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2020 Vol. 17, No. 25 Published: 2020-09-05

	4	Effects of Rabdosia Rubescens on lipid metabolism in metabolism-associated fatty liver disease
		MA Wenjun1 SHI Tingting2 BAI Minghui1 CHEN Xiaowei1 YANG Xingxin3▲
		Objective To investigate the effect of Rabdosia Rubescens on the expression of lipid metabolism-associated proteins in rats with metabolism-associated fatty liver disease (MAFLD). Methods The rats were fed with high-fat diet to replicate the metabolic-related fatty liver disease model. A total of 36 SD male rats were adaptively fed for one day, and they were divided into normal group, model group, and Rabdosia Rubescens low, medium, and high-dose groups by random number table method, each with six animals. The normal group was fed with ordinary feed, and the other groups were fed with high-fat feed. The low, medium, and high-doses of Rabdosia Rubescens were given 50, 100 mg/(kg·d) and 150 mg/(kg·d) per day, respectively; the normal group and the model group were given a gavage with the same volume of normal saline as the other experimental groups every day. HE staining was used to observe the degree of fatty degeneration of rat MAFLD liver tissue; automatic biochemical analyzer was used to detect triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL- C), fasting blood glucose (FBG), fasting insulin (FINS); Western blot method was used to detect the expressions of peroxisome proliferator-activated receptor-α (PPAR-α), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) protein. Results The liver tissue of rats in the normal group showed clear and complete structure under microscope, the structure of liver lobules was normal, and the hepatocyte cords were neatly arranged. Hepatocyte damage in the model group showed diffuse hepatocyte steatosis with balloon-like hepatocytes, inflammatory cell infiltration in the portal area, and partial punctate hepatocyte necrosis and detrital necrosis. The degree of liver damage in the Rabdosia Rubescens high-dose group was significantly less than that of the model group. The fatty degeneration of hepatocytes was reduced. There was only a few punctate necrosis, a few fat droplets, and no obvious inflammatory cell infiltration in the portal area. The levels of TC, TG, HDL-C, LDL-C, FBG, and FINS of rats in each group were compared, and the differences were statistically significant (P ＜ 0.05). The levels of serum TC, TG, LDL-C, FBG, and FINS in the model group were higher than those in the normal group, while the level of HDL-C was lower than that in the normal group, and the differences were statistically significant (P ＜ 0.05). The content of TG and FINS in the low-dose Rabdosia Rubescens group were lower than those of the model group, and the differences were statistically significant (P ＜ 0.05); the content of TC, TG, LDL-C, FBG, and FINS in the medium-dose Rabdosia Rubescens group were lower than those of the model group, while TG and FBG were lower than those of the low-dose Rabdosia Rubescens group, and the differences were statistically significant (P ＜ 0.05). The content of TC, TG, LDL-C, FBG, and FINS in the high-dose Rabdosia Rubescens group were lower than those of the model group, while the level of HDL-C was higher than that of the model group, and TC, TG, LDL-C, FBG were lower than those of the low-dose Rabdosia Rubescens group, and the differences were statistically significant (P ＜ 0.05). The expressions of PPAR-α and ACC protein in the model group were lower than those of the normal group, while the expressions of SREBP-1c and FAS protein were higher than those of the normal group, and the differences were statistically significant (P ＜ 0.05). The expressions of PPAR-α and ACC protein in the low dose of Rabdosia Rubescens group were higher than those of the model group, while the expression of FAS protein was lower than that of the model group, and the differences were statistically significant (P ＜ 0.05). The expressions of PPAR-α and ACC protein in the medium and high-doses Rabdosia Rubescens group were higher than those of the model group and the low-dose Rabdosia Rubescens group, while the expressions of SREBP-1c and FAS protein were lower than those of the model group and the low-dose Rabdosia Rubescens group, and the differences were statistically significant (P ＜ 0.05). Conclusion Rabdosia Rubescens can regulate lipid metabolism and associated protein expression in rats with MAFLD, which lays a foundation for further study on the mechanism of the occurrence and development of MAFLD.
		2020 Vol. 17 (25): 4-9 [Abstract] ( 86 ) HTML (1 KB) PDF (995 KB) ( 151 )

	10	Content determination of chlorogenic acid in traditional Chinese medicine and their preparations by quantitative analysis of multi-components by single marker
		ZHANG Qiuyan1 ZHANG Ni1 ZHANG Chunli2 GUO Wenquan2 CUI Hanming1
		Objective To establish the quantitative analysis of multi-components by single marker (QAMS) method for the analysis of six chlorogenic acids in traditional Chinese medicine and their preparations. Methods A high performance liquid chromatography-photodiode array detector (HPLC-DAD) method was developed with acetonitrile-0.4% phosphoric acid as mobile phase ingradient elution. The column temperature was 25℃. The flow rare was 1.0 mL/min and the detection wavelength was 327 nm. Then the relative correction factors among the other five chlorogenic acids were calculated, when the chlorogenic acid was used as internal referring substances. The ruggedness of relative correction factors was evaluated to establish the QAMS method, when the chlorogenic acid was used as internal referring substances. The content of chlorogenic acid in traditional Chinese medicine (Lonicerae Japonicae Flos and Chrysanthemi Indici Flos) and their eye drops were calculated by the established QAMS method and external standard method respectively, and the content difference of different algorithms was analyzed by t-test and relative error analysis to evaluate the accuracy of the QAMS method. The relative retention time method was used to accurately locate the chromatographic peaks of the six constituents. Results The established relative correction factor with chlorogenic acid as internal referring substances had good ruggedness. Two methods were used to calculate the content of chlorogenic acid in 10 batches of eye drops and three batches of Lonicerae Japonicae Flos and Chrysanthemi Indici Flos. The relative error range was -3.32% to 4.99%, and there was no statistically significant difference (P ＞ 0.05). Conclusion A rapid, accurate and convenient QAMS method for simultaneous measurement of six chlorogenic acids has been established, and this method can be used for quality analysis of six chlorogenic acids in Lonicerae Japonicae Flos, Chrysanthemi Indici Flos and their eye drops.
		2020 Vol. 17 (25): 10-14 [Abstract] ( 91 ) HTML (1 KB) PDF (821 KB) ( 77 )

	15	Establishment of mice endometriosis fibrosis model by allogeneic transplantation
		CHANG Xiangyu DENG Mengqi ZHANG Yanqin WU Di MIAO Jinwei
		Objective To explore the feasibility of using allogeneic transplantation to establish a mouse model of endometriosis. Methods Thirty-six BALB/c mice were randomly divided into experimental group, control group and donor group, with 12 mice in each groups. The uterine horn was extracted from donor group and cut into pieces to make the uterine tissue suspension. Experimental group was intraperitoneally injected with uterine tissue suspension, while control group was injected with phosphate buffer solution. On the 7th and 14th days after uterine tissue suspension injected, the success of the model was observed by laparotomy and pathological verification was conducted. Results On the 14th day after uterine tissue suspension was injected, the modeling of experimental group was successful and the fibrosis characteristics were obvious. Conclusion The allogeneic transplantation method can be used to construct mice model of endometriosis fibrosis.
		2020 Vol. 17 (25): 15-18 [Abstract] ( 133 ) HTML (1 KB) PDF (1088 KB) ( 117 )

	19	Effect of Ampelopsin on the differentiation of Treg/Th17 cells in rats with experimental colitis
		WANG Chao1 WANG Xiaojuan1 ZHU Meirong2 WAN Yugang3
		Objective To investigate the effect of Ampelopsin on the differentiation of Treg/Th17 cells in experimental colitis rats. Methods Forty-eight male SD rats were divided into control group, model group, high dose group, medium dose group, low dose group and Sulfasalazine group by random number table method, with eight rats in each groups. Except for control group, the other five groups of rats were used Trinitrobenzene Sulfonic Scid to establish experimental colitis model. After three days of modeling, drug treatment was given for seven days. Rats in high, medium, and low dose groups were given 500, 250 and 125 mg/(kg·d) of Ampelopsin respectively, and Sulfasalazine group was given 100 mg/(kg·d) of Sulfasalazine, and control group was given quantitative normal saline. The levels of transformed growth factor-β1 (TGF-β1), interleukin-10 (IL-10), IL-17, forkhead box P3 (Foxp3), signal transducers and activators of transcription 5 (STAT5), retinoic related orphan receptor γt (RORγt), STAT3 and IL-35 in six groups were compared. Results The pathological injury score of model group was higher than that of control group (P < 0.05); and the pathological injury scores of high, medium dose groups and Sulfasalazine group were lower than those of model group (all P < 0.05). The expression levels of TGF-β1, IL-10, IL-35, Foxp3 and STAT5 of model group were lower than those of control group, while the expression levels of IL-17, RORγt and STAT3 were higher than those of control group (all P < 0.05). The expression levels of TGF-β1, IL-10, IL-35, Foxp3 and STAT5 of high, medium, low dose groups and Sulfasalazine group were higher than those of model group, while the expression levels of IL-17, RORγt and STAT3 were lower than those of model group (all P < 0.05). Conclusion Ampelopsin can regulate Treg/Th17 cell differentiation and enhance cell function in experimental colitis rats.
		2020 Vol. 17 (25): 19-23 [Abstract] ( 95 ) HTML (1 KB) PDF (1585 KB) ( 94 )

	24	Experimental study on the safety of skin medication of herpes ointment
		SHEN Dexin1 LI Dengpan1 QIN Zhen1 YUE Wei1 QU Jun2 CHU Xia3▲
		Objective To observe the safety of skin medication of herpes ointment. Methods Eight healthy adult New Zealand rabbits were selected and divided into intact skin group and damaged skin group by random number table method, four rabbits in each group. The skin irritation test was carried out by coating herpes ointment and herpes ointment matrix (0.5 g each) with the homologous control method, and the skin was administered for histopathological examination 14 days later. Forty healthy adult guinea pigs were selected and divided into herpes ointment group, matrix group, dinitrochlorobenzene group by random number table method, twenty in herpes ointment group and ten in other groups. The skin sensitization test was carried out by coating herpes ointment (0.2 g each), herpes ointment matrix (0.2 g each), and 2,4-dinitrochlorobenzene (0.2 mL each). Erythema and edema were used as evaluation indexes in two tests. Twenty-four New Zealand rabbits were selected and divided into herpes ointment group, matrix group and blank control group by random number table method. Each group had eight rabbits. Acute skin toxicity tests were carried out on New Zealand rabbits coated with 10 g/kg, 2 g/kg, 2 mL/kg herpes ointment, herpes ointment matrix and normal saline in groups, and the changes of body mass, toxic reaction and death of rabbit in each group were observed within 14 days. On the 14th day after dosing, general anatomy was performed on all New Zealand rabbits, and histopathological examination was performed if there were any toxic reactions and general anatomy abnormalities. Results Herpes ointment had no irritating effect on intact and damaged skin of New Zealand rabbits, and the histopathological examination of skin was normal. Herpes ointment had no skin allergic reaction to guinea pigs, and the sensitization intensity score was 0； there was no acute toxicity reaction to New Zealand rabbits, no obvious abnormalities were found in tissues and organs after dissection, body weight growth was consistent with the growth law. Compared with the blank control group, there was no significant difference in the weight of New Zealand rabbits of the herpes ointment group (P ＞ 0.05). Conclusion Herpes ointment has no skin irritation, allergy, or acute toxicity. The topical skin medication is safe and can be used for clinical applications.
		2020 Vol. 17 (25): 24-28 [Abstract] ( 96 ) HTML (1 KB) PDF (908 KB) ( 139 )

