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| Clinical effect of Qilin Pills combined with Dapoxetine Hydrochloride in treatment of premature ejaculation |
| HU Yue1 LI Weiwei2 |
1.Department of Reproductive Medicine, First Hospital of Qinhuangdao, Hebei Province, Qinhuangdao 066000, China;
2.Department of Reproductive Medicine, Maternal and Child Care Center of Qinhuangdao, Hebei Province, Qinhuangdao 066004, China |
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Abstract Objective To investigate the clinical effect of Qilin Pills combined with Dapoxetine Hydrochloride in the treatment of premature ejaculation. Methods A total of 96 patients with premature ejaculation who were admitted to the Male Infertility Clinic of First Hospital of Qinhuangdao, Hebei Province from September 2018 to November 2019 were selected as the subjects. Using the random number table, starting from any one number, along the same direction to obtain one random number in each experimental unit, according to the remainder method, the premature ejaculation patients were divided into control group and experimental group, 48 cases in each group. The control group was given Dapoxetine Hydrochloride, 30 mg orally 1-3 h before each sexual intercourse. The experimental group was given Qilin Pills on the basis of control group, 6 g, 3 times a day. Both groups were treated for three months. Intravaginal ejaculatory latency time (IELT), premature ejaculation diagnostic tool (PEDT) score, and premature ejaculation profile (PEP) score were compared between the two groups before treatment, after treatment and at the end of follow-up. The recurrence rate after discontinuation and adverse drug reactions of patients during treatment were followed up. Results Overall analysis showed that there were statistically significant differences in IEDT and PEDT scores, ejaculation control ability, distress related to premature ejaculation among groups, time point comparison and interaction (all P ＜ 0.05). There were statistically significant differences in the effects of sexual satisfaction and premature ejaculation on partner relationship between groups and time points (all P ＜ 0.05), while there was no statistically significant difference in interaction (P ＞ 0.05). Comparison within the group: compared with before treatment, IELT value, ejaculation control ability and sexual satisfaction were increased after treatment and at the end of follow-up, while PEDT score, distress related to premature ejaculation and the impact of premature ejaculation on partner relationship were decreased in both groups, with statistical significance (all P ＜ 0.05). After treatment, IELT value, ejaculation control ability and sexual satisfaction of the two groups decreased, while PEDT score, distress related to premature ejaculation, and the influence of premature ejaculation on partner relationship increased at the end of follow-up, with statistical significance (all P ＜ 0.05). Comparison between groups: after treatment and at the end of follow-up, IELT value, ejaculation control ability and sexual satisfaction in the experimental group were higher than those in the control group, while the effects of PEDT score, distress related to premature ejaculation and premature ejaculation on partner relationship in the experimental group were lower than those in the control group, with statistical significance (all P ＜ 0.05). There was no significant difference in the total effective rate between the two groups (P ＞ 0.05), and the recurrence rate of the experimental group was lower than that of the control group, with statistical significance (P ＜ 0.05). There was no statistical significance in the incidence of adverse drug reactions between the two groups (P ＞ 0.05). Conclusion The efficacy of Qilin Pills combined with Dapoxetine Hydrochloride in the treatment of premature ejaculation was significantly better than that of Dapoxetine Hydrochloride alone. And it can effectively reduce the recurrence rate of premature ejaculation after Dapoxetine Hydrochloride withdrawal.
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