中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2017 Vol. 14, No. 31
Published: 2017-11-05
 
 
4 Study on entrapment efficiency, drug release in vitro and stability of Crebanine long circulating liposome
LIU Na WANG Qilei CHEN Lingyun MA Yunshu
Objective To study the entrapment efficiency, drug release in vitro and stability of Crebanine long circulating liposome. Methods The concentration of Crebanine in long circulating liposome was determined by high performance liquid chromatography. The liposome and free Crebanine were separated by the sephadex gel column chromatography and the centrifugal ultrafiltration, the entrapment efficiency and drug loading were determined. The release behavior of the drug from liposome was studied by the dialysis method. The liposome appearance, particle size and leakage rate were studied by the effects of different temperature and light storage. Results The entrapment efficiency was 79.46% by the gel column chromatography and 81.02% by the centrifugal ultrafiltration. Crebanine long-circulating liposome drug loading was 5.6%; the Higuchi equation of Crebanine long-circulating liposome in vitro release was y = 0.1419 x1/2+ 0.1475, the R2 value was 0.9338; Crebanine long-circulating liposome was stabilized in the avoid light of 4℃ under refrigeration. Conclusion The centrifugal ultrafiltration is simple and reproducible. The prepared liposome is typical sustained-release, the liposome needs to be kept in cold storage.
2017 Vol. 14 (31): 4-8 [Abstract] ( 265 ) HTML (1 KB)  PDF (804 KB)  ( 274 )
9 Experiment study of healing effects of glutathione skin gel on superficial second-degree burn wounds in rats
WANG Qing1 TAO Jishan2 ZHU Xuanxuan1 ZHANG Di1 YANG Chen1 FU Rui1
Objective To observe the effects of glutathione skin gel on wound healing of superficial second-degree burn in rats. Methods 60 SPF male SD rats were divided into normal group, model group, growth factor group, Kangfuxin group, low-dose and high-dose glutathione skin gel groups, each group had 10 rats. The superficial second-degree burn model was successfully established by scalding the hair-removed area (3 cm × 3 cm) of rats with 75℃ water bath for 25 s. The rats were subjected to application of glutathione skin gel on wound without coverage (1 mL, bid) for 16 days, and recombinant human basic fibroblast growth factor and Kangfuxin were used as control. The wound healing process and whole body conditions of animals (physical signs and scabs formation) were observed daily for 20 days. Results Compared with the model group, treatment of high-dose glutathione skin gel shortened the time of wound healing and getting rid of scabs, reduced healing area in superficial second-degree burn model of rats (P < 0.05 and P < 0.01). Histopathological examination results showed that the wound scab was visible in model group, but with excessive inflammatory exudate. Granulation tissue had been repaired and regenerated under the scabs, and small quantities of epithelia had been regenerated around the wound edge, covering the wound gradually. Compared with the model group, all other groups promoted wound healing and decreased inflammatory exudates. And regeneration of the granulation tissue and epithelia were more obvious and significant in these groups. High-dose glutathione skin gel group and growth factor group had comparable effects on the wound healing. Conclusion Glutathione skin gel significantly promotes wound healing of superficial second-degree burn in rats.
2017 Vol. 14 (31): 9-14 [Abstract] ( 248 ) HTML (1 KB)  PDF (1273 KB)  ( 141 )
15 Experimental study of monoclonal antibody targeted microbubble carrying P-selectin and connecting SelS gene in combination with ultrasound in treating early diabetic nephropathy
WANG Yan1 LI Jing2▲ HUANG Ruizhu3 HUANG Ping1 HUANG Yuyu2
Objective To study the effect of monoclonal antibody targeted microbubble carrying P-selectin and connecting SelS gene in combination with ultrasound in treating early diabetic nephropathy. Methods A total of 60 specific pathogen free SD male rats were selected as the research objects to build type 2 diabetes rat models. Then the rat models were randomly divided into the control group, SelS group, SMBp group and UE+SMBp group, each group had 15 rats. The food intake, water intake, urine volume, body weight, fasting blood-glucose, 24 h urine protein, β2 microglobulin, blood and urine biochemical indexes, P-selectin, Ang Ⅱ, TGF-β1 and SelS levels of rats in the four groups were compared. Results Before treatment, the differences in general conditions of rats among the four groups were not statistically significant (P > 0.05). The differences in fasting blood-glucose, 24 h urine protein, β2 microglobulin level, blood and urine biochemical indexes, P-selectin, Ang Ⅱ, TGF-β1 and SelS levels were statistically significant after treatment (P < 0.05). Conclusion Monoclonal antibody targeted microbubble carrying P-selectin and connecting SelS gene in combination with ultrasound in treating early diabetic nephropathy has definite therapeutic effect and high safety, thus it can be used as an effective means for prevention and treatment of early diabetic nephropathy.
2017 Vol. 14 (31): 15-18,23 [Abstract] ( 290 ) HTML (1 KB)  PDF (738 KB)  ( 79 )
19 The value of Xuebijing Injection on the rehabilitation of rabbits with acute lung injury induced by firearm injury and the effect on the expression of NF-κB in lung tissue
XU Xiaofeng XU Xiujuan HAO Jian WU Sheng QIAN Jun LI Shuwen LI Xiaoqian
Objective To investigate the value of Xuebijing Injection (XBJ) on the rehabilitation of rabbits with acute lung injury (ALI) induced by firearm injury and the effect on the expression of nuclear factor kappa B (NF-κB) in lung tissue. Methods Sixty healthy male rabbits were randomly divided into normal control group, ALI model group, normal saline group, low dose of XBJ treatment group, medium dose of XBJ treatment group, high dose of XBJ treatment group by random number table mehtod, with 10 rats in each group. The rabbits of ALI model group, normal saline group, low dose of XBJ treatment group, medium dose of XBJ treatment group, high dose of XBJ treatment group were inhaled with high-temperature gas, so as to complete the model of rabbits with ALI. After modeling for half an hour, low, medium, high dose of XBJ treatment groups were respectively received intraperitoneal injection of 10, 20, 30 mg/kg XBJ, normal saline group was injected with normal saline, while normal control group and ALI model group were not dealt with any treatment. After 12 h, the rabbits were killed and the lung tissue of left upper lobe was taken to detect the expression of NF-κB in lung tissue; under the light microscope, the lung tissue was taken to make pathological examination, and the pathological changes were recorded in time. Results The results of pathological examination: in the normal control group, the alveolar structure was clear, the alveolar wall was thin, and no edematous fluid was found in the lung tissue; in the ALI model group and normal saline group, the alveolar structure was fuzzy, the alveolar wall was broken, there were a lot of inflammatory cells infiltration in the lung, obvious edema was found in the pulmonary mesenchyme and alveolar space, many red blood cells could be seen, and the mesenchyme of alveolar wall was thickened, the hyaline membrane was formed; after treatment by XBJ, the alveolar structures in all groups were still existed, the inflammatory cells infiltration in the lung was reduced, pulmonary mesenchyme and alveolar space showed moderate edema, less cataclysm and bleeding could be seen. Western blot of lung tissue showed that, the activity of NF-κB in ALI model group was significantly higher than that of normal control group (P ＜ 0.01); compared with ALI model group and normal saline group, the activity of NF-κB in lung tissue of low, medium, high dose of XBJ treatment groups were all decreased, the differences were all highly statistically significant (P ＜ 0.01), among which, medium dose of XBJ treatment group was decreased most significantly, which had statistically significant differences compared with those of low, high dose of XBJ treatment groups (P ＜ 0.05, P ＜ 0.01). Conclusion XBJ injection has protective effects on rabbits with ALI induced by firearm injury, and the protective effect of medium dose of XBJ is the most obvious.