	29	Value of two dimensional shear wave elastography in differential diagnosis of cervical lymph nodes with different pathological types
		LIANG Kui WANG Xiaorong SONG Tao
		Objective To investigate the differential diagnosis value of two dimensional shear wave elastography (2D-SWE) in different pathological types of cervical lymph nodes. Methods A total of 101 patients with 145 enlarged cervical lymph nodes from October 2017 to May 2019 in the First Affiliated Hospital of Xinjiang Medical University were selected, and they underwent routine ultrasound and 2D-SWE examination. They were grouped according to lymph node pathology or results after six months of follow-up. Nodal tuberculosis, lymphoma and metastatic lymph nodes were selected as the case group (92 cases) and reactive hyperplasia lymph nodes as the control group (53 cases). Binary logistic regression was used to screen the elastic parameter with high differential value between the case group and the control group, and the diagnostic boundary value was determined by the comparison of this parameter between the groups and the ROC curve. Results Binary logistic regression showed that lymph node blood flow type, internal echo and 2D-SWE parameter Emax had higher differential diagnostic value between the case group and the control group. The Emax values of lymphomas, nodal tuberculosis and metastatic lymph nodes were higher than those of reactive hyperplasia lymph nodes (all P ＜ 0.01) and increased step by step. The Emax boundary value of lymphomas and reactive hyperplasia lymph nodes was 30.0 kPa (P ＜ 0.01), and the AUC, sensitivity and specificity were 0.783, 78.57% and 67.92%, respectively. The Emax boundary value of nodal tuberculosis and lymphoma was 47.53 kPa (P ＜ 0.01), and the AUC, sensitivity and specificity were 0.856, 71.43% and 91.30%, respectively. There was no significant difference in Emax value between reactive hyperplasia lymph nodes and nodal tuberculosis (P ＞ 0.05). Conclusion The 2D-SWE parameter Emax is the preferred elastic parameter to reflect the difference in hardness of cervical lymph nodes of different pathological types, which can be used as an important supplementary indicator for the ultrasonic differential diagnosis of cervical lymph node diseases.
		2020 Vol. 17 (25): 29-32,41 [Abstract] ( 102 ) HTML (1 KB) PDF (972 KB) ( 120 )

	33	Analysis of UBQLN-1 expression and clinical significance in rectal cancer tissues and correlation with prognosis
		SUN Guangyuan1 WU Xueliang1 XUE Jun1 ZHANG Haiyan2 MA Haiyan1 LIU Xiaoning3 HAN Lei1 QU Ming1
		Objective To explore the expression and clinical significance of ubiquitin-1 (UBQLN-1) in rectal cancer, and correlation analysis with prognosis . Methods From December 2015 to January 2016, a total of 90 patients who underwent rectal cancer surgery in the Department of General Surgery of the First Affiliated Hospital Hebei North University were selected. The rectal cancer foci and normal tissues adjacent to the cancer were collected. Reverse transcription polymerase chain reaction (Rt-PCR) was used. The expression of UBQLN-1 mRNA of specimens in the two groups were detected, while immunohistochemistry was used to detect the expression of UBQLN-1 protein of specimens in the two groups, and the relationship with the clinicopathological characteristics of the tumor was analyzed. The survival period of the included patients was followed up, Kaplan-Meier was used to draw survival curves, and the relationship between the expression of UBQLN-1 protein and the prognosis of rectal cancer patients were analyzed by multi-factor prognosis. Results The relative expression of UBQLN-1 mRNA in rectal cancer tissues was significantly higher than that in normal tissues adjacent to cancer, and the difference was highly statistically significant (P < 0.01). The positive expression of UBQLN-1 in rectal cancer tissues was significantly higher than that in normal tissues adjacent to cancer, and the difference was highly statistically significant (P < 0.01). The positive expression of UBQLN-1 in rectal cancer tissues of patients with different levels of differentiation, T stage, lymph node metastasis and liver metastasis were compared, and the differences were statistically significant (P ＜ 0.05). The 5-year disease-free survival rate of rectal cancer patients with positive expression of UBQLN-1 was significantly lower than that of patients with negative expression, and the difference was statistically significant (P ＜ 0.05). T staging (HR = 1.246), lymph node metastasis (HR = 2.538), liver metastasis (HR = 2.256) and UBQLN-1 expression (HR = 5.820) were independent risk factors that affected the prognosis of patients (P ＜ 0.05). Conclusion The high expression of UBQLN-1 in rectal cancer tissue is closely related to the occurrence, development, invasion and metastasis of rectal cancer. It is also an independent risk factor for the prognosis of rectal cancer patients. Therefore, it can be used as a potential molecular biological indicator for early diagnosis and prognosis evaluation of rectal cancer.
		2020 Vol. 17 (25): 33-37 [Abstract] ( 132 ) HTML (1 KB) PDF (842 KB) ( 94 )

	38	Study on ACTN3 gene polymorphism related to the difference of athletic ability in Northern HanZú and MongguZú population
		WU Jian1 GAO Yuxue2 YANG Pengxiang3 GUO Xianghua2
		Objective To investigate the frequency distribution characteristics of α-actinin 3 (ACTN3) gene R577X polymorphism in northern HanZú and MongguZú populations. Methods From September to November 2019, a total of 85 northern HanZú people who participated in the health checkup at Beijing You′an Hospital and a total of 58 health checkup population from the 2019 preparatory class of MongguZú in Baotou Medical College were selected as the research objects. High-throughput fluorescence real-time quantitative polymerase chain reaction was used to analyze the R577X polymorphism of ACTN3 gene of different races and genders. Results The three genotypes were in accordance with Hardy-Weinberg equilibrium in different groups of people. The genotype frequency (RR) and allele frequency (R) of the northern HanZú population were higher than those of the MengguZú population, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the distribution of ACTN3 gene R577X genotypes between different genders of northern HanZú and MongguZú (P ＞ 0.05). The differences in different genotype frequencies, and different allele frequencies were no statically signifrcant between the northern HanZú and the MongguZú in different genders (P ＞ 0.05). Conclusion The differences in ACTN3 gene R577X genotype frequency and allele frequency between northern HanZú and MongguZú populations have nothing to do with gender. RR genotype frequency related to explosive power is higher in northern HanZú population, while XX genotype frequency reflecting endurance in MongguZú population is higher.
		2020 Vol. 17 (25): 38-41 [Abstract] ( 74 ) HTML (1 KB) PDF (335 KB) ( 149 )

	42	Application of moxibustion therapy in immune related diseases
		GUO Shiqi1 HE Rui1 YAO Qin1 HAN Li2 ZHAO Baixiao2
		Moxibustion therapy, as one of the unique therapies in traditional Chinese medicine, has a two-way benign regulation effect on human immune function. Immune-related diseases include immune-related diseases and diseases closely related to immunity. And immune disease refers to the disease caused by the imbalance of immune regulation of the body, which affects the immune response of the body. In this paper, the application of moxibustion in immune-related diseases in recent five years is discussed, and it is divided into autoimmune diseases, immunodeficiency diseases, immunodeficiency diseases and other diseases with immunodeficiency manifestations from three aspects of immunohyperactivity, immunodeficiency and immunodeficiency. The clinical symptoms of patients with cancer, chronic glomerulonephritis and primary kidney disease, AIDS, ankylosing spondylitis are reviewed.
		2020 Vol. 17 (25): 42-44,52 [Abstract] ( 77 ) HTML (1 KB) PDF (469 KB) ( 74 )

	45	Research progress in the relationship between 3-nitrotyrosine and diabetic vascular disease
		ZHAO Ruohan1 WANG Lixin2▲ TIAN Fengsheng3 BAI Hailong3
		Vascular disease is one of the chronic complications of diabetes, basically involves the heart, the kidney, the peripheral blood vessel, the eye and so on. As the disease progresses, oxidative stress reaction aggravates, and promote the conversion of protein tyrosine residues to 3-nitrotyrosine. The increase of 3-nitrotyrosine exacerbates occurrence and development of diabetic vascular disease as well, and attracted more and more people′s attention. For the past few years, there are more and more studies on 3-nitrotyrosine in Chinese and Westerm medicine. This article reviews the recent advances in the study of relationship between 3-nitrotyrosine and diabetic vascular disease. It provides a possibility for the effective prevention and treatment of diabetic vascular disease.
		2020 Vol. 17 (25): 45-48 [Abstract] ( 81 ) HTML (1 KB) PDF (509 KB) ( 82 )

	49	Common psychological issues and diagnosis and treatment progress in patients with inflammatory bowel disease
		XU Lingyun1 CHEN Siwei1 LIU Huanyu2 RAN Yan1 CHEN Ningning1 SUN Lin1 CHEN Yu1 LI Yingchao1
		The Patients with inflammatory bowel disease (IBD) have significantly higher rates of psychological issues than the general population. Anxiety, depression and chronic abdominal pain are the most notable. The disorder of brain-gut axis is the important mechanism in bi-directional interactions between IBD disease activity and psychological issues. More and more attention has been paid to the diagnostic approaches of psychological conditions and standardized psychological treatments in IBD. Psychotherapy, an important supplement to the traditional treatment of IBD, can not only reduce the symptoms of psychological issues in IBD patients, but also reduce the activity of IBD disease. Moreover it can prevent unnecessary treatment escalation and improve the quality of life of patients. It can also change the disease course. A new “bio-psycho-social” medical model of IBD is emerging. This article reviews the common psychological issues in IBD patients, the interactions between psychological issues and IBD disease activity, and the progress of diagnosis and treatment.
		2020 Vol. 17 (25): 49-52 [Abstract] ( 86 ) HTML (1 KB) PDF (511 KB) ( 95 )

