 18 (4): 41-44 [Abstract] ( 391 ) HTML (1 KB)  PDF (496 KB)  ( 67 )
45 Progress in the diagnosis of sepsis in children
LIN Xiaofei1 GU Xiaohai1 YU Chunlin1 ZHU Hongli1 WU Yunduo1 ZHANG Jun1 WANG Yumei2
The early diagnosis and treatment of sepsis has always been the focus of pediatric critical illness. In recent years, the World Health Organization (WHO) bring forth the concept of “integrated intervention of prevention, diagnosis and clinical treatment”. A group of authoritative experts in the field of emergency treatment in China have also taken the lead in projecting the “prevention of sepsis campaign in China” (PSCC), but how to effectively coordinate and deal with relevant issues in clinical work, especially how to make early accurate diagnosis and take bundle strategy of intensive treatment for the later stage is still a hot issue that needs active attention. In this paper, some new reaearch and related progress of the diagnostic methods of children sepsis, such as biomarkers, multi-dimensional scoring methods, physiological parameters and variables of diagnostic significance, and the prediction system of mechanical sepsis are reviewed in order to provide reference for early diagnosis and accurate treatment of children sepsis in the future, and to offer assistance for clinicians.
2021 Vol. 18 (4): 45-48,60 [Abstract] ( 418 ) HTML (1 KB)  PDF (945 KB)  ( 35 )
49 Competency oriented teaching design of hospital practice course for undergraduates of traditional Chinese medicine
CHANG Xinnan1 XUN Peijun1 GU Chenchen1 SHEN Lan2 JIN Yong3 LIU Li1
Taking pharmacist’s post competency as the guidance, taking the social demand and the deficiency of existing hospital practice courses as the breakthrough point, the teaching contents and methods of hospital practice course for undergraduates of traditional Chinese medicine are adjusted and optimized. In order to improve the teaching depth of identification of Chinese herbal decoction pieces, the contents of identification of refined decoction pieces and specimen decoction pieces and pharmaceutical care practice are introduced. The teacher standardized patient teaching method and three-step teaching method are adopted to make students become the main body of learning, so as to cultivate students’ ability of pharmaceutical care, identification of Chinese herbal pieces and autonomous learning. This kind of teaching mode of hospital practice course is helpful to cultivate students’ post competency, lay the foundation for students to go to pharmacist’s post and realize their all-round development, which is worthy of further development and promotion.
2021 Vol. 18 (4): 49-52 [Abstract] ( 241 ) HTML (1 KB)  PDF (663 KB)  ( 57 )
53 Thoughts on the construction of the first-rate specialty of medical laboratory technology in provincial undergraduate colleges
ZHANG Hong DAI Min LIN Lin GUO Lijuan ZENG Xianchun ZHANG Qinglian▲
In the new era, under the background of “double first-class” and “double ten thousand plan”, Chengdu Medical College, as a provincial undergraduate college, is facing both opportunities and challenges in the construction of the first-rate specialty. Taking medical laboratory technology as an example, this paper puts forward the main measures for the construction of the first-rate specialty centering on the basic idea of the construction of first-rate specialty. First, it highlights its own advantages and explores the new mode of talent classification, subsection and level training to realize characteristic development. Second, the top-level design should be improved from the perspective of social needs, the curriculum system of “three platforms and six modules” should be built, the core courses of majors should be constructed, and the blended online+offline teaching should be implemented. Third, we should introduce and cultivate teachers at the same time, build a “double-qualified” teacher team, and build a first-class teaching team in the new era. Fourth, carry out the comprehensive reform of experimental teaching, construct the “three-stage” practical teaching system, hold the test of practical skills competition, and strengthen the construction of practical teaching platform. Fifth, we should deepen the integration of industry and education, promote school-enterprise cooperation, pay attention to applied research, and improve social service capacity.
2021 Vol. 18 (4): 53-56,80 [Abstract] ( 87 ) HTML (1 KB)  PDF (972 KB)  ( 37 )
57 Research and practice of open training system of Chinese medicine clinical skills based on media convergence technology
ZHAI Chunmei1 LIU Dezhu1 MU Jinglong1 LIU Yichang1 ZHAO Nan1 DI Jinlin1 SUI Bowen2
According to the advantages of training teaching at Clinical Skills Center of Heilongjiang University of Chinese Medicine, clinical training model centered on “media convergence + simulation training + assessment selection + clinical bedside practice” is established. When students enter clinical training, first, apply the theory of “internet+” in the clinical practice skills of multimedia courses such as Moore, micro class, etc., and make an appointment into clinical skills training room to conduct medical simulation and self-discipline training. Then after passing the examination, in order to strengthen the clinical practice skills of medical students, they are recommended to participate in clinical bedside practice after passing the examination by experts. This model can not only effectively promote the improvement of students’ skills, but also ensure the effect of clinical bedside practice, save the work intensity of clinicians, and enhance the clinical thinking ability of students, so as to improve the post competency of medical students.
2021 Vol. 18 (4): 57-60 [Abstract] ( 88 ) HTML (1 KB)  PDF (867 KB)  ( 87 )
61 Discussion on the teaching effect of “food toxicology” in traditional Chinese medicine colleges and universities based on recessive truancy
ZHANG Zhigang TIAN Minmin SHI Chuandao LIU Longzhu QI Baoning ZHOU Jing LI Juan
Objective To know the situation of recessive truancy in food hygiene and nutrition in Shaanxi University of Chinese Medicine (“our school” for short), and explore its influence on teaching effect of food toxicology. Methods Fifty undergraduates on May 6th 2016 of food hygiene and nutrition in our school were selected as research objects, the data of recessive truancy and teaching effect were collected, and its impact on teaching effect were analyzed. Results The incidence rate of recessive truancy was 87.76%, and there were no significant differences in the incidence rate of recessive truancy and the score of each factor among different genders, places of origin and college entrance examination volunteers (P > 0.05). There were no significant differences in grades and grade points between recessive truant students and non recessive truant students (P > 0.05). There was a significant negative correlation between learning environment and grade points (r = -0.343, P < 0.05), and learning habits and learning environment had the greatest effect on grade points. Conclusion Recessive truancy has a certain influence on teaching effect of “food toxicology”, especially on study habits and learning environment.
2021 Vol. 18 (4): 61-64 [Abstract] ( 203 ) HTML (1 KB)  PDF (833 KB)  ( 41 )
65 Application of creating problem situation teaching in clinical demonstration of Chinese medicine nursing technology
WANG Ye1 HE Min2 FU Wenyan1▲ LIN Yuxiao1 LIU Xiao1 ZHAO Yue1 CUI Xiaoqing1 AN Peng1
Objective To understand application effect of creating problem situation teaching in clinical demonstration of Chinese medicine nursing technology. Methods From June 2017 to February 2019, 74 nursing students of grade four in Xi’an Innovation College of Yan’an University internship in the Second Affiliated Hospital of Xi’an Jiaotong University were selected. Among them, 37 students in 2017 academic year served as control group, and 37 students in 2018 academic year served as observation group. Before the internship, traditional teaching was used in control group, and the creation of problem situation teaching was used in observation group. Six weeks of clinical practice of Chinese medicine nursing was started immediately after the end of teaching. The scores of Chinese medicine nursing technology theory and operation examination, critical thinking ability of two groups were compared. Results The scores of Chinese medicine nursing theory and operation, total score of critical thinking ability, and search for truth, open mind, analytical ability, systematic ability, curiosity and cognitive maturity scores in observation group were higher than those in control group (P < 0.05). Conclusion Application of problem scenario teaching in clinical teaching of Chinese medicine nursing technology can improve the theoretical knowledge and operation ability of nursing students, improve their critical thinking ability and teaching effect, which is worthy of promotion.