2017 Vol. 14 (31): 19-23 [Abstract] ( 228 ) HTML (1 KB)  PDF (1016 KB)  ( 180 )
24 The effect of 15-LOX-1 on proliferation of pulmonary arterial endothelial cells and inflammatory cytokines by LPS
LIU Ye XING Wenjing LI Sijia
Objective To explore the effect of 15-LOX-1 on proliferation of pulmonary arterial endothelial cells (PAECs) and inflammatory cytokines by LPS. Methods PAECs were cultured in vitro, and divided into 4 groups, including control group, LPS group, 15-LOX-1 siRNA scramble group (scramble group) and 15-LOX-1 siRNA group. The expression of 15-LOX-1 mRNA was detected by Real-time PCR. The proliferation of PAECs was examined by MTT. The expressions of 13-HODE, IL-1α and IL-6 were detected by ELISA. Results In the 15-LOX-1 siRNA group, the expression of 15-LOX-1 mRNA was reduced, the proliferation of PAECs was increased, and the secretions of 13-HODE, IL-1α and IL-6 were reduced compared with the LPS group with statistically significant difference (P < 0.05)Conclusion Down-regulation of 15-LOX-1 can inhibit inflammatory cytokines, regulate PAECs proliferation, and improve endothelial injury induced by LPS.
2017 Vol. 14 (31): 24-26 [Abstract] ( 280 ) HTML (1 KB)  PDF (831 KB)  ( 139 )
27 Pharmacokinetic study of rhein from the ultra-micro and fine powder of Shanzha Xiaozhi Capsules in rats
LIANG Xiuqing1 SHEN Xiao2 LI Zihong1 LI Huaiguo1 LIU Dongwen1 WANG Lisheng2
Objective To compare the differences of pharmacokinetic characteristics of rhein after rats received ultra-micro and fine powder of Shanzha Xiaozhi Capsules by gavage. Methods The experimental rats were given suspensions of the ultra-micro and fine powder of Shanzha Xiaozhi Capsules. The plasma concentration of rhein in rats was measured by high performance liquid chromatography. Uranus C18 (250 mm× 4.6 mm, 5 μm) was used as the analytical column. The mobile phase was methanol-water-0.1% phosphoric acid (85∶15), the wavelength of detection was set at 254 nm, and the flow rate was 1.0 mL/min. Serum concentration-time data was processed by pharmacokinetics software PKSolver 2.0. Results The linear range of rhein was from 0.16 to 40.00 μg/mL. The concentration-time curves of rhein in rats fitted well into two compartment model. The main pharmacokinetic parameters of the AUC of rhein from the ultra-micro and fine powder of Shanzha Xiaozhi Capsules were (4.08±4.96) μg/(mL·h) and (0.74±0.06) μg/(mL·h) (P ＜ 0.05), the maximum plasma concentration of rhein from the ultra-micro and fine powder of Shanzha Xiaozhi Capsules were (0.79±0.15) μg/mL and (0.17±0.02) μg/mL (P ＜ 0.05). Conclusion The ultra-micro porphyrization can make the absorption of rhein more complete in rats and improve bioavailability.
2017 Vol. 14 (31): 27-30 [Abstract] ( 283 ) HTML (1 KB)  PDF (760 KB)  ( 129 )
31 Effect of Red Yeast Rice Capsules containing coenzyme Q10 and Lovastatin on lumbar vertebral in elderly osteoporosis rats
LV Simin1 YU Qiong2 SITU Yongli2 SUN Jinying2 CUI Liao2 WU Tie1,2▲
Objective To investigate the effects on lumbar of Red Yeast Rice Capsules containing coenzyme Q10 and Lovastatin in elderly osteoporosis rats. Methods 45 three-month old female Sprague-Dawley rats were randomly divided into sham group （CON group）, ovariectomized group （OVX group）, model group （MOD group）, diethylstilbestrol group （DES group）, and Red Yeast Rice Capsules group （RYR group） according the weigh, and each group of 9 rats. All rats were received subcutaneous injection of calcein (7 mg/kg) on day 14, day 13, and day 4, day 3 before drawing the tissue samples. After 60 days, the fourth lumbar was performed on Micro CT, and then was measured in undecalcified sections for static and dynamic histomorphometric analysis. Results Compared with the CON group, in MOD group the Micro CT indexes of BV/TV, Tb.Th, Tb.N, Conn-Dens, Density decreased significantly (P < 0.01), Tb.Sp and SMI increased significantly (P < 0.01), and the histomorphometry indexes of %Tb.Ar and Tb.N were reduced significantly (P < 0.01), but Tb.Sp, %Oc.Pm, Oc.N, BFR/BS, BFR/BV, BFR/TV, %L.Pm, increased significantly (P < 0.01). Compared with the MOD group, in RYR group BV/TV, Tb.Th, Tb.N, Conn-Dens, Density increased significantly (P < 0.01), Tb.Sp and SMI were reduced significantly (P < 0.01), and the histomorphometry indexes of %Tb.Ar, Tb.N increased significantly (P < 0.01), while Tb.Sp, %Oc.Pm, Oc.N, BFR/BS, BFR/BV, BFR/TV, %L.Pm decreased significantly (P < 0.01). Conclusion The bone loss was less significant and serious degradation of the bone microstructure were observed in lumbar vertebralin the rats treated with ovariectomy combined with D-galactose. Red yeast rice capsules containing coenzyme Q10 and Lovastatin showed effective prevention effects on osteoporosis induced by ovariectomy combined with D-galactose in rats.
2017 Vol. 14 (31): 31-35,47 [Abstract] ( 246 ) HTML (1 KB)  PDF (1177 KB)  ( 182 )
36 Application of self-microemulsifying drug delivery system to  improve the bioavailability of poorly soluble drugs in the field of Chinese medicine
LIU Yanping
Self-microemulsifying drug delivery system is a new delivery system, which can significantly enhance the bioavailability of poorly soluble drugs. This paper reviews the characteristics, mechanisms and application in the filed of Chinese medicine of self microemulsion by reviewing the literature in recent years, introduces the research progress of application of active ingredients which pharmacological effects of these medicinal plants are clear and significant, including baicalin, camptothecin, tanshinoneⅡA, silymarin, puerarin, quercetin and so on, in order to provide reference for preparation of insoluble Chinese medicine to self microemulsion.
2017 Vol. 14 (31): 36-39 [Abstract] ( 247 ) HTML (1 KB)  PDF (434 KB)  ( 148 )
40 The research progress in mechanism of optogenetics activated astrocytes release ATP and glutamate to protect neurons in Alzheimer′s disease
LIU Puqing HE Bingbing CHEN Feng
Alzheimer disease′s (AD) is one kind of degenereratly neuropathic disease. The pathomechanism of AD is the deposite of Aβ peptide, including ATP and glutamate insufficiency resulted Aβ deposite. Application of phogenetic technology can selectively activate astrocytes transfected with ChR2, promote the release ATP and glutamate, block the Aβ aggregation producing by insufficient of ATP and glutamate. Conclusion as a result, ChR2 mediated optogenetic technology can be used for AD treatment. This new treropeutical method will avoid the defects of non-selective and extensive side-effects.
2017 Vol. 14 (31): 40-43 [Abstract] ( 235 ) HTML (1 KB)  PDF (435 KB)  ( 201 )
44 Clinical diagnosis and treatment of 43 cases of eosinophilic lymphatic granuloma of head and neck
JIANG Yang1 HUA Qingquan1 REN Jie1 ZENG Feng1 SHENG Jianfei1 ZHANG Zhijian1 GUAN Hongxia2 YUAN Jingping3
Objective To explore the clinical features and diagnosis and treatment of eosinophilic lymphatic granuloma (ELG) of head and neck, in order to improve awareness of the disease in clinicians, reduce the clinical misdiagnosis, missed diagnosis rate and the recurrence rate. Methods The clinical data of 43 patients with ELG of head and neck surgery were confirmed by pathological examination in Renmin Hospital of Wuhan University from July 2000 to January 2017 were collected. The detailed data were summarized, including basic information, clinical symptoms, routine blood tests, imaging examination, pathological examination and recurrence. Results The patients were often treated with recurrent painless swelling as the initial symptom, which could be single or multiple, and could be accompanied by skin itching or pigmentation. The diseased region was mainly in the neck (24 cases), followed by the parotid gland (9 cases). In laboratory examination, eosinophilic granulocytes in 33 cases were significantly elevated, and IgE in 31 cases were increased significantly. 26 cases were treated by simple surgery, with 9 cases recurrence; 13 cases were treated with combined treatment (surgical + radiotherapy or hormone + radiotherapy), with only one case recurrence. Conclusion The main clinical manifestations of ELG are painless mass, increased peripheral blood eosinophils and serum IgE, and its diagnosis relies on pathological examination. Surgical treatment is the preferred treatment, and combined radiotherapy and hormone therapy can reduce recurrence rate.
