|
|
|
| Discussion on the medication rules of softening handness and dispersing mass in the treatment of vocal nodules based on data mining |
| LIU Caifeng LI Siting WANG Zhiguo |
| Institute of Chinese Medical Clinical Basic Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China |
|
|
|
Abstract Objective To explore the clinical application rules of softening handness and dispersing mass in treating vocal nodules and to explore the core drug combinations. Methods CNKI, Wanfang, VIP, CBM published literatures of Chinese herbal compound in the treatment of vocal nodules were searched by using computer. The key words were “ruanjian”, “sanjie”, “xiaojian” and “vocal nodule”, etc. The retrieval time was from the establishment of the database to September 2019. The data from the literatures to WPS 2019 was extracted and database for frequency statistical analysis was established. Clementine 12 was used to establish Apriori association analysis model. R-type clustering was conducted to further study the prescriptions of Chinese medicine by using SPSS 23.0. The core drug pairs and core prescriptions for vocal nodules were analyzed. Medication rules were explored. Results A total of 55 prescriptions of Chinese medicine were included, involving 133 kinds of Chinese medicine, and the frequency of use was 631. The first three rules supported by association rule analysis were: the first three rules with high support degree in association rule analysis were as follows: Semen Oroxyli → Radix Platycodonis, Sargassum → Thallus Laminariae, Rhizoma Curcumae → Rhizoma Sparganii, as the core drug pairs for the treatment of vocal nodules. Three core prescriptions were obtained by cluster analysis, Formula C1: Rhizoma Sparganii, Rhizoma Curcumae, Sargassum, Thallus Laminariae, Semen Persicae, Flos Carthami. Formula C2: Radix Scrophulariae, Radix Ophiopogonis, Radix Rehmanniae Recens, Bulbus Fritillariae Thunbergii, Spica Prunellae. Formula C3: Rhizoma Atractylodis Macrocephalae, Poria, Radix Platycodonis, Semen Oroxyli, Radix Glycyrrhizae. The prescriptions for the treatment of vocal nodules is mainly phlegm-resolving formula and blood-activating formula. Combined with syndrome differentiations, drugs of dispelling pathogenic wind, nourishing yin, nourishing blood, clearing heat and others were used. Conclusion The basic principle of treating vocal nodules is dissipating phlegm and resolving masses, resolving stasis and softening hardness. The medication mainly use the drugs of dissipating phlegm and resolving stasis, clearing heat and resolving masses, combine with strengthening vital qi.
|
|
|
|
|
|
[1] 牧彦敏.纤维喉镜下治疗声带息肉并声带小结患者的临床护理方法研究[J].中国医药指南，2014，12（27）：328-329.
[2] 孙玲玲.声带小结微瓣手术治疗后病理观察及声学分析[D].天津：天津医科大学，2011.
[3] 丁国章.逍遥散合西药治疗声带小结68例[J].上海中医药杂志，1995（3）：29.
[4] 付登敏，纳玉萍.声带良性病变的病因及治疗研究进展[J].山西医药杂志，2019，48（15）：1849-1851.
[5] 张雷，汤建国.声带瘢痕的概念与对策[J].中华耳鼻咽喉头颈外科杂志，2005，40（4）：314-315.
[6] 石学敏.中药学[M].北京：中国中医药出版社，2011.
[7] 国家技术监督局.GB/T 16751.2—1997 中医临床诊疗术语·证候部分[S].北京：中国标准出版社，1997.
[8] 王士贞.中医耳鼻喉科学[M].北京：中国中医药出版社，2003.
[9] 崔妍，包志强.关联规则挖掘综述[J].计算机应用研究，2016，33（2）：330-334.
[10] 陈崇乐.改进的关联规则挖掘算法在网络用户访问日志分析中的应用[D].上海：上海师范大学，2007.
[11] 王琛，陈鹏，蔡云，等.基于数据挖掘的林培政治疗岭南地区头痛用药规律分析[J].中药新药与临床药理，2019， 30（8）：1002-1007.
[12] 岳程鹏，李兴.基于聚类分析的乌梁素海水质因子研究[J].人民黄河，2019，41（5）：67-70，76.
[13] 姜月蓬，张楠，曲苗，等.近年来代谢综合征中药疗法用药规律的文献研究[J].广州中医药大学学报，2019，36（9）：1470-1475.
[14] 胡稀恕.胡稀恕伤寒论讲座[M].北京：学苑出版社，2008：547-548.
[15] 魏郁晖，张雪雁.新疆红花的药理作用及临床应用[J].海峡药学，2011，23（12）：181-182.
[16] 朱庆伟，高小威.三棱莪术的临床运用体会[J].四川中医，2015，33（6）：90-91.
[17] 杜娜然.海藻玉壶汤加减治疗血瘀痰凝型声带小结的临床观察[D].太原：山西中医药大学，2018.
[18] 周玉霞，林露，于君平.自拟散结汤治疗声带小结76例[J].中医药学刊，2003，21（5）：768.
[19] 马凤梅，石会，马蕴蕾.活血化瘀祛痰散结方治疗慢性结节性喉炎体会[J].四川中医，2017，35（2）：127-128.
[20] 岑瑞祥，万浪，彭聪，等.发声训练联合药物治疗声带小结疗效观察[J].听力学及言语疾病杂志，2015，23（3）：265-268.
[21] 曹常乐，王斌全.声带小结诊断与治疗进展[J].临床耳鼻咽喉头颈外科杂志，2016，30（24）：1980-1982. |
|
|
|
