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2017 Vol. 14, No. 17
Published: 2017-06-15
 
 
4 Clinical efficacy of Gimeracil and Oteracil Porassium Capsules combined with Cisplatin concomitant radiotherapy and radiotherapy treatment for elderly patients with advanced non-small cell lung cancer
NIE Li SHAO Tengfei GE Weihong
Objective To observe the clinical efficacy of Gimeracil and Oteracil Porassium Capsules combined with Cisplatin concomitant radiotherapy and radiotherapy treatment for elderly patients with advanced non-small cell lung cancer. Methods 38 cases of elderly patients with advanced non-small cell lung cancer treated in Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School were selected from March 2012 to March 2014. They were randomly divided into the observation group (n=19) and the control group (n=19) according to completely randomized grouping method. Patients of the observation group were treated with Gimeracil and Oteracil Porassium Capsules combined with medicine concomitant radiotherapy, and the patients of the control group were treated with radiotherapy only. The two groups both received 3 cycles of chemotherapy. The total effective rate, toxicity and 1-year survival rate of the two groups were compared. Results The total effective rate was significantly higher in the observation group than that in the control gorup (P < 0.05). The incidence of radiation pneumonitis and esophagitis between the two groups had no significant differences (P > 0.05). The incidence of leucopenia reduction, blood platelet reduction, nausea, vomiting and diarrhea were significantly higher in the observation group than those in the control gorup (P < 0.05). 1-year survival rate was significantly higher in the observation group than that in the control gorup (P < 0.05). Conclusion Compared with the treatment of radiotherapy only, the clinical efficacy of Gimeracil and Oteracil Porassium Capsules combined with Cisplatin concomitant radiotherapy is significant, it can significantly improve the survival rate.
2017 Vol. 14 (17): 4-7 [Abstract] ( 173 ) HTML (1 KB)  PDF  (0 KB)  ( 28 )
8 Gas chromatograph quantification and osteoblast cells stimulation study on lipophilic products from Bushen Huoxue Recipe
QIAN Yafang1，2 SHAN Letian3 JIN Hongting3 GU Mancang2
Objective To establish determination method of lipophilic components in Bushen Huoxue Recipe by gas chromatography(GC), and investigate the activity of this component to induce osteoblast differentiation. Methods Multiply supercritical fluids were employed to extract lipophilic products SFEⅠ and SFEⅡ from Bushen Huoxue Recipe. Linoleic acid and oleic acid were determined by GC. The proliferation and ALP activity of osteoblast cells were explored after exposure to drug-loaded serums from SFEⅠ and SFEⅡ treated rats. Results Methyl linoleic acid and methyl oleic acid had good linear relationship within the inlet range of 0.2-1.2 μg. Methodological findings met the requirements. Linoleic acid and oleic acid content of SFEⅠ were 318.51-328.64 mg/g and 454.25-460.82 mg/g. Linoleic acid and oleic acid content of SFEⅡ were 205.22-211.32 mg/g and 228.55-235.13 mg/g. The drug-loaded serum from SFEⅠ and SFEⅡ treatment group could significantly stimulate the proliferation and ALP activity in MC3T3E1 cells in vitro compared with that of ethanol-water extraction groups (P < 0.05). Conclusion The supercritical fluid extracts of Bushen Huoxue Recipe SFEⅠ and SFEⅡ are mainly linoleic acid and oleic acid, and the osteoblast differentiation activity is better than that of alcohol extract.
2017 Vol. 14 (17): 8-11 [Abstract] ( 265 ) HTML (1 KB)  PDF  (0 KB)  ( 34 )
12 Establishment of high-fat and high-glucose and low dose of Streptozocin induced rat models of diabetic nephropathy
YAO Lan1 ZHANG Yujie2,3 WANG Jian3 LIU Jing3 LI Linlin3 WANG Ye3 LAN Yi4 MAO Xinmin5
Objective To establish the early diabetic nephropathy (DN) rat model induced by high-fat and high-glucose and low dose of Streptozocin (STZ), so as to simulate the pathologic and renal function changes of early DN. Methods Thirty SPF level of normal male SD rats were divided into normal group and model group by weight. Normal group was fed with normal diet, model group was fed with high-fat and high-glucose diet for 8 weeks continuously, then 35 mg/kg of STZ was injected intraperitoneally to establish diabetic rats model, after that, high-fat and high-glucose diet was fed for 4 weeks continuously. Renal pathological changes, biochemical and renal function indexes of two groups were observed. Results The body weight of rats in the model group was significantly lower than that of normal group (P ＜ 0.01), while the random blood glucose level was higher than that of normal group (P ＜ 0.01), which had reached to standard of diabetes mellitus. The level of serum insulin in the model group was lower than that of normal group, the values of relative kidney weight, 24 h microalbuminuria, α1-microglobulin, β2-macroglobulin were higher than those of normal group, the differences were highly statistically significant (P ＜ 0.01). The pathological characteristics of model group presented the thickening of glomerular basement membrane, mesangial broadening, accumulation of glycogen and collagen fiber in both glomerulus and kidney tubules. Conclusion This molding method can imitate the basic characteristics of early DN.
2017 Vol. 14 (17): 12-15 [Abstract] ( 191 ) HTML (1 KB)  PDF  (0 KB)  ( 24 )
16 The significance of ultrastructuralelectron microscopy diagnosis in pituitary adenomas
YANG Zhijun ZHOU Qiangyi WANG Zhenmin LI Peng WANG Bo LIU Pi′nan▲
Objective To investigate the significance and perspective of ultrastructural characteristics in diagnosis of pituitary adenoma. Methods From August 2010 to August 2015, the specimens of 112 patients with pituitary adenoma at the Department of Neurosurgery, Beijing Tiantan Hospital were analyzed retrospectively. Making a comparison of the routine pathology approaches and electron microscope in diagnosis of pituitary adenoma. Results In 112 pituitary adenoma species, 47 tumors met the routine criterion of clinically non-functioning adenoma. Within those tumors, 20 were diagnosed as clinically nonfunctioning adenoma by electron microscope, the others including 21 oncocytoma subtype of non-functioning pituitary adenomas, 3 stem cell adenomas, 2 gonadotropins adenomas and 1 mixed type adenoma. Besides, 65 tumors met the routine criterion of functional pituitary adenoma, including 10 prolactinomas, 15 growth hormone-producing adenomas, 5 ACTH-secreting adenomas, 2 gonadotropins adenomas, 2 TSH-secreting adenomas, 1 stem cell adenoma and 30 mixed type adenomas by electron microscope. Conclusion Evaluation of ultrastructural characteristics evaluating of pituitary adenomas can provide extraordinary information, which has contributed considerably to the diagnosis of pituitary adenomas.
2017 Vol. 14 (17): 16-18,27 [Abstract] ( 176 ) HTML (1 KB)  PDF  (0 KB)  ( 26 )
19 Study on establishment of premature ovarian function and poor ovarian response mice model through chronic stress
SHEN Kejia SHEN Zouqinxuan LIU Biyuan FU Lingmei XIONG Jie
Objective To explore the method of chronic immobilization stress which can establish the mice model of premature ovarian function (POF) and poor ovarian response (POR). Methods Self-made brakes were used to make chronic stress stateon SPFICR female mice, during the general situation, body weight and estrous cycle of these mice were observed. The microstimulated super ovulation was used on the mice after immobilization, and the follicles of the mice were counted respectively on the third day of superovulation and 24 h after HCG injection. Results Compared with those in the non-immobilization mice, the general situation such as eating, hair color and so on were worse, the body weight significantly reduced (P < 0.05), and the number of abnormal estrous cycle distinct increased (P < 0.05) in the immobilization mice during the braking period. But there was no obvious difference of the follicle number between the immobilization mice and the non-immobilization mice at various levels on the third day of superovulation and 24 h after HCG injection (P > 0.05). Conclusion Chronic immobilization stress can causethe disorder or degradation of ovarian function,and further study is needed to find whetherit can cause premature ovarian function and poor ovarian response.