2017 Vol. 14 (31): 44-47 [Abstract] ( 260 ) HTML (1 KB)  PDF (807 KB)  ( 91 )
48 Clinical study on modified self-made Qingre Tongluo Decoction in treating peripheral facial paralysis due to wind-heat
LIU Haiyong1 XU Xuewen1▲ XU Yan2 WU Yanfang2 ZHANG Xiaojuan2 QU Guangxin2 ZHAO Man1
Objective To study the effect of modified self-made Qingre Tongluo Decoction in treating peripheral facial paralysis due to wind-heat. Methods 100 patients with peripheral facial paralysis due to wind-heat in Sanhe Hospital and Sanhe Traditional Chinese Medicine Hospital from August 2015 to January 2017 were selected. They were divided into treatment group and control group by random number table, with 50 cases in each group. The treatment group was treated by modified self-made Qingre Tongluo Decoction. The control group was treated by routine western medicine treatment. They were treated for 30 days. The clinical efficacy, scores of symptoms and signs and adverse reactions were compared. Results After treatment, the cure rate and total effective rate in the treatment group were significantly higher than those in the control group, with statistically significant difference (P < 0.05). After treatment, the scores of symptoms and signs including facial expressions, forehead wrinkles disappear, eyes closed, nasolabial fold shallow, mouth askew degree in two groups were significantly lower than those before treatment; and those scores in the treatment group were significantly lower than those in the control group, with statistically significant difference (P < 0.05). There were no serious adverse reactions between the two groups. Conclusion It is effective and safe to treat peripheral facial paralysis due to wind-heat by modified self-made QingreTongluo Decoction, which is worthy of clinical application.
2017 Vol. 14 (31): 48-51 [Abstract] ( 249 ) HTML (1 KB)  PDF (566 KB)  ( 150 )
52 Clinical study on the effect of self-made Qingre Tongluo Decoction combined with acupuncture in the treatment of peripheral facial paralysis due to wind-heat
ZHANG Jianjun1 LIU Haiyong2▲ MA Chunhua2 SUN Xiaoxin1 LI Wanjun1 ZHANG Xiaojuan1 ZHAO Man2
Objective To study the effect of self-made Qingre Tongluo Decoction combined with acupuncture in the treatment of peripheral facial paralysis due to wind-heat. Methods 86 patients with peripheral facial paralysis due to wind-heat who were treated in Sanhe Traditional Chinese Medicine Hospital and Sanhe Hospital from August 2015 to March 2017 were selected. They were divided into treatment group and control group by random number table, with 43 cases in each groups. The treatment group was treated by the self-made Qingre Tongluo Decoction combined with acupuncture, while the control group was treated by routine acupuncture treatment. They were treated for 30 days. The treatment effect, the scores of House-Brackmann (H-B) facial nerve function, physical function (FDIP) and social function (FDIS), as well as adverse reactions of two groups were compared. Results After treatment, the total efficiency of the treatment group was significantly higher than that in the control group, with statistically significant difference (P < 0.05). After treatment, the H-B facial nerve function score of two groups were lower than those before treatment, and the H-B facial nerve function score of the treatment group was lower than that of the control group, with statistically significant difference (P < 0.05). After treatment, the scores of FDIP and FDIS in the two groups were higher than those before treatment, besides the scores of FDIP and FDIS in the treatment group were significantly higher than those in the control group, with statistically significant difference (P < 0.05). There was no serious adverse reaction between the two groups. Conclusion It is effective and safe to treat peripheral facial paralysis due to wind-heat by self-made Qingre Tongluo Decoction combined with acupuncture, which can effectively improve the patient's physical function and the quality of life. Therefore it is worthy of clinical application.
2017 Vol. 14 (31): 52-55,71 [Abstract] ( 259 ) HTML (1 KB)  PDF (1087 KB)  ( 73 )
56 Value of T cell spot test in diagnosis of the infection of tuberculosis in patients with rheumatic diseases
ZHAO Liping ZHANG Yifan BAI Yunjing JIANG Dexun▲
Objective To investigate the value of T cell spot test (T-SPOT.TB) in the diagnosis of the infection of tuberculosis in patients with rheumatic diseases. Methods From July 2010 to July 2014, 266 patients screened for tuberculosis using T- SPOT.TB and examine the sputum in Department of Rheumatology, PLA Army General Hospital were selected. Among the patients, 132 cases were diagnosed with rheumatic diseases (rheumatic diseases group), and 134 cases were non-rheumatic immunity (non-rheumatic immunity group). The results of T-SPOT.TB, sputum culture and anti-acid staining of patients were collected. The positive rate of tuberculosis diagnosed by T-SPOT.TB between the two groups. Results The positive rate of tuberculosis diagnosed by T-SPOT.TB in the rheumatic diseases group was 39.39% (52/132), and the positive rate in the non-rheumatic diseases group was 46.53% (67/134). There was no statistical significance difference (P > 0.05). Conclusion T-SPOT.TB has certain diagnostic value for the screening of mycobacterium tuberculosis in patients with rheumatoid immunity.
2017 Vol. 14 (31): 56-59 [Abstract] ( 362 ) HTML (1 KB)  PDF (544 KB)  ( 89 )
60 A retrospective analysis of clinical features and prognostic of patients with bloodstream infections caused by multi-drug resistant Acinetobacter baumannii
ZHOU Ting* LIANG Xiuting* WU Jie
Objective To analyze the clinical manifestations and risk factors of patients with bloodstream infections (BSI) caused by multi-drug resistant Acinetobacter baumannii (MDR-AB). Methods Clinical data of patients with BSI caused by MDR-AB hospitalized in Chinese PLA General Hospital from January 2012 to December 2015 were analyzed retrospectively. According to the 14-day survival after diagnosis, the patients were divided into survival group and death group. The risk factors of death were investigated by single-factor analysis and multifactor Logistic regression analysis. Results Among the 157 patients, 55.4% were collected from ICU, and the 14-day mortality was 54.8%. Single-factor analysis showed that the survival group was significantly lower than the death group in malignancy, immunosuppressive therapy, neutropenia,ventilator use and Pitt Bacteremia Score (PBS), with statistically significant difference (P < 0.05). And the survival group was significantly higher than the death group in appropriate therapy and treatment with Sulbactam, with statistically significant difference (P < 0.05). Multifactor Logistic regression analysis showed malignancy (OR=4.78, 95%CI: 1.30-15.32, P < 0.05), neutropenia (OR=16.01, 95%CI: 1.64-172.21, P < 0.05) and increased PBS (OR=0.47, 95%CI: 0.32-0.63, P < 0.05) were independent risk factors of 14-day mortality. Patients with hematological malignancies were often accompanied with neutropenia, and the survival analysis revealed that mortality in patients with hematological malignancies was higher than that in patients with solid tumors (P < 0.05).The percentage of patients treated with antibiotics containing Sulbactam in the survival group was significantly higher than that in the death group (P < 0.05), but it was not revealed as a death protection factor in multivariate analysis. Conclusion The patients with BSI caused by MDR-AB usually have serious sunder lying diseases from ICU, and the mortality is quite high. Malignancy, neutropenia and increased PBS are independent risk factors of early mortality. Antimicrobial regimens containing Sulbactam may be a candidate for the treatment of BSI caused by MDR-AB, but its clinical efficacy deserves further exploration.
