同种异体移植方法小鼠子宫内膜异位症纤维化模型的建立

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Abstract Objective To explore the feasibility of using allogeneic transplantation to establish a mouse model of endometriosis. Methods Thirty-six BALB/c mice were randomly divided into experimental group, control group and donor group, with 12 mice in each groups. The uterine horn was extracted from donor group and cut into pieces to make the uterine tissue suspension. Experimental group was intraperitoneally injected with uterine tissue suspension, while control group was injected with phosphate buffer solution. On the 7th and 14th days after uterine tissue suspension injected, the success of the model was observed by laparotomy and pathological verification was conducted. Results On the 14th day after uterine tissue suspension was injected, the modeling of experimental group was successful and the fibrosis characteristics were obvious. Conclusion The allogeneic transplantation method can be used to construct mice model of endometriosis fibrosis.

Key words： Endometriosis Fibrosis Transplant Mice model

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	CHANG Xiangyu DENG Mengqi ZHANG Yanqin WU Di MIAO Jinwei

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CHANG Xiangyu DENG Mengqi ZHANG Yanqin WU Di MIAO Jinwei. Establishment of mice endometriosis fibrosis model by allogeneic transplantation[J]. 中国医药导报, 2020, 17(25): 15-18.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I25/15

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