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| Efficacy of hypophysin combined with Octreotide in the treatment of liver cirrhosis with upper gastrointestinal hemorrhage: a Meta-analysis |
| CAI Yanping1 XUE Shunhe2▲ |
1.College of Nursing, Weinan Vocational and Technical College, Shaanxi Province, Weinan 714000, China;
2.Department of Gastroenterology, Affiliated Hospital of Yan'an University, Shaanxi Province, Yan'an 716000, China |
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Abstract Objective To systemically review the efficacy of hypophysin combined with Octreotide in the treatment of liver cirrhosis with upper gastrointestinal hemorrhage. Methods The literatures about the efficacy of hypophysin combined with Octreotide in the treatment of upper gastrointestinal hemorrhage were searched systemically in the database of PubMed, The Cochrane Library, Web of Science and WanFang, CNKI, CBM and VIP, the search words included "hypophysin, Octreotide, upper gastrointestinal hemorrhage", the retrieval time limit was from the establishment of database to July 2016, 2 reviewers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. Then Meta-analysis was performed using RevMan5.2 software. Results A total of 7 RCTs involving 658 patients were included, including 337 cases in the experimental group and 321 cases in the control group. The results of Meta-analysis showed that the total effective rate of experimental group was higher than that of the control group, the hemostatic time was shorter than that of control group, the differences were all statistically significant (MD = 7.33, 95%CI: 3.83-14.03, P ＜ 0.01; MD = -8.57, 95%CI: -13.62 - -3.52, P ＜ 0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Compared to the single use of Octreotide, hypophysin combined with Octreotide can effectively improve the total effective rate and shorten the hemostatic time.
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