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| The significance of ultrastructuralelectron microscopy diagnosis in pituitary adenomas |
| YANG Zhijun ZHOU Qiangyi WANG Zhenmin LI Peng WANG Bo LIU Pi′nan▲ |
| Department of Neurosurgery , Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China |
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Abstract Objective To investigate the significance and perspective of ultrastructural characteristics in diagnosis of pituitary adenoma. Methods From August 2010 to August 2015, the specimens of 112 patients with pituitary adenoma at the Department of Neurosurgery, Beijing Tiantan Hospital were analyzed retrospectively. Making a comparison of the routine pathology approaches and electron microscope in diagnosis of pituitary adenoma. Results In 112 pituitary adenoma species, 47 tumors met the routine criterion of clinically non-functioning adenoma. Within those tumors, 20 were diagnosed as clinically nonfunctioning adenoma by electron microscope, the others including 21 oncocytoma subtype of non-functioning pituitary adenomas, 3 stem cell adenomas, 2 gonadotropins adenomas and 1 mixed type adenoma. Besides, 65 tumors met the routine criterion of functional pituitary adenoma, including 10 prolactinomas, 15 growth hormone-producing adenomas, 5 ACTH-secreting adenomas, 2 gonadotropins adenomas, 2 TSH-secreting adenomas, 1 stem cell adenoma and 30 mixed type adenomas by electron microscope. Conclusion Evaluation of ultrastructural characteristics evaluating of pituitary adenomas can provide extraordinary information, which has contributed considerably to the diagnosis of pituitary adenomas.
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