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| Research progress of treatment of myocardial fibrosis based on TGF-β1/Smads pathway |
| FU Weiwu1 OUYANG Yarong1 HUANG Caiyi1 HUANG Jingwei1 WU Cong1 QIN Xiaojun1 WANG Qinggao2 |
1.College of Graduate, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530001, China;
2.Department of Cardiology, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530023, China |
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Abstract Myocardial fibrosis is a pathological manifestation of heart tissue and structure destroyed by various diseases throughout the body, which can lead to heart failure. Therefore, inhibiting myocardial fibrosis is of great significance for improving heart structure and protecting heart function. Although there are many signal pathways that affect myocardial fibrosis, the transforming growth factor (TGF)-β1/Smads signaling pathway is a classic pathway that affects myocardial fibrosis. In recent years, various studies on its inhibition of myocardial fibrosis have been very extensive. This article combines the latest related documents published at home and abroad in recent years to explain the latest developments of TGF-β1/Smads signaling pathway in the treatment of myocardial fibrosis in Chinese and Western medicine, in order to provide new ideas and directions.
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