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2023 Vol. 20, No. 25 Published: 2023-09-05

	4	Screening of differentially expressed genes regulated by methylation related to prognosis in osteosarcoma based on bioinformatics methods
		DAI Yi1 ZHANG Zhimin1 YUE Xing1 QING Hengzhen1 YUAN Changshen2 DUAN Kan2 ZHENG Hangbing3
		DOI: 10.20047/j.issn1673-7210.2023.25.01
		Objective To screen the differentially expressed genes (DEGs) methylated in osteosarcoma (OS) patients related to prognosis based on bioinformatics methods, and to provide a direction for the treatment and research of OS. Methods The OS gene chip (GSE36001) and OS methylation gene chip (GSE36002) were downloaded from the gene expression omnibus database, and the differences were analyzed and pooled to obtain the DEGs. Enrichment analysis of DEGs was performed, and the protein- protein interaction (PPI) network of DEGs was constructed by the STRING database. Cytoscape 3.6 software was used to screen the core genes of PPI network, and survival analysis was performed. Results A total of 532 up- regulated and 281 down-regulated DEGs were identified in differential analysis of GSE36001, and 3 433 hypermethylated DEGs and 2 212 hypomethylated DEGs were identified in differential methylation analysis of GSE36002, after intersection, 128 down-regulated OS hypermethylated DEGs and 44 up-regulated OS hypomethylated DEGs were obtained. OS hypermethylated DEGs were mainly involved in epidermal development and skin cell differentiation, and hypomethylated DEGs were mainly involved in cell differentiation and other biological processes. OS hypermethylated DEGs involved cytokine- cytokine receptor interactions and hypomethylated DEGs involved Ca2+ and other pathways. Eight core genes were identified by PPI analysis. Survival analysis results showed that the survival rate of OS patients with high expression of ALOX5AP, HCK, LAPTM5, RAC2, LCP2, AIF1, TYROBP, and PLEK were higher than those of patients with low expression (P＜0.05). Conclusion Eight core methylated DEGs, including ALOX5AP, HCK, and LAPTM5, etc. may affect the prognosis of patients with OS.
		2023 Vol. 20 (25): 4-11 [Abstract] ( 16 ) HTML (1 KB) PDF (2271 KB) ( 77 )

	12	Construction and validation of a senescence-associated secretory phenotype associated lncRNAs model to predict prognosis in patients with hepatocellular carcinoma
		ZHOU Dingjie GE Wei CAO Dedong
		DOI: 10.20047/j.issn1673-7210.2023.25.02
		Objective To construct a senescence-associated secretory phenotype(SASP) related risk model that can independently predict the prognosis of hepatocellular carcinoma (HCC), and to improve the clinical efficacy of HCC. Methods Sequencing and clinical data of HCC were obtained from the cancer genome atlas(TCGA) database, and lncRNA were isolated. SASP related genes with correlation coefficient ＞ seven were searched and screened from the GeneCard website, and genes related to differentially expressed SASP associated lncRNAs were screened using the R language “limma” package. Cox regression analysis and lasso were used to construct the lncRNAs prediction model related to SASP. HCC patients were divided into high-risk group and low-risk group according to the median risk score of the samples. Kaplan-Meier curve was used for survival analysis. Single sample gene set enrichment analysis (ssGSEA) was used to investigate the association between risk scores and immune status in samples. Results A total of 374 tumor samples and 50 normal tissue samples were obtained from the TCGA database. Six lncRNAs associated with SASP were selected form a prognostic model, and the risk scores of each sample were calculated. Survival analysis showed that the prognosis of patients in the low-risk group was better than that in the high-risk group. Area under one-year survival receiver operating characteristic curve of risk model was 0.812. Univariate and multivariate regression analysis showed that patient risk score was an independent risk factor for HCC prognosis (OR ＞ 1, P ＜ 0.05). ssGSEA results showed higher expression levels of immune checkpoint specific targets and associated pathways in the high-risk group. Conclusion In this study, the SASP-related lncRNAs risk model is successfully constructed, and the risk model can independently predict the prognosis of HCC patients.
		2023 Vol. 20 (25): 12-19 [Abstract] ( 16 ) HTML (1 KB) PDF (2546 KB) ( 59 )

