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| Clinical diagnosis and treatment of 43 cases of eosinophilic lymphatic granuloma of head and neck |
| JIANG Yang1 HUA Qingquan1 REN Jie1 ZENG Feng1 SHENG Jianfei1 ZHANG Zhijian1 GUAN Hongxia2 YUAN Jingping3 |
1.Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.Department of Otolaryngology, Hubei Material and Child Health Hospital, Hubei Province, Wuhan 430070, China; 3.Department of Pathology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Objective To explore the clinical features and diagnosis and treatment of eosinophilic lymphatic granuloma (ELG) of head and neck, in order to improve awareness of the disease in clinicians, reduce the clinical misdiagnosis, missed diagnosis rate and the recurrence rate. Methods The clinical data of 43 patients with ELG of head and neck surgery were confirmed by pathological examination in Renmin Hospital of Wuhan University from July 2000 to January 2017 were collected. The detailed data were summarized, including basic information, clinical symptoms, routine blood tests, imaging examination, pathological examination and recurrence. Results The patients were often treated with recurrent painless swelling as the initial symptom, which could be single or multiple, and could be accompanied by skin itching or pigmentation. The diseased region was mainly in the neck (24 cases), followed by the parotid gland (9 cases). In laboratory examination, eosinophilic granulocytes in 33 cases were significantly elevated, and IgE in 31 cases were increased significantly. 26 cases were treated by simple surgery, with 9 cases recurrence; 13 cases were treated with combined treatment (surgical + radiotherapy or hormone + radiotherapy), with only one case recurrence. Conclusion The main clinical manifestations of ELG are painless mass, increased peripheral blood eosinophils and serum IgE, and its diagnosis relies on pathological examination. Surgical treatment is the preferred treatment, and combined radiotherapy and hormone therapy can reduce recurrence rate.
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