Livin在胃癌中表达及与临床相关性的Meta分析

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Abstract Objective To systematically assess the expression and clinical relevance of Livin in gastric cancer. Methods Published studies regarding the expression of Livin in gastric cancer with different pathological parameters (age, gender, differentiation, lymph node metastasis, invasion depth, tumor diameter) were searched (no time limit on literature) from PubMed, Embase, Corchrane library, Web of science, CBM, Wanfang and CNKI. Eligible studies were selected according to the inclusion/exclusion criteria and principle of quality evaluation, and Meta-analysis was performed by RevMan 5.3 software. Results A total of 20 studies with 1802 patients were included. The results of Meta analysis showed that Livin expression levels in patients with poorly differentiation were higher than those with moderately and highly differentiation (OR=0.19, 95%CI 0.15-0.25，P < 0.05). Livin expression levels in patients with lymphnode metastasis were higher than those without lymph node metastasis (OR=3.15, 95%CI 2.28-4.36, P < 0.05). Livin expression levels in patients with serosa and serosa outside invasion were higher than those with only subserosa invasion (OR=2.72, 95%CI 1.80-4.10, P < 0.05). Livin expression levels in patients with tumor diameter ≥5 cm were higher than those with tumor diameter <5 cm (OR=1.62, 95%CI 1.16-2.28, P < 0.05). Livin expression in male and female had no significant difference (OR=1.19, 95%CI 0.95-1.49, P > 0.05). Livin expression in patients aged ≥60 years and aged <60 years had no significant difference (OR=1.32, 95%CI 1.00-1.74, P=0.05). Conclusion Livin expression in gastric cancer is obviously related to the size of tumor, differentiation, lymph node metastasis and invasion depth. Livin can be used as an indicator for evaluation of malignant degree and progression of gastric cancer.

Key words： Gastric cancer Stomach neoplasm Cancer of stomach Livin Meta analysis

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	WU Yayun ZHANG Zhi WANG Jin DONG Xiaoqiang HE Songbing▲

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WU Yayun ZHANG Zhi WANG Jin DONG Xiaoqiang HE Songbing▲. Meta analysis of the expression and clinical relevance of Livin in gastric cancer[J]. 中国医药导报, 2017, 14(17): 73-79.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I17/73

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