	20	Effect of homoharringtonine on lapoptosis and proliferation of leukemia cells and its inhibitory effect on Ras/Raf/MEK pathway
		QI Haiyan LAN Jianping SONG Xiaolu WANG Xiaogang WANG Wensong
		DOI: 10.20047/j.issn1673-7210.2023.25.03
		Objective To investigate the effect of homoharringtonine (HHT) on apoptosis and proliferation of leukemia cells and its inhibitory effect on Ras/Raf/MEK pathway. Methods The logarithmic growth phase K562 and Kasum-1 cells were taken for study and treated with HHT of 0, 10, 20 , and 50 ng/ml, respectively. MTT was used to detect relative cell viability, clone formation assay was used to detect the number of cell clones, cell IC50 was calculated at 24, 48, and 72 hours, flow cytometry was used to detect the level of apoptosis, and Western blot was used to detect the relative levels of Ras/Raf/MEK pathway proteins and apoptosis-related proteins. Results At 24, 48, and 72 hours, the IC50 of HHT on K562 cells was 80.69, 65.28, and 50.76 ng/ml, respectively. The IC50 of HHT on Kasum-1 cells was 85.16, 70.11, and 51.14 ng/ml, respectively. When cultured for 24, 48, and 72 h, the survival rate of 10, 20 and 50 ng/ml HHT cells was lower than 0 ng/ml, and the survival rate of 20 and 50 ng/ml HHT cells was lower than 10 ng/ml. The survival rate of 50 ng/ml HHT cells was lower than that of 20 ng/ml HHT cells, and the differences were statistically significant (P＜0.05). The clones of 10, 20 and 50 ng/ml HHT cells were all lower than 0 ng/ml; the clones of 20 and 50 ng/ml HHT cells were all lower than 10 ng/ml HHT cells; the clones of 50 ng/ml HHT cells were all lower than 20 ng/ml HHT cells, and the differences were statistically significant (P＜0.05). The apoptosis rate of 10, 20, and 50 ng/ml HHT cells was higher than that of 0 ng/ml HHT cells, the apoptosis rate of 20 and 50 ng/ml HHT cells was higher than that of 10 ng/ml HHT cells, and the apoptosis rate of 50 ng/ml HHT cells was higher than that of 20 ng/ml HHT cells, and the differences were statistically significant (P＜0.05). The expression levels of RAS, p-cRAF, and p-MEK protein at 10, 20, and 50 ng/ml HHT were all lower than 0 ng/ml HHT, and the expression levels of RAS, p-cRAF, and p-MEK protein at 20 and 50 ng/ml HHT were all lower than 10 ng/ml HHT. The expression levels of RAS, p-cRAF, and P-MEK at 50 ng/ml HHT were lower than those of 20 ng/ml HHT, and the differences were statistically significant (P＜0.05). Survivan expression levels at 10, 20, and 50 ng/ml HHT were lower than 0 ng/ml HHT, Cleaved caspase-3 and Cleaved PARP were higher than 0 ng/ml HHT. Survivan expression at 20 and 50 ng/ml HHT was lower than that at 10 ng/ml HHT. Survivan expression levels were lower than 10, and 50 ng/ml HHT, respectively, Cleaved caspase-3 and Cleaved PARP expression levels were higher than 20 ng/ml HHT. The protein expression levels of Cleaved caspase-3 and Cleaved PARP were higher than 20 ng/ml HHT, and the differences were statistically significant (P＜0.05). Conclusion HHT can inhibit the activity of Ras/Raf/MEK pathway, inhibit the proliferation of leukemia cells, and promote apoptosis of leukemia cells.
		2023 Vol. 20 (25): 20-25,42 [Abstract] ( 16 ) HTML (1 KB) PDF (1565 KB) ( 19 )

	26	Study on the protective effect and mechanism of Tibetan Medicine Ershiwuwei Feibing Pills on acute lung injury in rats
		LI Yaxuan1 LI Weihong1 REN Qingjia2 YE Fei1 GUO Haolin1 LI Tenghui1 FAN Angran1 DU Qinghong1
		DOI: 10.20047/j.issn1673-7210.2023.25.04
		Objective To prove the protective effect and mechanism of Tibetan Medicine Ershiwuwei Feibing Pills on acute lung injury (ALI) rats. Methods A total of 84 SPF grade male SD rats (weighing [200±20] g, 6-8 weeks old) were divided by random number table into blank group, model group, Shuanghuanglian group (Shuanghuanglian Oral Solution 6 ml/kg), Dexamethasone group (2 mg/kg), and Ershiwuwei Feibing Pills high, medium, and low dose group (6.0, 3.0, 1.5 mg/kg) with 12 rats in each group. Except for the blank group, others were established by sublingual intravenous injection of lipopolysaccharide(LPS) (5 mg/kg). Administration by gavage 24 and 2 hours before modeling. The blood gases of the rats were measured by sampling blood from the abdominal aorta 24 h after modeling:partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), and pH value. Hematoxylin-Eeosin staining staining was used to observe lung histopathological changes and to perform lung injury histopathology score. ELISA detection of tumor necrosis factor-α (TNF-α), interleukin-1β(IL-1β), and interleukin-10 (IL-10) content in alveolar lavage fluid (BALF); lung tissue was analyzed by Western blot for Toll like receptor 4(TLR4), myeloid differentiation factor 88(MyD88), nuclear factor kappa-B(NF-κB), and myeloperoxidase (MPO) protein expression levels. Results Compared with the blank group, arterial blood PO2, PCO2, and pH value in the model group decreased (P＜0.05 or P＜0.01); compared with the model group, PO2 increased in the Ershiwuwei Feibing Pills high, medium dose groups, while PCO2 and pH value increased in the Ershiwuwei Feibing Pills high, medium and low dose groups (P＜0.05 or P＜0.01); compared with the Ershiwuwei Feibing Pills medium and low dose groups, PO2 in the Ershiwuwei Feibing Pills high dose group increased (P＜0.05). Compared with the blank group, the lung tissue of model group showed severe injury and significantly higher pathological scores(P＜0.01); compared with the model group, the lung tissue damage was reduced and the pathology score was significantly reduced in the Ershiwuwei Feibing Pills high, medium, and low dose groups (P＜0.01). Compared with the blank group, TNF-α, IL-1β, and IL-10 in the BALF of the model group increased (P＜0.01 or P＜0.05); compared with the model group, IL-1β and TNF-α content in the Ershiwuwei Feibing Pills high and medium dose groups significantly decreased (P＜0.01), but IL-10 increased (P＜0.05), and IL-1β content in the Ershiwuwei Feibing Pills low dose groups reduced (P＜0.05); compared with the Ershiwuwei Feibing Pills medium and low dose groups, IL-1β content in the Ershiwuwei Feibing Pills high dose group decreased, but IL-10 content increased (P＜0.05). Compared with the blank group, TLR4, MyD88, NF-κB, and MPO protein expression levels in the lung tissue of the model group significantly increased (P＜0.01); compared with the model group, TLR4, MyD88, NF-κB, and MPO protein expression levels in the Ershiwuwei Feibing Pill high, medium, and low dose groups significantly reduced(P＜0.01); compared with the Ershiwuwei Feibing Pills low dose group, TLR4, MyD88, and NF-κB protein expression levels in the Ershiwuwei Feibing Pills high dose group reduced (P＜0.05 or P＜0.01); compared with the Ershiwuwei Feibing Pills medium dose group, MyD88 protein expression level in the Ershiwuwei Feibing Pills high dose group significantly decreased (P＜0.01). Conclusion Ershiwuwei Feibing Pills can significantly improve LPS induced ALI in rats and its mechanism may be related to the regulation of TLR4/MyD88/NF-κB signaling pathway is related to reducing inflammation and the high-dose has the best effect.
		2023 Vol. 20 (25): 26-31 [Abstract] ( 16 ) HTML (1 KB) PDF (1722 KB) ( 68 )