	53	Application of the WeChat combined with problem-based learning model in clinical practice teaching of periodontology
		AN Ying LIU Lingxia CHEN Fang TONG Yuxin LIU Rui LI Ping
		Objective To explore the effect of WeChat combined with problem-based learning (PBL) model in undergraduate clinical practice teaching of periodontology. Methods Forty undergraduates interns were selected as the research objects during clinical practice in the Department of Periodontology of School of Stomatology of the Fourth Military Medical University between July 2018 and June 2019. Simple random method was used to divide the patients into the experimental group (n = 20) and the control group (n = 20). The experimental group adopted WeChat combined with PBL teaching mode, while the control group adopted traditional lecture-based learning teaching mode. The internship lasted for 8 weeks. At the end of the internship, the teaching was evaluated in two ways, namely, subject examination and student satisfaction survey. Results The total score of the experimental group was higher than that of the control group, and the scores of oral examination, medical record writing and standardized operation were higher than those of the control group, with statistically significant differences (P ＜ 0.05). The total scores of boys and girls in the experimental group were higher than those in the control group, and the difference was statistically significant (P ＜ 0.05). Ninety-five percent of the students in the experimental group were satisfied with the joint teaching mode, and 85 percent were very satisfied. Conclusion In periodontal clinical practice teaching, WeChat combined with PBL teaching mode is easier to arouse students′ interest in learning, inspire students′ independent thinking ability, greatly improve students′ practice effect, and obtain good clinical teaching effect, which should be widely applied.
		2020 Vol. 17 (25): 53-56 [Abstract] ( 72 ) HTML (1 KB) PDF (650 KB) ( 108 )

	57	Discussion on the application of multi-modality teaching mode in clinical teaching of plastic surgery
		BIAN Yongqian LI Yuejun LI Jing LI Jinqing LI Xueyong
		Objective To explore the effect of multi-modality teaching method of combination of lecture-based learning (LBL), problem-based learning (PBL) and micro-course in plastic surgery clinical teaching. Methods A total of 73 undergraduates who were intern at the Department of Burn and Plastic Surgery in the Second Affiliated Hospital of Air Force Military Medical University from June 2018 to May 2019 were selected, and they were divided into the control group (n = 36) and experimental group (n = 37) according to the random number table method. Undergraduates in the control group were subjected to the multi-modality teaching method of combination of LBL, PBL and micro-course and the experimental group to the combination of LBL and PBL. At the end of the study, the effects were evaluated by the written tests, clinical operations, and questionnaire survey. Results The written test scores, operation scores, and total scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The results of questionnaire survey showed that the experimental group undergraduates′ learning interest and enthusiasm, and knowledge understanding ability were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Multi-modality teaching method of combination of LBL, PBL and micro-course has a significant effect in the clinical teaching practice of plastic surgery, which is worthy more promotion.
		2020 Vol. 17 (25): 57-60 [Abstract] ( 82 ) HTML (1 KB) PDF (683 KB) ( 56 )

	61	Remodeling and development of basic-level clinical teaching organization in colleges and universities from the perspective of medical and educational collaboration
		GAO Jinbiao HUANG Guicheng
		The basic-level clinical teaching organizations play an indispensable role in the training of medical professionals, but their construction and development have not received due attention, and the relevant planning and function positioning are not suitable for the development and reform of higher medical education, so it is urgent to rethink and design. In the context of the continuous and in-depth advancement of medical and educational collaboration, it is necessary to take collaborative education as the orientation, and take the cultivation of students′ ability and the academic growth of clinical teachers as the core, take the improvement of clinical teaching quality as the goal, and take curriculum construction as the main mean, from the idea renewal, organizational structure optimization, working mechanism, the academic community building, etc, to promote development and remodeling.
		2020 Vol. 17 (25): 61-64 [Abstract] ( 81 ) HTML (1 KB) PDF (650 KB) ( 165 )

	65	Application of colleges and universities combine “1.5+1.5” mode in the training of higher vocational pediatric nursing professionals
		CHEN Shaochuan1 WANG Xin2 HUANG Li1 SUN Rong1 GAO Xi3
		Objective To explore the advantages of colleges and universities combine “1.5+1.5” mode in the training of higher vocational pediatric nursing professionals, so as to lay a foundation for training pediatric nursing professionals in higher vocational colleges to meet the development needs of modern pediatric nursing career, and to provide new ideas for the development of hospitals and related disciplines. Methods From March 2017 to August 2019, two classes of 2016 nursing (pediatric direction) major students of a higher vocational college were selected as the experimental group and the control group. The control group (45 students) adopted the traditional training mode, while the experimental group (44 students) adopted the colleges and universities combine “1.5+1.5” training mode. The core competence was evaluated by the Chinese version of the core competence scale for nursing students, and the scores of pediatric nursing, employment status and teaching satisfaction of the two groups of students were compared. Results The scores of moral and responsibility dimensions and general clinical skills dimensions of the experimental group were higher than those of the control group, while the scores of critical thinking and reasoning ability of the experimental group were lower than those of the control group, and the differences were statistically significant (all P ＜ 0.05). The scores of pediatric nursing, employment and teaching satisfaction in the experimental group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Conclusion The colleges and universities combine “1.5+1.5” mode has significant advantages, which is conducive to the cultivation of a large number of high-quality, professional and competent pediatric nursing professionals for the society, and is worthy of promotion.
		2020 Vol. 17 (25): 65-68 [Abstract] ( 168 ) HTML (1 KB) PDF (685 KB) ( 34 )

	69	The practice and influence of bioinformatics concept in postgraduate education of gynecological oncology
		CHEN Changxian LI Li
		The traditional postgraduate education of gynecological oncology focuses on the pure knowledge impartation of a single subject, with outdated educational concepts, complicated teaching contents and old teaching methods, thus it is difficult to cultivate innovative postgraduate students with interdisciplinary thinking that meet the requirements of modern medicine. Bioinformatics is not only an interdisciplinary subject, but also an embodiment of thinking mode and educational philosophy. Introducing bioinformatics knowledge and concepts into postgraduate education of gynecological oncology can not only impact the traditional medical education model, but also cultivate the ability of postgraduates to think from multiple perspectives, thus produces unique research methods and innovative thinking, and cultivate postgraduates′ ability to find problems, analyze problems and solve problems from different professional perspectives.
		2020 Vol. 17 (25): 69-72 [Abstract] ( 132 ) HTML (1 KB) PDF (648 KB) ( 112 )

	73	Discussion on the reform of medical cell biology flipped classroom based on online course
		SHA Baoyong1 LI Yuan1 FENG Hao1 LIU Jie1 JING Xiaohong1 GAO Wei2
		Objective To explore the teaching effect of the flipped classroom teaching model in medical cell biology. Methods The study period was from February to July 2019. By means of random number table method, 178 undergraduate students in general practice in 2018 of Xi′an Medical University were randomly divided into the control group and the teaching reform group, with 89 students in each group. The control group was taught with the traditional teaching mode and the teaching reform group carried out the flipped classroom mode. Learning records of online course, quizzes, experimental results, cell structure function diagrams and questionnaires were used to evaluate the teaching effects between the two groups. Results The scores of online course, multiple-choice question quizzes in class, experimental results, cell structure and function diagrams in the teaching reform group were all higher than those of the control group, the differences were statistically significant (P ＜ 0.05). According to the questionnaire, the scores of course recognition degree, course inspiration, rationality of teaching design, change of learning attitude, cultivation of learning methods, cultivation of practical ability, and teachers′ guidance strength in the teaching reform group were all higher than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Compared with traditional teaching, flipped classroom allows students to have clearer learning objectives, promote students′ internalization and absorption of knowledge, further train students′ practical ability to apply what they have learned, and turn students from passive learning to autonomous learning.
		2020 Vol. 17 (25): 73-75,79 [Abstract] ( 107 ) HTML (1 KB) PDF (696 KB) ( 111 )

	76	Reform of the ecological environment of pharmacy undergraduate teaching in the new situation
		WANG Chenping LIN Yongyao JIA Yi DOU Yin LI Xiaohui
		In order to comply with the requirements of the human society for the development of pharmacy under the new situation and cultivate high-quality pharmacy professionals facing the future, the Army Military Medical University has exploratory reconstruction of the ecological environment of pharmacy undergraduate teaching on the basis of fully evaluating the characteristics of the development of pharmacy in the new era. It mainly includes the revision of teaching documents, the innovation of teaching models and methods, and the construction of smart classrooms, with three aspects. We should strive to create an innovative discipline ecological environment that meets the development requirements of the new era of pharmacy, and nurture a group of diversified discipline talents with a sense of mission and responsibility. After the implementation of the reform, teachers and students have a strong sense of belonging, a strong learning atmosphere, a significant increase in theoretical academic performance, and a large output of basic scientific research results. This reform measure provides a reference for cultivating comprehensive pharmaceutical talents in the new era.
		2020 Vol. 17 (25): 76-79 [Abstract] ( 120 ) HTML (1 KB) PDF (648 KB) ( 81 )

	80	Application of 3D model based on CT/MRI in experimental teaching of regional anatomy
		YU Penghui LI Qiao JU Xiaojun LIU Yu CAI Shichang
		Traditional local anatomy experiment teaching mostly uses cadavers as the main teaching resources, and there are problems such as fewer sources of cadaver specimens, easy damage, and poisonous gas that can damage the health of teachers and students. The application of virtual three-dimensional model in the local anatomy experiment teaching can reduce the resource consumption of cadaver specimens caused by anatomy, shorten the time in the toxic gas environment, and have the advantages of independent design, repeated use, and multi-directional observation, while it is not limited by using time and space. At the same time, it also has certain limitations. Combining the traditional autopsy teaching mode with the virtual three-dimensional model, and learning from each other, can effectively improve the quality of regional anatomy experimental teaching and enhance the level of anatomy.
		2020 Vol. 17 (25): 80-82,91 [Abstract] ( 96 ) HTML (1 KB) PDF (1024 KB) ( 141 )

