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| Effects of early serum bilirubin level on the prognosis of patients with acute cerebral infarction |
| JI Li ZHANG Qinjun |
| Department of Neurology, Xianyang Hospital of Yan'an University, Shaanxi Province, Xianyang 712000, China |
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Abstract Objective To investigate the effects of early serum bilirubin level on the prognosis of patients with acute cerebral infarction. Methods The clinical data of 257 patients with acute cerebral infarction (acute cerebral infarction group) admitted to Department of Neurology, Xianyang Hospital of Yan'an University from February to October 2016 was analyzed retrospectively, and they were divided into higher group (≥10.9 μmol/L) and lower group (＜10.9 μmol/L) according to different serum bilirubin levels. At the same time, 30 healthy persons were taken as control group. The serum bilirubin level at the second day after admission was detected, and the incidence of hemorrhagic transformation (HT) and multiple organ dysfunction syndrome (MODS) after admission was made statistics, the prognosis at discharge was evaluated, and the patients with different serum bilirubin levels were compared with the events above. Results The early serum bilirubin level of acute cerebral infarction group was lower than that of control group, the difference was highly statistically significant (P ＜ 0.01). During patients with different bilirubin levels, the incidence of HT between lower group and higher group had no statistically significant difference (P ＞ 0.05), while the incidence of MODS in the higher group was lower than that of lower group, the difference was statistically significant (P ＜ 0.05). Compared with those at admission, the scores of neural function deficient scale (NDS) in the two groups at discharge were all decreased, the scores of activity of daily living (ADL) in the two groups at discharge were all increased, the differences were all highly statistically significant (P ＜ 0.01). At discharge, the score of NDS in the higher group was slightly lower than that of lower group, but there was no statistically significant difference (P ＞ 0.05), while the score of ADL in the higher group was higher than that of lower group, the difference was highly statistically significant (P ＜ 0.01). Conclusion Compared with normal persons, the serum bilirubin level of patients with acute cerebral infarction is lower, and among the patients with acute cerebral infarction, the higher the serum bilirubin level is, the lower the incidence of complications is, the better the prognosis is.
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