	32	Experimental study on long-term toxicity test of Scorzonera Herpes Zoster Ointment
		HUANGFU Jiaxin1 CHU Xia2 QIN Zhen1 SHEN Dexin1
		DOI: 10.20047/j.issn1673-7210.2023.25.05
		Objective To observe the long-term toxicity test of Scorzonera Herpes Zoster Ointment on New Zealand rabbits. Methods A total of 32 healthy and specific pathogen free New Zealand rabbits aged 10-14 weeks and weighing 2.0-2.5 kg, half male and half female were selected, and they were divided into control group, Scorzonera Herpes Zoster Ointment high dose group (2 g crude drug/kg), Scorzonera Herpes Zoster Ointment middle dose group (1 g crude drug/kg), and Scorzonera Herpes Zoster Ointment low dose group (0.5 g crude drug/kg), with eight rabbits with each group. The hairs on both sides of the spine were symmetrically removed in four groups, with a total of 150 cm2. Each group was given percutaneous administration for six days a week for four weeks, and the general situation was observed and recorded. After four weeks of administration, four New Zealand rabbits were selected from each group to detect hematological indexes and blood biochemical indexes; then the New Zealand rabbit was dissected, its organs were weighed, and the organ index was calculated; histopathological examination of the organs and the local skin were performed. The remaining animals were fed and recovered for two weeks after drug withdrawal, and the above indexes were detected. Results Four weeks after administration and two weeks after withdrawal, no obvious erythema, edema and other irritant reactions were found in four groups; the general condition of four groups was good, no abnormalities were found in drinking water, feeding, fur luster, activity, and bowel movements. The body weight increased gradually and the growth was good. There were no death or other toxic side effects caused by Scorzonera Herpes Zoster Ointment high, medium, and low dose groups. Four weeks after administration and two weeks after withdrawal, there were no significant differences in white blood cell count, neutrophil ratio, lymphocyte ratio, monocyte ratio, red blood cell count, hemoglobin, hematocrit, platelet count, prothrombin time, thrombin time, glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, total protein, albumin, total bilirubin, alkaline phosphatase, potassium, sodium, chlorine, urea nitrogen, creatinine, creatine kinase, blood glucose, and the coefficients of liver, heart, spleen, lung, pancreas, and kidney among four groups (P＞0.05). Four weeks after administration and two weeks after withdrawal, the morphology, hardness, and color of organs among four groups were not abnormal due to drugs; no abnormal histological changes were observed in heart, liver, spleen, lung, kidney, adrenal gland, pancreas, brain, stomach, testis, small intestine, rectum, bladder, and thymus in each group by histopathology examination, and no edema, epidermal hyperplasia, and keratosis were found in skin histopathological examination. Conclusion There is no obvious toxic effect on New Zealand rabbits after long-term administration of Scorzonera Herpes Zoster Ointment.
		2023 Vol. 20 (25): 32-37 [Abstract] ( 12 ) HTML (1 KB) PDF (963 KB) ( 46 )

	38	Effect and mechanism of miR-16 on proliferation and apoptosis of human breast cancer cells MDA-MB-231
		LIU Jiaqi ZHOU Fubo LIN Feng FU Hui
		DOI: 10.20047/j.issn1673-7210.2023.25.06
		Objective To investigate the effect and mechanism of miR-16 on proliferation and apoptosis of human breast cancer cells MDA-MB-231. Methods The cells cultured in vitro were divided into the following groups: human mammary epithelial cells HBL-100 (HBL-100 group ) and human breast cancer cells MDA-MB-231 (MDA-MB-231 group ). Real-time fluorescent quantitative PCR was used to detect miR-16 expression, and Western blot was used to detect β2 adrenergic receptor (β2-AR) protein expression. Transient transfection of cells was grouped as follows: MDA-MB-231 group, MDA-MB-231+miR-16 mimics (miR-16 mimics group), MDA-MB-231+miR-16 inhibitor (miR-16 inhibitor group), MDA-MB-231+ negative control (negative control group). The effects of miR-16 on proliferation and apoptosis of MDA-MB-231 cells were observed by MTT colorimetry and Annexin V-FITC double dye flow cytometry. The targeting relationship between miR-16 and β2-AR was verified by dual luciferase reporter genes. Results The expression of miR-16 in MDA-MB-231 group was lower than that in HBL-100 group, and the expression of β2-AR protein was higher than that in HBL-100 group, and the differences were statistically significant (P＜0.05). There was no significant difference in cell proliferation between MDA-MB-231 group and negative control group (P＞0.05). Cell proliferation in miR-16 mimics group was lower than that in MDA-MB-231 group, and cell proliferation in miR-16 inhibitor group was higher than that in MDA-MB-231 group, and the differences were statistically significant (P＜0.05). There was no significant difference in apoptosis rate between MDA-MB-231 group and negative control group (P＞0.05). The apoptosis rate in miR-16 mimics group was higher than that in MDA-MB-231 group, and the apoptosis rate in miR-16 inhibitor group was lower than that in MDA-MB-231 group, and the differences were highly statistically significant (P＜0.01). The results of dual luciferase reporter gene showed that, compared with MDA-MB-231 group, luciferase activity in miR-16 inhibitor group and negative control group had no significant changes, with no statistical significance (P＞0.05). Compared with MDA-MB-231 group, the luciferase activity of miR-16 mimics group with β2-AR 3’UTR sequence decreased, the difference was highly statistically significant (P＜0.01). Compared with MDA-MB-231 group, there was no significant change in luciferase activity in miR-16 mimics group with mutated β2-AR 3’UTR sequence, with no statistical significance (P＞0.05). Conclusion miR-16 may regulate the proliferation and apoptosis of breast cancer cells by targeting β2-AR.
		2023 Vol. 20 (25): 38-42 [Abstract] ( 13 ) HTML (1 KB) PDF (1035 KB) ( 70 )