2021 Vol. 18 (4): 65-68 [Abstract] ( 213 ) HTML (1 KB)  PDF (728 KB)  ( 42 )
69 Current situation and thinking of teaching reform based on ideological and political theory education in nursing specialty
LI Yan QIAO Yuanjing WANG Jinfang
Specialized course is one of the major channel of ideological and political theory education. In order to train nursing students into practical nursing professionals with noble moral character and good professional quality, nursing educators must carry out ideological and political education throughout the whole educational process. This paper expounds the connotation of curriculum ideological and political education, the necessity of developing curriculum ideological and political education in nursing specialty, and introduces the current situation of curriculum ideological and political education in professional basic courses, clinical nursing courses, humanistic nursing courses and practice modules. This paper analyzes the existing problems and causes, and puts forward relevant suggestions, in order to provide practical basis and experience for the reform of ideological and political teaching of nursing courses.
2021 Vol. 18 (4): 69-72 [Abstract] ( 414 ) HTML (1 KB)  PDF (729 KB)  ( 34 )
73 Exploring a new mode of surgery teaching based on clinical practitioner qualification examination
LIU Zhan’ao PEI Yanqin WU Honghui LI Yonggang
Compared with internal medicine, surgery is more operable in practice, abstract and boring in content. At the same time, the obsolete teaching methods and boring methods, it is not easy to grasp the key points and difficulties of surgery for medical students in classroom learning, which leads to poor surgical teaching effect. In view of the shortcomings of the existing surgery teaching, the author reforms the teaching model of surgery based on the clinical practitioner qualification examination. Through innovative teaching methods and models, it not only stimulates the interest of medical students in learning surgery, but also cultivates the clinical thinking of surgery for medical students which plays an important guiding role in consolidating the foundation of surgery.
2021 Vol. 18 (4): 73-76 [Abstract] ( 135 ) HTML (1 KB)  PDF (663 KB)  ( 110 )
77 Study on english teaching model in Chinese medicine institutions from bilingual and bicultural perspective
LI Yanwei1 BAO Lei2
In the critical period of the great rejuvenation of the Chinese nation, Chinese medical workers practice the benevolent heart of doctors and carry forward the spirit of doctors, which provides a new perspective for humanistic literacy education in English teaching in medical institutions. This paper reviews bilingual and bicultural schema theory, analyzes the meaning and necessities of bilingual and bicultural ability cultivation in Chinese Medicine institutions, illustrates teaching strategies of bilingual and bicultural teaching in teaching objectives, methods, activities and evaluation system. The aim is to improve the language ability of medical students to communicate excellent traditional Chinese culture, to improve the sense of family and professional responsibility of medical students, and to enhance the effect and level of bilingual and bicultural teaching in English teaching.
2021 Vol. 18 (4): 77-80 [Abstract] ( 192 ) HTML (1 KB)  PDF (727 KB)  ( 51 )
81 Clinical comparison of colon polyps detection rate in different periods and population
MENG Tong1,2 CHEN Xing2
Objective To explore the detection rate and importance of colon polyps in high-risk population and general population undergoing colonoscopy at different periods. Methods The electronic colonoscopy reports of patients undergoing colonoscopy in the Endoscopy Center, Cancer Hospital Affiliated to Shanxi Medical University from January 2000 to December 2004 and from January 2014 to December 2019 were retrospectively analyzed, and the differences in the detection rate of colon polyps at different stages in terms of age and gender and the changes in the detection rate were analyzed. Results From January 2000 to December 2004, the detection rate of colon polyps in 13 238 high-risk population was 48.32%, and the detection rate of colon polyps in 8412 general population was 33.67%. From January 2014 to December 2019, the detection rate of colon polyps in 17 345 high-risk population was 62.30%, and the detection rate of colon polyps in 24 335 general population was 57.84%. There was a significant difference in the detection rate of colon polyps between the general population and the high-risk population in different periods (P ＜ 0.01). The detection rate of colon polyps in male subjects was 60.82%, and that in female subjects was 44.87%. The difference in the detection rate of colon polyps among different genders was highly statistically significant (P ＜ 0.01). In the general population and high-risk population, the detection rate of colon polyps in males was significantly higher than that in females at different periods, and the difference was highly statistically significant (P ＜ 0.01). From January 2000 to December 2004, and from January 2014 to December 2019, the detection rate of colon polyps in different populations and different age groups had high statistical significance (P < 0.01). From January 2014 to December 2019, there was a small difference in the detection rate between high-risk population and general population in the same age group. From January 2014 to December 2019, the detection rate of colon polyps in high-risk population and general population aged 40 to 45 years old was 52.94% and 48.93%, respectively. From January 2000 to December 2004, the detection rate of colon polyps in high risk population with > aged 55 to 60 was 49.44%. Conclusion The detection rate of colon polyps is now significantly higher. From January 2000 to December 2004, the detection rate of colon polyps in high-risk population was significantly higher than that in general population and from January 2014 to December 2019, the detection rate of colon polyps in high-risk population was close to that of the general population. Should cause extensive attention of the society, so it is necessary to take colonoscopy as one of the routine physical examination items and people over the age of 40 should have colonoscopy regularly.
2021 Vol. 18 (4): 81-84,89 [Abstract] ( 135 ) HTML (1 KB)  PDF (628 KB)  ( 47 )
85 Clinical effect of Qilin Pills combined with Dapoxetine Hydrochloride in treatment of premature ejaculation
HU Yue1 LI Weiwei2
Objective To investigate the clinical effect of Qilin Pills combined with Dapoxetine Hydrochloride in the treatment of premature ejaculation. Methods A total of 96 patients with premature ejaculation who were admitted to the Male Infertility Clinic of First Hospital of Qinhuangdao, Hebei Province from September 2018 to November 2019 were selected as the subjects. Using the random number table, starting from any one number, along the same direction to obtain one random number in each experimental unit, according to the remainder method, the premature ejaculation patients were divided into control group and experimental group, 48 cases in each group. The control group was given Dapoxetine Hydrochloride, 30 mg orally 1-3 h before each sexual intercourse. The experimental group was given Qilin Pills on the basis of control group, 6 g, 3 times a day. Both groups were treated for three months. Intravaginal ejaculatory latency time (IELT), premature ejaculation diagnostic tool (PEDT) score, and premature ejaculation profile (PEP) score were compared between the two groups before treatment, after treatment and at the end of follow-up. The recurrence rate after discontinuation and adverse drug reactions of patients during treatment were followed up. Results Overall analysis showed that there were statistically significant differences in IEDT and PEDT scores, ejaculation control ability, distress related to premature ejaculation among groups, time point comparison and interaction (all P ＜ 0.05). There were statistically significant differences in the effects of sexual satisfaction and premature ejaculation on partner relationship between groups and time points (all P ＜ 0.05), while there was no statistically significant difference in interaction (P ＞ 0.05). Comparison within the group: compared with before treatment, IELT value, ejaculation control ability and sexual satisfaction were increased after treatment and at the end of follow-up, while PEDT score, distress related to premature ejaculation and the impact of premature ejaculation on partner relationship were decreased in both groups, with statistical significance (all P ＜ 0.05). After treatment, IELT value, ejaculation control ability and sexual satisfaction of the two groups decreased, while PEDT score, distress related to premature ejaculation, and the influence of premature ejaculation on partner relationship increased at the end of follow-up, with statistical significance (all P ＜ 0.05). Comparison between groups: after treatment and at the end of follow-up, IELT value, ejaculation control ability and sexual satisfaction in the experimental group were higher than those in the control group, while the effects of PEDT score, distress related to premature ejaculation and premature ejaculation on partner relationship in the experimental group were lower than those in the control group, with statistical significance (all P ＜ 0.05). There was no significant difference in the total effective rate between the two groups (P ＞ 0.05), and the recurrence rate of the experimental group was lower than that of the control group, with statistical significance (P ＜ 0.05). There was no statistical significance in the incidence of adverse drug reactions between the two groups (P ＞ 0.05). Conclusion The efficacy of Qilin Pills combined with Dapoxetine Hydrochloride in the treatment of premature ejaculation was significantly better than that of Dapoxetine Hydrochloride alone. And it can effectively reduce the recurrence rate of premature ejaculation after Dapoxetine Hydrochloride withdrawal.
