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| Research progress on Drebrin in the development of dendritic spines and the formation of cognitive function |
| XIE Mei XU Ping |
| Department of Neurology, Affiliated Hospital of Zunyi Medical University, Guizhou Province, Zunyi 563000, China |
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Abstract Drebrin is a cerebrum development regulation protein, mainly express in the cerebrum and concentrat in the dendritic spines of neurons, which plays a key role in most excitatory synapses. The structural of neuronal dendritic spines are driven by actin dynamics. Drebrin is an actin-binding protein that can interact with cellular actin to regulate its actin skeleton and participate in the formation of dendritic spines, synaptic plasticity changes, cell communication and other neuronal activities. The level of Drebrin drops significantly in some cognitive dysfunction diseases and shows cognitive dysfunction. This article intends to review and analyze the research progress of Drebrin in the development of dendritic spines and the formation of cognitive function.
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