	43	Research progress on prevention and treatment of ventricular remodeling by regulating relevant signaling pathways with traditional Chinese medi- cine
		XU Cun1 WANG Baohe2
		DOI: 10.20047/j.issn1673-7210.2023.25.07
		Ventricular remodeling (VR) is a complex pathological process, which is a key factor leading to increased morbidity and mortality of heart failure, and its mechanism involves a variety of cytokines involved in signal regulation. The prevention and treatment of VR by traditional Chinese medicine is closely related to the regulation of TGF-β/Smad, NF-κB, MAPK, NLRP3 inflammatome, PI3K/Akt/mTOR, Ca2+, and VEGF/VEGFR2 signaling pathways. In this paper, the pathological changes of VR and the mechanism of Chinese medicine monomer and compound regulation related signal pathway to prevent and treatment VR were reviewed, and the regulation related signal pathway intervention in VR treatment of heart failure has a positive effect, aiming to provide a reference for clinical prevention and treatment of VR.
		2023 Vol. 20 (25): 43-46 [Abstract] ( 12 ) HTML (1 KB) PDF (524 KB) ( 251 )

	47	Research progress of LRG1 in glucolipid metabolic diseases
		ZHENG Shuyue XIA Yue JIA Jue DENG Xia WANG Dong
		DOI: 10.20047/j.issn1673-7210.2023.25.08
		Leucine-rich-α-2-glycoprotein 1 (LRG1) is one of the highly conserved member of the leucine-rich repeat protein family. Recent studies have found that LRG1 is a novel adipokine, which is closely related to glycolipid metabolism. In terms of glucose metabolism, LRG1 gene knockout can improve insulin resistance induced by high fat feeding, and LRG1 can inhibit insulin signaling and promote liver gluconeogenesis. In terms of lipid metabolism, LRG1 gene knockout can inhibit lipid synthesis and reduce serum triglyceride and cholesterol levels. In addition, the levels of LRG1 in obese people and obese mice are significantly higher, and the level of LRG1 is significantly correlated with a variety of diabetes complications, suggesting that LRG1 may be a risk factor for obesity and diabetes vascular complications. This article reviews the research progress of LRG1 in glycolipid metabolism and related diseases, in order to provide a new direction for the prediction and treatment of glycolipid metabolism related diseases.
		2023 Vol. 20 (25): 47-50 [Abstract] ( 13 ) HTML (1 KB) PDF (465 KB) ( 74 )

	51	Research progress on the application of hyperoxia therapy in the treatment of patients with malignant tumors
		ZHUANG Yan JIANG Chunping WU Junhua
		DOI: 10.20047/j.issn1673-7210.2023.25.09
		In recent years, more and more studies have been conducted on the application of hyperoxia in tumor therapy. Hyperoxic therapy can play an antitumor role by alleviating tumor hypoxia and affecting complex biological responses. At the same time, hyperoxia improves the effectiveness of existing therapies, such as radiotherapy, chemotherapy, and immunotherapy. This article summarizes and discusses the internal mechanism of hyperoxia therapy against tumor, reviewed the auxiliary function of hyperoxia therapy as existing tumor treatment, and reveals the anti-tumor effect of hyperoxia therapy and the potential of hyperoxia as an auxiliary therapy for tumor, and provides a new strategy for the application of hyperoxia in the treatment of tumor.
		2023 Vol. 20 (25): 51-53 [Abstract] ( 9 ) HTML (1 KB) PDF (352 KB) ( 95 )

	54	Research progress in the application of digital medicine in medical education
		LIU Ganggang1 XIE Xinsheng1 GAO Lu1 GAO Xuejiao2 LI Fuzhen3
		DOI: 10.20047/j.issn1673-7210.2023.25.10
		With the continuous development of information science and bioengineering, digital medicine has become the development trend of modern medicine, and medical education is also beginning to enter the digital age. 3D printing, virtual reality, augmented reality, mixed reality, 3D visualization, remote robotics, digital teaching platform, and other digital technologies are increasingly widely used in basic medical education and clinical teaching. This paper reviews the research progress of the application of digital medicine in medical education, summarizes the problems, and looks into the future.
		2023 Vol. 20 (25): 54-57 [Abstract] ( 25 ) HTML (1 KB) PDF (604 KB) ( 275 )

	58	Research progress on surgical methods of submandibular gland resection
		LI Nian LI Tiancheng
		DOI: 10.20047/j.issn1673-7210.2023.25.11
		Resection of submandibular gland via neck approach is the preferred treatment for submandibular gland benign tumors, however, there is a risk of injury to the mandibular branch of the facial nerve in this operation, and the neck will leave scars, affecting the appearance of the neck. The increasing aesthetic requirements of patients promote the development of surgical incision of submandibular gland in the direction of beauty and concealment. Endoscopic-assisted surgery can avoid obvious neck scars and help to observe important anatomical structures of the neck. Meanwhile, it is found in surgical practice that the risk of complications is not significant, and the glands and tumors can be completely removed. At present, the application of endoscopic-assisted submandibular gland excision is very limited. This article will review endoscopic submandibular gland surgeries with various approaches, in order to provide reference for clinicians.
		2023 Vol. 20 (25): 58-61,69 [Abstract] ( 15 ) HTML (1 KB) PDF (691 KB) ( 82 )

