菌群多样性与巴雷特食管患者病理特征的相关性分析

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Abstract Objective To analyze the correlation between the bacterial diversity and pathological characteristics of patients with Barrett’s esophagus (BE). Methods A total of 141 BE patients who were diagnosed and treated in the Department of Gastroenterology the First Affiliated Hospital of Xinjiang Medical University from January 2016 to December 2019 were included in the study (BE group), and a total of 138 persons with normal physical examination during the same period were selected as control. The differences in esophageal flora composition between the two groups were compared. According to the pathological examination results of BE, patients were divided into cardia gland type (53 cases), fundus gland type (59 cases) and special intestinal metaplasia type (29 cases). The clinical data such as age and gender, and flora diversity of patients with different types were compared. Spearman model was used to analyze the correlation between patients’ dysplasia and flora diversity. Results The abundances of Streptococcus, Fusobacterium, Haemophilus, and Staphylococcus in the BE group were lower than those in the control group (P < 0.05); while in the BE group, the abundance of Campylobacter, Veronococcus and Pasteurella, the abundance of Bacillus, Prevotella and Neisseria were higher than those of the control group (P ＜ 0.05). Comparison of the degree of dysplasia in patients with different types, and the differences was statistically significant (P ＜ 0.05). There were no statistically significant differences in age, gender and columnar epithelium length of patients with different types (P ＞ 0.05). The Chao1, Ace, and Shannon indexes of severe group were significantly higher than those of mild and moderate group, and the differences were statistically significant (P ＜ 0.05), while those in moderate group were higher than those in mild group (P ＜ 0.05); the Simpson index in severe group was significantly lower than that of mild and moderate group, while moderate group was lower than mild group, and the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that Chao1, Ace and Shannon indexes were positively correlated with the degree of dysplasia in patients (r = 0.622, 0.593, 0.588, P ＜ 0.05), while the Simpson index was negatively correlated with the degree of dysplasia in patients (r = -0.582, P ＜ 0.01). Conclusion The esophageal flora of patients with BE esophagus changes, and the diversity of the flora is related to the pathological characteristics of patients with BE esophagus, which may be related to the poor prognosis of patients.

Key words： Barrett’s esophagus Flora diversity Pathological characteristics Correlation analysis

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	KALARE·Ahemati HE Xiaolei HALIDA·Xiaerfuhazi ZHANG Zhiqiang GAO Hongliang

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KALARE·Ahemati HE Xiaolei HALIDA·Xiaerfuhazi ZHANG Zhiqiang GAO Hongliang. Correlation analysis of bacterial diversity and pathological characteristics of patients with Barrett’s esophagus[J]. 中国医药导报, 2021, 18(4): 24-28.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I4/24

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