|
|
|
| Effect of Bifid-Triple Viable Capsule for the abdominal pain symptom and mental function of patients with functional abdominal pain syndrome |
| WANG Ying1 GUO Xin2 NING Chunhong2 CHEN Yangfang3 YU Yingcong1 LAN Qiaoli1 WENG Xuejian1 YUAN Jie2▲ |
1.Department of Gastroenterology, Wenzhou People's Hospital, Zhejiang Province, Wenzhou 325000, China;
2.Graduate School, North China University of Science and Technology, Hebei Province, Tangshan 063000, China;
3.Department of Clinical Laboratory, Wenzhou People's Hospital, Zhejiang Province, Wenzhou 325000, China |
|
|
|
Abstract Objective To explore the effect of Bifid-Triple Viable Capsule for the abdominal pain symptom and mental function of patients with functional abdominal pain syndrome (FAPS). Methods Sixty-five patients with FAPS admitted to Wenzhou People's Hospital and Affiliated Hospital of North China University of Science and Technology from October 2015 to December 2016 were selected as research objects, and 67 cases taken healthy examination at the same time were selected as healthy control. The patients with FAPS were divided into two groups by random number table, with 33 cases in Bifid-Triple Viable Capsule group and 32 cases in Sertraline group. The scores of abdominal pain symptom and symptom check-list 90 (SCL-90) before and after treatment in the two groups were compared. Results Among 65 patients with FAPS, total 54 cases (83.1%) finished the study, with 28 cases in Bifid-Triple Viable Capsule group and 26 cases in Sertraline group. ①The scores of SCL-90 and its factors (somatization, force, interpersonal relationship, depression, anxiety, hostility, terror, stubborn, psychoticism) in FAPS patients were all higher than those of healthy controls, the differences were statistically significant (P ＜ 0.05). ②The total effective rate was 75.0% in Bifid-Triple Viable Capsule group, and 80.8% in Sertraline group, the difference between the two groups was not statistically significant (χ2=2.856, P ＞ 0.05). ③After treatment, the scores of severity degree and seizure frequency of abdominal pain in the two groups were all lower than those before treatment (P ＜ 0.05), while there were no statistically significant differences on the scores of severity degree and seizure frequency of abdominal pain between the two groups after treatment (P ＞ 0.05). ④After treatment, the SCL-90 scores in the two groups were lower than those before treatment (P ＜ 0.05). But the score difference of SCL-90 and its factors before and after treatment between the two groups had no statistically significant differences (P ＞ 0.05). Conclusion The Bifid-Triple Viable Capsule can effectively improve the abdominal pain symptom and mental states of patients with FAPS by modulating intestinal flora, and the efficacy is almost the same with Sertraline.
|
|
|
|
|
|
[1] 李菊兰，朱戎.功能性腹痛综合征患者伴发的抑郁焦虑特征和氟西汀干预效应[J].中国组织工程研究，2005，9（8）：18-19.
[2] Mazaheri M，Roohafza HR，Mohammadi M，et al. The structural model of pain，cognitive strategies，and negative emotions in functional gastrointestinal disorders [J]. J Res Med Sci，2016，21：107.
[3] Slyepchenko A，Carvalho AF，Cha DS，et al. Gut emotions-mechanisms of action of probiotics as novel therapeutic targets for depression and anxiety disorders [J]. CNS Neurol Disord Drug Targets，2014，13（10）：1770.
[4] Kennedy PJ，Cryan JF，Dinan TG，et al. Kynurenine pathway metabolism and the microbiota-gut-brain axis [J]. Neuropharmacology，2016，112（Pt B）：399.
[5] 汪向东，王希林，马弘.心理卫生评定量表手册（增订版）[M].北京：中国心理卫生杂志社，1999：159-161，194-196.
[6] 汪涛，候鹏.分别基于行为疗法和口服帕罗西汀在治疗功能性腹痛综合征中的临床研究[J].疑难病杂志，2010， 9（6）：415-418.
[7] Yacob D，Lorenzo CD，Bridge JA，et al. Prevalence of pain-predominant functional gastrointestinal disorders and somatic symptoms in patients with anxiety or depressive disorders [J]. J Pediatr，2013，163（3）：767-770.
[8] Strigo IA，Simmons AN，Matthews SC，et al. Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain [J]. Arch Gen Psychiatry，2008，65（11）：1275-1284.
[9] Olden KW，Drossman DA. Psychologic and psychiatric aspects of gastrointestinal disease [J]. Med Clin North Am，2000，84（5）：1313-1327.
[10] 胡艳，陈黎，陈芳，等.培菲康在儿童腹型过敏性紫癜中的应用[J].中国微生态学杂志，2011，23（1）：64-65.
[11] Kamiya T，Wang L，Forsythe P，et al. Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats [J]. Gut，2006，55（2）：191.
[12] Kunze WA，Mao Y，Wang B，et al. Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening [J]. J Cell Mol Med，2009，13（8b）：2261-2270.
[13] Rousseaux C，Thuru X，Gelot A，et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors [J]. Nat Med，2007，13（1）：35.
[14] 秦旭华，李祖伦，金沈锐.白芷总香豆素对偏头痛模型小鼠5-HT和MAO的影响[J].时珍国医国药，2012，23（9）：2190-2191.
[15] 张莉华，方步武.脑肠轴及其在胃肠疾病发病机制中的作用[J].中国中西医结合外科杂志，2007，13（2）：199-201.
[16] Jakobsson HE，Abrahamsson TR，Jenmalm MC，et al. Decreased gut microbiota diversity，delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section [J]. Gut，2014，63（4）：559-566.
[17] Ochoa-Repáraz J，Mielcarz DW，Ditrio LE，et al. Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis [J]. J Immunol，2009，183（10）：6041.
[18] Clarke G，Grenham S，Scully P，et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner [J]. Mol Psychiatry，2013，18（6）：666-673. |
|
|
|