	62	Research progress on novel molecular marker of glioma
		LI Xiaorong1 WANG Hongkun2 BIAN Wei1 ZHENG Huixia2 XIAO Hong2
		DOI: 10.20047/j.issn1673-7210.2023.25.12
		Glioma is an intracranial malignant tumor with high morbidity and mortality, which causes a huge burden to public health. At present, relying solely on imaging and pathological classification based on traditional biopsy tissue morphology cannot meet the needs of clinical diagnosis and treatment. Therefore, it is urgent to explore auxiliary diagnostic tools with higher sensitivity and stronger specificity. In recent years, the clinical application of molecular marker has become a research hotspot, which helps to clarify disease classification and ensure early detection, diagnosis, and treatment. This article summarizes the potential roles of some genetic molecular markers in disease diagnosis and prognosis prediction, aiming to lay a theoretical foundation for the clinical application of glioma and make personalized and precise treatment possible.
		2023 Vol. 20 (25): 62-65 [Abstract] ( 19 ) HTML (1 KB) PDF (543 KB) ( 109 )

	66	Research progress of platelet-rich plasma therapy for repeated implantation failure
		HUANG Ying LIU Xiru
		DOI: 10.20047/j.issn1673-7210.2023.25.13
		The incidence of infertility is increasing year by year, and it will become the third largest disease in the world after tumors and cardiovascular and cerebrovascular diseases, bringing great impact to families and society. Platelet-rich plasma is rich in a variety of bioactive substances, which has biological effects of promoting cell proliferation, promoting angiogenesis, modulating inflammation, and immune regulation. Intrauterine perfusion platelet plasma therapy may improve pregnancy outcomes in patients with recurrent implantation failure, and may be a promising new treatment strategy. This article summarizes the efficacy, safety and limitations of platelet-rich plasma in patients with repeated implantation failure, and elucidates its potential mechanism for improving endometrial receptivity, in order to provide new ideas for clinical diagnosis and treatment.
		2023 Vol. 20 (25): 66-69 [Abstract] ( 19 ) HTML (1 KB) PDF (517 KB) ( 43 )

	70	Research progress of transitional nursing model in rehabilitation nursing of stroke patients with limb dysfunction
		NIU Shaoqian WANG Rui YANG Weidong FENG Ling▲
		DOI: 10.20047/j.issn1673-7210.2023.25.14
		Limb dysfunction is a complication of stroke, which can affect the quality of life. The early post-hospital rehabilitation nursing is an important part of the treatment of stroke complicated with limb dysfunction. However, rehabilitation is a long-term process, and most patients who survive the acute phase will leave sequelae, and the incidence of limb dysfunction is very high, reducing self-care ability and quality of life of patients. At present, our country has not realized the multi-linkage of hospitals, families, and patients, and the community service capacity is relatively insufficient, and the management of chronic diseases is limited. In recent years, transitional nursing model has been proposed, which is a nursing model adopted to ensure the coordination and continuity of nursing work during the transition period of patients at all levels of medical and health care institutions, and is widely used in continuous nursing from hospital to community. This paper reviews the application of this model in limb dysfunction of stroke patients, hoping to provide reference for rehabilitation nursing of patients with this disease.
		2023 Vol. 20 (25): 70-72,76 [Abstract] ( 14 ) HTML (1 KB) PDF (554 KB) ( 908 )

	73	Teaching effect of virtual reality combined with orthodontic bracket positioning training method
		XUE Chaoran LI Bin WANG Yipeng WANG Peiqi XU Hui
		DOI: 10.20047/j.issn1673-72102023.25.15
		Objective To introduce a virtual reality combined with orthodontic bracket positioning training method, and to evaluate its teaching effect. Methods Twenty postgraduate students learning at Department of Orthodontics, West China Hospital of Stomatology, Sichuan University from March to December 2022 were divided into experimental and control group according to the random number table method, with 10 students in each group. The experimental group was taught by the virtual reality combined with orthodontic bracket positioning training method. The control group was taught by the plaster model bracket positioning training method. After the training, each student in both groups was asked to bond brackets on a dental model in a dental mannequin for examination. The digital models of the dentitions bonded with brackets by the students were acquired and the brackets’ positions were evaluated, and the students were investigated for the satisfaction for the two training methods. Results A total of 280 brackets were bonded by the experimental group, and a total of 280 brackets were bonded by the control group. No bracket bonding failure was found in any of the two groups. There was no significant difference between the two groups in the absolute values of proximal and distal translation error (P＞0.05), and the absolute values of axial tilt rotation error in the experimental group were smaller than those in the control group (P＜0.05). The satisfaction of the students in the experimental group was significantly higher than that of the control group (P＜0.05). Conclusion The virtual reality combined bracket positioning method can help the students reduce the error in positioning the brackets in the angulation and improve the students’ satisfaction for the teaching.
		2023 Vol. 20 (25): 73-76 [Abstract] ( 17 ) HTML (1 KB) PDF (1242 KB) ( 15 )

	77	Practice and research of E-learning in the field of medical education
		DONG Huilin1　QIU Fei2
		DOI: 10.20047/j.issn1673-72102023.25.16
		The development of science and technology and medical education puts forward new requirements for the process and approach of medical education. As a new teaching method, electronic learning(E-learning) has been widely used in education, training, and other fields, especially in foreign countries. In the field of domestic medical education, E-learning has also developed rapidly and played an active role. With the development of this application trend, many scholars have carried out related research on it. Based on the interpretation of E-learning mode, this paper traces its development history and application status in the field of medical education, reviews relevant research materials at home and abroad, and provides constructive inspiration for the practice research of E-learning in domestic medical education.
		2023 Vol. 20 (25): 77-80 [Abstract] ( 21 ) HTML (1 KB) PDF (623 KB) ( 89 )

