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| Effect of Dexmedetomidine combined with Flurbiprofen Axetil on hemodynamics and stress response during rehabilitation in patients with colorectal cancer underwent laparoscopic radical resection |
| ZHANG Jianhua HUANG Xu LIANG Jianqun HE Baojia LU Xianqing |
| Department of Anesthesiology, the First People's Hospital of Zhaoqing City, Guangdong Province, Zhaoqing 526000, China |
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Abstract Objective To investigate the effect of Dexmedetomidine combined with Flurbiprofen Axetil on hemodynamics and stress response during rehabilitation in patients with colorectal cancer underwent laparoscopic radical resection. Methods A total of 78 cases of patients with colorectal cancer underwent laparoscopic radical resection in the First People′s Hospital of Zhaoqing City from January 2013 to December 2015 were selected and divided into three groups by random number table, each group had 26 cases. Control group A was given Flurbiprofen Axetil 50 mg 30 min before the end of surgery; control group B was given Dexmedetomidine 0.5 μg/kg 30 min before the end of surgery; and the combination group received Flurbiprofen Axetil 50 mg combined with Dexmedetomidine 0.25 μg/kg 30 min before the end of surgery. Levels of MAP, HR, IL-6 and CRP were recorded before tracheal extubation (T0), immediately after tracheal extubation (T1) and 5 min after tracheal extubation (T2), and the grade of restlessness, recovery time, extubation time, Ramsay sedation score and VAS pain score were compared among the three groups. Results Compared with control group A, the levels of MAP, HR in the control group B and the combined group at T1 and T2 were decreased (P ＜ 0.05). Compared with the control group A and the control group B, the serum levels of IL-6 and CRP were lower in the combined group at T1 and T2 (P < 0.05). The incidence of restlessness in the combined group was lower than the control group A and the control group B (P < 0.05). The recovery time, extubation time and Ramsay sedation score of the combined group and the control group A were lower than the control group B, and the VAS pain score of the combined group and the control group B was lower than the control group A(P < 0.05). Conclusion Dexmedetomidine combined with Flurbiprofen Axetil can effectively reduce restlessness after laparoscopic radical resection for colorectal cancer, improve hemodynamics and inhibit the stress response recovery period, and can not prolong the recovery time and extubation time.
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