威伐光联合卡介菌多糖核酸及液氮冷冻治疗甲周疣的临床研究

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Abstract Objective To observe the clinical effect of water-filtered infrared-A combined with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy in the treatment of periungual warts. Methods From January 2018 to March 2019, 60 patients with periungual warts who admitted to the Outpatient Department of Dermatology of the Third Affiliated Hospital of Qiqihar Medical University were selected and divided into control group (29 cases) and treatment group (31 cases) according to the random number table method. The control group was treated with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy, and the treatment group was treated by local irradiation with water-filtered infrared-A on the basis of the control group. The clinical effects of the two methods and their effects on serum CD4+, CD8+ and interleukin-2 (IL-2) were observed. Results The total effective rate of the treatment group was higher than that of the control group, with statistically significant difference (P ＜ 0.05). After treatment, the levels of CD4+, CD4+/CD8+ and IL-2 in both groups were increased compared with those before treatment, and the levels in the treatment group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in CD8+ level between the two groups (P ＞ 0.05). In the control group, edema and pain occurred to different degrees after surgery, and some patients even appeared blisters. While in the treatment group, there were no significant postoperative adverse reactions. The incidence of adverse reactions between the two groups was statistically significant (P ＜ 0.05). Conclusion The combination of BCG polysaccharides nucleic acid and liquid nitrogen cryotherapy combined with local irradiation of water-filtered infrared-A can significantly improve the immune response of the body and promote the illnessrehabilitation of patients. This combination therapy method is worthy of clinical promotion.

Key words： Water-filtered infrared-A Cryotherapy BCG polysaccharide nucleic acid Periungual warts

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	LIN Xiuying YIN Shuhong WANG Hongyan CUI Yao LIN Yuan WANG Jingbo

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LIN Xiuying YIN Shuhong WANG Hongyan CUI Yao LIN Yuan WANG Jingbo. Clinical study on the treatment of periungual warts with water-filtered infrared-A combined with BCG polysaccharide nucleic acid and liquid nitrogen cryotherapy[J]. 中国医药导报, 2020, 17(25): 104-107.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I25/104

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