2021 Vol. 18 (4): 85-89 [Abstract] ( 607 ) HTML (1 KB)  PDF (590 KB)  ( 50 )
90 Effect of Budesonide Suspension combined with Ipratropium Bromide in COPD patients and its influence on lung function
ZHANG Lei1 LI Weili2 WANG Chun3▲
Objective To investigate the effect of Budesonide Suspension combined with Ipratropium Bromide in patients with chronic obstructive pulmonary disease (COPD) and its effect on lung function. Methods A total of 100 COPD patients admitted to the Fourth Affiliated Hospital of Anhui Medical University from January to December 2019 were selected and divided into observation group and control group according to random number table method, with 50 patients in each group. The control group was treated with Budesonide Suspension, and the observation group was treated with Budesonide Suspension combined with Ipratropium Bromide for 10 days. The lung function (forced expiratory volume in the first second [FEV1], forced vital capacity [FVC], FEV1/FVC), inflammatory factors (tumor necrosis factor-α [TNF-α], hypersensitivity C-reactive protein [hs-CRP]) were compared between the two groups before treatment and 10 days after treatment, and the changes of signs, remission time of clinical symptoms, length of hospital stay and the incidence of adverse reactions were recorded. Results The length of hospital stay, disappearance time of shortness of breath and dyspnea, disappearance time of lung signs, disappearance time of asthma and relief time of cough in the observation group were significantly shorter than those in the control group, with statistical significance (all P ＜ 0.05). After treatment, the levels of FEV1, FVC and FEV1/FVC of lung function in the observation group were higher than those in the control group, while the levels of TNF-α and hs-CRP in the observation group were lower than those in the control group, with statistical significance (all P ＜ 0.05). Conclusion The combination of drugs has significant therapeutic effect and high safety for COPD patients.
2021 Vol. 18 (4): 90-93 [Abstract] ( 296 ) HTML (1 KB)  PDF (579 KB)  ( 70 )
94 Changes of serum IL-35, IL-17 and TGF-β1 levels in patients with chronic spontaneous urticaria and their clinical significance
QIN Kaiwei TAO Yanxia WANG Jiarui
Objective To investigate the changes and clinical significance of serum levels of interleukin (IL)-35, IL-17 and transforming growth factor β1 ( TGF- β1) levels in patients with chronic spontaneous urticaria (CSU). Methods A total of 350 CSU patients admitted to the People’s Hospital of Kaizhou District of Chongqing (hereinafter referred to as “our hospital”) from January 2016 to January 2019 were selected as the case group. According to urticaria activity score (UAS), they were divided into 142 cases in mild group, 124 cases in moderate group, 84 cases in severe group, and 60 healthy subjects in our hospital were selected as the control group. Serum levels of IL-35, IL-17 and TGF-β1 were detected, and their relationship with UAS score was analyzed. Results The serum level of IL-35 in the case group was significantly lower than that in the control group, and the levels of IL-17 and TGF-β1 were significantly higher than those in the control group, with statistical significances (all P < 0.05). The serum level of IL-35 in severe group was lower than that in moderate group and mild group, and that in moderate group was lower than that in mild group, with statistical significances (all P < 0.05). The serum levels of IL-17 and TGF-β1 in severe group were higher than those in moderate group and mild group, and that in moderate group were higher than those in mild group, with statistical significances (all P < 0.05). Pearson correlation analysis results showed that serum IL-35 was negatively correlated with UAS (r = -0.687，P = 0.029), and serum IL-17 and TGF-β1 levels were positively correlated with UAS (r = 0.684, 0.709; P = 0.028, 0.022). Conclusion The serum IL-35 level of CSU patients is negatively correlated with the severity of the patient’s condition, and the levels of IL-17 and TGF-β1 are positively correlated with the severity of the patient’s condition. The detection of serum levels of IL-35, IL-17 and TGF-β1 in patients with CSU can evaluate the severity of the patient’s condition, which is helpful for clinical diagnosis and treatment.
2021 Vol. 18 (4): 94-97 [Abstract] ( 239 ) HTML (1 KB)  PDF (581 KB)  ( 22 )
98 Dose-response relationship between ratio of triglyceride to high-density lipoprotein cholesterol based on body mass index classification and risk of nonalcoholic fatty liver disease
KANG Xiaoping1* HE Jian’gen2* GUO Xiuhua3 WU Liang2 ZHANG Xuesong1
Objective To explore the dose-response relationship between the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) and the risk of nonalcoholic fatty liver disease (NAFLD) in non-overweight and overweight people. Methods A total of 6495 physical examination subjects who participated in the Beijing Health Management Cohort (Beijing Xiaotangshan Hospital, Beijing Physical Examination Center, etc.) from January 2012 to December 2016 were selected as the research subjects. According to their body mass index, they were divided into non-overweight population (4473 people) and overweight population (2022 people). The influence of TG/HDL-C on the incidence of NAFLD in different population was analyzed. Results The incidence of NAFLD was 18.37%, including 10.08% in non-overweight population and 36.70% in overweight population. After adjusting for confounding factors, TG/HDL-C was statistically associated with the risk of NAFLD among different populations (OR = 1.84, 95%CI: 1.64-2.06). Restricted cubic spline analysis showed that there was a linear dose-response relationship between the TG/HDL-C ratio and the risk of NAFLD (linear test, P < 0.0001). Moreover, in non-overweight population, when TG/HDL-C ratio ＜ 1 might also increase the risk of NAFLD. Conclusion TG/HDL-C ratio has a great influence on NAFLD, and the change of TG/HDL-C ratio should be monitored.
