血清miR-10a、IL-33水平对重症急性胰腺炎患者并发急性肾损伤的预测价值

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Abstract Objective To analyze the predictive value of serum microRNA-10a (miR-10a) and interleukin-33 (IL-33) levels in patients with severe acute pancreatitis (SAP) complicated by acute kidney injury (AKI). Methods A total of 163 SAP patients from January 2016 to December 2019 in Chengdu Fifth People’s Hospital Affiliated to Chengdu University of Traditional Chinese Medicine were selected and divided into AKI group (48 cases) and non AKI group (115 cases) according to whether AKI was complicated. The serum miR-10a, IL-33 and general clinical data between the two groups were compared. The influencing factors of AKI in SAP patients were discussed, and the predictive value of miR-10a and IL-33 on AKI in SAP patients were analyzed. Results The serum levels of miR-10a, IL-33, Ranson score, high-sensitivity C-reactive protein (hs-CRP), procalcitonin, and neutrophil gelatinase-associated lipocalin in the AKI group were significantly higher than those in the non-AKI group, and the differences were statistically significant (P ＜ 0.05). Logistic multivariate regression analysis showed that miR-10a (OR = 1.764), IL-33 (OR = 1.863), Ranson score (OR = 1.631), hs-CRP (OR = 1.547) were all risk factors for SAP patients with AKI (P ＜ 0.05). The area under the ROC curve (AUC) predicted by miR-10a and IL-33 for SAP patients with AKI were 0.828 and 0.807, respectively. The combined predicted AUC of the two was 0.893, which was higher than miR-10a and IL-33, and the differences were statistically significant. (P ＜ 0.05). Conclusion Serum levels of miR-10a and IL-33 are significantly increased in SAP patients with AKI, and they have good predictive value for AKI. Combined detection can provide help for the early identification of AKI.

Key words： Severe acute pancreatitis Acute kidney injury MicroRNA-10a Interleukin-33

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	HUANG Xian ZHANG Lijuan WANG Ping

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HUANG Xian ZHANG Lijuan WANG Ping. Predictive value of serum miR-10a and IL-33 levels in patients with severe acute pancreatitis complicated with acute kidney injury[J]. 中国医药导报, 2021, 18(4): 29-32.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2021/V18/I4/29

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