	83	Retrospective analysis of 36 AIDS patients in Junchuan Country, Hubei Province
		ZHAO Xin1 YANG Yi2 NI Wei3
		Objective To retrospectively analyze the population characteristics of 36 patients with acquired immune deficiency syndrome (AIDS) combined with cough (type of phlegm-fever stagnating in the lung) diagnosed by traditional Chinese medicine syndrome differentiation in Junchuan Country, Hubei Province, and to explore whether there was any difference in the number of peripheral blood cells in patients with AIDS combined with cough of different physique was discussed. Methods July 2017 to February 2018, the implementation unit of the National Traditional Chinese Medicine Treatment AIDS Pilot Project in Wenxinjiayuan, Junchuan Town, Hubei Province, a total of 36 cases who were diagnosed with AIDS combined with cough (phlegm-heat-stagnation lung type) traditional Chinese medicine diagnosis and treatment plan clinical verification study were collected and consulted, while the original medical records of each patient were statistically analyzed by descriptive epidemiological methods. At the same time, according to the classification standard of Chinese body mass index, the test population were divided into the lean group (6 cases), the normal group (24 cases) and the overweight group (6 cases). The single factor variance analysis was used to compare the levels of CD4+T lymphocytes, platelets and white blood cells in the three groups. Results The 36 AIDS patients with cough (phlegm-heat stagnation lung type) were mostly middle-aged and elderly patients. The main route of infection was blood, and the level of AIDS awareness was low. Comparison of platelets and white blood cells of the three groups showed statistically significant differences (P ＜ 0.05). Further pairwise comparisons, the platelets of lean group and the overweight group were higher than that of the normal group, and the differences were statistically significant (P ＜ 0.05), while the white blood cells of lean group was higher than that of the normal group and the overweight group, and the differences were statistically significant (P ＜ 0.05). Conclusion The screening, education and publicity of middle-aged and elderly people with lower cultural level should be intensified, and effective treatment and prevention and control measures should be implemented as soon as possible. In clinical work, attention should be paid to the impact of physical factors on AIDS patients, so as to formulate and improve more reasonable diagnosis and treatment plans, and provide new ideas for better treatment of AIDS patients.
		2020 Vol. 17 (25): 83-86 [Abstract] ( 146 ) HTML (1 KB) PDF (626 KB) ( 87 )

	87	Influence of obesity on intra-abdominal pressure of patients undergoing retroperitoneal laparoscopic surgery
		WANG Zhe1 LYU Jieping2
		Objective To analyze the influence of obesity on intra-abdominal pressure (IAP) of patients undergoing retroperitoneal laparoscopic surgery. Methods From October 2018 to July 2019, patients who underwent retroperitoneal partial nephrectomy at the First Hospital of Shanxi Medical University were divided into obese group and normal group according to their body mass index (BMI) level, with 30 cases in each group. The patients in both groups were maintained by retroperitoneal approach and total intravenous anesthesia. The IAP levels of supine position after anesthesia (T), the anterior and lateral position of the pneumoperitoneum (T0), 30 min after the pneumoperitoneum (T1), 60 min after the pneumoperitoneum (T2), 90 min after the pneumoperitoneum (T3), and the end of the pneumoperitoneum after 10 min (T4) were measured. The mean arterial pressure (MAP), airway pressure (Peak), oxygenation index (PaO2/FiO2), radial artery blood pH value and radial artery blood lactic acid value (Lac) at T, T0, T1, T2, T3, and T4 were recorded respectively. Results There were statistically significant differences of IAP levels in time, between groups and the interaction between the two groups (P ＜ 0.05). Among them, T0 time point was higher than T time point, T1-T3 time points were higher than T0 time point, T4 time point was lower than T1-T3 time points; IAP levels of obesity group was higher than that of normal group at each time point, and the differences were statistically significant (P ＜ 0.05). The difference between the two groups of MAP levels were statistically significant (P ＜ 0.05). The differences in time, inter-group and interaction of Peak, PaO2/FiO2, blood pH, blood Lac between the two groups were statistically significant (P ＜ 0.05). Among them, the Peak levels of the obesity group was higher than that of the normal group at each time point, while the T1-T3 time points of the two groups were higher than the T0 and T4 time points, and the differences were statistically significant (P ＜ 0.05); PaO2/FiO2 of obesity group at the T3 and T4 time points were lower than that of normal group, while T1-T4 time points were lower than T0, T3 and T4 time points were lower than T1 time point, T4 time point was lower than T2 time point, while T2-T4 time points of normal group were lower than T0 and T3 time points, T4 time point was lower than T1 time point, while T4 time point was lower than T2 time point, and the differences were statistically significant (P ＜ 0.05); the blood pH at T3 and T4 points in the obese group were lower than the normal group, while T2-T4 time points were lower than T0 time points, T3 and T4 time points were lower than T1 and T2 time points, while T2 and T3 time points of normal group were lower than T0 time point, T3 time point was lower than T1 time point, and the differences were statistically significant (P ＜ 0.05); the levels of blood Lac at T3 and T4 time points of obesity group were higher than those of control group, while the two groups at T2-T4 time points were higher than T0 time point, T3 and T4 time points were higher than T1 time point, while T4 time point was higher than T2 time point, and the differences were statistically significant (P ＜ 0.05). Conclusion Obese patients will further increase the IAP during retroperitoneal laparoscopic surgery, even exceeding the set pressure of the pneumoperitoneum, and are more likely to have increased airway pressure, decreased oxygenation index, and acid-base imbalance. For obese patients, IAP can not be simply equated with pneumoperitoneal pressure. Intraoperative monitoring should be strengthened, and IAP can be monitored if necessary.
		2020 Vol. 17 (25): 87-91 [Abstract] ( 120 ) HTML (1 KB) PDF (639 KB) ( 103 )

	92	Effect of continuous Meropenem pumping combined with Ulinastatin for injection in the treatment of severe pneumonia
		CHENG Weipeng WANG Lei CAI Zhenhua GUO Shengwen
		Objective To explore the clinical effect of continuous Meropenem pumping combined with Ulinastatin for injection in the treatment of severe pneumonia. Methods A total of 80 patients with severe pneumonia admitted to Wanbei Coal-Electricity Group General Hospital from January 2017 to September 2019 were divided into control group (40 cases) and observation group (40 cases) according to the random number table method. The control group was treated with Meropenem intravenous drip, while the observation group was treated with continuous intravenous pumping of Meropenem combined with intravenous drip of Ulinastatin for injection, and the treatment was continued for 7 days. The clinical efficacy, the removal of bacteria, the improvement time of clinical symptoms, the inflammatory indexes, lung function indexes before and after treatment and safety of the two groups were evaluated. Results The total effective rate and bacterial clearance rate of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The disappearance time of cough and sputum, the disappearance time of lung rales, and the time to reduce fever in the observation group were significantly shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, C-reactive protein, tumor necrosis factor-α, interleukin-1β, and procalcitonin in the two groups after treatment were significantly lower than those before treatment, while the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The forced end-expiratory volume in the first second, forced vital capacity, and mid-maximum respiratory flow rate of the two groups after treatment were significantly higher than those before treatment, while the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period (P ＞ 0.05). Conclusion Continuous infusion of Meropenem combined with Ulinastatin for injection has a better clinical effect in the treatment of severe pneumonia, which can effectively shorten the time of clinical symptoms improvement, prompt the effect of bacterial clearance, reduce inflammatory reaction and improve lung function, and has a higher safety of medication.
		2020 Vol. 17 (25): 92-95,107 [Abstract] ( 124 ) HTML (1 KB) PDF (640 KB) ( 106 )

	96	Analysis of risk factors for esophagogastric variceal bleeding in liver cirrhosis
		LIU Limin1,2 ZHU Bin1,2
		Objective To investigate the risk factors of esophagogastric variceal bleeding (EVB) in patients with liver cirrhosis. Methods A total of 185 patients with liver cirrhosis complicated with esophagogastric varices treated in the First Affiliated Hospital of Xinxiang Medical College from July 2017 to July 2019 were retrospectively collected. They were divided the into bleeding group and the non-bleeding group according to whether they were complicated with EVB. There were 125 cases in the non-bleeding group and 60 cases in the bleeding group. The general data, laboratory indexes, Child-Pugh classification of liver function, gastroscopy results, ultrasound or imaging examination results of the two groups were analyzed by univariate analysis, and the indexes with statistical significance differences after univariate analysis were analyzed by binary logistic regression analysis. Results The white blood cell count, total bilirubin, the activated partial thromboplastin time and serum creatinine levels were no significant differences between the two groups (P ＞ 0.05). The serum albumin and fibrinogen and platelet count in the bleeding group were lower than those in the non-bleeding group, and the differences were statistically significant (all P ＜ 0.05). The prothrombin time and thrombin time in the bleeding group were longer than those in the non-bleeding group, and the differences were statistically significant (all P ＜ 0.05). The diameter of portal vein and the thickness of spleen in the bleeding group were wider than those in the non-bleeding group, and the differences were statistically significant (all P ＜ 0.05). Compared with the non-bleeding group, there were statistically significant differences in red sign, severe esophageal varices, gastric varices, portal vein thrombosis, ascites, and Child-Pugh classification of liver function in the bleeding group (P ＜ 0.05). Binary logistic regression results showed that serum albumin was the protective factor of EVB (OR = 0.874, 95%CI: 0.788-0.968, P = 0.01), the severe esophageal varices (OR = 4.389, 95%CI: 1.084-17.774, P = 0.038) and red sign (OR = 4.106, 95%CI: 1.392-12.113, P = 0.011) were the independent risk factors of EVB. Conclusion The red sign and severe esophageal varices are the independent risk factors of EVB complicated with liver cirrhosis, and serum albumin is the protective factor.
		2020 Vol. 17 (25): 96-98 [Abstract] ( 104 ) HTML (1 KB) PDF (584 KB) ( 28 )

