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| Changes of serum IL-35, IL-17 and TGF-β1 levels in patients with chronic spontaneous urticaria and their clinical significance |
| QIN Kaiwei TAO Yanxia WANG Jiarui |
| Department of Skin Burn, the People’s Hospital of Kaizhou District of Chongqing, Chongqing 405400, China |
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Abstract Objective To investigate the changes and clinical significance of serum levels of interleukin (IL)-35, IL-17 and transforming growth factor β1 ( TGF- β1) levels in patients with chronic spontaneous urticaria (CSU). Methods A total of 350 CSU patients admitted to the People’s Hospital of Kaizhou District of Chongqing (hereinafter referred to as “our hospital”) from January 2016 to January 2019 were selected as the case group. According to urticaria activity score (UAS), they were divided into 142 cases in mild group, 124 cases in moderate group, 84 cases in severe group, and 60 healthy subjects in our hospital were selected as the control group. Serum levels of IL-35, IL-17 and TGF-β1 were detected, and their relationship with UAS score was analyzed. Results The serum level of IL-35 in the case group was significantly lower than that in the control group, and the levels of IL-17 and TGF-β1 were significantly higher than those in the control group, with statistical significances (all P < 0.05). The serum level of IL-35 in severe group was lower than that in moderate group and mild group, and that in moderate group was lower than that in mild group, with statistical significances (all P < 0.05). The serum levels of IL-17 and TGF-β1 in severe group were higher than those in moderate group and mild group, and that in moderate group were higher than those in mild group, with statistical significances (all P < 0.05). Pearson correlation analysis results showed that serum IL-35 was negatively correlated with UAS (r = -0.687，P = 0.029), and serum IL-17 and TGF-β1 levels were positively correlated with UAS (r = 0.684, 0.709; P = 0.028, 0.022). Conclusion The serum IL-35 level of CSU patients is negatively correlated with the severity of the patient’s condition, and the levels of IL-17 and TGF-β1 are positively correlated with the severity of the patient’s condition. The detection of serum levels of IL-35, IL-17 and TGF-β1 in patients with CSU can evaluate the severity of the patient’s condition, which is helpful for clinical diagnosis and treatment.
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