2017 Vol. 14 (31): 60-63 [Abstract] ( 343 ) HTML (1 KB)  PDF (603 KB)  ( 110 )
64 Effect of Dexmedetomidine combined with Flurbiprofen Axetil on hemodynamics and stress response during rehabilitation in patients with colorectal cancer underwent laparoscopic radical resection
ZHANG Jianhua HUANG Xu LIANG Jianqun HE Baojia LU Xianqing
Objective To investigate the effect of Dexmedetomidine combined with Flurbiprofen Axetil on hemodynamics and stress response during rehabilitation in patients with colorectal cancer underwent laparoscopic radical resection. Methods A total of 78 cases of patients with colorectal cancer underwent laparoscopic radical resection in the First People′s Hospital of Zhaoqing City from January 2013 to December 2015 were selected and divided into three groups by random number table, each group had 26 cases. Control group A was given Flurbiprofen Axetil 50 mg 30 min before the end of surgery; control group B was given Dexmedetomidine 0.5 μg/kg 30 min before the end of surgery; and the combination group received Flurbiprofen Axetil 50 mg combined with Dexmedetomidine 0.25 μg/kg 30 min before the end of surgery. Levels of MAP, HR, IL-6 and CRP were recorded before tracheal extubation (T0), immediately after tracheal extubation (T1) and 5 min after tracheal extubation (T2), and the grade of restlessness, recovery time, extubation time, Ramsay sedation score and VAS pain score were compared among the three groups. Results Compared with control group A, the levels of MAP, HR in the control group B and the combined group at T1 and T2 were decreased (P ＜ 0.05). Compared with the control group A and the control group B, the serum levels of IL-6 and CRP were lower in the combined group at T1 and T2 (P < 0.05). The incidence of restlessness in the combined group was lower than the control group A and the control group B (P < 0.05). The recovery time, extubation time and Ramsay sedation score of the combined group and the control group A were lower than the control group B, and the VAS pain score of the combined group and the control group B was lower than the control group A(P < 0.05). Conclusion Dexmedetomidine combined with Flurbiprofen Axetil can effectively reduce restlessness after laparoscopic radical resection for colorectal cancer, improve hemodynamics and inhibit the stress response recovery period, and can not prolong the recovery time and extubation time.
2017 Vol. 14 (31): 64-67 [Abstract] ( 274 ) HTML (1 KB)  PDF (404 KB)  ( 105 )
68 Study on TCM sanjiao by factor analytical method based on the data of infrared thermography
WANG Cuiwei1 YUAN Yun′e2▲ HOU Lei3▲
Objective To explore the relationship of sanjiao and the space energy of zang-fu viscera projection zones involved in sanjiao by infrared thermography technology. Methods The space energy of projection zones of body surface of lung, heart, liver, spleen, kidney five zang organs and stomach, small intestine, bladder, large intestine four fu-organs, and sanjiao of 450 cases of healthy volunteers (male or female) in Beijing area were taken automatic positioning measurement by infrared thermography technology from March to November 2009. The sanjiao common factors and zang-fu common factors involved in sanjiao were extracted by factor analytical method, and they were explained by combining with basic theories of Chinese medicine. Results The upper jiao-lower jiao common factors were extracted in the related data set of upper jiao, middle jiao, lower jiao, the factors above could be still extracted after grouping by gender and age, and the accumulative contribution rates were all more than 85.0%; the heart-lung-bladder-large intestine common factors, liver-spleen-stomach common factors, kidney-small intestine common factors were extracted in the related data set of zang-fu involved in sanjiao, the accumulative contribution rate of each group was more than 75.0%. Conclusion The upper jiao and lower jiao has correlation in the energy distribution, there is a strong correlation between heart-lung involved in upper jiao and bladder-large intestine involved in lower jiao, which provides data support and objective evidence for the study of holism of TCM, and provides new ideas for the further research of basic theories of Chinese medicine.
2017 Vol. 14 (31): 68-71 [Abstract] ( 223 ) HTML (1 KB)  PDF (805 KB)  ( 91 )
72 Effect of European Renaissance and New Culture Movement for the modernity of medical history
XU Wenjie1 XU Shijie1 DI Bo2 DU Xinliang2▲
The concept of "modernity" originates from and reflects the nature and state of human and things since the European Renaissance in the 14th century. At the end of the 20th century, the New Culture Movement became the symbol of Chinese society stepping from tradition to modernity. Under the social background of “save the nation from subjugation and ensure its survival” and belief crisis, traditional Chinese medicine field faced the rebound of powerful pressures of modern medicine, and formed "radical-conservative" "resist-adapting" and "traditional invention" three basic research paradigms, which were corresponding to the ideological trend of “abolishing Chinese medicine”“scientization of Chinese medicine”“keeping traditional Chinese medicine”“confluence of Chinese and western medicine” of Chinese medical development at the same period. The modernity of medical history in China and Europe is the process of transforming external knowledge and system into one's own culture. In the form of retrospective innovation, it shows medical rationality, innovation and strategy similar to the modern society.
2017 Vol. 14 (31): 72-74 [Abstract] ( 270 ) HTML (1 KB)  PDF (741 KB)  ( 137 )
75 Key factors contributing to the clinical effect and safety in warm needling studies: a literature review
CHENG Xiaofang1* QING Lunxue2* SUN Yanyan3 LIU Changxin3 WANG Xiyou3 YU Changhe3
Warm needling is first recorded in Shanghan Lun. As the demand of treatment and the improvement of instruments, five types of warm needling have been developed. This review is aimed at analyzing the factors contributing to the therapeutic effect and safety of warm needling. The results release that the warm needling is good at treating the diseases including musculoskeletal pain, diseases due to motion dysfunction, and inflammation of soft tissue in internal diseases, and especially the diseases with the main TCM patterns like yang deficiency and excessive cold. The factors contributing to the clinical effect and safety are the needling factors such as needles with large diameter and intensive needling with trigger points, and the temperature factors such as proper intense of temperature, proper needle's length outside body, the depth of needling, silver needles as medium, and electronic temperature control. The clinical practitioners have to apply the proper type of warm needling for the patients with pattern identification and medical setting, due to the low quality of methodology and report of clinical trials, heterogeneity of trials and medical practices. Thus, it is suggested that the evaluation of safety, therapeutic effect and medical economics of warm needling should accord to the principle of evidence-based medicine; and the experiment helps to reveal the common and individual mechanism of the warm needling for different diseases, and discusses the difference and same among all types of warm needling.
2017 Vol. 14 (31): 75-80 [Abstract] ( 324 ) HTML (1 KB)  PDF (784 KB)  ( 149 )
81 Empirical analysis of Feng Jianchun in treating recurrent mouth ulcers
WANG Jiajia CHEN Yuyi WANG Zhiyu▲
Recurrent oral ulcer is a kind of unexplained and intractable disease. Using traditional Chinese medicine to treat recurrent mouth ulcers has advantages of significant effect and difficult recurrence. Feng Jianchun considers that the pathogenesis is closely related to dampness-heat, phlegm, blood stasis and damp-toxin. Examining the meridian linking of the ulcers is to distinguish the zang-fu organs. Looking the shapes of the ulcers is to diagnose the disease nature. Differentiating syndrome is to distinguish cold, hot, deficiency, excess. In urgent conditions, treat the branch. While in moderate conditions, treat the root. It is very important to regulate qi activity of spleen and stomach and protect healthy qi. The therapeutic effects are remarkable to treat stubborn recurrent mouth ulcers by promoting blood circulation to dredge collaterals when persistent illness entering collaterals. Feng Jianchun attaches great importance to the holistic therapy and treat disease before it arises.
2017 Vol. 14 (31): 81-83,102 [Abstract] ( 304 ) HTML (1 KB)  PDF (1044 KB)  ( 126 )
84 Clinical therapeutic efficacy of massage acupoint pressing plus bloodletting in the treatment of postpartum acute mastitis
CHEN Pengdian1 CHEN Qiulan1▲ NING Yan1 BEI Jianhong1 LIU Fang1 LING Wenli1 ZHU Yueming2 CHEN Jilong2
Objective To explore the clinical therapeutic effects of massage acupoint pressing plus bloodletting in the treatment of postpartum acute mastitis. Methods Total 200 cases of patients with postpartum acute mastitis treated in Department of Traditional Chinese Medicine, Shenzhen Maternity & Child Healthcare Hospital Affiliated to Southern Medical University from January 2016 to January 2017 were randomized into treatment group and control group by random number table method, with 100 cases in each group. In the control group, massage acupoint pressing was applied; in the treatment group, massage acupoint pressing plus bloodletting was used, with the therapeutic sessions as two weeks. The mass sizes, symptom scores and the clinical therapeutic effects between the two groups were compared. Results The cured rate was 86.00% in the treatment group, and 67.00% in the control group, with highly significant differences between the two groups (P ＜ 0.01). The total effective rate was 93.00% in the treatment group, and 90.00% in the control group, with no significant difference between the two groups (P ＞ 0.05). After treatment, the mass sizes and the symptom scores in both groups were obviously decreased compared with those before treatment, with significant differences (P ＜ 0.01). After treatment, the mass sizes and the symptom scores in the treatment group were apparently lower than those in the control group, with significant differences (P ＜ 0.05, P ＜ 0.01). Conclusion Massage acupoint pressing plus bloodletting has definite effects in the treatment of postpartum acute mastitis, which can obviously improve the clinical symptom scores and the breast mass sizes, enhance the quality of life, with better effects than the simple massage acu-point pressing therapy.