	100	Correlation between serum hepcidin, growth differentiation factor 15 and serum ferritin in β-thalassemia intermedia patients
		LEI Yu ZENG Qing CHENG Weiming
		Objective To analyze the correlation of serum hepcidin, growth differentiation factor 15 (GDF15) and serum ferritin (SF) in β-thalassemia intermedia (β-TI) patients. Methods Using stratified sampling method, a total of 56 patients with β-TI confirmed by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) from September 2016 to March 2019 in the Department of Hematology, the First Affiliated Hospital of Guangxi University of Chinese Medicine (hereinafter referred to as “our hospital”) were selected as the β-TI group and a total of 68 patients who came to the Physical Examination Department of our hospital from November 2018 to March 2019 were selected as the healthy control group. Serum hepcidin and SF and GDF15 levels were analyzed in the two groups. Results In the healthy control group, hemoglobin (Hb), hepcidin and SF were all lower in females than in males, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in GDF15 between male and female (P ＞ 0.05). In β-TI group, there were no significant differences in Hb, hepcidin, GDF15 and SF between male and female (P ＞ 0.05). In β-TI group, Hb and hepcidin were lower than those in the healthy control group, while GDF15 and SF were higher than those in the healthy control group, and the differences were statistically significant (all P ＜ 0.05). In β-TI group, hepcidin was negatively correlated with GDF15 (r = -0.25), GDF15 was negatively correlated with Hb (r = -0.24), GDF15 was negatively correlated with SF (r = -0.28), and SF was positively correlated with age (r = 0.36); In the healthy control group, GDF15 was positively correlated with hepcidin (r = 0.26), SF was positively correlated with hepcidin (r = 0.34), GDF15 was positively correlated with SF (r = 0.36), and the correlation was statistically significant (all P ＜ 0.05). Conclusion In β-TI patients, serum hepcidin levels are significantly decreased, while GDF15 and SF are significantly increased. GDF15 may be an important regulatory factor of hepcidin in β-TI patients.
		2020 Vol. 17 (25): 100-103 [Abstract] ( 127 ) HTML (1 KB) PDF (587 KB) ( 76 )

	104	Clinical study on the treatment of periungual warts with water-filtered infrared-A combined with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy
		LIN Xiuying YIN Shuhong WANG Hongyan CUI Yao LIN Yuan WANG Jingbo
		Objective To observe the clinical effect of water-filtered infrared-A combined with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy in the treatment of periungual warts. Methods From January 2018 to March 2019, 60 patients with periungual warts who admitted to the Outpatient Department of Dermatology of the Third Affiliated Hospital of Qiqihar Medical University were selected and divided into control group (29 cases) and treatment group (31 cases) according to the random number table method. The control group was treated with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy, and the treatment group was treated by local irradiation with water-filtered infrared-A on the basis of the control group. The clinical effects of the two methods and their effects on serum CD4+, CD8+ and interleukin-2 (IL-2) were observed. Results The total effective rate of the treatment group was higher than that of the control group, with statistically significant difference (P ＜ 0.05). After treatment, the levels of CD4+, CD4+/CD8+ and IL-2 in both groups were increased compared with those before treatment, and the levels in the treatment group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in CD8+ level between the two groups (P ＞ 0.05). In the control group, edema and pain occurred to different degrees after surgery, and some patients even appeared blisters. While in the treatment group, there were no significant postoperative adverse reactions. The incidence of adverse reactions between the two groups was statistically significant (P ＜ 0.05). Conclusion The combination of BCG polysaccharides nucleic acid and liquid nitrogen cryotherapy combined with local irradiation of water-filtered infrared-A can significantly improve the immune response of the body and promote the illnessrehabilitation of patients. This combination therapy method is worthy of clinical promotion.
		2020 Vol. 17 (25): 104-107 [Abstract] ( 91 ) HTML (1 KB) PDF (584 KB) ( 66 )

	108	Influence of Propofol and Dexmedetomidine for intraoperative stress in patients with total intravenous anesthesia undergoing abdominal surgery
		LIN Guoxiong MAO Haifei
		Objective To investgate the influence of Propofol and Dexmedetomidine for intraoperative stress in patients with total intravenous anesthesia undergoing abdominal surgery. Methods From May 2018 to June 2019, 98 cases who underwent abdominal surgery in Shangrao People′s Hospital of Jiangxi Province were selected as study objects. They were divided into the control group and the study group according to the random number table method, with 49 cases in each group. The control group was given the Propofol anesthesia, while the study group was given the Propofol and Dexmedetomidine anesthesia. The levels of norepinephrine (NE), glucocorticoid (COR), serum angiotensin Ⅱ (A-Ⅱ) and epinephrine (E) at before anesthesia for 5 min (t0), during theskin incision (t1), before operation for 30 min (t2), the end of operation (t3) of the two groups were compared. Results The levels of NE, COR, A-Ⅱ and E of the two groups at t1, t3 were higher than those at t0 (all P < 0.05). There were no statistically significant differences in the levels of NE, COR, A-Ⅱ and E at t0 between the two groups (P > 0.05); and the levels of NE, COR, A-Ⅱ and E at t1, t3 in the study group were lower than those in the control group (all P < 0.05). Conclusion Propofol and Dexmedetomidine in patients with total intravenous anesthesia undergoing abdominal surgery which can effectively inhibit intraoperative stress response and improve surgical safety, thus it is worth promoting in the clinical.
		2020 Vol. 17 (25): 108-110,114 [Abstract] ( 97 ) HTML (1 KB) PDF (502 KB) ( 175 )

	111	Clinical study of Shentongzhuyu Decoction combined with Oxycodone Hydrochloride Sustained Release Tablets in the treatment of moderate and severe cancer pain
		LI Dongmei1 DUAN Gaofeng2 ZHANG Qianshan1 LIU Zhenchang1
		Objective To explore the effect of Shentongzhuyu Decoction combined with Oxycodone Hydrochloride Sustained Release Tablets of moderate and severe cancer pain. Methods A total of 80 patients with moderate and severe cancer pain who admitted to Traditional Chinese Medicine of Taihe County, Fuyang City, Anhui Province from June 2017 to May 2019 were selected as study objects. They were divided into control group (40 cases) and study group (40 cases) according to the random number table method． Control group was given Oxycodone Hydrochloride Sustained Release Tablets, study group was given Shentongzhuyu Decoction on the basis of control group. Both groups were treated for a course of treatment. The clinical efficacy, onset time and duration of pain relief, quality of life between two groups were compared. The occurrence of adverse reactions during treatment in both groups were recorded. Results The total effective rate of study group was higher than that of control group (P ＜ 0.05). The onset time of pain relief in study group was shorter than that in control group, the duration of pain relief in study group was longer than that in control group (all P ＜ 0.01). The numerical rating scale (NRS) scores of two groups after treatment were lower than those before treatment, while the quality of life scores were higher than those before treatment, and the NRS scores of study group were lower than those of control group, while the quality of life scores were higher than those of control group (all P < 0.01). There was no significant difference in the incidence of adverse reactions between two groups (P ＞ 0.05)． Conclusion Shentongzhuyu Decoction combined with Oxycodone Hydrochloride Sustained Release Tablets can effectively improve the analgesic effect, quality of life and safety of patients with moderate and severe cancer pain．
		2020 Vol. 17 (25): 111-114 [Abstract] ( 109 ) HTML (1 KB) PDF (491 KB) ( 119 )

	115	Application of high frequency with low tidal volume by pressure controlled ventilation mode in infant thoracoscopic surgery
		ZOU Nan ZHANG Jianmin XIN Zhong▲
		Objective To investigate the application of high frequency with low tidal volume by pressure controlled ventilation mode in thoracoscopic surgery for infants, and to provide a feasible ventilation method for infants who cannot achieve one lung ventilation in thoracoscopic surgery. Methods Nineteen infants who received thoracoscopic surgery in Beijing Children′s Hospital, Capital Medical University from December 2016 to August 2019 were selected as study objects. Single lumen main endotracheal intubation was performed after induction of anesthesia. The respiratory rate (RR) was 24-34 times/min, the inspiration/exhalation ratio (I∶E) was 1∶1.5, and the tidal volume was maintained at 9-10 mL/kg. After the establishment of artificial pneumothorax, used high frequency with low tidal volume by pressure controlled ventilation mode, RR was 30-40 times/min, I∶E was 1∶1, and the tidal volume was maintained at 6-7 mL/kg. Heart rate (HR), percutaneous pulse oxygen saturation (SpO2), mean arterial pressure (MAP), RR, the airway peak pressure (PPEAK), and end-expiratory partial carbon dioxide (PETCO2) were observed and recorded at before used high frequency with low tidal volume by pressure controlled ventilation mode (Ta), 10 min after used high frequency with low tidal volume by pressure controlled ventilation mode (T10), 30 min after used high frequency with low tidal volume by pressure controlled ventilation mode (T30) and bilateral ventilation was restored 10 min (Tz). Anaesthesia related complications were recorded. Results HR, RR, PPEAK and PETCO2 levels at T10, T30 were higher than those at Ta, SpO2 and MAP levels were lower than those at Ta (all P < 0.05). HR and PETCO2 levels at T30 were lower than those at T10, while SpO2, MAP and RR levels were higher than those at T10 (all P < 0.05). HR, RR, PPEAK and PETCO2 levels at Tz were lower than those at T10 and T30, SpO2 and MAP levels were higher than those at T10 and T30 (all P < 0.05). PPEAK and PETCO2 levels at Tz were higher than those at Ta (all P < 0.05). There were no complications related to anesthesia such as hoarseness and atelectasis occurred after extubation. Conclusion For infants who cannot achieve one lung ventilation in thoracoscopic surgery, the application of high frequency with low tidal volume by pressure controlled ventilation mode is a feasible method.
		2020 Vol. 17 (25): 115-118 [Abstract] ( 81 ) HTML (1 KB) PDF (494 KB) ( 76 )

	119	Effect of Tiaowei Chengqi Decoction on gastrointestinal function and immune status in patients with gastrointestinal injury caused by sepsis
		ZHANG Xianjin LIU Min LIN Xinfeng WEN Minyong WU Sihui ZHAO Fu ZHAO Fengli▲
		Objective To observe the effects of Tiaowei Chengqi Decoction on gastrointestinal function and immune status in patients with gastrointestinal injury caused by sepsis. Methods From October 2017 to May 2019, 56 patients with gastrointestinal injury caused by sepsis admitted to Department of Critical Care Medicine in the First Affiliated Hospital of Guangzhou University of Chinese Medicine were selected. They were numbered according to the order of treatment and divided into control group and treatment group by using odd even number method, with 28 cases in each group. Control group was given conventional Western medicine treatment, while treatment group was given Tiaowei Chengqi Decoction, once one dose, twice a day, oral or nasal feeding, seven days as a course of treatment. Traditional Chinese medicine syndrome efficacy, bowel sound abdominal circumference, intra-abdominal pressure, scores of disease severity, white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), human leukocyte antigen-DR (HLA-DR), total lymphocyte count, CD3+, CD4+, CD8+, CD4+/CD8+, natural killer (NK) cells and complications were observed between two groups. Results Total effective rate of treatment group was higher than that of control group (P < 0.05). After treatment, the bowel sound of two groups was more than that before treatment, the abdominal circumference was shorter than that before treatment, and the intra-abdominal pressure was lower than that before treatment, and the bowel sound of treatment group was more than that of control group, the abdominal circumference was shorter than that of control group, and the intra-abdominal pressure was lower than that of control group, the differences were statistically significant (P < 0.05). After treatment, the sequential organ failure assessment score and acute physiology and chronic health status Ⅱ score of two groups were lower than those before treatment, and treatment group was lower than control group, the differences were statistically significant (P < 0.05). The levels of WBC, CRP and PCT in two groups after treatment were lower than those before treatment, and those in treatment group were lower than those in control group, the differences were statistically significant (P < 0.05). After treatment, HLA-DR, total lymphocyte count, CD3+, CD4+, CD8+, CD4+/CD8+ and NK cells in two groups were higher than those before treatment, and those in treatment group were higher than those in control group, the differences were statistically significant (P < 0.05). No obvious toxic and side effects were observed in both groups. Conclusion Tiaowei Chengqi Decoction combined with Western medicine treatment can effectively improve gastrointestinal function of patients with sepsis gastrointestinal injury, benign regulation of immune state of patients, the curative effect is better than simple Western medicine treatment. It is safe and has no side effects.
		2020 Vol. 17 (25): 119-124 [Abstract] ( 82 ) HTML (1 KB) PDF (803 KB) ( 129 )

