|
|
|
| Clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression |
| LI Shiqiang WANG Wei SONG Ying WEI Jingpei▲ |
| The First Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
|
|
|
Abstract Objective To investigate clinical effect of Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Tablets in the treatment of depression. Methods By using the principle of random, controlled and blind method, a total of 90 outpatients and inpatients with depression of liver depression and spleen deficiency type in Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2018 to August 2019 were selected and divided into Western medicine group, Chinese medicine group and combination group according to the random number table method, with 30 cases in each group. Western medicine group was treated with Duloxetine Hydrochloride Enteric-coated Tablets, Chinese medicine group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction, combination group was treated with Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets. All patients were treated for six weeks. The curative effect of depression, curative effect of Chinese medicine symptoms, Hamilton depression scale (HAMD) score and Chinese medicine syndrome scale score before and after treatment among three groups were observed. Results Total effective rate of depression, total effective rate of Chinese medicine syndrome in combination group were higher than those in Western medicine group and Chinese medicine group (P < 0.017). Overall analysis found that there were significant differences in HAMD score and Chinese medicine syndrome scale score between inter group effect and time effect (P < 0.05), but there was no significant difference in interaction (P > 0.05). Intra group comparison: HAMD score and Chinese medicine syndrome scale score of three groups at three and six weeks after treatment were lower than those before treatment (P < 0.05). Comparison between groups: HAMD score and Chinese medicine syndrome scale score of combination group were lower than those of Western medicine group and Chinese medicine group at three and six weeks of treatment, the differences were statistically significant (P < 0.05). Conclusion Xiaoyao Powder combined with Huatan Tongluo Decoction and Duloxetine Hydrochloride Enteric-coated Tablets is effective in the treatment of depression, it may treat the depression as the quite ideal method clinically.
|
|
|
|
|
|
[1] 龚绍麟.抑郁症[M].北京：人民卫生出版社，2003：1-6.
[2] 王庆其.中医郁证之抑郁症辨治心验[J].上海中医药大学学报，2018，32（3）：17-21.
[3] 中华医学会精神学会.中国精神障碍分类与诊断标准第三版（CCMD-Ⅲ）[M].济南：山东科学技术出版社，2001：87.
[4] 朱文锋.中医内科疾病诊疗常规[M].长沙：湖南科学技术出版社，1999：190.
[5] 国家中医药管理局.24个专业105个病种中医诊疗方案[M].北京：中国中医药出版社，2012：76-79.
[6] 刘浩，张鸿燕，肖卫东，等.5种抑郁症状评定工具评估精神分裂症患者抑郁症状的比较[J].中国心理卫生杂志，2015，29（8）：570-575.
[7] 中华人民共和国卫生部.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002：367.
[8] 朱紫青，季建林，肖世富.抑郁障碍诊疗关键[M].南京：江苏科学技术出版社，2003：44，51，71-75.
[9] 宋·太平惠民和剂局.太平惠民和剂局方[M].北京：人民卫生出版社，1985：308.
[10] 修春，宓穗卿，王宁生.逍遥散的药理研究进展[J].中国药房，2015，18（9）：702.
[11] 张颖，陈宇霞，黄世敬，等.柴胡及柴胡类复方的抗抑郁研究现状[J].世界中西医结合杂志，2014，9（9）：985-988.
[12] 徐露，董志，陈洪，等.当归多糖对Ｄ-半乳糖致衰老小鼠学习记忆的影响[J].激光杂志，2008，29（2）：92-93.
[13] 廖铭能，王艳平，张永平，等.阿魏酸钠的神经保护和神经发生增强作用[J].中国细胞生物学学报，2010，32（6）：840-849.
[14] 崔广智.芍药苷抗抑郁作用的实验研究[J].现代药物和临床，2009，24（4）：231-233.
[15] 张明发，赵迎春，沈雅琴.甘草及其黄酮类化合物的神经保护作用[J].抗感染药学，2013，10（3）：170-175.
[16] 薛劲松，李鸿雁，傅强，等.左旋薄荷酮抗抑郁作用及机制研究[J].药学与临床研究，2015，23（3）：238-241.
[17] 张立娟，张进强，贺慧，等.丹参抗抑郁的神经免疫机制研究探讨[J].世界科学技术-中医药现代化，2017，19（8）：1289-1291.
[18] 雷辉，顾乃兵，刘志勤，等.miR-1202通过调控小鼠脑内的mGluR4的表达在重度抑郁症中的作用[J].陕西医学杂志，2015，44（9）：109.
[19] 傅春燕，刘永辉，李明娟，等.三七叶总皂苷的提取纯化及其抗抑郁活性研究[J].河北医药，2012，35（17）：2578-2580.
[20] 周中流，刘永辉.香附提取物的抗抑郁活性及其作用机制研究[J].中国实验方剂学杂志，2012，18（7）：191-192.
[21] 周红伟，张惠实，朱宏飞，等.大黄素对大鼠抑郁症行为学变化和脑内单胺类神经递质的影响[J].华中科技大学学报：医学版，2017，46（2）：150-154. |
|
|
|