2017 Vol. 14 (31): 84-87 [Abstract] ( 199 ) HTML (1 KB)  PDF (762 KB)  ( 176 )
88 Curative effect of Ruanjian Sanjie Prescription combined with bubble hardening in the treatment of lower limb venous ulcer
GUO Haiguo1,2 FENG Zhijun1,2 WANG Junchen1,2 LI Yuechun1,2 HU Wei1,2 YU Xinlin1,2 ZHANG Huifang1,2 WANG Ruiju1,2
Objective To investigate the curative effect of Ruanjian Sanjie Prescription combined with bubble hardening in the treatment of lower limb venous ulcer. Methods Seventy-nine cases of primary varicose veins of lower limbs with active ulcer patients admitted to the Second People's Hospital of Gansu Province from June 2014 to September 2019 were selected and randomly divided into observation group (39 cases) and control group (40 cases). Both groups were given preoperative examination and foam sclerotherapy, on basis of which, the observation group was given external application of Ruanjian Sanjie Prescription. The course was one month. The patients were followed up, the chronic venous insufficiency questionnaire of quality of life (CIVIQ) and venous disease clinical severity score (VCSS) were used respectively to assess the scores of CIVIQ and VCSS on admission and at discharge, 1 month, 6 months after discharge. The therapeutic effect and complications related to the operation of the two groups were observed. Results At different time points, the scores of CIVIQ in the observation group and control group were increased (F = 13.242, 7.543, P ＜ 0.05). The VCSS score in the observation group was decreased continuously (F = 12.009, P ＜ 0.05). All patients were successfully followed up to the end of the follow-up period, and observation group was significantly better than the control group (P ＜ 0.05). The proportion of the swelling pain in the 1 month period and the proportion of venous inflammation, infection of the wound, and the swelling of the operative area in the 6 months period were significantly lower than those in control group (P ＜ 0.05). Conclusion Ruanjian Sanjie Prescription combined with bubble hardening in the treatment of lower limb venous ulcer can obviously improve the conditions of ulcer wound and the surrounding skin blood supply, reduce the incidence of complications, and improve their quality of life.
2017 Vol. 14 (31): 88-91 [Abstract] ( 214 ) HTML (1 KB)  PDF (767 KB)  ( 85 )
92 Effects of chrono moxibustion combined with rehabilitation exercises on joint function and quality of life in patients with knee osteoarthritis
JIANG Xiumei YANG Xia ZENG Xiangyi
Objective To observe the effects of chrono moxibustion combined with rehabilitation exercises on joint function and quality of life in patients with knee osteoarthritis. Methods Ninety patients with knee osteoarthritis admitted to Department of Orthopedics of Liuzhou Hospital of Traditional Chinese Medicine from March 2015 to May 2016 were selected, and they were divided into observation group and control group according to the random number table method, with 45 cases in each group. Patients in control group were given oral Celecoxib treatment, while the patients in observation group were treated with chrono moxibustion combined with rehabilitation exercises. The clinical comprehensive efficacy of the two groups was observed, the changes of the pain, knee joint function and quality of life before and after treatment between the two groups were compared. Results The clinical comprehensive effect of observation group was better than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the scores of visual analogue scale (VAS) in the two groups were all lower than those before treatment, and the observation group was lower than that of control group, the difference of VAS in observation group before and after treatment was significantly higher than that in control group, the differences were all statistically significant (all P ＜ 0.05). After treatment, the Lysholm knee joint function scores of patients in the two groups were higher than those before treatment, and the score of observation group was higher than that of control group, the difference of Lysholm knee functional scores in observation group before and after treatment was significantly higher than that in control group, the differences were all statistically significant (all P ＜ 0.05). After treatment, the scores of arthritis impact measurement scale 2 (AIMS2-SF) in the two groups were higher than those before treatment, and the observation group was higher than that of control group, the difference of AIMS2-SF in observation group before and after treatment was significantly higher than that in control group, the differences were all statistically significant (all P ＜ 0.05). Conclusion The clinical effect of chrono moxibustion combined with rehabilitation exercises in the treatment of knee osteoarthritis is significant, which can effectively relieve patients' pain, improve knee joint function and the quality of life.
2017 Vol. 14 (31): 92-95 [Abstract] ( 310 ) HTML (1 KB)  PDF (729 KB)  ( 221 )
96 Clinical efficacy of Bo abdominal acupuncture in the treatment of senile vertigo
CHEN Wei
Objective To observe the clinical efficacy of Bo abdominal acupuncture in the treatment of senile vertigo. Methods One hundred and forty-two cases of patients with senile vertigo treated in Department of Traditional Chinese Medicine, Beijing Pinggu Hospital from January 2015 to December 2016 were selected and randomly divided into treatment group (71 cases) and control group (71 cases). The treatment group was taken abdominal acupuncture, once a day, 40-60 min each time, 10 times were as a course, total for 3 courses. The control group was given Flunarizine Hydrochloride Tablets orally, 10 mg every night. The clinical efficacy of the two groups was observed. Results The total effective rate in the treatment group was 98.59%, which was significantly higher than that of control group (90.14%), the difference was statistically significant (P ＜ 0.05). Conclusion Bo abdominal acupuncture therapy in the treatment of senile vertigo is effective, which is better than drug therapy.
2017 Vol. 14 (31): 96-98 [Abstract] ( 320 ) HTML (1 KB)  PDF (719 KB)  ( 108 )
99 Clinical analysis of the application of diclofenac diethylamine ointment for conduction matrix of ultrasound in the treatment of stress pain in the neck
SHEN Lufeng1 DU Xiaomei1 ZHANG Suihui2 XIAO Zebu1 SUN Yanqun3
Objective To evaluate the efficacy of the application of diclofenac diethylamine ointment as conduction matrix of ultrasound in the treatment of stress pain in the neck. Methods 120 patients were diagnosed as neck stress pain in the Department of Rehabilitation Medicine of Jiangxi Provincial People′s Hospital from March 2015 to February 2017. They were divided into A, B, C three groups using random number table method, each group with 40 cases. Rest and Diclofenac diethylamine ointment topical was used in the group A, ordinary coupling agent as the conduction matrix of ultrasound was used in the group B, diclofenac diethylamine ointment as the conduction matrix of ultrasound was used in the group C. Treatment for 5 d. The visual analogue scores (VAS) before and after treatment, onset time of pain treatment, and clinical efficacy of three groups were compared. Results Compared with before treatment, VAS scores of the three groups were significantly improved after treatment (P < 0.05);VAS score of the group C after treatment was lower than that of the group A and group B, and the onset time of pain treatment of group C was significantly shorter than that of the group A and group B, the differences were statistically significant (P < 0.05). There was no significant difference in the effective rate and the total effective rate between group B and group A (P > 0.05). there was no statistically significant difference in the effective rate and the total effective rate between group A and group B, and the effective rate and the total effective rate of the group C were higher than that of the group A and group B, the differences were statistically significant (P < 0.05). Conclusion The use of diclofenac diethylamine ointment as a conductive matrix can improve the clinical efficacy of ultrasound in the treatment of stress pain in the neck.