	125	Effect of fast track surgery concept combined with acupuncture on gastrointestinal function recovery after colorectal cancer surgery
		LIANG Zunxiao YANG Jia WANG Zhenzhai ZHANG Chengsheng
		Objective To explore application effect of fast track surgery concept combined with acupuncture rehabilitation in the recovery of gastrointestinal function after colorectal cancer surgery. Methods A total of 120 patients with colorectal cancer surgery from May 2016 to January 2018 in Department of Gastrointestinal Surgery of the Second Affiliated Hospital of Hainan Medical University were selected and divided into combined group and control group by random number table method, with 60 cases in each group. Patients in the two groups were given radical surgery for colorectal cancer, during the perioperative rehabilitation surgery period, they were given fast track surgery treatment. At the same time, combined group was given shǒusānlǐ, hégǔ, tiānshū, zúsānlǐ and shàngjùxū acupuncture and moxibustion therapy. Basic operation condition, gastrointestinal motility recovery, gastrointestinal hormone level, abdominal distension score and quality of life score were compared between the two groups. Results There were no significant differences in operation time, intraoperative blood loss, specimen resection length and number of lymph nodes between the two groups (P ＞ 0.05). The recovery time of bowel sounds, time of first exhaust, time of eating liquid diet and time of defecation in combined group were shorter than those in control group (P ＜ 0.05). The overall analysis showed that there were significant differences in motilin and gastrin levels between the two groups, time point comparison and interaction (P ＜ 0.05). Further intra group comparison showed that, the levels of motilin and gastrin in two groups were compared with those at the previous time point in the same group, the differences were statistically significant (P ＜ 0.05). Comparison between groups: three and seven days after operation, the levels of motilin and gastrin in combined group were higher than those in control group (P ＜ 0.05). The overall analysis showed that there was statistically significant difference in abdominal distension score between two groups, time point comparison and interaction (P ＜ 0.05). Further pairwise comparison, intra group comparison: the abdominal distension scores of two groups were significantly different from the previous time point in the same group (P ＜ 0.05). Comparison between groups: three and seven days after operation, the abdominal distension score of combined group was lower than that of control group (P ＜ 0.05). Seven days after operation, the scores of physical function, role function, cognitive function, social function and emotional function in combined group were higher than those in control group (P ＜ 0.05). Conclusion The fast track surgery concept combined with acupuncture rehabilitation is helpful to promote the recovery of gastrointestinal function and improve the quality of life of patients after colorectal cancer surgery.
		2020 Vol. 17 (25): 125-128,140 [Abstract] ( 109 ) HTML (1 KB) PDF (767 KB) ( 161 )

	129	Clinical effect of Centipede Powder external application combined with blood-letting puncturing and cupping in the treatment of postherpetic neuralgia
		LI Lianying LI Aimin HONG Rongqing
		Objective To explore clinical effect of Centipede Powder external application combined with blood-letting puncturing and cupping in the treatment of postherpetic neuralgia (PHN). Methods Sixty patients with PHN admitted to Yangjiang Hospital of Traditional Chinese Medicine in Guangdong Province from January to July 2019 were selected as research objects, they were divided into control group (30 cases) and observation group (30 cases) by random number table method. Control group was treated with conventional Western medicine treatment (Acyclovir + Mecobalamin Tablets + Gabapentin Capsules), observation group was treated with Centipede Powder external application and blood-letting puncturing and cupping on the basis of control group. The visual analogue score, pain relief time, other symptom scores before and after treatment, clinical treatment effect, sleep quality, adverse reactions and the incidence of postoperative neuralgia in three and six months after discharge between two groups were observed. Results The visual analogue scores of two groups after treatment were significantly lower than those before treatment, and observation group was lower than that in control group, the differences were statistically significant (P ＜ 0.05). The pain relief time of observation group was shorter than that of control group (P ＜ 0.05). The scores of itching, tactile sensitivity and burning sensation in observation group after treatment were significantly lower than those in control group and before treatment (P ＜ 0.05). Total effective rate of observation group was significantly higher than that of control group (P ＜ 0.05). The scores of Pittsburgh sleep quality index scale in two groups after treatment were significantly lower than those before treatment, and observation group was lower than that in control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). The incidence rates of postoperative neuralgia in observation group at three and six months after discharge were lower than those in control group, the differences were statistically significant (P ＜ 0.05). Conclusion Centipede Powder external application combined with blood-letting puncturing and cupping therapy in the treatment of PHN has positive effect. It can effectively relieve clinical symptoms, improve sleep quality, shorten the time of pain onset, reduce the degree of pain, high safety, less adverse reactions. It is worthy of clinical application.
		2020 Vol. 17 (25): 129-132 [Abstract] ( 135 ) HTML (1 KB) PDF (781 KB) ( 133 )

	133	Application of metabonomics technology based on liquid chromatograph-mass spectrometer in chemical components of traditional Chinese medicine
		JIANG Meifang GAO Qi WANG Dandan
		Metabonomics, as an important branch of system biology, has attracted extensive attention and made great progress in the field of traditional Chinese medicine in recent years. This paper summarizes the application of liquid chromatograph-mass spectrometer (LC-MS) metabonomics technology in the chemical composition of traditional Chinese medicine in recent years. Metabonomics technology has the characteristics of high throughput, integrity and objectivity. It has remarkable advantages in the research of multi-component and multi-target traditional Chinese medicine. This paper introduces the development and characteristics of LC-MS metabonomics technology, analysis process and method, as well as its application in the research of traditional Chinese medicine, mainly including the application in the identification of authenticity, origin, authenticity, quality control and pharmacodynamic mechanism of traditional Chinese medicine. This paper mainly provides a new idea for the study of chemical constituents of traditional Chinese medicine, and provides reference for the identification, quality evaluation and pharmacodynamic mechanism of traditional Chinese medicine.
		2020 Vol. 17 (25): 133-136 [Abstract] ( 112 ) HTML (1 KB) PDF (902 KB) ( 94 )

	137	Effect of Yiqi Huayu and Pinggan Zishen Decoction on heart and kidney function in patients with hypertension retinopathy
		ZHANG Qiaona1 FANG Fang2 CAO Yan2
		Objective To investigate the effect of Yiqi Huayu and Pinggan Zishen Decoction on heart and kidney function in patients with hypertension retinopathy (HRP). Methods One hundred and sixty HRP patients treated in Tangshan Traditional Chinese Medicine Hospital from June 2017 to June 2018 were selected and divided into control group and observation group according to random digital table method, with 80 cases in each group, of which, two cases fell off in control group and one case in observation group. Control group was given Western medicine basic hypotension and Western medicine complication symptomatic treatment, on the basis of conventional Western medicine treatment, observation group was added with Yiqi Huayu and Pinggan Zishen Decoction, treatment course of two groups was one month. Clinical efficacy, traditional Chinese medicine syndrome efficacy, cardiac and renal function indexes [serum creatinine (Scr), blood urea nitrogen (BUN), brain natriuretic peptide (BNP), ejection fraction (EF)] were observed in two groups. Results Clinical total effective rate and traditional Chinese medicine syndrome total effective rate of observation group were higher than those of control group, the differences were statistically significant (P < 0.05). After treatment, BNP level of two groups was lower than that before treatment, EF was higher than that before treatment, BNP level of observation group was lower than that of control group, EF was higher than that of control group, the differences were statistically significant (P < 0.05). After treatment, Scr and BUN levels of two groups were lower than those before treatment, and observation group was lower than that of control group, the differences were statistically significant (P < 0.05). Conclusion Conventional Western medicine basic treatment combined with Yiqi Huayu and Pinggan Zishen Decoction has significant effect in improving heart and kidney function in patients with HRP, which is worthy of clinical promotion.
		2020 Vol. 17 (25): 137-140 [Abstract] ( 111 ) HTML (1 KB) PDF (743 KB) ( 40 )

	141	Study on diagnostic criteria of chronic prostatitis with syndrome of damp heat and blood stasis
		DING Jiasen1 SHAO Kuiqing2 SHEN Jianwu2 MENG Jun2 LI Ding2 LI Qi2 KE Liupan2 YANG Xiaoqin2 QIN Pengxu2 GAO Zhan2
		Objective To establish a unified diagnostic standard of chronic prostatitis with syndrome of damp heat and blood stasis in line with clinical practice. Methods In the early stage, literature retrieval and analysis were carried out, and an expert consultation meeting was held to conduct expert consultation on the modified Delphi method. Questionnaire survey was used to make statistical opinions, and analytic hierarchy process was used to analyze and discuss the methodology. Results Forty-eight syndrome elements of syndrome of damp heat and blood stasis for chronic prostatitis were determined, the syndrome elements were stratified, and the weight of each syndrome element was assigned and ranked. Conclusion The diagnostic criteria of chronic prostatitis with syndrome of damp heat and blood stasis should be clear about syndrome elements, which should be weighted according to clinical practice, and the final order should be determined after expanding the sample size.
		2020 Vol. 17 (25): 141-144,148 [Abstract] ( 151 ) HTML (1 KB) PDF (846 KB) ( 89 )