2017 Vol. 14 (17): 19-22 [Abstract] ( 185 ) HTML (1 KB)  PDF  (0 KB)  ( 22 )
23 Effect of lentivirus targeted to bring Akt1 shRNA on apoptosis and proliferation of gastric carcinoma SGC-7901 Cells
TAN Wei YU Honggang LUO Hesheng ZHOU Wei▲
Objective To investigate the apoptosis and proliferation effect of lentiviral vectors shRNA for Akt1 to human gastric carcinoma SGC-7901 cells. Methods The lentiviral vectors Akt1-shRNA were constructed, lentivirus Akt1-shRNA was transfected into human gastric carcinoma SGC-7901 cells, the SGC-7901 cell strained with Akt1 gene silencing perpetually (SGC-LV-shCON) was as conrol group cell and amplified (SGC LV-shAkt1) was as experiment group cell. Effect of Akt1 on SGC-7901 cells were measured by RT-PCR, Western-blot, flow cytometry of annexin V-FITC/PI, tumor growth curve. Results Akt1 RNAi lentiviral vectors LV-shAkt1 was established successfully, virus titer was 5×108 TU/mL. After SGC-7901 cell transfection, the expression of Akt1 mRNA in experiment group (SGC- LV-shAkt1) was weaker than that in the control group (SGC-7901, SGC- LV-shCON), and Akt1, p-Akt and bcl-2 protein expressions in experiment group was inhabited (P < 0.01), (38.7±3.5)% cell in experiment group happened apotosis (P < 0.05). The cell growth curve of SGC-LV-shAkt1 cell was gentle, compared with SGC-7901 cell or SGC- LV-shCON cell, the growth was lower. Conclusion The lentiviral vectors mediated shRNA for Akt1 can significantly inhibit the expression of Akt1 gene in vitro and markedly inhibit SGC-7901 cell growth and induce the apoptosis of gastric carcinoma cell.The mechanism may be down-regulation of PI3K/Akt signal pathway and anti-apoptosis protein bcl-2 expression.
2017 Vol. 14 (17): 23-27 [Abstract] ( 148 ) HTML (1 KB)  PDF  (0 KB)  ( 27 )
28 Research progress of Sestrin2 anti-oxidative stress effect in ischemia reperfusion
GUO Ming XIA Zhongyuan
Sestrin2 is a highly conserved, stress-inducible protein. As a important protein for P53-regulated mammalian target of rapamyein complex (mTORC1) signaling pathway, Sestrin2 activates AMP activated protein kinase (AMPK) and target it to phosphorylate tuberous seleresis complex (TSC2), thereby inhibiting mTORC1, reducing the ischemia-reperfusion injury. In recent years, there are great progress in the studis of Sestrin2. This paper reviews the role of Sestrin2 in anti-oxidative stress and the potential clinical application as a therapeutic target to prevent/treat related diseases.
2017 Vol. 14 (17): 28-31 [Abstract] ( 135 ) HTML (1 KB)  PDF  (0 KB)  ( 24 )
32 Homocysteine levels in different populations　　
YUE Ping1 LIN Ning2 GUAN Xie1 WU Yulin2 SUN Xiaoru2▲
The detection of homocysteine is more widely applied in clinic. Hyperhomocysteinemia is not only an independent risk factor for stroke, but also associates with adverse pregnancy outcomes, childhood diseases and elderly cardiovascular diseases. However, the level of homocysteine in healthy people varies by gender, age and physiological status. This article determines the abnormal homocysteine level for diagnose of hyperhomocysteinemia in different popu?鄄lations by a review on homocysteine levels in different groups.
2017 Vol. 14 (17): 32-34 [Abstract] ( 179 ) HTML (1 KB)  PDF  (0 KB)  ( 23 )
35 Treatment progress of uncomplicated Stanford type B aortic dissection aneurysm
FU Ruihong HAN Tiesheng LIU Wei
Thoracic endovascular aortic repair (TEVAR) treatment is superior to the best medical treatment for acute/subacute uncomplicated Stanford type B aortic dissection. The best time window of TEVAR treatment is from 2 weeks to 6 months. TEVAR can be used for treatment of chronic uncomplicated Stanford type B aortic dissection. Although there are complications of TEVAR, but it is still relatively safe and effective in the treatment of uncomplicated Stanford type B aortic dissection. 
2017 Vol. 14 (17): 35-38 [Abstract] ( 161 ) HTML (1 KB)  PDF  (0 KB)  ( 32 )
39 Prognostic value of fragmented QRS wave on patient with old myocardial infarction
ZHAO Rong1 ZHANG Chenyu2 FENG Yan1
Objective To investigate the prognostic value of fragment QRS (fQRS) wave on patient with old myocardial infarction. Methods 143 patients with old myocardial infarction from January 2014 to March 2015 in People′s Hospital of Xinjiang Uygur Autonomous Region were subjected to ECG examination. According to fQRS fragment occurrence, all the patients were divided into four groups: without of pathologic Q wave and fQRS wave group (group A), with only pathologic Q wave group (group B), with only fQRS wave group (group C), with both pathologic Q wave and fQRS wave group (Group D). The incidence rate of ventricular arrhythmias and major cardiovascular events were compared among four groups. Results The incidence rates of grade Ⅲ, ⅣA and ⅣB ventricular arrhythmia in group C and group D were higher than those in group A and group B, the differences were statistically significant (P < 0.05). There was no significant difference between group C and group D (P ＞ 0.05). The incidence rates of major cardiovascular events in group C and group D were significantly higher than those in group A and group B, the differences were statistically significant (P < 0.05). There was no significant difference between group C and group D (P ＞ 0.05). Conclusion fQRS wave closely related with ventricular arrhythmia occurrence，it can be effective in prognosis of independent cardiac events of patients with old myocardial infarction, and can be an independent predictor of mortality.
2017 Vol. 14 (17): 39-41 [Abstract] ( 226 ) HTML (1 KB)  PDF  (0 KB)  ( 35 )
42 Risk factor analysis of arrhythmia with coronary heart disease during guardianship period after placing the stent
LIU Fang ZHANG Yongquan WANG Liping
Objective To analyze the risk factor of arrhythmia with coronary heart disease during guardianship period after placing the stent. Methods Clinical data of 264 patients with placing the stent due to coronary heart disease in Xinhua Hospital Affiliated to Dalian University from January 2013 to June 2015 were analyzed retrospectively. They were classified by different factors to analyze the difference by chi-square test. The factors were analyzed with Logistic regression analysis to get the risk factors that effect arrhythmia to patients with coronary heart disease during guardianship period after placing the stent. Results 73 cases among 264 patients happened arrhythmia during guardianship period after placing the stent and the rate was 27.65%. The result showed arrhythmia ratio in patients with less than 65 years old, preoperative cardiac function grade Ⅰ-Ⅱ, preoperative LVEF was less than 50%, no hypertension, no hyperlipidemia, no diabetes, no COPD, no smoking history, number of stents was one and no cardiopulmonary bypass in the surgery were lower than the ratio of contradictory factors, and the differences all were statistically significant (P < 0.05). Then the multivariate Logistic regression analysis showed that age, preoperative cardiac function grade, LVEF, high blood lipids, COPD and number of stents were independent risk factors of arrhythmia to patients with coronary heart disease during guardianship period after placing the stent (P < 0.05). Conclusion The arrhythmia rate of patients with different age, preoperative cardiac function grade, LVEF, high blood lipids, COPD and number of stents will have differences.
2017 Vol. 14 (17): 42-45 [Abstract] ( 159 ) HTML (1 KB)  PDF  (0 KB)  ( 26 )
46 Analysis of clinical characteristics of hospitalized thrombocytopenia patients in our hospital
YE Fang WANG Ling SUN Jianli WANG Huan LI Ningning SHU Ya′nan ZHANG Li′nan TONG Chun
Objective To investigate the department distribution and the causes of hospitalized patients with thrombocytopenia in Beijing Chuiyangliu Hospital Affiliated to Tsinghua University ("our hospital" for short). Methods 358 hospitalized patients with thrombocytopenia were retrospectively analysed in our hospital from August 2015 to July 2016 through the hospital information management system (HIS), the degree of thrombocytopenia, department distribution and pathogeny were monitored. Results The patients of platelet count ≤20×109/L accounted for 5.86%, the patients of platelet count >20×109~50×109/L accounted for 16.76%, the patients of platelet count >50×109~100×109/L accounted for 77.38%. The 358 patients were mainly distributed in Department of Respiratory Medicine, Department of General Surgery, Department of ICU, Department of Obstetrics and Gynecology, Department of Neurology, Department of Cardiology, Department of Haematology and other departments. 43 patients of thrombocytopenia were diagnosed with hematological system disorders, and 315 patients were diagnosed with thrombocytopenia because of other reasons, such as infection and drugs. Conclusion The main cause of thrombocytopenia patients from our hospital between 2015 and 2016 are the non-hematological system disorders. We need to attach importance to the effects of infection and drugs on thrombocyte. However those patients suffer to a lesser degree, and can be recovered by positive control of the primary reasons.