2017 Vol. 14 (31): 99-102 [Abstract] ( 231 ) HTML (1 KB)  PDF (493 KB)  ( 117 )
103 Values of transvaginal ultrasound in the diagnosis of cervical lymph node metastasis
ZHENG Weiwei1 YANG Jing1 ZHANG Xiufang1 WANG Xinyuan2
Objective To investigate the values of transvaginal ultrasound in the diagnosis of cervical lymph node metastasis. Methods The clinical data of 56 cases of cervical cancer diagnosed and treated in Tangshan People′s Hospital of Hebei Province from January 2014 to April 2017 were analyzed retrospectively. The results of operation and pathology were regarded as the gold standard. The conventional ultrasonic characteristics and the ultrasonic blood flow typing were recorded, and were to determine the effect of ultrasonic diagnosis. Results In the 56 patients, there were 38 patients were confirmed intra iliac lymph node metastasis by ultrasound, and the positive rate was 67.9%. In the patients with positive iliac lymph node metastasis (n = 38), the lesions were more with mostly round, necrosis in the center and multiple invasion with extra capsular involvement, and the size of the lesions was significantly higher than that of patients with negative iliac lymph node metastasis (n = 18) (P < 0.05). The color Doppler flow typeⅠ, Ⅱ, Ⅲ and IV in the patients with positive iliac lymph node metastasis were 30 cases, 6 cases, 2 cases and 0 cases, and were 0 cases, 2 cases, 6 cases, 10 cases in the patient with negative iliac lymph node metastasis, with statistical significance the difference (P < 0.05). There were 36 cases of positive lymph node metastasis and 20 cases of negative by the pathological analysis, so the sensitivity and specificity of transvaginal ultrasonography in the diagnosis of lymph node metastasis of cervical cancer were 97.2% and 85.0%, respectively. Conclusion Iliac lymph node metastasis in cervical cancer is common, the application of transvaginal ultrasound and color Doppler ultrasound can effectively display the intra iliac lymph node metastasis and blood flow, improve the sensitivity and specificity of diagnosis, and it has good application value.
2017 Vol. 14 (31): 103-106 [Abstract] ( 235 ) HTML (1 KB)  PDF (545 KB)  ( 108 )
107 The clinical study of single energy image in arterial enhancement of abdominal artery
GUAN Wei ZHANG Tingting ZHONG Zhaohui▲
Objevtive To study the enhancement effect of spectral imaging in arterial enhancement of abdominal artery. Methods 44 patients underwent contrast enhanced abdominal CTA with spectral imaging in Beijing Friendship Hospital,Capital Medical University from October 2015 to May 2016 were collected. Discovery CT750HD scanner was use among patients of the group A (60 keV, 40 cases), group B (70 keV, 40 cases) and group C (40 cases) mixed energy (140 kVp). The amount of the contrast agent was 350 mgI/kg, the CT value, SD value of the abdominal aorta, proper hepatic artery and splenic artery were measured, and the CNR attenuation value of the arteria hepatica propria was calculated, then those results were compared with a paired t-test. Results The CNR of the proper hepatic artery and the CT value of the group A was significantly increased compared with that of group B and group C, the differences were statistically significant (P < 0.05). Conclusion The use of spectral images at the 60 keV energy level can significantly improve the contrast enhancement degree in the artery compared with the conventional 140 kVp and 70 keV images.
2017 Vol. 14 (31): 107-110 [Abstract] ( 180 ) HTML (1 KB)  PDF (945 KB)  ( 79 )
111 Recombinant Human Interferon α2b Vaginal Effervescent Capsules in the treatment of patients with HPV infection: a Meta-analysis
ZHANG Shudan1 LI Qi2 LI Ge3
Objective To review systematically the curative effect and safety of Recombinant Human Interferon α2b Vaginal Effervescent Capsules (Xinfuning) on HPV infection, and provide clinicians with an evidence base for their clinical decision making. Methods The databases of PubMed, EMbase, Cochrane Library, CBM, Wanfang, CNKI and VIP were retrieved for collecting RCT and CCT about the treatment of HPV infection with Xinfuning before May 2017, and reference lists were also searched. According to the inclusion and exclusion criteria, two reviewers screened and assessed the potential studies independently, and then the data was extracted. The data was given a Meta-analysis by using RevMan 5.3 software. Results Twenty-three study articles were included, involving 3442 patients. After 3 months, the test results showed that the clinical curative effect of Xinfuning treatment group in treating human papilloma virus was better than that of control group (OR = 11.67, 95%CI: 5.50-24.75, P ＜ 0.000 01). After 6 months, the test results showed that the clinical curative effect of Xinfuning treatment group in treating human papilloma virus was better than that of control group (OR = 2.03, 95%CI: 1.41-2.92, P = 0.0001). After 12 months, the test results showed no significant differences of clinical curative effect between Xinfuning treatment group and the control group (OR = 1.24, 95%CI: 0.85-1.81, P = 0.26). There were no obvious adverse reactions in the two groups. Conclusion Xinfuning has significant curative effect in treating HPV infection, and the safety is good.
2017 Vol. 14 (31): 111-115 [Abstract] ( 334 ) HTML (1 KB)  PDF (878 KB)  ( 81 )
116 Clinical distribution and change of drug resistance of Proteus mirabilis causing nosocomial infections in our hospital from 2012 to 2015
YU Boxin1 ZHANG Yajie2 LIU Dan1 LI Qiang3 WANG Jiahe1
Objective To analyze the clinical distribution and drug resistance of Proteus mirabilis causing nosocomial infections in Shengjing Hospital of China Medical University (“our hospital” for short), in order to provide evidence for choosing antibiotics reasonably. Methods The clinical distribution and drug resistance of Proteus mirabilis in hospitalized patients from 1 January 2012 to 31 December 2015 were studied retrospectively. Results A total of 266 strains were isolated. The specimens mainly isolated from urine (57.89%), followed by secretion (9.02%), drainage fluids (7.89%), sputum (7.89%), pus(7.14%) and blood(3.76%). The specimens were mainly isolated from the Department of Urinary Surgery (19.92%), followed by Intensive Care Unit (12.78%) and Department of Rehabilitation (10.53%). The drug resistance rates of Proteus mirabilis to Furantoin, Tetracycline were >90%, to Ticarcillin/Clavulanic Acid, Ertapenem were lowest，both 0. The resistance rate of Proteus mirabilis to Cefazolin increased markedly, from 54.55% to 92.59%, to Ceftazidime and Cefepime decreased sharply, from 33.33%, 36.11% to 3.70% and 7.32%, respectively. Conclusion Proteus mirabilis separation rate from 2012 to 2015 is in a growing trend. This trend reminds that along with the extensive use of antibiotics clinically, the hospital infection rate showes a trend of rising. Proteus mirabilis has different drug resistance to different antimicrobial drugs. It is essential for strengthening the management of antimicrobial abuse and monitoring results of antibiotic resistance.
2017 Vol. 14 (31): 116-119 [Abstract] ( 249 ) HTML (1 KB)  PDF (335 KB)  ( 183 )
120 A teaching method based on Cabrera lead in the electrocardiogram training of nurses in high risk departments
BAI Lu PAN Ruihong▲ JI Jin
Objective To evaluate the application effect of Cabrera lead electrocardiogram teaching methods in ECG training of nurses in high risk department. Methods 106 nurses in high risk Departments of Cardiology, CCU, ICU and of Emergency Medical in Suizhou Central Hospital were selected from June to October 2015. They were divided into two groups by random number table, and given Wilson lead (control group consists of 53 cases) and Cabrera lead (observation group consists of 53 cases) ECG teaching training respectively. At the end of the course, the examination of performance of ECG knowledge was compared between the two groups, and the questionnaire survey was conducted to evaluate the satisfaction of students on teaching effectiveness. Results The scores of ECG examination and teaching satisfaction in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion The teaching method of ECG based on Cabrera lead can obviously improve the ability of ECG interpretation of nurses in high-risk positions, which also can improve the satisfaction of nurses in teaching ECG, and provide a theoretical basis for exploring new methods of nursing ECG teaching.
2017 Vol. 14 (31): 120-123 [Abstract] ( 248 ) HTML (1 KB)  PDF (669 KB)  ( 144 )
124 Probe into the professional degree postgraduate students training on children's ophthalmology
GAO Xu OUYANG Lijuan YANG Jing XIA Yuanyou ZHU Xiaohui ZHAO Rulian WANG Yang PI Lianhong
The training of clinical postgraduates is an important part of the medical and health services in China. At present, the domestic medical graduate degree is divided into professional degree and scientific degree, however, the traditional training of clinical professional degree postgraduates has the problems of weak basic knowledge, insufficient clinical skills and scientific research ability. The Department of Ophthalmology, Children′s Hospital of Chongqing Medical University by conducting PBL teaching method, attention to the cultivation of clinical skills and scientific research innovation ability according to the training requirements and years experiences of postgraduates training, effectively improve the quality of postgraduates graduate education, which provide reference for the training of postgraduates with high level and high quality in clinical medicine.
