光基因技术调控星形胶质细胞释放ATP和谷氨酸及其对阿尔茨海默病神经元保护机制的研究展望

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Abstract Alzheimer disease′s (AD) is one kind of degenereratly neuropathic disease. The pathomechanism of AD is the deposite of Aβ peptide, including ATP and glutamate insufficiency resulted Aβ deposite. Application of phogenetic technology can selectively activate astrocytes transfected with ChR2, promote the release ATP and glutamate, block the Aβ aggregation producing by insufficient of ATP and glutamate. Conclusion as a result, ChR2 mediated optogenetic technology can be used for AD treatment. This new treropeutical method will avoid the defects of non-selective and extensive side-effects.

Key words： Alzheimer′s disease Optogenetic technology ChR2 ATP Glutamate

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	LIU Puqing HE Bingbing CHEN Feng

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LIU Puqing HE Bingbing CHEN Feng. The research progress in mechanism of optogenetics activated astrocytes release ATP and glutamate to protect neurons in Alzheimer′s disease[J]. 中国医药导报, 2017, 14(31): 40-43.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I31/40

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