2017 Vol. 14 (17): 46-49 [Abstract] ( 162 ) HTML (1 KB)  PDF  (0 KB)  ( 42 )
50 Lp-PLA2 level and its significance in patients with ischemic stroke
HAN Xiaoxia ZUO Ruiju HAN Tingting MA Xiao
Objective To investigate the level and significance of serum lipoprotein associated phospholipase A2 (Lp-PLA2) in patients with ischemic stroke, in order to analyze the correlation between Lp-PLA2 and cholesterol (CHO), low density lipoprotein (LDL) and triglyceride (TG). Methods From January 2015 to January 2016, 200 patients with ischemic stroke diagnosed and treated at Department of Neurology, Cangzhou People′s Hospital neurology department were selected as the experimental group, and 200 healthy cases were selected as control group, The serum levels of Lp-PLA2, CHO, LDL and TG in the two groups were detected. The collected data were analyzed by statistical software SPSS 17.0. The correlation was analyzed by Pearson test. Results The serum levels of Lp-PLA2, CHO, LDL and TG in the experimental group were higher than those in the control group, with statistically significant difference (P < 0.05). The levels of Lp-PLA2 in patients with ischemic stroke were positively correlated with the levels TG, CHO, and LDL (r=0.689, 0.755, 0.889, P < 0.05). Conclusion The level of Lp - PLA2 in patients with ischemic stroke is increased, and it is correlated with the levels of TG, CHO, and LDL, which is one of the risk factors for ischemic stroke.
2017 Vol. 14 (17): 50-53 [Abstract] ( 175 ) HTML (1 KB)  PDF  (0 KB)  ( 25 )
54 Comparative study on spastic cerebral palsy treated by lectromyography-guided botulinum toxin type A and selective posterior rhizotomy
Aikebaier·Halike LU Xia Mutalifu·Lureihamaiti XU Jian YAN Baofeng Maieraba XU Jufang LUAN Xinping▲
Objective To study the effect of electromyography-guided botulinum toxin type A and selective posterior rhizotomy (SPR) for treatment of spastic cerebral palsy. Methods The clinical data of 40 patients with spastic cerebral palsy were retrospectively analyzed from December 2015 to June 2016 in the Cerebral Palsy Center, the Second Affiliated Hospital of Xinjiang Medical University. According to the treatment method, these patients were divided into the observation group and the control group. There were 20 cases treated with electromyogram-guided botulinum toxin type A in the control group. And there were 20 cases treated with SPR in the observation group. The postoperative complications, the comprehensive spasticity scale (CSS) and the gross motor function scale (GMFM) at different time before and after treatment were compared between the two groups. Results There was no statistical significance between two groups (P ＞ 0.05). Two weeks after treatment, the CSS score in the observation group began to decrease. One month after treatment, the CSS score in the control group began to decline. At 2 weeks, 1 month, 3 months and 6 months after treatment, the scores of CSS in the observation group were significantly lower than those in the control group and decreased degree in the observation group were more than those in the control group, with statistically significant difference (P ＜ 0.05). One month after treatment, the GMFM score in the observation group began to increase. Three months after treatment, the GMFM score in the control group began to increase. At 1 month, 3 months and 6 months after treatment, the GMFM score in the observation group were significantly more than those in the control group and increased degree in the observation group were more than those in the control group, with statistically significant difference (P ＜ 0.05). At 1 month and 3 months after treatment, MAS score for triceps surae and the motion of ankle-joint were significantly improvement compared with those before treatment (P ＜ 0.05), and the improvement for MAS score of triceps surae and the motion of ankle-joint in the observation group were more than those in the control group, with statistically significant difference (P ＜ 0.05). Conclusion Electromyography guided botulinum toxin type A and SPR for treatment of spastic cerebral palsy are effective and safe. Based on strict operative indications, the latter has advantages of relieving muscle spasm and improving the children's motor capacity.
2017 Vol. 14 (17): 54-57 [Abstract] ( 152 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
58 Effect of serum phospholipase A2 levels on Azithromycin sequential therapy for children with Mycoplasma pneumonia
SONG Xilan YU Xiahui WANG Xihui
Objective To investigate the effect of serum phospholipase A2 (PLA2) on Azithromycin sequential therapy for children wiht Mycoplasma pneumonia. Methods 84 cases with Mycoplasma pneumonia were recruited from June 2015 to December 2016 in Pediatrics Department of People's Hospital of Chongzhou. The changes of serum PLA2 were measured. The patients were divided into high/low PLA2 groups according to the median values of PLA2. The clinical efficacy of Azithromycin sequential therapy for Mycoplasma pneumonia was compared between different PLA2 levels groups. Results The overall effective rate of low PLA2 group was 95.24%, which was significantly higher than that in high PLA2 group (78.57%), with statistically significant difference (P < 0.05). The improved time of asthma, cough, fever, pulmonary rales symptom in low PLA2 group were significantly shorter than those in high PLA2 group (P < 0.01). There was no significant difference in overall adverse reaction rate between low PLA2 group and high PLA2 group (P > 0.05). Conclusion Azithromycin treatment for Mycoplasma pneumonia in children can get better effect in patients with low PLA2 levels.
2017 Vol. 14 (17): 58-60,68 [Abstract] ( 144 ) HTML (1 KB)  PDF  (0 KB)  ( 22 )
61 Influence of small doses of hormones on serum sTREM-1, PCT, CD64 in pediatric sepsis
ZHANG Mingtao MIAO Naiying ZHANG Xiang LIANG Hongyan WEN Huimin▲
Objective To explore the influence of small doses of hormones on serum sTREM-1, PCT, CD64 in pediatric sepsis. Methods 66 cases of children with sepsis treated in Pediatrics Department of CNPC Central Hospital from March 2014 to March 2016 were selected as research objects. They were divided into two groups according to random number table method, 33 cases in each group. All pateints were given symptomatic treatment. Patients in the control group were given bundle of treatment, inculding antibiotics, intensive insulin, nutritional support. On the basis of the control gorup, patients in the study group were given small dose Methylprednisolone Sodium Succinate for Injection for 7 d. The levels of peripheral blood T lymphocyte, inflammatory index (PCT, CRP, IL-8) and sTREM-1, sICAM-1 and sVCAM-1 were detected. The scores of PCIS and APACHE Ⅱ were evaluated. The therapeutic effect was compared between the two groups. Results Compared with before treatment, after treatment two groups of CD3+, CD4+ and CD8+ increased (P < 0.01), CD64+ decreased (P < 0.01), levels of PCT, CRP, IL-8 decreased (P < 0.01), levels of sTREM -1, sICAM-1, sVCAM-1 decreased (P < 0.01), PCIS score increased (P < 0.01), APACHE Ⅱ score decreased (P < 0.01). Compared with the control group, the study group had higher CD3+, CD4+ and CD8+ (P < 0.01), lower CD64+ (P < 0.01), lower levels of PCT, CRP, IL-8 and sTREM-1、sICAM-1、sVCAM-1 (P < 0.01), higher PCIS score (P < 0.05), lower APACHE Ⅱ score (P < 0.01), and higher total effective rate (P < 0.05). Conclusion Small doses of glucocorticoid can effectively reduce serum sTREM-1, PCT, CD64+ levels of sepsis patients, which has important clinical value.
2017 Vol. 14 (17): 61-64 [Abstract] ( 159 ) HTML (1 KB)  PDF  (0 KB)  ( 22 )
65 Analysis of risk factors of acute renal injury and fluid overload in infants after congenital heart disease surgery
DAI Wei LUO Deqiang CHEN Rui HUANG Lihua ZHU Zhigang
Objective To investigate the clinical risk factors of acute kidney injury (AKI) and fluid overload (FOL) in infants after congenital heart disease (CHD) surgery. Methods Date of 95 patients aged ≤2 years underwent CPB surgery for CHD were reviewed retrospectively from May 2012 to May 2016. The serum creatinine level was recorded for 3 days after surgery. According to the AKIN standard of AKI, patients were divided into two groups: AKI group and non-AKI group. Preoperative, intraoperative and postoperative variables were collected and analyzed as the potential risk factors of AKI. Percentage FOL was recorded cumulatively at 24, 48, and 72 h after surgery. The influence of AKI and FOL on hospital length of stay, postoperative mechanical ventilation days, and mortality were analyzed. Results The incidence of infants AKI was 45%, of which 87% had AKI at stage I. Multivariate Logistic regression analysis showed factors association with cardiopulmonary bypass time, selective cerebral perfusion, preoperative creatinine value and vasoactive drugs score independently respectively (P < 0.05). A total of 8 patients died (5 cases of AKI of stage 1, 3 cases of AKI of stage 2). Single factor analysis showed that patients of the AKI group had longer hospital stay, ventilator days, and a higher mortality rate than the non- AKI group (P < 0.05). FOL of 62 infants were ≤15% in the first 72 h after surgery, FOL of 33 infants were ＞15%. Infants with FOL >15% had longer hospital stay, ventilator days, and a higher mortality rate than infants with FOL ≤15% FOL group (P < 0.05). Conclusion CPB duration, selective cerebral perfusion, preoperative creatinine value and vasoactive drugs score are relative risk factors of AKI after CHD surgery with CPB in infants. Postoperative AKI and FOL increased hospital stay, mechanical ventilation time and mortality.
2017 Vol. 14 (17): 65-68 [Abstract] ( 154 ) HTML (1 KB)  PDF  (0 KB)  ( 30 )
69 Study on the suitable range of blood lipid control in patients with gestational diabetes mellitus
LI Nan1 YAN Dan2
Objective To analyze the suitable range of blood lipid control in patients with gestational diabetes mellitus. Methods From August 2015 to February 2017 in Beijing Tongzhou Maternal and Child Health Hospital, 1909 cases of patients with gestational diabetes mellitus were selected as research objects, excluded hypertensive disorder complicating pregnancy, fetal macrosomia, fetal growth restriction, twin pregnancy, premature delivery and insufficient information pregnant women. The total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterin (HDL-C), low density lipoprotein cholesterin (LDL-C) were measured by Roche cobas c311 automatic biochemical analyzer in 28-30 weeks of pregnancy and 37 weeks of pregnancy-before delivery. The suitable range of blood lipid control in patients with gestational diabetes mellitus were provided. Results The suitable range of blood lipid control in pregnant women with gestational diabetes mellitus in 28-30 weeks of pregnancy as follow: TC 4.43-6.62 mmol/L, TG 1.09-3.71 mmol/L, HDL-C 1.35-2.54 mmol/L, LDL-C 2.01-4.51 mmol/L; in 37 weeks of pregnancy-before delivery as follow: TC 4.68-8.23 mmol/L, TG 1.68-5.02 mmol/L, HDL-C 1.28-2.57 mmol/L, LDL-C 2.27-5.35 mmol/L. Conclusion In the process of management of patients with gestational diabetes, should pay attention to monitoring blood lipid levels and control in the appropriate range at the same time of blood glucose monitoring, so as to reduce the complications of mothers and infants, and it has important significance for prenatal care and clinical guidance.
2017 Vol. 14 (17): 69-72 [Abstract] ( 152 ) HTML (1 KB)  PDF  (0 KB)  ( 28 )
73 Meta analysis of the expression and clinical relevance of Livin in gastric cancer
WU Yayun ZHANG Zhi WANG Jin DONG Xiaoqiang HE Songbing▲
Objective To systematically assess the expression and clinical relevance of Livin in gastric cancer. Methods Published studies regarding the expression of Livin in gastric cancer with different pathological parameters (age, gender, differentiation, lymph node metastasis, invasion depth, tumor diameter) were searched (no time limit on literature) from PubMed, Embase, Corchrane library, Web of science, CBM, Wanfang and CNKI. Eligible studies were selected according to the inclusion/exclusion criteria and principle of quality evaluation, and Meta-analysis was performed by RevMan 5.3 software. Results A total of 20 studies with 1802 patients were included. The results of Meta analysis showed that Livin expression levels in patients with poorly differentiation were higher than those with moderately and highly differentiation (OR=0.19, 95%CI 0.15-0.25，P < 0.05). Livin expression levels in patients with lymphnode metastasis were higher than those without lymph node metastasis (OR=3.15, 95%CI 2.28-4.36, P < 0.05). Livin expression levels in patients with serosa and serosa outside invasion were higher than those with only subserosa invasion (OR=2.72, 95%CI 1.80-4.10, P < 0.05). Livin expression levels in patients with tumor diameter ≥5 cm were higher than those with tumor diameter <5 cm (OR=1.62, 95%CI 1.16-2.28, P < 0.05). Livin expression in male and female had no significant difference (OR=1.19, 95%CI 0.95-1.49, P > 0.05). Livin expression in patients aged ≥60 years and aged <60 years had no significant difference (OR=1.32, 95%CI 1.00-1.74, P=0.05). Conclusion Livin expression in gastric cancer is obviously related to the size of tumor, differentiation, lymph node metastasis and invasion depth. Livin can be used as an indicator for evaluation of malignant degree and progression of gastric cancer.
2017 Vol. 14 (17): 73-79 [Abstract] ( 164 ) HTML (1 KB)  PDF  (0 KB)  ( 30 )
80 Effect of high risk HPV infection on the genes expression of apoptosis and proliferation in cervical intraepithelial neoplasia
TAO Minfeng1 WANG Xiaorong2
Objective To study the effect of high risk HPV infection on the expression of apoptosis and proliferation genes in cervical intraepithelial neoplasia (CIN). Methods CIN tissues and inflammatory lesions tissues received biopsy in Beijing Maternal and Child Health Care Hospital, Beijing Obstetrics and Gynecology Hospital, Capital Medical University from May 2013 to December 2016 were collected, respectively enrolled in CIN group and control group. CIN tissues were divided into <1 RLU/CO group, 1-100 RLU/CO group, >100-1000 RLU/CO group, >1000 RLU/CO group according to HPV-DNA RLU/CO. Meanwhile, cell cycle protein and its kinase, inhibitor of apoptosis proteins in cervical tissue were determined. Results Expression levels of cyclinB1, cyclinD1, cyclinE, CDK4, CDK6, Apollon, c-IAP1, Survivin, Livin mRNA in cervical tissue of CIN group were significantly higher than those of control group, with statistically significant differences (P < 0.05). Expression levels of cyclinB1, cyclinD1, cyclinE, CDK4, CDK6, Apollon, c-IAP1, Survivin, Livin mRNA in CIN cervical tissue of 1-100 RLU/CO group, >100-1000 RLU/CO group, >1000 RLU/CO group were significantly higher than those of the <1 RLU/CO group, and the higher the HPV-DNA RLU/CO, the higher the expression of cyclinB1, cyclinD1, cyclinE, CDK4, CDK6, Apollon, c-IAP1, Survivin, Livin mRNA, with statistically significant differences (P < 0.05). Conclusion High risk HPV infection in cervical intraepithelial neoplasia can increase the expression of cyclin and its kinase and inhibitor of apoptosis protein genes.
2017 Vol. 14 (17): 80-83,91 [Abstract] ( 155 ) HTML (1 KB)  PDF  (0 KB)  ( 22 )
84 Retrospective analysis of prognostic factors in elderly patients with stage Ⅰ-ⅢA non-small cell lungcancer after radical resection
MI Yuling1 HU Xingsheng1 WANG Ziping2 ZHU Yixiang1
Objective To identify prognostic factors associated with survival in elderly patients with non-small cell lung cancer (NSCLC) after radical resection. Methods From August 2003 to August 2011, in Cancer Hospital, Chinese Academy of Medical Sciences  Peking Union Medical College, the clinical data of 82 elderly patients (≥65 years old) with pathologic stage Ⅰ-ⅢA underwent radical resection were retrospective analyzed. And the correlation between clinical characteristics and prognostic factors was evaluated by Cox proportional hazards regression analysis. Results The median of DFS was 38.28 months (95% CI: 15.583-60.967 months). 1, 2, 5-year DFS rates were 73.2%,57.3% and 35.4%, respectively. Cox regression analysis showed: pathological type, lymph node involvement and ACT status were identified as the independent factors influenced the prognosis (P ＜ 0.05). Conclusion Pathological type, lymph node involvement and ACT status are identified as the independent factors influencing the prognosis of NSCLC elderly patients.
2017 Vol. 14 (17): 84-87 [Abstract] ( 161 ) HTML (1 KB)  PDF  (0 KB)  ( 23 )
88 Clinical effect of laparoscopic surgery and traditional laparotomy in colorectal cancer radical operation
LI Bin JIANG Yuan▲ HU Yujuan
Objective To discuss the clinical effect of laparoscopic surgery and traditional laparotomy in colorectal cancer radical operation. Methods Clinical data of 126 cases with colorectal cancer treated in General Surgery Department, Center Hospital of Shandong Energy Zibo Mining Group from February 2014 to March 2016 were retrospective analyzed. According to surgical treatment methods, patiens were divided into the laparoscopic surgery group and traditional laparotomy gorup, each gorup had 63 cases. The operative indicators, postoperative recovery, cancer radical index and postoperative complications were recorded in the two groups. Results The peroperative bleeding, incision length of the laparoscopic surgery group were less than those of the traditional laparotomy gorup, the operation time and rate of sphincter-saving were longer or higher than those of the traditional laparotomy group, with statistically significant differences (P < 0.05). The postoperativeanus exhaust time, hospital stay, drainage tube time, urinary catheter time, liquid diet time, leaving bed time of the laparoscopic surgery group were shorter than those of the traditional laparotomy gorup, with statistically significant differences (P < 0.05). The incdence of postoperative bleeding and infection of the laparoscopic surgery group were lower than those of the traditional laparotomy gorup, with statistically significant differences (P < 0.05). There were no statistically significant differences in lymph node cleaning number, length of specimen excision, length of tumors distal end between the two groups (P > 0.05). Conclusion Compared with traditional laparotomy, application of laparoscopic surgery in colorectal cancer radical operation has less intraoperative trauma, faster postoperative recovery and lower complication incidence rate. It is worthy of clinical application.
2017 Vol. 14 (17): 88-91 [Abstract] ( 173 ) HTML (1 KB)  PDF  (0 KB)  ( 21 )
92 Study on relationship between abnormality of blood lipid level and liver metastasis of colorectal
ZHANG Rui
Objective To investigate the relationship between colorectal cancer patients with liver metastases and abnormal blood lipid levels. Methods From June 2008 to March 2016, in Department of General Surgery and Department of Anorectal Surgery, Chinese Medicine Hospital of Baoji City, the clinical data of 336 patients with colorectal cancer were analyzed retrospectively. They were divided into coloractal cancer with liver metastases group (52 cases) and colorectal cancer without liver metastases group (284 cases). The clinical data and initial blood lipid levels of colorectal cancer were analyzed and compared, the relationship of colorectal cancer with liver metastases patients and lipid levels, abnormal blood lipids was analyzed statistically. Results There were statistically significant differences in the depth of tumor invasion, regional lymph node metastasis and tumor differentiation degree between the two groups (P < 0.05). There was no statistically significant differences in the primary CEA level between the two groups (P > 0.05). The blood lipid levels of colorectal cancer with liver metastases group were higher than the colorectal cancer without liver metastases group, the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that hypertriglyceridemia and hypercholesterolemia were both independent risk factors with liver metastasis in colorectal cancer (P < 0.05), but it had no association with high density lipoprotein and low density lipoprotein (P > 0.05). Conclusion High cholesterol and high triglyceride levels may promote liver metastasis in colorectal cancer.
2017 Vol. 14 (17): 92-95 [Abstract] ( 150 ) HTML (1 KB)  PDF  (0 KB)  ( 27 )
96 Analysis of surgical complications of huge meningiomas
WANG Rui SUN Hongwei WANG Chao ZHANG Rende LI Dongming
Objective To study the influencing factors and harm of the surgical complications of huge meningiomas, and summarize the experience for huge meningiomas prevention and treatment. Methods The clinical data of 64 patients with huge meningioma were analyzed retrospectively from September 2011 to September 2016 in the First Affiliated Hospital of Zhengzhou University. The quality of life was assessed by KPS score. Single factor chi-square test and multiple factor Logistic regression for statistics data,and then combined with clinical and related literature to summarize the causes of surgical complications, influencing factors, preventive measures and outcome. Results Univariate analysis showed that age, preoperative KPS score, tumor location and degree of resection were related to the surgical complications (P < 0.05). Multivariate analysis showed that age was ≥60 years old  and incomplete resection were independent risk factors for complications. Severe cerebral edema and intracranial hemorrhage are independent risk factors for perioperative outcome (P < 0.05). Conclusion Severe cerebral edema and intracranial hemorrhage are serious complications of huge meningioma. The patients are older and the tumor is incomplete resection were Independent risk factors for surgical complications. Scientific and fine surgical operation and reasonable perioperative management can be reduced the risk of surgical complications.
2017 Vol. 14 (17): 96-99 [Abstract] ( 151 ) HTML (1 KB)  PDF  (0 KB)  ( 25 )
100 Comparison of treatment colon cancer by laparoscope right hemicolectomy and laparotomy
WANG Rui SHANG Jing
Objective To approach clinical result of colorectal cancer radical prostatectomy by laparoscopic surgery and open surgery. Methods From January 2011 to February 2014, in Second Hospital of Yulin City, they were divided into two group by different operation treatment methods, laparoscopic surgery group (86 cases) and laparotomy group (72 cases). The record indicators related to operation,  postoperative complications and local recurrence and distant metastasis of two groups colorectal cancer radical prostatectomy patients were detected. Results The incision length, intraoperatve blood soss, postoperative hospital stay, evacuation time of laparotomy group were higher than laparoscope group, operation time was shorter than laparoscope group, the differences were statistically significant (P < 0.05). The postoperative complications of laparotomy group were higher than laparoscope group, the difference was statistically significant (P < 0.05). The local recurrence rate and distant metastasis rate of two group were compared, the differences were not statistically significant (P > 0.05). Conclusion The laparoscope right hemicolectomy treatment colon cancer patients, operative wound is little, postoperative recovery is quick, prognosis is good，it is worth to be used.
2017 Vol. 14 (17): 100-103 [Abstract] ( 165 ) HTML (1 KB)  PDF  (0 KB)  ( 28 )
104 Effect of the intervention of aerobic exercise and pulmonary rehabilitation training combined with inhalation of Seretide and Tiotropium Bromide for the pulmonary function, exercise tolerance and quality of life in patients with moderate-severe COPD
HU Liangbin1 YANG Jianquan2
Objective To explore the effects of the intervention of aerobic exercise and pulmonary rehabilitation training combined with inhalation of Seretide and Tiotropium Bromide for the pulmonary function, exercise tolerance and quality of life in patients with moderate-severe chronic obstructive pulmonary disease (COPD). Methods One hundred and forty-seven patients with moderate-severe COPD admitted to the Affiliated Hospital of Xi'an Medical University from July 2013 to July 2015 were selected and randomly divided into experimental group 1, experimental group 2 and control group, with 49 cases in each group. The control group was given drug therapy, the experimental group 1 was given aerobic exercise intervention, the experimental group 2 was given the aerobic exercise combined with pulmonary rehabilitation training and drug intervention. After intervention for 8 weeks, the changes of pulmonary function, exercise tolerance and quality of life among the three groups were observed. Results The vital capacity, forced vital capacity, maximal voluntary ventilation in the experimental group 2 were better than those of control group and experimental group 1, the differences were statistically significant (P ＜ 0.05); the contents of secretary immunoglobulin A, noradrenaline in the experimental group 2 were all lower than those of control group and experimental group 1, the differences were statistically significant (P ＜ 0.05); the 6 min walking test in the experimental group 2 was higher than that of control group and experimental group 1, the score of quality of life was higher than that of control group and experimental group, the differences were statistically significant (P ＜ 0.05). Conclusion Intervention of comprehensive aerobic exercise and pulmonary rehabilitation training combined with inhalation of Seretide and Tiotropium Bromide for patients with moderate-severe COPD can improve the pulmonary function, exercise tolerance and quality of life, which is worthy of promotion and application.
2017 Vol. 14 (17): 104-107 [Abstract] ( 159 ) HTML (1 KB)  PDF  (0 KB)  ( 29 )
108 Effect of Bifid-Triple Viable Capsule for the abdominal pain symptom and mental function of patients with functional abdominal pain syndrome
WANG Ying1 GUO Xin2 NING Chunhong2 CHEN Yangfang3 YU Yingcong1 LAN Qiaoli1 WENG Xuejian1 YUAN Jie2▲
Objective To explore the effect of Bifid-Triple Viable Capsule for the abdominal pain symptom and mental function of patients with functional abdominal pain syndrome (FAPS). Methods Sixty-five patients with FAPS admitted to Wenzhou People's Hospital and Affiliated Hospital of North China University of Science and Technology from October 2015 to December 2016 were selected as research objects, and 67 cases taken healthy examination at the same time were selected as healthy control. The patients with FAPS were divided into two groups by random number table, with 33 cases in Bifid-Triple Viable Capsule group and 32 cases in Sertraline group. The scores of abdominal pain symptom and symptom check-list 90 (SCL-90) before and after treatment in the two groups were compared. Results Among 65 patients with FAPS, total 54 cases (83.1%) finished the study, with 28 cases in Bifid-Triple Viable Capsule group and 26 cases in Sertraline group. ①The scores of SCL-90 and its factors (somatization, force, interpersonal relationship, depression, anxiety, hostility, terror, stubborn, psychoticism) in FAPS patients were all higher than those of healthy controls, the differences were statistically significant (P ＜ 0.05). ②The total effective rate was 75.0% in Bifid-Triple Viable Capsule group, and 80.8% in Sertraline group, the difference between the two groups was not statistically significant (χ2=2.856, P ＞ 0.05). ③After treatment, the scores of severity degree and seizure frequency of abdominal pain in the two groups were all lower than those before treatment (P ＜ 0.05), while there were no statistically significant differences on the scores of severity degree and seizure frequency of abdominal pain between the two groups after treatment (P ＞ 0.05). ④After treatment, the SCL-90 scores in the two groups were lower than those before treatment (P ＜ 0.05). But the score difference of SCL-90 and its factors before and after treatment between the two groups had no statistically significant differences (P ＞ 0.05). Conclusion The Bifid-Triple Viable Capsule can effectively improve the abdominal pain symptom and mental states of patients with FAPS by modulating intestinal flora, and the efficacy is almost the same with Sertraline.
2017 Vol. 14 (17): 108-111 [Abstract] ( 187 ) HTML (1 KB)  PDF  (0 KB)  ( 26 )
112 The role of blood glucose monitoring in diabetes mellitus management of Shanghai rural community
ZENG Yuanyuan ZHU Chaoyu XIAO Yuanyuan GAO Qingge XU Li WEI Li
Objective To analyze the effect of hospital-community integrated management and blood glucose monitoring in the management of patients with diabetes mellitus. Methods Five hundred and forty-one patients with diabetes mellitus coming from one Shanghai rural community from April 2014 to April 2015 were applied with hospital-community integrated strengthening management and blood glucose monitoring for one year, and the indexes of blood glucose, blood pressure, blood lipid were recorded, the clinical and laboratory data before and after management was collected and taken statistical analysis. Results After management for one year, the glycosylated hemoglobin, fasting blood-glucose, two-hour postprandial plasma glucose, insulin resistance index, systolic blood pressure, diastolic blood pressure, triacylglycerol, low density lipoprotein cholesterin, waistline of patients with diabetes mellitus were all decreased compared with those before management, the differences were statistically significant (P ＜ 0.05). After management, the good control rates of glycosylated hemoglobin, blood pressure, blood lipid were all increased compared with those before management, which increased from 63.40%, 9.98%, 50.46% to 72.27%, 22.18%, 58.96% respectively, the differences were statistically significant (P ＜ 0.05). After management, the good control rates of single, two, three indexes of glycosylated hemoglobin, blood pressure, blood lipid were all increased compared with those before management, the differences were statistically significant (P ＜ 0.05). Conclusion Increasing the frequency of blood glucose monitoring for patients with diabetes mellitus can have a positive impact on the good control rates of blood glucose, blood pressure, blood lipid of patients. Blood glucose monitoring is a good management measure for controlling the blood glucose, strengthening the blood glucose monitoring is an effective method of chronic diseases management of diabetes mellitus, which is important for the management of patients with diabetes mellitus in Shanghai rural community.
2017 Vol. 14 (17): 112-115 [Abstract] ( 165 ) HTML (1 KB)  PDF  (0 KB)  ( 25 )
116 Analysis on the causes of fever in children under elective surgery and its countermeasures
WANG Ling WANG Ning▲ LI Xiaojie
Objective To investigate and analyze the causes of fever in children under elective surgery and its countermeasures. Methods Two hundred children underwent elective surgery in Department of Pediatric Surgery of Chinese PLA General Hospital from January 2014 to July 2016 were selected and randomly divided into the experimental group and the control group, with 100 patients in each group. The control group received routine preoperative preparation. In addition to routine preoperative preparation, the experimental group was given preoperative fluid replacement. The gender, categories of disease, age, height and weight were analyzed between the two groups, and the results of average body temperature, average hospitalization time and fever conditions of the two groups were analyzed with statistics. Results There were no significant differences of the gender, categories of disease, age, height and weight between the two groups (P ＞ 0.05). There were significant differences of average body temperature and average hospitalization time between the two groups (P ＜ 0.05). There were 10 cases (10%) of fever in the control group and 1 case (1%) of fever in the experimental group, the incidence of fever in the experimental group was significantly lower than that of the control group (χ2=7.792, P ＜ 0.05). At the same time, one case of fever in the experimental group was 8 months old. Among the 10 febrile children of control group, 4 cases of them were in the 0-12 months, 3 cases were in the ＞12-48 months range, 2 cases were in the ＞48-84 months range and 1 case was in the ＞84-168 months range, which showed that the younger were more prone to fever. Conclusion Preoperative intravenous fluid replacement for the prevention of elective surgery in children with fever has important clinical significance.
2017 Vol. 14 (17): 116-118 [Abstract] ( 186 ) HTML (1 KB)  PDF  (0 KB)  ( 29 )
119 Efficacy of hypophysin combined with Octreotide in the treatment of liver cirrhosis with upper gastrointestinal hemorrhage: a Meta-analysis
CAI Yanping1 XUE Shunhe2▲
Objective To systemically review the efficacy of hypophysin combined with Octreotide in the treatment of liver cirrhosis with upper gastrointestinal hemorrhage. Methods The literatures about the efficacy of hypophysin combined with Octreotide in the treatment of upper gastrointestinal hemorrhage were searched systemically in the database of PubMed, The Cochrane Library, Web of Science and WanFang, CNKI, CBM and VIP, the search words included "hypophysin, Octreotide, upper gastrointestinal hemorrhage", the retrieval time limit was from the establishment of database to July 2016, 2 reviewers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. Then Meta-analysis was performed using RevMan5.2 software. Results A total of 7 RCTs involving 658 patients were included, including 337 cases in the experimental group and 321 cases in the control group. The results of Meta-analysis showed that the total effective rate of experimental group was higher than that of the control group, the hemostatic time was shorter than that of control group, the differences were all statistically significant (MD = 7.33, 95%CI: 3.83-14.03, P ＜ 0.01; MD = -8.57, 95%CI: -13.62 - -3.52, P ＜ 0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Compared to the single use of Octreotide, hypophysin combined with Octreotide can effectively improve the total effective rate and shorten the hemostatic time.
2017 Vol. 14 (17): 119-122 [Abstract] ( 181 ) HTML (1 KB)  PDF  (0 KB)  ( 17 )
123 Bleeding complications caused by treatment of Aspirin and Clopidogrel for IS/TIA: a Meta-analysis
TIAN Fangyuan1,2 WU Bin1 XU Ting1
Objective To systematically assess the bleeding complications caused by treatment of Aspirin and Clopidogrel for ischemic stroke or transient ischemic attack. Methods Taking "ischemic stroke", "transient ischemic attack", "Aspirin" and "Clopidogrel" as the search terms to search the database. Databases of PubMed, EMBase, The Cochrane Library, CBM, CNKI, VIP and WanFang Data were searched from inception to February 2017. Two reviewers independently screened literatures, extracted data and assessed quality of included studies. Then Meta-analysis was conducted by RevMan 5.3 software. Results A total of 15 studies involving 11 200 patients were included. The results of Meta-analysis showed that: during the treatment of ischemic stroke, drug combination could increase the risk of gastrointestinal bleeding (OR = 2.18, 95%CI: 1.43-3.34, P = 0.0003); during the treatment of transient ischemic attack/light stroke, drug combination could increase the risk of mild bleeding (OR = 1.50, 95%CI: 1.10-2.04, P = 0.01). Conclusion Based on current evidence, long term application of combination of Aspirin and Clopidogrel in the treatment of transient ischemic attack will increase the risk of mild bleeding, long term application of the two drugs in the treatment of ischemic stroke will increase the risk of gastrointestinal bleeding. Due to the impact of quantity and quality of the included studies, the conclusion above still needs carrying out more high-quality studies to confirm.
2017 Vol. 14 (17): 123-126 [Abstract] ( 164 ) HTML (1 KB)  PDF  (0 KB)  ( 6 )
127 Effects of early serum bilirubin level on the prognosis of patients with acute cerebral infarction
JI Li ZHANG Qinjun
Objective To investigate the effects of early serum bilirubin level on the prognosis of patients with acute cerebral infarction. Methods The clinical data of 257 patients with acute cerebral infarction (acute cerebral infarction group) admitted to Department of Neurology, Xianyang Hospital of Yan'an University from February to October 2016 was analyzed retrospectively, and they were divided into higher group (≥10.9 μmol/L) and lower group (＜10.9 μmol/L) according to different serum bilirubin levels. At the same time, 30 healthy persons were taken as control group. The serum bilirubin level at the second day after admission was detected, and the incidence of hemorrhagic transformation (HT) and multiple organ dysfunction syndrome (MODS) after admission was made statistics, the prognosis at discharge was evaluated, and the patients with different serum bilirubin levels were compared with the events above. Results The early serum bilirubin level of acute cerebral infarction group was lower than that of control group, the difference was highly statistically significant (P ＜ 0.01). During patients with different bilirubin levels, the incidence of HT between lower group and higher group had no statistically significant difference (P ＞ 0.05), while the incidence of MODS in the higher group was lower than that of lower group, the difference was statistically significant (P ＜ 0.05). Compared with those at admission, the scores of neural function deficient scale (NDS) in the two groups at discharge were all decreased, the scores of activity of daily living (ADL) in the two groups at discharge were all increased, the differences were all highly statistically significant (P ＜ 0.01). At discharge, the score of NDS in the higher group was slightly lower than that of lower group, but there was no statistically significant difference (P ＞ 0.05), while the score of ADL in the higher group was higher than that of lower group, the difference was highly statistically significant (P ＜ 0.01). Conclusion Compared with normal persons, the serum bilirubin level of patients with acute cerebral infarction is lower, and among the patients with acute cerebral infarction, the higher the serum bilirubin level is, the lower the incidence of complications is, the better the prognosis is.
2017 Vol. 14 (17): 127-130 [Abstract] ( 174 ) HTML (1 KB)  PDF  (0 KB)  ( 7 )
131 Application of standardized management based on Joint Commission certificated by American Medical Institutions on high risk drugs management in Department of Urology of our hospital
TANG Shouyan SHENG Xia▲
Objective To explore the application of standardized management based on Joint Commission certificated by American Medical Institutions (JCI) on high risk drugs management in Department of Urology of Changhai Hospital of Shanghai ("our hospital" for short). Methods Since July 2016, standardized management model based on American JCI system were applied into high-risk drug management in Department of Urology of our hospital. The management satuation of high-risk drugs in Department of Urology  before implementation of the model (from January to June 2016) was compared with that after implementation (from July to December 2016). Results After implementation, high-risk drug classification, disease, contraindication, storage, allocation, audit knowledge by nurses were significantly higher than those before implementation, the differences were statistically significant (P < 0.05). After implementation, high risk drug classification storage, double check, independent storage, personal management, base management, list of spare drugs, effective management, warning signs pass rate were significantly higher than those before implementation, the differences were statistically significant (P < 0.05). Conclusion Standardized management based on American JCI system can improve nurses' awareness of safe medication, and strengthen the management of high-risk drugs.
2017 Vol. 14 (17): 131-133,149 [Abstract] ( 151 ) HTML (1 KB)  PDF  (0 KB)  ( 21 )
134 Characteristic and drug choice of Urology surgical postoperative infection
LI Lixia1 LI Yongyang2▲
Objective To analyze the characteristics and trends of urology surgical postoperative infection, in order to provide references for clinical pharmacists. Methods From January 2010 to December 2015, in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 228 urology surgical postoperative infection patients with clinical pharmacists were consulted were analyzed retrospectively. According to these diseases categories, they were divided into four groups, kidney stone group (n = 90), ureteral calculus group (n = 35), kidney and ureteral calculus group (n = 21) and other disease group (n = 82). The infection sites, bacterial categories, anti-infection treatment schedules, and treatment outcome were analyzed individually. Results The infection sites were mainly urinary tract, blood system or lungs. Except for the blood system infection, the difference of incidence rate of the other infection sites among the four groups was statistically significant (P < 0.01). E. coli had the highest detection rate, and the difference of its infection rate among four groups was statistically significant (P < 0.01). Candida albicans had the second highest infection rate, and Enterococcus had the third highest infection rate. Imipenem had the highest usage rate, and Piperacillin-Tazobactam had the second highest usage rate. 47% patients were cured, 50.9% patients were improved. the difference of recovery rate among the four groups was statistically significant (P < 0.05). Conclusion Clinical pharmacists analyze the common infection sites, pathogens and effective anti-infection treatment schedules, and take an active role in curing infection and reducing infection mortality rate.
2017 Vol. 14 (17): 134-137 [Abstract] ( 152 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
138 Investigation and process optimization of application status of automatic drug dispensing machine in military outpatient pharmacy of our hospital
WANG Ru1 XIN Haili1 SHI Huayu2 GUO Daihong1
For the maximum efficiency of hospital pharmacy the dispensing machine, to promote the implementation of hospital pharmacy automation. Combining with the actual work, this article summarizes the application of drug development process problems, develops countermeasures and implementation. After optimization, it improves dispensing machine efficiency, reduces pharmacists work intensity, and improves the working efficiency of whole pharmacy. But there are still some problems should be solved, it should continue to research and optimize the application of dispensing machine, improve the overall service level of pharmacy.
2017 Vol. 14 (17): 138-141 [Abstract] ( 182 ) HTML (1 KB)  PDF  (0 KB)  ( 25 )
142 Clinical effect of Ganzao Liquid in the treatment of Sj■gren's syndrome and its influence on the levels of IL-33 and IL-22
LI Lingxiao DING Wei
Objective To observe the curative effect of Ganzao Liquid in the treatment of Sj■gren's syndrome and its influence on the levels of interleukin (IL)-33 and IL-22. Methods Forty patients with primary Sj■gren's syndrome admitted to Department of Rheumatism of Suzhou Hospital of Traditional Chinese Medicine from December 2014 to August 2016 were selected and randomly divided into control group and experimental group by random number table method, with 20 cases in each group. The control group was given Hydroxychloroquine, on basis of which, the experimental group was added with Ganzao Liquid. The course was three months. The clinical effect, TCM symptom scores and serum levels of IL-22, IL-33 of the two groups were compared and analyzed. Results The total effective rate of experimental group was 90%, which was higher than that of control group (60%), the difference was statistically significant (P ＜ 0.05). After treatment, the TCM symptoms scores of dry mouth, dry eye, chest distress, joint pain in the experimental group were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05); the TCM symptoms scores of dry mouth, dry eye, joint pain in the control group were all lower than those before treatment (P ＜ 0.05), while there was no statistically significant difference of chest distress score in the control group before and after treatment (P ＞ 0.05); the TCM symptoms scores of dry mouth, dry eye, chest distress, joint pain in the experimental group after treatment were all lower than those of control group (P ＜ 0.05). After treatment, the levels of IL-22, IL-33 in the two groups were all lower than those before treatment (P ＜ 0.05), and the levels of IL-22, IL-33 in the experimental group were all lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion On basis of symptomatic treatment of western medicine, Ganzao Liquid in the treatment of Sj■gren's syndrome is effective, which can effectively improve the dry mouth, dry eye, joint pain, chest distress, and inflammatory reactions.
2017 Vol. 14 (17): 142-145 [Abstract] ( 140 ) HTML (1 KB)  PDF  (0 KB)  ( 25 )
146 Effect of Aidi Injection combined with chemotherapy scheme in the treatment of advanced colorectal cancer
LYU Xiazhi
Objective To explore the effect of the Aidi Injection combined with chemotherapy scheme in the treatment of advanced colorectal cancer. Methods From June 2013 to June 2016, the clinical data of 70 patients with advanced colorectal cancer treated in Lu'an Hospital Affiliated to Anhui Medical University were retrospectively analyzed, patients were divided into control group and observation group according to the different methods of treatment, each group of 35 cases. The control group was treated by the standard chemotherapy of Oxaliplatin combined with Capecitabine, while the observation group was treated by Aidi Injection on the basis of the treatment of control group. The clinical efficacy of the two groups was compared; the quality of life was assessed before and after treatment by Karnofsky performance status (KPS) score, the improvement of quality of life after treatment was observed; the occurrence of adverse reactions of the two groups was compared. Results The effective rate of the observation group was higher than that of the control group (71.43% vs 60.00%), the difference was statistically significant (P ＜ 0.05). After treatment, the improvement of KPS score in observation group was better than that of the control group, the difference was statistically significant (P ＜ 0.05). The degree of white blood cells decline of the observation group was obviously lower than that of the control group (P ＜ 0.05); the severity of platelet decline, gastrointestinal reaction, neurotoxicity were lighter than those of the control group, but there were no statistically significant differences between the two groups (P ＞ 0.05). Conclusion The effect of Aidi Injection combined with chemotherapy scheme in the treatment of advanced colorectal cancer is significantly better than that of the pure chemotherapy, with less adverse reactions, which can obviously improve the quality of life, and it is worthy of clinical popularization and application.
2017 Vol. 14 (17): 146-149 [Abstract] ( 124 ) HTML (1 KB)  PDF  (0 KB)  ( 25 )
150 Psychological status of patients with myocardial infarction interventional therapy and nursing countermeasures
FENG Jing1 ZHANG Guangwei2
Objective To survey  psychological state of the patients with myocardial infarction in interventional therapy, in order to formulate various form education intervention method. Methods 120 cases with myocardial infarction in interventional therapy in the First Hospital of China Medical University from June 2014 to June 2016 were selected, and they were received survey questionnaire about psychological state, to formulat various form education intervention method. Results The subjective psychological experience survey after interventional therapy showed that the satisfaction about the effect of interventional treatment was the highest, accounted for 82.50%. The general attitudes towards the interventional treatment was positive, accounted for 85.00%. The proportion of willing to accept the doctor's advice was 79.17%, and the proportion of opinion held a negative attitude to the doctor was 20.83%. The highest requirements  of this group was the phone call or message advisory, accounted for 90.00%. Conclusion The general attitudes of patients towards the interventional treatment are positive, while some patients have a negative attitude toward their doctors, so effective interventions should be  made, which can be suitable for the different psychological states of patients with myocardial infarction .
2017 Vol. 14 (17): 150-152 [Abstract] ( 161 ) HTML (1 KB)  PDF  (0 KB)  ( 24 )
153 Application effect of exercise rehabilitation pathway on rehabilitation of elderly patients with chronic heart failure
CHENG Mengying1 YANG Jianquan2
Objective To investigate the effect of exercise of rehabilitation pathway on rehabilitation treatment of elderly patients with chronic heart failure. Methods 130 elderly patients with chronic heart failure treated in the first Affiliated Hospital of Xi'an Medical University from June 2015 to June 2016 were selected. The patients were divided into experimental group and control group according to random number table, with 65 cases in each group. Patients in the control group were treated with routine nursing care, and the patients in the  experimental group were treated with exercise rehabilitation therapy. After treatment, the treatment effect of the two groups of patients were observed and evaluated, including the patient's cardiac function index and the incidence of re hospitalization within 6 months after discharge. Results The total efficiency of the treatment in the experimental group patients was higher than that of the control group, with statistically significant difference (P < 0.05). After treatment, the levels of LVEDV and LVESV in the experimental group were lower than those in the control group, the level of LVEF in the experimental group was higher than that in the control group, with statistically significant difference (P < 0.05); 6-minute ambulation distance of the exp?鄄erimental group was significantly higher than that of the control group, and the readmission rate was significantly lower than that of the control group, with statistically significant difference (P < 0.05). Conclusion The rehabilitation training path can improve the motivation and initiative of the rehabilitation of patients with chronic heart failure, the indexes of cardiac function and clinical effect.
2017 Vol. 14 (17): 153-155,164 [Abstract] ( 146 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
156 Early rehabilitation nursing on motor function and cognitive function in patients with cerebral apoplexy
WANG Hongjuan CHEN Bingkun LYU Zheng
Objective To explore the influence of early rehabilitation nursing intervention in patients with cerebral apoplexy hemiplegia on limb function and life quality. Methods 120 cases with cerebral apoplexy hemiplegia treated in the First Affiliated Hospital of Harbin Medical University from October 2014 to October 2016 were selected. All the patients were divided into control group and observation group according to random number table, with 60 cases in each group. The control group patients was given to the routine nursing, and the observation group was given to the early rehabilitation nursing, for the continuous 3 months. The Barthel index (BI), Fugl-Meyer score (FMA) and the improvement about the cognitive function and the life quality of the two groups patients before and after nursing were compared. Results The BI, FMA score of two groups after treatment were increased than before, and the improvement of the observation group was more remarkable than that of the control group, with statistically significant difference (P < 0.05). The total effective rate of cognitive function improvement in the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). The physical function, role function, emotional function, cognitive function and social function score of the two groups were increased than before, and the increase of the observation group was more remarkable than that of the control group (P < 0.05). Conclusion The application of early rehabilitation nursing for stroke patients with hemiplegia can effectively enhance the recovery of motor function and cognitive function, improve the quality of life.
2017 Vol. 14 (17): 156-159 [Abstract] ( 159 ) HTML (1 KB)  PDF  (0 KB)  ( 29 )
160 The application of multidisciplinary team cooperation in patients with liver cirrhosis after endoscopic esophageal varices ligation therapy
QIN Xixiang1 PENG Tieli1 LIU Junying1 OUYANG Meili1 GAN huoye1 JIANG Sheng2 GUO Dahai3
Objective To explore the effect of multidisciplinary team nursing model on patients with liver cirrhosis after endoscopic esophageal varices ligation therapy. Methods This was a retrospective trial. 100 patients with liver cirrhosis after endoscopic esophageal varices ligation therapy in Department of Gastroenterology in , the Sixth Affiliated Hospital of Guangzhou Medical University from January 2014 to December 2015 were enrolled. 50 patients in 2014 were divided into the control group, and 50 patients in 2015 were divided into experimental group. All patients were followed up for six months after discharge. Patients′ compliance behavior, satisfaction of discharge guidance service, rate of rebleeding and mortality were recorded. Results The patients′ compliance behavior and satisfaction of discharge guidance service in the experimental group were better than those in the control group (P < 0.05). The rate of rebleeding in the experimental group were lower than that of the control group(P < 0.05). The rate of mortality in the experimental group were lower than that of the control group, but there was no statistical significance (P > 0.05). Conclusion A multidisciplinary team of seamless nursing mode improves the treatment compliance and satisfaction with medical services and reduces the rate of rebleeding of patients with liver cirrhosis after endoscopic esophageal varices ligation therapy.
2017 Vol. 14 (17): 160-164 [Abstract] ( 146 ) HTML (1 KB)  PDF  (0 KB)  ( 21 )
165 Effect of health belief model intervention on long-term home oxygen therapy behaviors in patients with chronic obstructive pulmonary disease 
YAN Jinying1 ZHANG Erming2 YU Lijun1
Objective To explore the effects of health belief model (HBM) intervention on long-term home oxygen therapy behaviors in COPD patients. Methods From June 2016 to January 2017, 68 patients with COPD in Peking University Shougang Hospital and China Medical University Aviation General Hospital were selected, and they were divided into control group and intervention group, according to throw coins, with 34 cases in each group．Patients of the control group were received routine nursing intervention and patients of the intervention group were received intervention based on HBM. Long-term home oxygen therapy behaviors of patients in the two groups before and after intervention were compared． Results Average daily oxygen time and long-term home oxygen therapy behaviors of two groups before the intervention had no significant differences (P > 0.05), while the two indexes of intervention group after the intervention were all better than those of control group and the results before the intervention, the comparison indexes had significant differences (P < 0.05); compared with the control group, there was significant difference in the implementation rate of items (P < 0.05). Conclusion Intervention based on HBM can improve the long-term home oxygen therapy behaviors and improve the quality of life of patients
2017 Vol. 14 (17): 165-169 [Abstract] ( 152 ) HTML (1 KB)  PDF  (0 KB)  ( 30 )
170 Effect of stress management on the quality of life of patients with early-stage non- small cell lung cancer treated by video-assisted thoracoscopic surgery
KANG Xiaoyan1 WU yan1 CHANG Haixia2▲
Objective To investigate the effect of stress management on the quality of life of patients with early-stage non-small cell lung cancer treated by video-assisted thoracoscopic surgery. Methods Date were from Department of Thoracic Surgery, the First Affiliated Hospital of Xinjiang Medical University, an intervention study of 60 patients with early-stage non-small cell lung cancer treated by video-assisted thoracoscopic surgery who were admitted from August 2014 to August 2016. Patients were divided into intervention group (30 cases) and control group (30 cases) by random number table. Two groups were received conventional care, and implemented stress management on the intervention group for 6 months. The quality of life of two groups was assessed using the cancer patients' quality of life scale developed by the European Organization for cancer research and treatment (EORTC QLQ-C30). Results After intervention, the overall quality of life, physical function, role function, emotional function, cognitive function and social function of the patients in the intervention group were significantly higher than those in the control group (P < 0.05). After intervention, the scores of the patients in the intervention group were significantly lower than those in the control group (P < 0.05), such as pain, nausea and vomiting, dyspnea, insomnia, loss of appetite, constipation, diarrhea, and economic influence. Conclusion Stress management can relieve the pressure and improve the quality of life of patients with early-stage non-small cell lung cancer treated by video-assisted thoracoscopic surgery.
2017 Vol. 14 (17): 170-173,177 [Abstract] ( 166 ) HTML (1 KB)  PDF  (0 KB)  ( 22 )
174 Observation of curative effect of acupoint massage therapy on bloating and constipation in patients with thoracolumbar fractures
ZHONG Wen HUANG Huifen SUN Qiaoyu
Objective To explore the effect of acupoint massage therapy on bloating and constipation in patients with thoracolumbar fractures. Methods Fifty patients with thoracolumbar fractures treated by the Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from October 2015 to October 2016 were selected as the subjects, and they were divided into control group and observation group according to  random number table, with 25 patients in each group. The patients in the control group were treated with routine nursing after horacolumbar fractures surgery. The patients in the observation group were treated with routine nursing plus acupoint massage-abdominal acupoints (Zhongwan, Tianshu, Qihai) massage for 1 week. First anal exhaust time, bloating improvement time, first defecation time and the defecation frequency in one week of the patients after the operation in the two groups were compared, in order to evaluate the clinical effect. Results  The first anal exhaust time, bloating improvement time, first defecation time in the observation group were shorter than those in the control group, with statistically significant difference (P < 0.05). The defecation frequency in one week in the observation group was significantly higher than that in the control group, with statistically significant difference (P < 0.05). The total effective rate of the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). Conclusion Acupoint massage therapy can significantly improve the symp toms of bloating and constipation in patients with thoracolumbar fractures. It has a positive guiding significance for the treatment of bloating constipation in patients with thoracolumbar surgery.
2017 Vol. 14 (17): 174-177 [Abstract] ( 153 ) HTML (1 KB)  PDF  (0 KB)  ( 30 )
178 Li Liyun's experience on treatment of recurrent spontaneous abortion based on emotional disorder
LI Yin1 WANG Xiufang1 LIU Qun1 XU Min2 LI Liyun2
This paper summarizes the experience of Professor Li Liyun, a famous TCM veteran gynecology doctor, on the diagnosis and treatment of recurrent spontaneous abortion according to emotional disorder. It will give some unique insights to clinical practice about RSA along with one proven case. Li Liyun considers that emotional disorder will cause habitual abortion owing to disharmony of Chong and Conception Channels, discordance between Qi and blood and non-consolidation of fetal origin. Before pregnancy, syndrome differentiation and treatment from liver is highly praised. After pregnancy, fetus-quieting should be paid more attention. Positive psychological intervention plays an important role throughout medical work.
2017 Vol. 14 (17): 178-180 [Abstract] ( 179 ) HTML (1 KB)  PDF  (0 KB)  ( 30 )
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