2017 Vol. 14 (31): 124-127 [Abstract] ( 317 ) HTML (1 KB)  PDF (608 KB)  ( 85 )
128 The application effects of the teaching model of online learning in combination with classroom teaching on teaching medical nursing
KONG Lingyu1 MAO Chun1▲ HUANG Chunrong1 CHEN Anming2 SU Xuehua1
Objective To explore the influence of online learning and classroom teaching on teaching medical nursing. Methods The students from nursing department of medical college in Hubei University of Arts and Science were as the research object, 79 cases of the 2015-level were as experimental group, and the 61 cases of 2014-level were as control group. The experimental group was treated by the teaching model of online learning and classroom teaching, while the control group was treated by the traditional model. The results of the homework, quizzes and modular examination in the two groups were compared. Results The results of the homework, quizzes and modular examination in the experimental group were better than those in the control group, with statistically significant difference (P < 0.05). Conclusion The combination of online learning and classroom teaching model can help to improve the teaching effects, students' academic performances and the quality of personnel training, so it is worth popularizing.
2017 Vol. 14 (31): 128-130,134 [Abstract] ( 221 ) HTML (1 KB)  PDF (656 KB)  ( 145 )
131 Analysis on the problems and countermeasures of elective course system construction in medical vocational colleges
JIN Yuzhong1 LI Xu1 WANG Zhong1 JIN Shan2 YANG Guiran3 WANG Sibei1
Taking the actual situation of elective courses of Cangzhou Medical College as an example, this paper discusses the building of elective course system of medical higher vocational colleges and effective ways to improve the overall teaching level of medical vocational colleges, solve the existing problems in elective courses of higher vocational colleges and improve the quality of talent cultivation, from perfect elective course system, choosing courses and teaching and the examine and assessment of elective courses.
2017 Vol. 14 (31): 131-134 [Abstract] ( 174 ) HTML (1 KB)  PDF (611 KB)  ( 175 )
135 The importance of multidisciplinary training in postgraduate training for glioma neurosurgeon
CHEN Baoshi ZHANG Zhong▲
Brain tumor is one of the ten most common tumors in China, glioma is the most common, accounting for 40%-60% of brain tumors. At the request of precision medicine, diagnosis and treatment of diseases is moving towards molecular diagnosis, individual and precise treatment of the direction of development, which puts a higher demand on the neurosurgical specialist. This article will present the importance in neurosurgery graduate students from the neurosurgery theory, the training of pathology and molecular pathology, sequencing and bioinformatics, radiochemotherapy, basic science research, neuroimaging, psychological intervention.
2017 Vol. 14 (31): 135-138 [Abstract] ( 253 ) HTML (1 KB)  PDF (598 KB)  ( 141 )
139 Analysis of target oriented training mode of professional master′s degree students in traditional Chinese medicine
MENG Yanyan1 CUI Yashan2 PAN Yanshu1 ZHANG Liping1 GAO Zhuye2
Professional degree of traditional Chinese medicine (TCM) is set under the category of clinical medicine before the year 2015. According to the document published by the academic degree′s committee of the state council "professional degree setting scheme of traditional Chinese medicine" (degree [2014] No.45), professional degree of TCM can be set independently by authorized unit from the year 2015. This change fully embodies the characteristics of Chinese medicine, improves the training system of TCM and improves the training quality of TCM students. The paper under the target oriented theory aims to provide references for the collaborative development of medical and education reform of higher TCM colleges of profession master's degree from the training model in course, clinical practice and quality assurance system.
2017 Vol. 14 (31): 139-143 [Abstract] ( 267 ) HTML (1 KB)  PDF (613 KB)  ( 105 )
144 The general situation and thinking on the course of pharmacology and toxicology in the University of New South Wales
JIN Jian1 LIU Lu2▲
The course of pharmacology and toxicology in the University of New South Wales is worth 6 unit of credit for 12 weeks′ teaching time. Teaching forms have lectures, tutorials and practicals. The assessment consists of mid-session test, assignment, lab quizzes, online quiz and final exam. This article introduces the advantage of the course, such as attaching great importance to the practical of safety education and management, multimedia network resources, diversified courses assessment and riching teaching mode. It should be useful to improve the pharmacy teaching skills in our country.
2017 Vol. 14 (31): 144-147 [Abstract] ( 246 ) HTML (1 KB)  PDF (647 KB)  ( 107 )
148 Analysis of the current situation and countermeasures of construction of clinic in military hospitals
HU Yujie LI Ping YE Ling ZHANG Manli TIAN Fei
The main direction of military hospitals construction in the new era is focus on the war time to win and peace time to keep healthy. The outpatient service is the main window of military hospital serving troops wounded soldiers. The quality of outpatient medical security ability directly affects the service for the army in military hospital work, so establishment of relatively independent and complete functions and facilities of military clinic area is the key to reflect the service of military hospital to the army. Through the investigation of 7 different military hospital soldiers treatment zone construction, this article analyzes and discusses the military clinic construction status and countermeasures, in order to provide strong evidences for better construction of modern logistics, security focus to win, accelerating the transformation and remodeling, achieving the goal of military strengthen.
2017 Vol. 14 (31): 148-151 [Abstract] ( 201 ) HTML (1 KB)  PDF (448 KB)  ( 108 )
152 Study on quality evaluation index system of running medical records for public hospitals in Beijing
DU Shuang1,2 MENG Kai1▲
Objective To establish a quality evaluation index system of running medical records for public hospitals in Beijing. Methods Items of running medical records quality evaluation index were collected using literature analysis and in-depth interview. Quality evaluation index system of running medical records was established and weight of indicators were determined using Delphi method. Results Quality evaluation index system of running medical records for public hospitals in Beijing was established, including 5 grade Ⅰindicators, 23 grade Ⅱ indicators, and 87 grade Ⅲ indicators. Conclusion Experts participating in this study have high authority and good coordination, which makes quality evaluation index system of running medical records for public hospitals in Beijing has high reliability and validity.
2017 Vol. 14 (31): 152-156 [Abstract] ( 280 ) HTML (1 KB)  PDF (448 KB)  ( 115 )
157 The effect of comprehensive nursing intervention on complications of percutaneous liver puncture drainage in the treatment of biliary carcinoma
REN Weiying YIN Dalong▲
Objective to explore and analyze the effect of comprehensive nursing intervention on complications of percutaneous liver puncture drainage in the treatment of biliary carcinoma. Methods Ninety cases of patients with biliary carcinoma underwent percutaneous liver puncture drainage from April 2015 to April 2017 in the First Affiliated Hospital of Harbin Medical University were selected and divided into the control group and the observation group by random number table, with 45 cases in each group. The control group was given routine nursing care and the observation group was given comprehensive nursing intervention. Each group was given continuous nursing for 2 months. The complication rate, nursing satisfaction and the quality of life were compared between the two groups. Results The rates of infection, abdominal bleeding, nausea and vomiting, bile leakage and shock in the observation group were lower than those of control group, with statistically significant differences(P ＜ 0.05). The nursing satisfaction in the observation group was higher than that of control group, with statistically significant difference(P ＜ 0.05). After nursing, the scores of physical function, role function, cognitive function, emotional function and social function in the two groups were all higher than those of before nursing, and the indicators above in the observation group increased more remarkablely, with statistically significant difference (all P ＜ 0.05). Conclusion Comprehensive nursing intervention in patients with bile duct carcinoma underwent percutaneous liver puncture drainage can reduce the complication rate, improve nursing satisfaction and promote the quality of life.
