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| Effect of serum phospholipase A2 levels on Azithromycin sequential therapy for children with Mycoplasma pneumonia |
| SONG Xilan YU Xiahui WANG Xihui |
| Department of Pediatrics, People's Hospital of Chongzhou, Sichuan Province, Chongzhou 611230, China |
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Abstract Objective To investigate the effect of serum phospholipase A2 (PLA2) on Azithromycin sequential therapy for children wiht Mycoplasma pneumonia. Methods 84 cases with Mycoplasma pneumonia were recruited from June 2015 to December 2016 in Pediatrics Department of People's Hospital of Chongzhou. The changes of serum PLA2 were measured. The patients were divided into high/low PLA2 groups according to the median values of PLA2. The clinical efficacy of Azithromycin sequential therapy for Mycoplasma pneumonia was compared between different PLA2 levels groups. Results The overall effective rate of low PLA2 group was 95.24%, which was significantly higher than that in high PLA2 group (78.57%), with statistically significant difference (P < 0.05). The improved time of asthma, cough, fever, pulmonary rales symptom in low PLA2 group were significantly shorter than those in high PLA2 group (P < 0.01). There was no significant difference in overall adverse reaction rate between low PLA2 group and high PLA2 group (P > 0.05). Conclusion Azithromycin treatment for Mycoplasma pneumonia in children can get better effect in patients with low PLA2 levels.
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