甘皂液治疗干燥综合征的临床效果及对IL-33、IL-22水平的影响

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Abstract Objective To observe the curative effect of Ganzao Liquid in the treatment of Sj■gren's syndrome and its influence on the levels of interleukin (IL)-33 and IL-22. Methods Forty patients with primary Sj■gren's syndrome admitted to Department of Rheumatism of Suzhou Hospital of Traditional Chinese Medicine from December 2014 to August 2016 were selected and randomly divided into control group and experimental group by random number table method, with 20 cases in each group. The control group was given Hydroxychloroquine, on basis of which, the experimental group was added with Ganzao Liquid. The course was three months. The clinical effect, TCM symptom scores and serum levels of IL-22, IL-33 of the two groups were compared and analyzed. Results The total effective rate of experimental group was 90%, which was higher than that of control group (60%), the difference was statistically significant (P ＜ 0.05). After treatment, the TCM symptoms scores of dry mouth, dry eye, chest distress, joint pain in the experimental group were all lower than those before treatment, the differences were statistically significant (P ＜ 0.05); the TCM symptoms scores of dry mouth, dry eye, joint pain in the control group were all lower than those before treatment (P ＜ 0.05), while there was no statistically significant difference of chest distress score in the control group before and after treatment (P ＞ 0.05); the TCM symptoms scores of dry mouth, dry eye, chest distress, joint pain in the experimental group after treatment were all lower than those of control group (P ＜ 0.05). After treatment, the levels of IL-22, IL-33 in the two groups were all lower than those before treatment (P ＜ 0.05), and the levels of IL-22, IL-33 in the experimental group were all lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion On basis of symptomatic treatment of western medicine, Ganzao Liquid in the treatment of Sj■gren's syndrome is effective, which can effectively improve the dry mouth, dry eye, joint pain, chest distress, and inflammatory reactions.

Key words： Sj■gren's syndrome Ganzao Liquid Interleukin-33 Interleukin-22

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LI Lingxiao DING Wei. Clinical effect of Ganzao Liquid in the treatment of Sj■gren's syndrome and its influence on the levels of IL-33 and IL-22[J]. 中国医药导报, 2017, 14(17): 142-145.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I17/142

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