2017 Vol. 14 (31): 157-160 [Abstract] ( 241 ) HTML (1 KB)  PDF (548 KB)  ( 114 )
161 The influence of social practice in pension institutions on nursing professional abilities for vocational nursing students in higher vocational college
YANG Lei ZHAO Jian
Objective To explore the effect of social practice in pension institutions on nursing professional abilities to vocational nursing students in higher vocational college. Methods One hundred and twenty seven nursing students of Grade 2014 from Shanghai urban construction vocational college were enrolled as researh objects and randomly divided into control group (65 cases) and observation group (62 cases) by digital draw. The control group was given routine teaching and the observation group added social practice in pension institution on the bases of control group. The comprehensive ability (knowledge acquisition, ability improvement, learning interest and willingness to participate in practical activities), self-regulated learning ability (self-management, information ability, cooperative learning), health assessment ability of the aged (inquiry ability, thinking ability, nursing assessment records) of nursing students in two groups were compared. Results The scores of comprehensive ability and self-regulated learning ability in the observation group were higher than those of control group (all P ＜ 0.05); the score of health assessment ability in the observation group was significantly higher than that of control group (P ＜ 0.05). Conclusion Social practice in pension institution can improve the nursing professional ability of students in higher vocational college.
2017 Vol. 14 (31): 161-164 [Abstract] ( 295 ) HTML (1 KB)  PDF (584 KB)  ( 119 )
165 Influences of cognitive intervention on quality of life, neurotransmitter, sphincter function in anxiety disorder patients with functional constipation
GAO Xiujun JIN Man▲ ZHANG Lihua
Objective To explore the effects of cognitive intervention on quality of life, neurotransmitter, sphincter function in anxiety disorder patients with functional constipation. Methods Ninety cases of anxiety disorder patients with functional constipation in the seventh People′s Hospital of Hangzhou during July 2013 to July 2016 were selected as research subjects and divided into control group(routine nursing intervention) and observation group (cognitive intervention) according to single blind randomized controlled method, with 45 cases in each group. Before and after intervention, quality of life in two groups was evaluated by patient assessment of constipation quality of life scale (PAC-QOL), serum contents of intestinal neurotransmitters were measured by radioimmunoassay, sphincter function indices were measured by total gastrointestinal motility instrument. Results Before intervention, there were no significant differences in the quality of life, neurotransmitter and sphincter function between the two groups (P ＞ 0.05). After intervention, scores of physical discomfort, psychosocial discomfort, anxiety and worry, satisfaction in observation group were lower than those of control group; serum contents of intestinal neurotransmitters such as nitric oxide, somatostatin were lower than those of control group, the content of peptide neurotransmitter-substance, 5-hydroxytryptamine was higher than those of control group; muscle function indices such as lower esophageal sphincter pressure was higher than that of control group, anorectal resting pressure, anal maximal squeeze pressure were lower than those of control group (all P ＜ 0.05). Conclusion Cognitive intervention can improve the quality of life in anxiety disorder patients with functional constipation, balance the secretion of enteric neurotransmitters and sphincter function.
2017 Vol. 14 (31): 165-168 [Abstract] ( 235 ) HTML (1 KB)  PDF (592 KB)  ( 78 )
169 Influences of perioperative nursing intervention on psychological status and stress factors in patients with proximal humeral fracture
WANG Haiyun WU Jinhua WAGN Kai DUAN Xiaoliang LIU Caixia
Objective To investigate the influences of perioperative nursing intervention on psychological status and stress factors in patients with proximal humeral fracture. Methods Eighty six patients with proximal humerus fracture treated with minimally invasive surgery from August 2015 to January 2017 in General Hospital of Jizhong Energy Fengfeng Group were selected and divided into the control group and the observation group by digital number table, with 43 cases in each group. The control group was given routine nursing care and the observation group was given perioperative nursing intervention on the basis of routine nursing care. Self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to evaluate the psychological status of the patients on admission time, before and after surgery. The levels of stress factors such as adrenocorticotrophic hormone (ACTH), cortisol (COR), C-reactive protein (CRP), white blood cell (WBC) and interleukin-6 in the two groups were measured preoperative and postoperative. The postoperative pain was evaluated by visual analogue scale (VAS) and nursing satisfaction was evaluated by self-designed questionnare. Results Before operation, the scores of SDS and SAS in the two groups were all higher than admission. After operation, the scores above were all lower than admission and preoperative, and the observation group decreased more remarkably, with statistically significant difference (P ＜ 0.05). After operation, the level of ACTH, COR, CRP, WBC and IL-6 were all higher than those of before operation, and the indexes above in the observation group were significantly lower than those of control group, with statistically significant difference (all P ＜ 0.05). The score of ＶＡＳ in the observation group was lower than that of control group, and the nursing satisfaction was higher than that of the control group, with statistically significant differences (all P ＜ 0.05). Conclusion The perioperative nursing intervention can reduce the negative emotions and pain experiences of patients with proximal humerus fracture, reduce the inflammatory reaction effectively, promote the comfort. It is worthy of clinical promotion and application.
2017 Vol. 14 (31): 169-172 [Abstract] ( 280 ) HTML (1 KB)  PDF (587 KB)  ( 74 )
173 Application study of comfort care model in postoperative conscious patients of ICU with tracheal intubation
SU Lin DONG Jingwen
Objective To explore the influence of comfort care model in the postoperative conscious patients with tracheal intubation in ICU. Methods From June 2015 to July 2016, 264 cases of conscious patients with tracheal intubation after Level four surgery in Aerospace Center Hospital were selected as research objects and divided into the control group (137 cases) and the intervention group (127 cases) based on the admission time. The control group was given routine nursing care and the intervention group was given comfort care model. The comfort level, nursing satisfaction, compliance behavier and the score of anxiety were compared between the two groups. Results Patients in the two groups had moderate degree uncomfortable (according to the scores VAS scale). The nursing satisfaction, comfort level, compliance behavior in the intervention group were higher than those of control group, with statistically significant differences (P ＜ 0.05). Before operalion, there was no statistically significant difference in the scores of anxiety in the two groups (P ＞ 0.05). After operalion, the score of anxiety in the intervention group was lower than that of before intervention, with statistically significant difference(P ＜ 0.05), but it was higher in the control group, with no significant difference compared with that of before intervention (P ＞ 0.05). Conclusion Comfort care model can improve comfort level and nursing satisfaction in postoperative conscious patients with tracheal intubation in ICU, promote the compliance behavior, relieve the anxiety, assist the patients pass through the mechanical ventilation period, promote recovery. It is worthy of clinical promotion and application.
2017 Vol. 14 (31): 173-176,181 [Abstract] ( 204 ) HTML (1 KB)  PDF (697 KB)  ( 180 )
177 Effects of predictive nursing intervention on neurological rehabilitation and quality of life in patients with intracerebral hemorrhage
SU Dan HU Xiulan
Objective To explore the effect of predictive nursing intervention on neurological rehabilitation and quality of life in patients with cerebral hemorrhage. Methods A total of 110 patients with cerebral hemorrhage treated in Beijing Tian Tan Hospital from March 2016 to January 2017 were selected as research objects and divided into the control group and the observation group by random number table, with 55 cases in each group. The control group was given routine nursing care and the observation group was given predictive nursing intervention. Quality of life, neurological rehabilitation, nursing satisfaction and incidence of complications were compared between two groups. Results Before nursing, there were no significant differences in the scores of indicators on quality of life between the two groups (includes physical function, social role, family role, emotional status, mental status and activity ability) (P ＞ 0.05). After nursing, the scores of indicators above in the two groups were all increased and those in the observation group increased more remarkably (P ＜ 0.05). After operation of 1, 5, 10 d and at discharge time, there were statistically significant differences in the scores of national institute of health stroke scale (NIHSS) within- groups and the scores in the observation group were all lower than those of control group at different time points, with statistically significant difference (P ＜ 0.05). The nursing satisfaction in the observation group (98.18%) were higher than that of control group (88.00%), with statistically significant difference(P ＜ 0.05). The incidence of complications in the observation group (5.45%) was  lower than that of control group (14.54%), but with no statistically significant difference (P ＞ 0.05). Conclusion Predictive nursing intervention can significantly improve the neurological rehabilitation in patients with cerebral hemorrhage, promote quality of life and prognosis, improve the nursing satisfaction. It is worthy of clinical promotion and application.
2017 Vol. 14 (31): 177-181 [Abstract] ( 247 ) HTML (1 KB)  PDF (658 KB)  ( 121 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech