β中间型地中海贫血患者血清铁调素、转化生长因子15和铁蛋白相关性研究

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Abstract Objective To analyze the correlation of serum hepcidin, growth differentiation factor 15 (GDF15) and serum ferritin (SF) in β-thalassemia intermedia (β-TI) patients. Methods Using stratified sampling method, a total of 56 patients with β-TI confirmed by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) from September 2016 to March 2019 in the Department of Hematology, the First Affiliated Hospital of Guangxi University of Chinese Medicine (hereinafter referred to as “our hospital”) were selected as the β-TI group and a total of 68 patients who came to the Physical Examination Department of our hospital from November 2018 to March 2019 were selected as the healthy control group. Serum hepcidin and SF and GDF15 levels were analyzed in the two groups. Results In the healthy control group, hemoglobin (Hb), hepcidin and SF were all lower in females than in males, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in GDF15 between male and female (P ＞ 0.05). In β-TI group, there were no significant differences in Hb, hepcidin, GDF15 and SF between male and female (P ＞ 0.05). In β-TI group, Hb and hepcidin were lower than those in the healthy control group, while GDF15 and SF were higher than those in the healthy control group, and the differences were statistically significant (all P ＜ 0.05). In β-TI group, hepcidin was negatively correlated with GDF15 (r = -0.25), GDF15 was negatively correlated with Hb (r = -0.24), GDF15 was negatively correlated with SF (r = -0.28), and SF was positively correlated with age (r = 0.36); In the healthy control group, GDF15 was positively correlated with hepcidin (r = 0.26), SF was positively correlated with hepcidin (r = 0.34), GDF15 was positively correlated with SF (r = 0.36), and the correlation was statistically significant (all P ＜ 0.05). Conclusion In β-TI patients, serum hepcidin levels are significantly decreased, while GDF15 and SF are significantly increased. GDF15 may be an important regulatory factor of hepcidin in β-TI patients.

Key words： Iron metabolism Hepcidin Thalassemia Growth differentiation factor 15

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	LEI Yu ZENG Qing CHENG Weiming

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LEI Yu ZENG Qing CHENG Weiming. Correlation between serum hepcidin, growth differentiation factor 15 and serum ferritin in β-thalassemia intermedia patients[J]. 中国医药导报, 2020, 17(25): 100-103.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I25/100

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