	81	Application of evidence-based medicine teaching method combined with scenario simulation in clinical nursing teaching in department of hematology
		CHEN Huiping1 YU Ying2▲ CHEN Chen3 SHEN Xinmei1
		DOI: 10.20047/j.issn1673-72102023.25.17
		Objective To explore the clinical effect of evidence-based medicine teaching method combined with scenario simulation in clinical nursing teaching in department of hematology. Methods A total of 100 interns in the Department of Hematology, Nanjing Hospital Affiliated to Nanjing Medical University from May 2021 to May 2022 were prospectively included, and they were divided into observation group and control group by random number table method, with 50 interns in each group. The control group implemented the evidence-based medicine teaching mode, and the observation group implemented the evidence-based medicine teaching mode combined with the scenario simulation teaching mode. Both groups were taught for a month. The assessment results (theoretical and operational techniques) and the critical thinking ability (using the Chinese version of California critical thinking disposition inventory [CTDI-CV]) between two groups were compared before and after teaching for a month. Results After a month of teaching, the theoretical and operational technical scores of the two groups were higher than those before teaching, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After a month of teaching, the scores of truth seeking, systematic ability, self-confidence, open mind, cognitive maturity, intellectual curiosity, and analytical ability of the two groups were higher than those before teaching, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion The application of evidence-based medicine teaching method combined with scenario simulation in clinical nursing teaching of department of hematology is good, which can effectively improve the professional and operational skills of hematology department of hematology interns and improve their critical thinking.
		2023 Vol. 20 (25): 81-84 [Abstract] ( 18 ) HTML (1 KB) PDF (1000 KB) ( 57 )

	85	Analysis of global research status and trends in septic liver injury based on VOSviewer and CiteSpace
		CHEN Mengxiao1 ZHANG Yiren1 WANG Yi2 Gulifeire Tayier2 YU Xiangyou2
		DOI: 10.20047/j.issn1673-72102023.25.18
		Objective To explore the global research current status and trends on septic liver injury. Methods The literature on septic liver injury research from January 2012 to November 2022 was searched through Web of Science core collection database, and then bibliometrics and visual analysis of countries, institutions, authors, journals, keywords, and relevant citations was performed using VOSviewer, CiteSpace, and other software. Results A total of 1 152 articles were included, and the number of publications was increasing. China had the most publications, but USA had the most international collaborations. Research institutions were mainly universities, and Pittsburgh University had the most international collaborations. Professor Bauer M had the highest number of publications and frequent international communication. Shock had the most publications. Co-citation analysis of the literature showed that the two papers with centrality ≥0.1 were published by Yan J and Pavel S. Keyword analysis showed that research can form 13 clusters, with pathophysiology, metabolism, and signaling pathways being the hot spots and trends in future. Conclusion This study uses visualization software to understand the current status and development trend of research in septic liver injury, which provides ideas and directions for future research.
		2023 Vol. 20 (25): 85-89,98 [Abstract] ( 19 ) HTML (1 KB) PDF (2515 KB) ( 22 )

	90	Relationship between serum viral load and inflammatory factors, T lymphocyte subsets, and liver enzymes in patients with chronic hepatitis B
		CHEN Zixi* LI Jinpeng* ZHENG Jin XIANG Fenfen KANG Xiangdong▲ WU Rong▲
		DOI: 10.20047/j.issn1673-72102023.25.19
		Objective To study the relationship between serum hepatitis B virus (HBV) load and inflammatory factors, peripheral blood T lymphocyte subsets, and liver enzymes in chronic hepatitis B patients. Methods A total of 85 patients with chronic hepatitis B admitted to Putuo Hospital, Shanghai University of Traditional Chinese Medicine from March 2019 to August 2022 were collected and divided into HBV DNA negative group (29 cases), HBV DNA low load group (28 cases), and HBV DNA high load group (28 cases) according to their HBV DNA expression load. The differences of inflammatory factors, peripheral blood T lymphocyte subsets, and liver enzyme levels among the three groups were compared, and the correlation was further analyzed. Results Interleukin (IL-6), IL-8, IL-10, tumor necrosis factor (TNF), percentage of CD8+, absolute count of CD3+, absolute count of CD8+, glutamic-pyruvic transaminase (GPT), and glutamic-oxaloacetic transaminase (GOT) in HBV DNA low and high load groups were higher than those in HBV DNA negative group, percentage of CD4+, absolute count of CD4+, CD4+/CD8+ were lower than those in HBV DNA negative group (P＜0.05). The levels of IL-6, IL-8, IL-10, TNF, GPT, GOT, and percentage of CD8+ in HBV DNA high load group were higher than those in HBV DNA low load group, and the percentage of CD4+, absolute count of CD3+, absolute count of CD4+, absolute count of CD8+, CD4+/CD8+ were lower than those in HBV DNA low load group (P＜0.05). Correlation analysis showed that the levels of IL-6, IL-10, and TNF were positively correlated with GPT and GOT in patients with chronic hepatitis B (r＞0, P＜0.05). Conclusion HBV infection causes changes in the levels of inflammatory factors, T lymphocyte subsets and liver enzymes in patients with chronic hepatitis B. Some inflammatory factors are correlated with liver enzymes, which may promote the immune cascade in the body.
		2023 Vol. 20 (25): 90-93 [Abstract] ( 14 ) HTML (1 KB) PDF (493 KB) ( 52 )

	94	Effect of family pharmacist service model on patients with stable chronic obstructive pulmonary disease
		XU Hui RUAN Weifeng▲ MA Tianhong LI Liang FAN Xiaoliang
		DOI: 10.20047/j.issn1673-72102023.25.20
		Objective To explore the effect of family pharmacist service model on patients with stable chronic obstructive pulmonary disease (COPD). Methods A total of 80 COPD patients with grade B and C of global initiative for COPD were selected from Jiaxing Traditional Chinese Medicine Hospital, Zhejiang Province from April 2019 to March 2020, and they were divided into observation group and control group according to random number table method, with 40 patients in each group. The observation group received the family pharmacist service, and the control group received routine medical treatment. Both groups were followed up for one year. The scores of medication compliance, St. George’s respiratory questionnaire (SGRQ), COPD assessment test (CAT) before and after intervention were compared between the two groups, and the differences in acute exacerbations between the two groups were compared. Results In the observation group, four cases were lost to follow-up, and 36 cases were finally included. In the control group, two cases were lost to follow-up, and 38 cases were finally included. After intervention, the medication compliance scores of both groups were higher than those before intervention, and those of observation group were higher than those of control group, the differences were statistically significant (P＜0.05). After intervention, the scores of SGRQ, CAT, and acute exacerbations in two groups were lower than those before intervention, and those of observation group were lower than those of control group, the differences were statistically significant (P＜0.05). Conclusion The family pharmacist service model can effectively improve the medication compliance of patients with stable COPD, promote the rational and standardized drug use of patients, and the clinical application of value.
		2023 Vol. 20 (25): 94-98 [Abstract] ( 20 ) HTML (1 KB) PDF (781 KB) ( 64 )

	99	Effect of Nd∶YAG pulsed laser combined with recombinant human basic fibroblast growth factor on recurrent herpes labialis
		ZHOU Lijing DAI Dongxiao SHI Yahong
		DOI: 10.20047/j.issn1673-72102023.25.21
		Objective To evaluate the effect of Nd∶YAG pulsed laser combined with recombinant human basic fibroblast growth factor (rh-bFGF) on recurrent herpes labialis. Methods A total of 94 patients with recurrent herpes labialis who were treated in Shijiazhuang Second Hospital from January 2020 to February 2021 were selected, and they were divided into control group and observation group by random number table method, with 47 cases in each group. The control group was treated with simple Nd∶YAG pulsed laser, while observation group was treated with Nd∶YAG pulsed laser combined with rh-bFGF. The clinical effect and wound healing status (Vancouver scar scale [VSS] score, herpes disappearance time, wound healing time, and scab shedding time] between two groups were compared; the levels of plasma transforming growth factor-β1(TGF-β1), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), macrophage inflammatory protein-1 (MIP-1), monocyte chemoattractant protein-1 (MCP-1), Toll-like receptor (TLR) 2, and TLR9 before and after treatment between two groups were compared. Results The efficacy of observation group was better than that of control group, and the difference was statistically significant (P＜0.05). The VSS score of observation group was lower than that of control group, and the herpes disappearance time, wound healing time, and scab shedding time of observation group were shorter than those of control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of plasma TGF-β1, bFGF, and VEGF between two groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of plasma of MIP-1, MCP-1, TLR2, and TLR9 of two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P＜0.05). Conclusion Nd∶YAG pulsed laser combined with rh-bFGF is effective in the treatment of recurrent herpes labialis, which can promote wound healing, and its mechanism is related to promoting the generation of TGF-β1, bFGF, and VEGF, inhibiting the generation of MIP-1, MCP-1, TLR2, and TLR9, thus eliminating local inflammation.
		2023 Vol. 20 (25): 99-102 [Abstract] ( 18 ) HTML (1 KB) PDF (604 KB) ( 21 )

	103	Expression and clinical significance of Toll-like receptor 4 and nuclear factor-κB p65 in skin lesions of patients with condyloma acuminatum
		ZHU Zhou GU Liqun REN Qi　HUA Hui GU Li
		DOI: 10.20047/j.issn1673-72102023.25.22
		Objective To investigate the expression and clinical significance of Toll like receptor 4 (TLR4) and nuclear factor-κB p65 (NF-κB p65) in skin lesions of patients with condyloma acuminatum. Methods Ninety-two patients with condyloma acuminatum treated in Nantong Third People’s Hospital of Jiangsu Province (hereinafter referred to as “our hospital”) from January 2020 to August 2022 were selected as the observation group, and 55 adult males who underwent circumcision and 37 adult females who underwent vulvoplasty in our hospital during the same period were selected as the control group. The expressions of TLR4 and NF-κB p65 protein in skin lesions of the observation group and skin tissues of the control group were detected by immunohistochemical staining. The differences in TLR4 and NF-κB p65 protein expression between the two groups were compared, and the differences in TLR4 and NF-κB p65 protein expression in patients with different clinical characteristics of the observation group were further analyzed. Results The positive rates of expression of TLR4 and NF-κB p65 in observation group were higher than those in control group (P＜0.05). The positive rate of expression of TLR4 protein in patients with disease course ≥ 3 months, number of warts ≥ 10, and maximum diameter of warts ≥10 mm were higher than those in patients with disease course ＜ 3 months, number of warts ＜ 10, and maximum diameter of warts ＜ 10 mm (P＜0.05). The positive rate of expression of NF-κB p65 protein in patients with number of warts ≥ 10 and maximum diameter of ≥10 mm were higher than those in patients with number of warts ＜ 10 and maximum diameter of ＜ 10 mm (P＜0.05). Conclusion The high expression of TLR4 and NF-κB p65 proteins in the skin lesions of patients with condyloma acuminatum may be related to the number of warts, the maximum diameter of warts, and the course of disease.
		2023 Vol. 20 (25): 103-106 [Abstract] ( 15 ) HTML (1 KB) PDF (842 KB) ( 124 )