	145	Clinical study of Tuoli Xiaodu Decoction combined with Xiangpi Shengji Ointment in the treatment of chronic skin ulcer
		MA Le XI Jianyuan BAO Qiuyu
		Objective To analyze clinical effect of Tuoli Xiaodu Decoction combined with Xiangpi Shengji Ointment in the treatment of chronic skin ulcer. Methods One hundred and eight patients with chronic skin ulcer treated in the First Affiliated Hospital of Hu′nan University of Chinese Medicine from June 2015 to December 2018 were selected and divided into control group and treatment group by random number table method, with 54 cases in each group. Both groups were treated with Xiangpi Shengji Ointment, while treatment group was treated with Tuoli Xiaodu Decoction. Clinical efficacy, cytokine indexes (interleukin 6 [IL-6], tumor necrosis factor-α [TNF-α], vascular endothelial growth factor [VEGF]), ulcer healing indexes and adverse reactions of two groups were observed and compared. Results Total effective rate in treatment group was significantly higher than that in control group (P < 0.05). After treatment, the levels of IL-6 and TNF-α in two groups were lower than those before treatment, and the level of VEGF in two groups was higher than that before treatment, the levels of IL-6 and TNF-α in treatment group were lower than those in control group, and VEGF level in treatment group was higher than that in control group, the differences were statistically significant (P < 0.05). The healing time, myogenic time and putrid purification time in treatment group were significantly shorter than those in control group, the differences were statistically significant (P < 0.05). There were no obvious adverse reactions in both groups. Conclusion Tuoli Xiaodu Decoction combined with Xiangpi Shengji Ointment has significant effect in treating chronic skin ulcer, which can promote wound healing faster, reduce the level of inflammatory factors, and it is safe and reliable.
		2020 Vol. 17 (25): 145-148 [Abstract] ( 125 ) HTML (1 KB) PDF (744 KB) ( 88 )

	149	Origin and development of Zhao Xianke′s theory of kidney edema and ming men fire and its influence on the treatment of cough in later generations
		QIAN Xuwu1 JIANG Yuchen1 XIE Wenxing2 JIANG Ying3
		Zhao Xianke is a famous representative doctor of warm-recuperation school. His theory of kidney edema and ming men fire is unique and has a profound influence on the later doctors. It greatly enriches the theoretical connotation of “mingmen theory” and plays an important guiding role in clinical application. Through extensive reading and systematic collation of literature, the author makes a detailed analysis of the historical background, theoretical connotation and application of the theory of kidney edema and ming men in cough, with a view to deeply understand Zhao Xianke′s theory of life gate and present it to scholars, strengthen the attention of traditional Chinese medicine scholars to the theory of kidney edema and ming men fire, and promote the inheritance and development of precious academic thoughts of traditional Chinese medicine.
		2020 Vol. 17 (25): 149-152 [Abstract] ( 102 ) HTML (1 KB) PDF (741 KB) ( 148 )

	153	Diagnostic value of ultrasound elastography in the static plasma cell mastitis
		LI Liang1 XIU Junqing2▲
		Objective To study the characteristics of elastography in the diagnosis of static plasma cell mastitis and to evaluate the value of ultrasound elastography in the diagnosis of static plasma cell mastitis. Methods From March 2018 to September 2019， 120 cases (120 mass) with suspected of plasma cell mastitis or breast cancer in China Academy of Chinese Medical Sciences Guang′anmen Hospital were selected as study objects. All patients were examined by ultrasound, including conventional ultrasound and ultrasound elastography. The gold standard was pathological results, and the diagnostic value of different ultrasound methods in the diagnosis of benign and malignant breast diseases were observed. Results The cut-off value of ultrasound of plasma cell mastitis was 2.44, sensitivity was 65.0% and specificity was 73.3%, respectively. The cut-off value of ultrasound elastography of plasma cell mastitis was 1.74, sensitivity was 76.7% and specificity was 96.7%, respectively. Conclusion Ultrasound elastography provides a new method for the differential diagnosis of plasma cell mastitis and breast cancer.
		2020 Vol. 17 (25): 153-155 [Abstract] ( 84 ) HTML (1 KB) PDF (332 KB) ( 66 )

	156	The mediating effect of job burnout on palliative nursing cognition level and nursing attitude of oncology nurses
		AN Fangfang1 JING Zhaoxia2 CHAO Xu3 LI Yuanyuan3
		Objective To explore the mediating effect of job burnout on palliative nursing cognition level and nursing attitude of oncology nurses. Methods From March to October 2019, a total of 380 registered nurses from the department of oncology in 3 specialized hospitals and 6 general hospitals in Shaanxi Province were investigated by means of general information questionnaire, palliative care knowledge questionnaire, Maslach burnout questionnaire and Bradley nursing attitude questionnaire. Results A total of 380 questionnaires were actually issued and 365 valid questionnaires were collected, with an effective recovery rate of 96.1%. Palliative care knowledge score of oncology nurses was (11.04±2.16) points; the score of burnout was (72.62±4.16) points. Nursing attitude score was (31.91±5.86) points. There was a negative correlation between job burnout and cognitive level of palliative care (r = -0.601, P ＜ 0.01). There was also a negative correlation with nursing attitude (r = -0.626, P ＜ 0.01). The mediating effect of job burnout between the cognitive level of palliative care and nursing attitude was 0.138, accounting for 17.3% of the total effect, and the mediating effect was significant (Z = 5.625＞1.96). Conclusion Oncology nurses are at a high level of job burnout, and their job burnout plays a part of the mediating effect between the cognitive level of palliative care and nursing attitude. Hospitals can improve nurses′ palliative care attitude towards patients by improving their cognitive level and reducing their sense of job burnout.
		2020 Vol. 17 (25): 156-159 [Abstract] ( 89 ) HTML (1 KB) PDF (741 KB) ( 23 )

	160	Clinical effect of traditional Chinese medicine extended nursing combined with Kushenfulv Decoction in the treatment of functional premature beat and heart rate variability
		ZHU Yan CHEN Min
		Objective To explore the clinical effect of traditional Chinese medicine extended nursing combined with Kushenfulv Decoction on functional premature beats and heart rate variability. Methods A total of 122 cases of functional ventricular premature beats diagnosed and treated in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 2017 to July 2019 were selected and they were divided into control group (61 cases) and combination group (61cases) according to the random number table method. The control group adopted traditional Chinese medicine extended nursing. The combination group was treated with traditional Chinese medicine extended nursing combined with Kushenfulv Decoction for one course of treatment for four weeks. The clinical efficacy of the two groups was compared. Standard deviation (SDNN), SDNN index (SDNN index), root mean square (RMSSD) of adjacent RR interval difference, percentage of adjacent R-R interval difference of 50 ms (PNN50), low frequency (LF) and high frequency (HF) parameters were recorded before and after intervention, respectively. Results The effective rate of the combination group was higher than that of the control group (P ＜ 0.05). Time domain analysis indexes (SDNN, SDNN index, RMSSD, PNN50) of the two groups were increased after intervention (P ＜ 0.05), and the combination group was higher than the control group (P ＜ 0.05). After intervention, HF and LF in the two groups were higher than those before intervention, and LF/HF was lower than that before intervention (P ＜ 0.05), HF and LF in the combination group were higher than those in the control group (P ＜ 0.05). Conclusion Traditional Chinese medicine extended nursing combined with Kushenfulv Decoction has obvious curative effect on functional premature beats, which can improve heart rate variability, reduce the frequency of attack, and has high safety.
		2020 Vol. 17 (25): 160-163 [Abstract] ( 90 ) HTML (1 KB) PDF (643 KB) ( 77 )

	164	Meta-analysis of the effect of mindfulness therapy on the quality of life and negative emotions of patients with breast cancer after surgery
		ZHANG Yajuan1 QIAN Chao1 LU Haiyan1 MENG Qianling2 AO Li3 SHEN Ying4 MA Lili1
		Objective To evaluate the effect of mindfulness therapy on the quality of life and negative emotions of patients with breast cancer after surgery. Methods Randomized controlled trials (RCTs) on the impact of mindfulness therapy on the quality of life and negative emotions of patients with breast cancer after surgery were searched in six databases: Cochrane, PubMed, CBM, CNKI, Weipu and Wanfang according to the retrieval strategy, the search period was from the construction of the database to December 2019，the literature quality was evaluated by JBI evaluation criteria, RevMan 5.3 was used for meta analysis. Results After screening, 8 articles were finally included in the literature. Compared with the control group (routine care), the experimental group (routine care + midfulness therapy) could reduce the patient′s perceived pressure (MD = -5.18，95%CI [-8.44, -1.93], P ＜ 0.000 01), anxiety (SMD = -6.56, 95%CI [-8.72, -4.40], P ＜ 0.000 01), depression (SMD = -4.92, 95%CI [-5.92, -3.92], P ＜ 0.000 01), and improve sleep quality (SMD = -3.65, 95%CI [-3.83, -3.47], P ＜ 0.000 01). Conclusion Short-term mindfulness therapy has a positive and significant positive effect on reducing perceived stress, anxiety, depression and improving sleep quality in patients with breast cancer after surgery.
		2020 Vol. 17 (25): 164-167,183 [Abstract] ( 148 ) HTML (1 KB) PDF (1235 KB) ( 180 )

	168	Effect of peer support on medication compliance and quality of life in patients with rheumatoid arthritis
		GAO Cuirong MENG Yan JI Peng LUO Li▲
		Objective To explore the effect of WeChat platform peer support on medication compliance and quality of life in patients with rheumatoid arthritis. Methods Patients with rheumatoid arthritis who were admitted to the Department of Rheumatology and Immunology, the First Affiliated Hospital of Xinjiang Medical University from August 2017 to June 2018 and who met the inclusion criteria were selected as study subjects, and they were divided into the control group (40 cases) and the experimental group (40 cases) according to the order of admission. The control group received routine health education after discharge and outpatient follow-up. On this basis, the experimental group adopted the peer support intervention with WeChat platform as the core for six months outside the hospital. The medication compliance, self-efficacy and life quality scores of the two groups at one, three and six months after discharge were compared. Results The overall analysis showed that there were statistically significant differences in medication compliance, self-efficacy, and quality of life between groups at one, three and six months after discharge (all P ＜ 0.05). It is suggested that peer support can improve patients′ medication compliance, self-efficacy and quality of life. The scores of medication compliance, self-efficacy and quality of life in the experimental group at six months after discharge were higher than those at one and three months after discharge, and those at three months after discharge were higher than those at one month after discharge, with statistically significant differences (all P ＜ 0.05). In the control group, scores of medication compliance, self-efficacy and quality of life at six months after discharge were lower than those at one and three months after discharge, and scores of medication compliance, self-efficacy and quality of life at three months after discharge were lower than those at one month after discharge, with statistically significant differences (all P ＜ 0.05). The scores of medication compliance, self-efficacy and quality of life in the experimental group were higher than those in the control group at one, three and six months after discharge, with statistically significant differences (all P ＜ 0.05). Conclusion Peer support intervention based on WeChat platform can improve drug compliance, self-efficacy and quality of life of patients.
		2020 Vol. 17 (25): 168-171,192 [Abstract] ( 116 ) HTML (1 KB) PDF (1039 KB) ( 89 )