2021 Vol. 18 (4): 98-102 [Abstract] ( 160 ) HTML (1 KB)  PDF (779 KB)  ( 55 )
103 Analysis of influencing factors of postoperative effect after low-temperature plasma ablation
GUO Yu’na1 LI Xiaolin2 LIU Jingjie1 DOU Zhi1 YANG Liqiang1 PANG Haitao2▲
Objective To analyze the influencing factors of low-temperature plasma ablation in the treatment of postoperative herpes zoster neuralgia (PHN). Methods A total of 150 PHN patients admitted to the Department of Pain, Xuanwu Hospital of Capital Medical University from January 2016 to December 2018 were selected as the research objects, according to the postoperative effect, the patients were divided into test group (excellent postoperative effect, 102 cases) and control group (postoperative poor effect, 48 cases). All patients underwent low-temperature plasma ablation. The age, gender, preoperative visual analogue scale (VAS), course of disease, body mass index, smoking, hyperalgesia, diabetes, hypertension, prodromal symptoms, pain location were listed as independent variables, and a logistic regression model was established to screen out statistics and to learn the meaning of variables. Results There were statistically significant differences between the two groups in age, course of disease, preoperative VAS, hyperalgesia, and history of diabetes (P ＜ 0.05). Age (OR = 2.675, 95%CI: 2.296-4.992), preoperative VAS ≥ 7 points (OR = 1.112, 95%CI: 1.101-1.253), course of disease ≥ 1 year (OR = 2.201, 95%CI: 1.342-2.223), combined hyperalgesia (OR = 1.984, 95%CI: 1.426-2.376) and history of diabetes (OR = 2.569, 95%CI: 1.673-3.721) were risk factors of postoperative effect of PHN (P ＜ 0.05). Conclusion During the treatment process, it is necessary to focus on the elderly with diabetes, patients with long course of disease, preoperative hyperalgesia, and high VAS.
2021 Vol. 18 (4): 103-106 [Abstract] ( 322 ) HTML (1 KB)  PDF (426 KB)  ( 20 )
107 Application of anesthesia management in lumbar spine surgery under the concept of enhanced recovery after surgery
QIAO Liyan HAO Zhanyuan ZUO Ling
Objective To explore the clinical effects of anesthesia management under the guidance of the concept of enhanced recovery after surgery (ERAS) on patients undergoing lumbar surgery. Methods A total of 80 patients with lumbar degenerative disease who underwent posterior lumbar decompression, bone grafting, fusion and internal fixation from March to August 2019 in Jizhong Energy Xingtai Mining Group General Hospital were selected and divided into control group and ERAS group according to the random number table method, with 40 cases in each group. The control group was adopted conventional anesthesia management, and the ERAS group was adopted the ERAS concept of anesthesia management. The intraoperative vital signs of the two groups were compared, including mean arterial pressure (MAP), heart rate (HR), postoperative wake-up time, orientation recovery time and extubation time, intraoperative opioid dosage, and postoperative adverse reactions (chills, nausea and vomiting), visual analogue scale (VAS) at different time points after surgery, and the length of hospital stay. Results The comparison of MAP and HR group, time and interaction between the two groups were statistically significant (P ＜ 0.05). Among them, there was no statistically significant differences in MAP and HR in the ERAS group at each time point (P ＞ 0.05). The comparison of MAP at each time point in the control group showed statistically significant differences (P ＜ 0.05); except for 1, 2 h, the HR comparison at other time points showed statistically significant differences (P ＜ 0.05). The MAP and HR of the ERAS group were lower than those of the control group at each time point, and the differences were statistically significant (P ＜ 0.05). The incidence of postoperative adverse reactions including nausea and vomiting, chills in the ERAS group were lower than those in the control group, and the differences were statistically significant (P < 0.05). The dosage of sufentanil in the ERAS group was lower than that in the control group, and the difference was statistically significant (P < 0.05). The postoperative recovery time, orientation recovery time, extubation time after operation and hospital stay in the ERAS group were shorter than those in the control group, and the differences were statistically significant (P < 0.05). The VAS score of the ERAS group was lower than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The application of anesthesia management guided by the concept of ERAS in lumbar surgery can make the patient’s vital signs more stable during the operation, shorten the patient’s recovery time after the operation, reduce the use of opioids, and decrease the incidence of postoperative adverse reactions. It is worthy of clinical application in spinal surgery.
2021 Vol. 18 (4): 107-110,138 [Abstract] ( 246 ) HTML (1 KB)  PDF (941 KB)  ( 76 )
111 Clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression
LI Shiqiang WANG Wei SONG Ying WEI Jingpei▲
Objective To investigate clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression. Methods By using the principle of random, controlled and blind method, a total of 90 outpatients and inpatients with depression of liver depression and spleen deficiency type in Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2018 to August 2019 were selected and divided into Western medicine group, Chinese medicine group and combination group according to the random number table method, with 30 cases in each group. Western medicine group was treated with Duloxetine Hydrochloride Enteric-coated Tablets, Chinese medicine group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction, combination group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets. All patients were treated for six weeks. The curative effect of depression, curative effect of Chinese medicine symptoms, Hamilton depression scale (HAMD) score and Chinese medicine syndrome scale score before and after treatment among three groups were observed. Results Total effective rate of depression, total effective rate of Chinese medicine syndrome in combination group were higher than those in Western medicine group and Chinese medicine group (P < 0.017). Overall analysis found that there were significant differences in HAMD score and Chinese medicine syndrome scale score between inter group effect and time effect (P < 0.05), but there was no significant difference in interaction (P > 0.05). Intra group comparison: HAMD score and Chinese medicine syndrome scale score of three groups at three and six weeks after treatment were lower than those before treatment (P < 0.05). Comparison between groups: HAMD score and Chinese medicine syndrome scale score of combination group were lower than those of Western medicine group and Chinese medicine group at three and six weeks of treatment, the differences were statistically significant (P < 0.05). Conclusion Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets is effective in the treatment of depression, it may treat the depression as the quite ideal method clinically.
2021 Vol. 18 (4): 111-114 [Abstract] ( 228 ) HTML (1 KB)  PDF (692 KB)  ( 48 )
115 Meta-analysis on correlation between traditional Chinese medicine constitution and cyclomastopathy
MA Yelin QIAN Xiaoling YANG Minchun▲
Objective To study the distribution of traditional Chinese medicine constitution in cyclomastopathy people through the meta-analysis of relevant clinical studies. Methods The literatures of CNKI, CBM, VIP, Wanfang, Embase and PubMed database from the database creation to October 2019 were searched with “cyclomastopathy” and “constitution” as key words, the data of the distribution of traditional Chinese medicine constitution in cyclomastopathy and non-cyclomastopathy people were extracted, then meta-analysis was performed by Review Manager 5.2. Results Finally 11 literatures were included with 5810 individuals. Meta-analysis results showed that balanced constitution (OR = 0.17, 95%CI: 0.12-0.23, P < 0.000 01) was a protective factor of cyclomastopathy while yang deficiency (OR = 1.46, 95%CI: 1.18-1.81, P = 0.0004), yin deficiency (OR = 1.58, 95%CI: 1.29-1.95, P < 0.0001), qi stagnation (OR = 4.76, 95%CI: 3.43-6.60, P < 0.000 01) and blood stasis (OR = 1.61, 95%CI: 1.24-2.10, P = 0.0004) constitutions were risk factors of it. Conclusion Female with biased constitutions, such as yang deficiency, yin deficiency, blood stasis and especially qi stagnation constitutions are more likely to suffer from cyclomastopathy.
2021 Vol. 18 (4): 115-118 [Abstract] ( 337 ) HTML (1 KB)  PDF (1569 KB)  ( 81 )
119 Discussion on the medication rules of softening handness and dispersing mass in the treatment of vocal nodules based on data mining
LIU Caifeng LI Siting WANG Zhiguo
Objective To explore the clinical application rules of softening handness and dispersing mass in treating vocal nodules and to explore the core drug combinations. Methods CNKI, Wanfang, VIP, CBM published literatures of Chinese herbal compound in the treatment of vocal nodules were searched by using computer. The key words were “ruanjian”, “sanjie”, “xiaojian” and “vocal nodule”, etc. The retrieval time was from the establishment of the database to September 2019. The data from the literatures to WPS 2019 was extracted and database for frequency statistical analysis was established. Clementine 12 was used to establish Apriori association analysis model. R-type clustering was conducted to further study the prescriptions of Chinese medicine by using SPSS 23.0. The core drug pairs and core prescriptions for vocal nodules were analyzed. Medication rules were explored. Results A total of 55 prescriptions of Chinese medicine were included, involving 133 kinds of Chinese medicine, and the frequency of use was 631. The first three rules supported by association rule analysis were: the first three rules with high support degree in association rule analysis were as follows: Semen Oroxyli → Radix Platycodonis, Sargassum → Thallus Laminariae, Rhizoma Curcumae → Rhizoma Sparganii, as the core drug pairs for the treatment of vocal nodules. Three core prescriptions were obtained by cluster analysis, Formula C1: Rhizoma Sparganii, Rhizoma Curcumae, Sargassum, Thallus Laminariae, Semen Persicae, Flos Carthami. Formula C2: Radix Scrophulariae, Radix Ophiopogonis, Radix Rehmanniae Recens, Bulbus Fritillariae Thunbergii, Spica Prunellae. Formula C3: Rhizoma Atractylodis Macrocephalae, Poria, Radix Platycodonis, Semen Oroxyli, Radix Glycyrrhizae. The prescriptions for the treatment of vocal nodules is mainly phlegm-resolving formula and blood-activating formula. Combined with syndrome differentiations, drugs of dispelling pathogenic wind, nourishing yin, nourishing blood, clearing heat and others were used. Conclusion The basic principle of treating vocal nodules is dissipating phlegm and resolving masses, resolving stasis and softening hardness. The medication mainly use the drugs of dissipating phlegm and resolving stasis, clearing heat and resolving masses, combine with strengthening vital qi.
2021 Vol. 18 (4): 119-122 [Abstract] ( 418 ) HTML (1 KB)  PDF (917 KB)  ( 99 )
123 Theoretical study on the prevention and treatment of colorectal adenoma with Sanzi Decoction of ethnic drug
QIU Renjing1 LIN Lin2 TIAN Yaozhou2
The study of colorectal adenoma has become an important topic of secondary prevention of colorectal carcinoma. Blocking or reversing the occurrence and development of colorectal adenoma is of great significance for the prevention and treatment of colorectal carcinoma. The advantages of Chinese medicine in the treatment of colorectal adenoma gradually appear, and the clinical effect of Sanzi Decoction of ethnic drug on colorectal adenoma is significant. The location of colorectal adenoma is in the intestine, which is related to spleen, liver and gallbladder. Deficiency of origin and excess are related to qi deficiency, yin deficiency, dampness-heat and blood stasis. Dampness and blood stasis are the key factors affecting its occurrence, development and outcome. From the perspective of the composition of Chinese medicine and pharmacology, this paper discusses the significance of the composition of Sanzi Decoction of ethnic drug. It is considered that the effect of this prescription on colorectal adenoma is based on the theory of principle-method-recipe-medicines with Chinese medicine. It is related to the modern pharmacological action of the drugs.
2021 Vol. 18 (4): 123-126 [Abstract] ( 242 ) HTML (1 KB)  PDF (690 KB)  ( 60 )
127 Study on the medication rule of traditional Chinese medicine in the treatment of chronic uric acid nephropathy based on association rule
WANG Yun1 JIA Yuanping2 QIU Xinping1
Objective To explore the rules of traditional Chinese medicine in the treatment of chronic uric acidnephropathy. Methods The literatures were searched in CNKI, Wanfang Data and VIP by the key words of “chronic uric acid nephropathy” or “gouty nephropathy” from the date of establishment to May 2020. The prescriptions of traditional Chinese medicine treatment were selected, and the data was enrolled by Excel 2017. The drug frequency analysis and cluster analysis were performed by SPSS statistics 25 software. Association rule analysis was applied by SPSS modeler 18 software, and network visualization display was applied by Cytoscape 3.8.0. Results One hundred and seven TCM formulas were included. There were 25 drugs that using frequency was more than 15 times. Cluster analysis clustered high-frequency drugs into seven categories. Association rule analysis suggested two types of “syndrome-prescription” rules. Conclusion The treatment of chronic uric acid nephropathy with TCM is mainly invigorating spleen and kidney, and at the same time, together with promoting blood circulation and diuresis, excessing turbid and clearing heat.
2021 Vol. 18 (4): 127-130 [Abstract] ( 433 ) HTML (1 KB)  PDF (1095 KB)  ( 66 )
131 Exploration on acupoint selection rules of acupuncture in treating sudden deafness based on data mining
MENG Yan1 BAI Peng1 WANG Xinru2 MA Li2 QI Xiaohan1 CHENG Jiangyan3
Objective To analyze the clinical characteristics and rules of points selection of acupuncture in treating sudden deafness based on data mining. Methods The clinical research literatures on sudden deafness collected by CNKI, Wanfang and VIP data platforms from October 2009 to October 2019 were retrieved and extracted by professional retrieval mode, the data was collected and the acupoint selection database was established by traditional Chinese medicine inheritance support system (V2.5), and statistical analysis was conducted by rule analysis, improved mutual information method, complex system entropy clustering and other methods. Results One hundred and seventy nine literatures were included, which involved 180 prescriptions and 65 acupoints. The total frequency was 1052 times. The high frequency acupoints were tīnggōng (81.7%), tīnghuì (74.4%), yìfēng (74.4%), ěrmén (69.4%), zhōngzhǔ (36.1%) and so on. The top three meridians with the highest frequency were Shaoyang channel of hand, Shaoyang channel of foot and governor channel. By setting the support level to 36 and the confidence level to 0.8, 25 pairs of commonly used acupoint combinations and 37 combination rules were gotten. By setting the support degree as 27 or 36, the corresponding network diagram of acupoints could be obtained respectively. The degree of correlation was eight and penalty was two, and four new prescriptions were concluded. Conclusion Acupuncture treatment of sudden deafness has considerable rules in selecting acupoint and compatibility, which can provide ideas for clinical treatment of the disease.
2021 Vol. 18 (4): 131-134 [Abstract] ( 424 ) HTML (1 KB)  PDF (763 KB)  ( 50 )
135 Discussion on refined management of TCM academic schools by taking the inheritance of Pingle Guo’s orthopedic and traumatology school as an example
YE Yanrong1 ZHANG Hong2
Under the new situation, refined management is an useful exploration to promote the sustainable development of academic schools of traditional Chinese medicine (TCM). This paper summarizes the problems faced in the construction of Pingle Guo’s orthopedic and traumatology school, analyzes the reasons and necessity of implementing refined management in Pingle Guo’s orthopedic and traumatology school, and takes the problems as the guide, expounds the practical application of refined management in Pingle Guo’s orthopedic and traumatology school. This paper puts forward the measures of refined management of TCM academic schools, in order to provide a reference for improving the modern management level of TCM academic schools.
2021 Vol. 18 (4): 135-138 [Abstract] ( 158 ) HTML (1 KB)  PDF (686 KB)  ( 29 )
139 Analysis of the consistency between transabdominal ultrasound and computed tomography urography in the diagnosis of bladder cancer and pathological diagnosis
ZHA Zongyu WANG Junli▲ HE Yong HU Aili
Objective To study the consistency between the diagnosis of bladder cancer and pathological diagnosis by by transabdominal ultrasound (TAUS) and to computed tomography urography (CTU). Methods A total of 125 patients with suspected bladder cancer admitted to Wuhu Second People’s Hospital from October 2014 to December 2018 were included as the research subjects. All patients underwent TAUS and CTU examinations before surgery, and the surgical pathological diagnosis results were used as the gold standard. The consistency of TAUS, CTU diagnosis of bladder cancer and pathological results were analyzed, and the consistency of TAUS, CTU diagnosis of bladder urothelial cell carcinoma and pathological results were observed. Results Among 125 suspected bladder cancer patients, TAUS diagnosis showed 115 malignant lesions and 10 benign lesions, CTU diagnosis showed 118 malignant lesions and 7 benign lesions. The sensitivity of TAUS and CTU in the diagnosis of bladder cancer was 92.56% and 96.69%, the specificity was 25.00% and 75.00%, the accuracy was 90.40% and 96.00%, and the Kappa values of the consistency test with pathological diagnosis were 0.10 and 0.53, respectively. The sensitivity of TAUS and CTU in the diagnosis of bladder urothelial carcinoma were 89.08% and 94.12%, the specificity was 66.67% and 83.33%, and the accuracy was 88.00% and 93.60%, and the Kappa values of the consistency test with pathological diagnosis were 0.30 and 0.53, respectively. Conclusion TAUS and CTU have important application value in bladder cancer diagnosis.
2021 Vol. 18 (4): 139-142,154 [Abstract] ( 101 ) HTML (1 KB)  PDF (746 KB)  ( 10 )
143 Predictive value of shear wave elastography in cervical lymph node metastasis of papillary thyroid carcinoma
WANG Lin ZHENG Weiwei SHE Tongsheng▲
Objective To investigate the predictive value of shear wave elastography(SWE) in cervical lymph node metastasis of papillary thyroid carcinoma (PTC). Methods A total of 52 patients with PTC admitted to the People’s Hospital of Xuancheng City from January 2017 to February 2020 were selected for routine ultrasound and SWE examinations the correlation between SWE parameters and cervical lymph node metastasis were analyzed, and the predictive value of conventional ultrasound and SWE were compared. Results The results of multiple regression analysis showed that no lymphatic hilum, disorganized/borderlined blood flow distribution of lymph nodes, and increased Emean, Emax, and Emin were the influencing factors for lymph node metastasis in the cervical and central areas of PTC. Lymph node aspect ratio ＞ 1/2 was the influencing factor of central lymph node metastasis (P ＜ 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of SWE in predicting PTC cervical lymph node metastasis were higher than conventional ultrasound. Area under the curve was 0.94, which was greater than conventional ultrasound. Conclusion SWE has a high sensitivity and specificity in the diagnosis of PTC cervical lymph node metastasis. It can predict whether PTC cervical lymph node metastasis can occur to a certain extent.
2021 Vol. 18 (4): 143-146 [Abstract] ( 135 ) HTML (1 KB)  PDF (602 KB)  ( 42 )
147 Clinical application of CT value and IC value of spectral CT scan in qualitative assessment of lymph nodes in gastric adenocarcinoma
LI Zuyin ZHU Di XIA Chunhua▲
Objective To explore the application value of CT value and iodine concentration (IC) value in the arterial and venous phase in the spectral CT scan in the qualitative assessment of the lymph nodes in gastric adenocarcinoma. Methods A total of 85 patients with gastric adenocarcinoma admitted to the First People’s Hospital of Hefei, from February 2016 to July 2020 were selected as the research objects. All patients underwent conventional CT scan and spectral CT scan. The CT values and IC values of the arterial and venous phases of metastatic lymph nodes and non-metastatic lymph nodes were compared, and the CT values and IC values of the arterial and venous phases of metastatic lymph nodes of different degrees of differentiation were compared. The receiver operating characteristic (ROC) curve of the quantitative parameters of spectral CT in the differential diagnosis of gastric adenocarcinoma lymph node metastasis was drawed, and its diagnostic efficiency was analyzed. Results The CT values and IC values of arterial and venous phase of metastatic lymph nodes were significantly higher than those of non-metastatic lymph nodes, the differences were statistically significant (all P ＜ 0.05). In metastatic lymph nodes, the CT values and IC values of arterial and venous phase of poorly differentiated adenocarcinoma were significantly lower than those of moderately and highly differentiated adenocarcinoma, the differences were statistically significant (all P ＜ 0.05). The area under the curve (AUC) of the arterial phase CT value, venous phase CT value, arterial phase IC value, and venous phase IC value in the diagnosis of gastric adenocarcinoma lymph node metastasis are 0.803, 0.712, 0.849 and 0.784, respectively, they had high accuracy in judging lymph node metastasis of gastric adenocarcinoma. Conclusion The CT value and IC value of arterial and venous phase in spectral CT scan have important value in preoperative evaluation of lymph node properties of patients with gastric adenocarcinoma, which can be used as quantitative indicators to evaluate the condition, efficacy and prognosis of patients with gastric adenocarcinoma.
2021 Vol. 18 (4): 147-150,183 [Abstract] ( 103 ) HTML (1 KB)  PDF (1159 KB)  ( 46 )
151 Application value of echocardiography in the evaluation of cardiac morphology and function in patients with acute cerebral infarction
LI Chuanqiang1 GAO Feng2 CHENG Yu1 LI Songnian1
Objective To study the application value of echocardiography in the evaluation of cardiac morphology and function in patients with acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction admitted to Bengbu First People’s Hospital of Anhui Province (“our hospital” for short) from March 2018 to March 2020 were selected as the acute cerebral infarction group, while 64 healthy people who had physical examination in Department of Outpatient of our hospital were selected as the control group. The left heart morphology, right heart morphology and cardiac function were compared between the two groups. Results The left ventricular end-systolic volume, left ventricular end-diastolic volume, left ventricular posterior wall diastolic thickness, left ventricular end-diastolic inner diameter and left atrial inner diameter in patients with the acute cerebral infarction group were larger than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The right ventricular diastolic interventricular septum thickness, right ventricular end diastolic inner diameter and main pulmonary artery inner diameter in patients with the acute cerebral infarction group were larger than those in the control group (all P ＜ 0.05). Stroke volume, left ventricular ejection fraction, early diastolic mitral valve maximum blood flow velocity and early diastolic mitral valve maximum blood flow velocity/late diastolic mitral valve maximum blood flow velocity in patients with the acute cerebral infarction group were lower than those of the control group, and late diastolic mitral valve maximum blood flow velocity was higher than that in the control group, and the differences were statistically significant (all P ＜ 0.05). Conclusion Left ventricular hypertrophy and left atrial enlargement are common echocardiographic changes in cardiac morphology in patients with acute cerebral infarction. Observing cardiac morphology and function of the heart by echocardiography can provide a reference for the diagnosis and treatment of acute cerebral infarction.
2021 Vol. 18 (4): 151-154 [Abstract] ( 213 ) HTML (1 KB)  PDF (516 KB)  ( 56 )
155 Application and SWOT analysis of informatization in quality control of outpatient medical records in Chinese medicine hospitals
CHEN Keyu TANG Wujun YU Jie
The use of information technology to strengthen the quality control of outpatient clinics has become a trend in modern hospital outpatient management. Information technology can help outpatient managers to solve the dilemma of outpatient management of paper medical records to a certain extent, and the improvement of the “clinical-research-teaching” level of outpatient services in Chinese medicine hospitals. The application of informatization to the quality control of outpatient medical records in traditional Chinese medicine hospitals can be carried out in three stages, namely, before, during and after the event, from the three levels of self-control, scientific control and hospital control. Hospital administrators should also focus on cultivating interdisciplinary management talents in outpatient clinics, improving outpatient informatization and protecting information security, so that information technology can be safely used in the quality control of outpatient medical records in Chinese medicine hospitals.
2021 Vol. 18 (4): 155-158 [Abstract] ( 208 ) HTML (1 KB)  PDF (457 KB)  ( 73 )
159 Application analysis of performance evaluation in public hospitals
WANG Mingli1 WU Dan▲
Performance evaluation application and analysis is an effective management tool and means for hospitals to achieve performance goals and performance management ideas. This paper analyzes the background, connotation, application analysis, evaluation effect and current evaluation application of performance analysis, multi-dimensional interpretation of performance evaluation application analysis mechanism is used to improve the comprehensive quality of hospital management and optimize the orderly cycle of hospital efficiency and effectiveness, improve service concepts, and promote and reflect the value of health innovation and development. Establish a scientific and reasonable hospital performance evaluation application analysis system and improve the performance mechanism to provide reference and experience reference.
2021 Vol. 18 (4): 159-162 [Abstract] ( 302 ) HTML (1 KB)  PDF (412 KB)  ( 35 )
163 Systematic evaluation of the application effect of nursing intervention based on Roy adaptation model on patients with mechanical ventilation in ICU
KANG Yannan WANG Ruirui YANG Ting ZHANG Chunmei
Objective To systematically reviewed the relevant literature on the application of Roy-based adaptive nursing intervention in patients with mechanical ventilation in intensive care unit (ICU) to confirm its application effect and provide reference for clinical practice. Methods Computer searched for PubMed, Cochrane Library, Embase, Ebsco, Elsevier, CNKI, Wanfang Data, VIP and CBM randomized controlled trials (RCTs) and semi-randomized controlled trials (CCTs), the retrieval time was from the establishment to May 2020. The intervention group received nursing intervention based on Roy adaptation model, and the control group received routine nursing intervention. The off-line success rate, ventilator days, hospitalization days and hospitalization costs were observed after intervention. After literature screening, data extraction and quality assessment by two researchers, meta-analysis was performed using RevMan 5.3 software. Results In the end, six studies were included with a total of 660 patients, and the quality evaluation results were all grade B. Meta-analysis results showed that the intervention group could improve the success rate of patients of-fline compared with the control group (RR = 1.27, 95%CI [1.16, 1.38], P ＜ 0.000 01); decrease ventilator days (MD = -3.88, 95%CI [-4.15, -3.61], P ＜ 0.000 01); reduce the patient length of hospital stay (MD = -3.13, 95%CI [-3.74, -2.52], P ＜ 0.000 01); reduce hospital costs (MD = -0.04, 95%CI[-0.08, -0.02], P ＜ 0.000 01). Conclusion The effect of Roy-based adaptive nursing intervention on ICU patients with mechanical ventilation is better than conventional nursing. However, the quality of the included literatures is not high, and the sample size is different from the standard of clinical intervention measures. Therefore, large-sample, multi-center standardized clinical studies need to be carried out for further confirmation.
2021 Vol. 18 (4): 163-167 [Abstract] ( 253 ) HTML (1 KB)  PDF (1274 KB)  ( 50 )
168 Application effect of mind map health education based on WeChat-led in febrile convulsion children
SUO Xin REN Junfen GUO Xiaohong
Objective To explore the influence of WeChat-led mind map health education on the prevention of knowledge, beliefs and behaviors of febrile convulsion children’s parents and the treatment effect of children. Methods A total of 128 children with febrile convulsion and their parents (128) who were admitted to Chaoyang Second Hospital from October 2018 to May 2019 were selected. According to the treatment time, they were divided into the treatment group (February to May 2019) 67 cases and the control group (October 2018-January 2019) 61 cases. The control group was given regular health education, and the treatment group combined with the WeChat-led mind map health education. After six months of follow-up, the psychological status of the parents of  children in the two groups, the level of prevention knowledge, belief and behavior, and the children’s clinical related indicators, complications and recurrence rates were compared. Results The self-rating anxiety scale (SAS), self-rating depression scale (SDS) scores of parents in the two groups decreased significantly, and the parents’ SAS and SDS scores of the treatment group were lower than those of the control group, the differences were highly statistically significant (P ＜ 0.01); between the two groups, the level of prevention knowledge and practice of parents was significantly higher than before education, parents’ scores on prevention knowledge, prevention beliefs, prevention behaviors, and prevention knowledge, beliefs and behaviors were higher than those of the control group, the differences were highly statistically significant (P ＜ 0.01); the time of fever, disappearance of convulsions, and hospital duration in children were shorter than those in the control group, the differences were highly statistically significant (P ＜ 0.01); complications and recurrence rates of children were lower than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Mind map health education based on WeChat can help alleviate the negative emotions of parents of children with febrile convulsion, improve the knowledge beliefs and behavior of prevention of febrile seizures, promote rapid recovery of children, reduce complications, and reduce the recurrence rate.
2021 Vol. 18 (4): 168-171 [Abstract] ( 409 ) HTML (1 KB)  PDF (739 KB)  ( 89 )
172 Effect of diversified health education and emotional support on conscious patients in ICU
WANG Hong MAO Xuejuan▲
Objective To explore the effect of diversified health education and emotional support on the emotional status and delirium incidence of conscious patients in intensive care unit (ICU). Methods A total of conscious 169 patients in ICU between January 2018 and December 2019 were selected to Huai’an Fourth People’s Hospital. A total of 86 patients receiving diversified health education and emotional support were selected as the observation group and 83 patients receiving routine health education and nursing intervention were selected as the control group by convenience sampling method, the emotional status, delirium incidence and satisfaction were compared between the two groups before and after intervention. Results After intervention, both groups had significantly lower scores of tension-anxiety, depression-depression, anger-enmity, fatigue-dullness, confusion-disturbance than before intervention the energy-vigor score was significantly higher than that before intervention (P ＜ 0.01), the scores of graded emotional status in treatment group: nervous-anxiety, depression-frustration, anger-hostility, fatigue-inactivity, confusion-disorder, were significantly lower than those before intervention and the control group (P ＜ 0.01); the energy-vigor score was significantly higher than that before intervention and the control group (P ＜ 0.01); the incidence of delirium in the treatment group was significantly lower than that in the control group (P ＜ 0.05); the satisfaction rate was significantly higher than that of the control group (P ＜ 0.05). Conclusion Diversified health education combined with emotional support can help improve the emotional state of ICU conscious patients, reduce the incidence of delirium, and improve patient satisfaction.
2021 Vol. 18 (4): 172-175 [Abstract] ( 333 ) HTML (1 KB)  PDF (630 KB)  ( 53 )
176 Application of detailed nursing intervention mode in operating room
WANG Minyu WANG Tingting YANG Meiling▲
Objective To explore the application effect of detailed nursing intervention mode in operating room nursing. Methods A total of 115 patients who underwent surgery in the First Affiliated Hospital with Nanjing Medical University from March 2018 to October 2019 were selected. According to operation time, they were divided into 61 cases in the treatment group (January to October 2019) and 54 cases in the control group (March to December 2018). The control group was given routine care in the operating room, while the treatment group combined with detailed care in the operating room. The quality of care in the operating room, surgical efficiency, adverse nursing events, and patient satisfaction were compared between the two groups. Results The total scores of instrument management, sanitation and disinfection, nursing cooperation and quality of care of the treatment group were higher than those of the control group (P ＜ 0.05); operation preparation time, pick-up time, and each operation time were shorter than those of the control group (P ＜ 0.01); the incidence of adverse nursing events was lower than that of the control group (P ＜ 0.05); patient care satisfaction was higher than the control group (P ＜ 0.05). Conclusion Detailed nursing intervention can help improve the quality of care in the operating room, shorten the operation time, reduce the incidence of adverse events in surgical care, and improve the doctor-patient relationship in the operating room.
2021 Vol. 18 (4): 176-179 [Abstract] ( 194 ) HTML (1 KB)  PDF (669 KB)  ( 64 )
180 Application of humanistic care on preventing stress response and accident in patients with pre-hospital fist aid
YANG Yuanyuan WU Longfei
Objective To explore the impact of humanistic care on the prevention of stress response and accidents in pre-hospital first aid patients. Methods A total of 85 cases of pre-hospital first aid patients in Fuyang Second People’s Hospital from January 2019 to August 2019 were selected as the research objects. According to the treatment time, they were divided into 44 cases in the treatment group (May to August 2019) and 41 cases in the control group (January to April 2019). The control group was given pre-hospital first aid routine care, while the treatment group was combined with humanistic care. The stress response, accidents during transportation, and patient satisfaction between the two groups were compared. Results The systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) of the two groups were significantly lower than before the first aid (P ＜ 0.05 or P ＜ 0.01). The SBP, DBP and HR in treatment group was significantly lower than the control group (P ＜ 0.05); there was no accident rate during transit in the two groups; the satisfaction of treatment group was significantly higher than that of the control group (P ＜ 0.05). Conclusion Humanistic care can help relieve the stress response of pre-hospital first aid patients, prevent accidents during transportation, and improve patient satisfaction.
2021 Vol. 18 (4): 180-183 [Abstract] ( 188 ) HTML (1 KB)  PDF (627 KB)  ( 68 )
184 Effect of medical and nursing integration health education on healthy behavior and symptom distress of patients with pituitary tumor after operation
ZHONG Chunlian TAO Yunna XU Yeping XU Xiaomei
Objective To explore the application effect of medical and nursing integration health education of patients with pituitary tumor after operation. Methods From January 2015 to December 2018, 80 patients with pituitary tumors who admitted to the No. 904 Hospital of the Joint Logistics Support Force were selected. According to the time of surgical treatment, they were divided into 40 cases in the intervention group (from January 2017 to December 2018) and 40 cases in the control group (from January 2015 to December 2016). The control group was given health education by specialist nurses, and the intervention group was given health education by medical and nursing integration health educution. Followed up for six months, the scores of healthy behavior, symptom distress and quality of life were compared between the two groups. Results Before education, there were no significant differences in healthy behavior scores between the two groups (P > 0.05). Follow up for six months, the healthy behavior scores of the two groups were higher than those of the same group before education (P < 0.05 or P < 0.01); and the scores of health responsibility, self-actualization, interpersonal support, stress coping, and healthy behaviors total scores of the intervention group were higher than those of the control group (P < 0.05 or P < 0.01). Before education, there were no significant differences in symptom distress scores between the two groups (P > 0.05). Follow up for six months, the symptom distress scores of the two groups were lower than those of the same group before education (P < 0.01); the scores of neuropsychiatric damage, endocrine disorders, nasal dysfunction, and total scores of the intervention group were lower than those of the control group (P < 0.05 or P < 0.01). Before education, there was no significant difference in quality of life scores between the two groups (P > 0.05). Follow up for six months, the quality of life scores of the two groups were higher than those of the same group before education (P < 0.05 or P < 0.01); and the scores of physiological function, overall health, vitality, emotional function, and mental health scores of intervention group were higher than those of the control group (P < 0.05). Conclusion The medical and nursing integration health education can help promote the development of healthy behavior of patients with pituitary tumor after operation, relieve the degree of symptom distress, and improve the quality of life of patients after operation.
2021 Vol. 18 (4): 184-188 [Abstract] ( 353 ) HTML (1 KB)  PDF (678 KB)  ( 33 )
189 Application effect of chain one-stop emergency care in pre-hospital emergency
BAO Herong
Objective To explore the effect of chain one-stop emergency care in pre-hospital emergency care. Methods From March 2018 to March 2020, 80 patients admitted to Lu’an People’s Hospital for pre-hospital emergency treatment were selected as research object, and they were divided into observation group and control group, according to the random number table method, with 40 cases in each group. Control group was given traditional emergency care measures, and observation group was given chain one-stop emergency care measures. The rescue success rate of two groups were compared; the required first aid time of two groups, including equipment preparation time, initial condition evaluation time, vital sign judgment time and basic life support rescue time were recorded and compared; the satisfaction of the family members of two groups to rescue care work was investigated by questionnaire. Results The rescue success rate of observation group was higher than that of control group, and the difference was statistically significant (P < 0.05). The equipment preparation time, initial condition evaluation time, vital sign judgment time and basic life support rescue time of observation group were shorter than those of control group, and the differences were statistically significant (P < 0.05). The satisfaction of family members in observation group was higher than that in control group (P < 0.05). Conclusion The chain one-stop emergency care model has outstanding effects in pre-hospital emergency care, which is conducive to shortening the first aid time, improving the success rate of rescue, improving the satisfaction of patients’ family members and worthy of clinical promotion and application.
2021 Vol. 18 (4): 189-192 [Abstract] ( 116 ) HTML (1 KB)  PDF (670 KB)  ( 47 )
193 Effect of nursing management measures based on FMEA model on dialysis complications, quality of life and psychological status of maintenance hemodialysis patients
WANG Yuanyuan TANG Lin SU Yin
Objective To analyze the effect of nursing management measures based on failure mode and effect analysis (FMEA) on dialysis complications, quality of life and psychological status of maintenance hemodialysis patients, so as to provide basis for clinical treatment. Methods From December 2018 to December 2019, 84 hemodialysis patients in Anqing Municipal Hospital of Anhui Province were selected as study objects. They were divided into the control group and the observation group by random table number method, with 42 cases in each group. The control group was given routine nursing intervention, while the observation group was given nursing management intervention based on FMEA model. Both groups were intervened for three months. Psychological status scores, quality of life scores and complications were compared between the two groups before and after intervention. Results Before intervention, there were no differences in self-rating anxiety acale (SAS) and self-rating depression scale (SDS) scores between the two groups (P > 0.05); After intervention, SAS and SDS scores of the two groups were lower than those before intervention, and the observation group was lower than the control group, and the differences were statistically significant (all P < 0.05). Before intervention, there were no significant differences in scores of general state, physical pain, physiological function, role physiological, role emotional, mental health and social function between the two groups (P > 0.05); after intervention, general state, physical pain, physiological function, role physiological, role emotional, mental health and social function in both groups were higher than those before intervention, and the observation group was higher than the control group, and the differences were statistically significant (all P < 0.05). The incidence of complications in the observation group was lower than that in the control group, with statistical significance (P < 0.05). Conclusion The nursing management measures based on FMEA model have significant effect on maintenance hemodialysis patients, which can play a prominent role in improving the quality of life, psychological state and preventing postoperative complications, which can be applied in clinical practice.
2021 Vol. 18 (4): 193-196 [Abstract] ( 413 ) HTML (1 KB)  PDF (626 KB)  ( 38 )
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