	172	Application of integrated Chinese and Western medicine clinical nursing pathway in the green channel of acute upper gastrointestinal bleeding
		WU Jian1 DENG Qiuying2
		Objective To evaluate the application effect of integrated Chinese and Western medicine nursing pathway in the green channel of acute upper gastrointestinal bleeding. Methods From February 2017 to March 2019, 252 patients with acute upper gastrointestinal bleeding admitted to the Department of Emergency, Guangdong Provincial Hospital of Chinese Medicine and entered the green channel were selected as subjects. The patients were divided into observation group (127 cases) and control group (125 cases) according to the sequence of medical treatment. The control group adopted the conventional emergency green channel nursing process for first aid nursing, while the observation group adopted the pre-constructed clinical nursing path of integrated traditional Chinese and Western medicine for first aid nursing. The duration of emergency outpatient service, expenses of emergency outpatient service, utilization rate of traditional Chinese medicine nursing technology were compared between the two groups. Results The duration of emergency outpatient servcce in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The expenses of emergency outpatient service in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The utilization rate of traditional Chinese medicine nursing technology in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The implementation of integrated Chinese and Western medicine clinical nursing pathway in the emergency green channel can effectively shorten the duration of emergency outpatient service for patients with acute upper gastrointestinal bleeding and reduce the expenses of emergency outpatient service. It also improves the efficiency of the green channel and is beneficial to the use and popularization of traditional Chinese medicine treatment and nursing technology.
		2020 Vol. 17 (25): 172-175 [Abstract] ( 190 ) HTML (1 KB) PDF (910 KB) ( 60 )

	176	Research on the effect of integrated management mode of health care based on health belief model on postoperative patients with gastrointestinal polyps
		SU Shaofeng1 CHEN Lixia1 LIU Zhenyi1 FU Xiaoyan1 LIU Hui2
		Objective To explore the effect of integrated health care management model based on health belief model on postoperative patients with gastrointestinal polyps. Methods In the Third People′s Hospital of Hainan Province from March 2016 to June 2018, 168 patients with gastrointestinal polyps were divided into the control group (84 cases) and the observation group (84 cases) according to the random number table method. The control group was received routine nursing and the observation group was given integrated nursing care model on the basis of health belief model, The health knowledge understanding status, postoperative gastrointestinal function, mental state, postoperative complications, and recurrence rate of the two groups were compared. Results The scores of onset causes, symptoms, dietary precautions, and postoperative precautions in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The anal exhaust time and defecation time in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Before intervention, there was no statistically significant difference in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) between two groups (P ＞ 0.05), and the SAS and SDS scores of the observation group were significantly lower than before intervention, and the observation was lower than the control group at one month after the intervention (P ＜ 0.05). The incidence of postoperative complications was significantly lower in the observation group than in the control group, and the difference was statistically significant (P ＜ 0.05). Six months after operation, the recurrence rate in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The integrated management model of health care based on the health belief model can promote the patient′s knowledge of gastrointestinal polyps health knowledge, better improve the gastrointestinal function and mental state of patients, and reduce the postoperative complications and recurrence rate. It is worthy of clinical further discussion.
		2020 Vol. 17 (25): 176-179 [Abstract] ( 124 ) HTML (1 KB) PDF (646 KB) ( 114 )

	180	Correlation between cognition degree of breastfeeding and lactation function in primipara
		WAN Li GU Yinyan▲
		Objective To explore the correlation between breastfeeding cognition and lactation function in primipara. Methods A total of 128 women who gave birth successfully in Nanjing Hospital Affiliated to Nanjing Medical University from January to December 2019 were selected as the research subjects. All of them were investigated by the cognition scale of primiparas, according to the final score, they were divided into group A: high cognitive level of breastfeeding (56 cases); group B: general cognitive level (42 cases); group C: low cognitive degree (30 cases). The postpartum lactation function of primiparas with different cognitive levels (postpartum lactation start time, postpartum lactation volume score at 24 and 48 hours) were observed and compared, to examine the correlation between breastfeeding cognition and lactation function in primiparas. Results Comparison of general data of age and gestational week of primipara in each group showed no statistically significant difference (P ＞ 0.05), the postpartum lactation start time of group C was longer than that of group A and B, while the time of group B was longer than that of group A, with statistically significant difference (P ＜ 0.05); the lactation volume scores of group C at 24 and 48 h postpartum were lower than those of group A and B, and those of group B at 24 and 48 h postpartum were lower than those of group A, with statistically significant differences (P ＜ 0.05). The results of bivariate Pearson linear correlation analysis showed that the cognitive level of breastfeeding of primipara was negatively correlated with the start time of lactation after delivery (r = -0.912, P ＜ 0.001), and the cognitive level of breastfeeding of primipara was positively correlated with the score of lactation 24 and 48 h after delivery (r = 0.851, 0.848, P ＜ 0.001). Conclusion The postpartum lactation function of primiparas is closely related to the cognitive level of breastfeeding, so clinical attention should be paid to the investigation of the cognitive function of breastfeeding of primiparas in the middle and third trimester of pregnancy, and targeted intervention measures should be carried out in time to those puerperas with low cognitive function, which is of great significance to improve the cognitive level of breastfeeding of primiparas and the success rate of breastfeeding after delivery.
		2020 Vol. 17 (25): 180-183 [Abstract] ( 127 ) HTML (1 KB) PDF (698 KB) ( 50 )

	184	Effects of predictive nursing in operating room on postoperative cognitive function in patients with combined spinal-epidural anesthesia
		MU Songhua
		Objective To investigate the effect of predictive nursing in the operating room on postoperative cognitive function of patients with combined spinal-epidural anesthesia. Methods From January to December 2019, 90 patients with fracture of lower extremity admitted to operating room of Huangshan City People′s Hospital were selected, the operation anesthesia mode was combined spinal-epidural anesthesia, and according to the random number method, they were divided into observation group and control group, with 45 cases in each group. The observation group was received predictive nursing, while the control group was received routine nursing. The scores of simple intelligent state check scale (MMSE) score and visual analogue scale (VAS) score were compared before and two, six, twelve hours after operation. The incidence of adverse reactions was recorded 24 hours after operation. At the time of discharge, the quality of nursing work in operating room was investigated. Results The MMSE score of the observation group was significantly higher than that of the control group at two hours and six hours after operation (P ＜ 0.05). The VAS scores at two, six and twelve hlours after surgery in both groups were significantly lower than those before surgery, and the observation group was significantly lower than the control group (P ＜ 0.05). The nursing technique, working attitude and communication ability of the observation group were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Predictive nursing in operating room has no adverse effect on postoperative cognitive function of patients with combined spinal-epidural anesthesia, which is safe and has high clinical application value.
		2020 Vol. 17 (25): 184-187 [Abstract] ( 125 ) HTML (1 KB) PDF (701 KB) ( 97 )

	188	Literature investigation research on the medicinal plants for the treatment of lumbar degenerative diseases of Lízú in Hainan Province
		BAI Manmo1 LIU Yangyang2 CAO Hong3 WANG Bingnan4
		Objective To investigate and study the general situation of the species, efficacy and application of commonly used medicinal plants for the treatment of lumbar degenerative diseases in Hainan Li Nationality in relevant literature, and to summarize the general rules of Lízú medicinal plants for the treatment of such diseases. Methods The medical plants of Lízú in Hainan for treating lumbar degenerative diseases recorded in the literatures like Introduction to Li Pharmacy, Records of Li Medicine, Collection of Folk Prescriptions of Lízú, Li Medicine, Atlas of Commonly Used Drugs of Lízú and Hainan Li Medicine were collected and summarized according to their genera and species, distribution areas, medical parts, drug efficacy, application methods, etc.. The commonly used medical plants with therapeutic efficacy certified by different experts and scholars and frequency of occurrence more than 2 times were selected and analyzed. Results A total of 24 species of commonly used medicinal plants for treating lumbar degenerative diseases were identified of Hainan Lízú in the early stage, mainly distributed in the tropical rain forests in the central and southern Hainan island. The root and vine parts were mostly used as medicine. The drug properties were mostly mild and mild. The medicine tasted bitter, pungent and sweet. Most of them were classified into liver and kidney meridians. Toxic drugs account for a certain proportion. The main medicinal effects were “promoting blood circulation, removing blood stasis, dispelling pathogenic wind, removing dampness, dredging collaterals, relieving pain, and tonifying liver and kidney”. There were many combinations of commonly used medicinal plants. Oral administration and dietotherapy were the main methods of administration. Alcohol was often used to guide the channels and channels. Conclusion Lízú in Hainan Province is rich in medicinal plants for the treatment of lumbar degenerative diseases, which had unique characteristics and efficacy and are worthy of in-depth study.
		2020 Vol. 17 (25): 188-192 [Abstract] ( 77 ) HTML (1 KB) PDF (553 KB) ( 177 )

	193	Application of PDCA circulation method to improve the practice of health education in cancer hospital
		GAO Fei WANG Wei ZHANG Ping
		In recent years, PDCA circulation method has been applied in many hospitals to ensure the integrity and scientificity of health education. This paper takes the Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College as an example, which using PDCA circulation method to carry out total quality management and analysis on the specific work of hospital health education, such as management method, health education method, and expert team construction, and continue to improve. The system of health education in cancer hospital has been improved continuously, the methods of health education have been innovated, and the team of popular science experts has been enriched, which makes the work of health education in hospital more professional, standardized and institutionalized, and has achieved certain results. Therefore, cancer hospital should pay more attention to health education, establish a high quality expert team for cancer prevention and health education, use the advantages of network communication to carry out health education. In order to improve the accessibility of cancer prevention and control core knowledge, and help build a healthy China.
		2020 Vol. 17 (25): 193-196 [Abstract] ( 180 ) HTML (1 KB) PDF (547 KB) ( 50 )

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