	107	Clinical effect of ultrasound-guided percutaneous taxol coated balloon dilation in the treatment of internal arteriovenous fistula stenosis
		ZHANG Ce ZHOU Feihong XU Xiaohong WANG Junsheng
		DOI: 10.20047/j.issn1673-72102023.25.23
		Objective To investigate the clinical effect of ultrasound-guided percutaneous taxol coated balloon dilation in the treatment of internal arteriovenous fistula stenosis. Methods A total of 112 patients with internal arteriovenous fistula stenosis in the Department of Nephrology, Nanjing Gulou Hospital Group Suqian Hospital from December 2020 to December 2022 were selected and divided into general group and drug group according to random number table method, with 56 patients in each group. Ultrasound-guided percutaneous selective balloon dilatation was performed in both groups, in which the conventional group was dilated by conventional balloon and the drug group was dilated by taxol coated balloon. The stenosis diameter and dialysis blood flow of the two groups were compared before and one week after surgery. The success rate and complication rate of the two groups were evaluated one month after surgery, and the total incidence of restenosis of the two groups was evaluated at nine months after surgery. Results At one week after surgery, the stenosis diameter and dialysis blood flow in two groups were higher than those before surgery, and those of the drug group were higher than those of general group (P＜0.05). The success rate of surgery in drug group was higher than that in general group (P＜0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). At nine months after surgery, the total incidence of restenosis in the drug group was lower than that in the general group (P＜0.05). Conclusion Ultrasound-guided percutaneous taxol coated balloon dilation in patients with internal arteriovenous fistula stenosis can improve the stenosis diameter and dialysis blood flow, improve the success rate of surgery, reduce the rate of postoperative restenosis, and have high safety.
		2023 Vol. 20 (25): 107-110 [Abstract] ( 14 ) HTML (1 KB) PDF (578 KB) ( 56 )

	111	Effect of group class-based sensory integration training in male patients with chronic schizophrenia
		HUANG Mei ZHU Ming WU Shanghui
		DOI: 10.20047/j.issn1673-72102023.25.24
		Objective To explore the effect of group class-based sensory integration training in male patients with chronic schizophrenia. Methods A total of 80 male patients with chronic schizophrenia treated in Wuhu Fourth People’s Hospital, Anhui Province from July to December 2021 were selected and divided into control group and experimental group according to random number table method, with 40 cases in each group. The control group received conventional sensory integration training, and the experimental group received group class-based sensory integration training. The intervention time of both groups was three months. The scores of the brief psychiatric rating scale (BPRS), social disability screening schedule (SDSS), nurses observation scale for inpatient evaluation-30 (NOSIE-30), schizophrenia quality of life scale (SQLS), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) were compared before and after the intervention. The differences between scores of measurement and treatment research to improve cognition in schizophrenia consensus cognitive battery of two groups after intervention were compared. Results After intervention, the BPRS, SDSS, SQLS, SAS, and SDS scores of the two groups were lower than those before intervention, and those of the experimental group were lower than those of the control group (P＜0.05). After intervention, the NOSIE-30 scores of the two groups were higher than those before intervention, and those of the experimental group were higher than those of the control group (P＜0.05). The scores of categorical fluency, continuous operation, spatial span, spatial memory, word learning, and emotion management in experimental group were higher than those in control group (P＜0.05). Conclusion Sensory integration training based on group class not only improves the initiative and self-care ability of male patients with chronic schizophrenia, but also improves the cognitive function of the patients.
		2023 Vol. 20 (25): 111-114 [Abstract] ( 12 ) HTML (1 KB) PDF (557 KB) ( 18 )

	115	Application effect of spontaneous ventilation general anesthesia with laryngeal mask in patients for thoracoscopic surgery
		KONG Xiangang1 WEI Yutao2 LIU Manman1 SONG Chengwei1▲
		DOI: 10.20047/j.issn1673-72102023.25.25
		Objective To explore the application effect of spontaneous ventilation general anesthesia with laryngeal mask in patients for thoracoscopic surgery. Methods Sixty patients undergoing thoracoscopic surgery in Jining No.1 People’s Hospital, Shandong Province from January to June 2022 were selected. They were divided into observation group and control group, with 30 cases in each group. Observation group took spontaneous ventilation general anesthesia with laryngeal mask, and control group took general anesthesia with double-lumen tube. The operation time, mean arterial pressure difference before and after intubation, heart rate difference before and after intubation, intraoperative general anesthetic dosage, minimum pulse oxygen saturation (SpO2), maximum end-tidal carbon dioxide pressure (PetCO2), surgical field exposure score, mediastinal oscillation, and incidence of cough were compared between two groups; arterial oxygen pressure (PaO2) and arterial carbon dioxide pressure (PaCO2) before anesthesia (T0), 30 min after thoracotomy (T1), and 30 min after chest closure (T2) were compared between two groups; the time of the postoperative extubation, anesthesia recovery room stay, the first time out of bed, chest tube retention, and postoperative hospitalization were compared between two groups; and the incidence of postoperative anesthesia-related complications and pulmonary complications were compared between two groups. Results Mediastinal oscillation was not observed in the two groups. The mean arterial pressure difference and heart rate difference before and after intubation in observation group were lower than those in control group, the intraoperative dosage of Remifentanil and Sufentanil were lower than those in control group, the maximum PetCO2 and the incidence of cough were higher than those in control group, and the differences were statistically significant (P＜0.05); there were no significant differences in operation time, minimum SpO2, and surgical field exposure score between two groups (P＞0.05). The pairwise comparison of PaO2 between two groups at different time points had statistical significance (P＜0.05). At T1-T2, PaCO2 in control group was higher than that at T0, and the difference was statistically significant (P＜0.05); the pairwise comparison of PaCO2 at different time points in observation group had statistical significance (P＜0.05). At T1, PaCO2 in observation group was higher than that in control group, and the difference was statistically significant (P＜0.05). The time of postoperative extubation, anesthesia recovery room stay, the first time out of bed, chest tube retention, and postoperative hospitalization in observation group were shorter than those in control group, and the differences were statistically significant (P＜0.05). The total incidence of postoperative anesthesia-related complications and pulmonary complications in observation group were lower than those in control group, and the differences were statistically significant (P＜0.05). Conclusion The application of spontaneous ventilation general anesthesia with laryngeal mask in thoracoscopic surgery can alleviate the reaction of intubation during induction, reduce the amount of general anesthesia during operation, reduce postoperative complications and promote rapid recovery.
		2023 Vol. 20 (25): 115-119 [Abstract] ( 14 ) HTML (1 KB) PDF (658 KB) ( 29 )

	120	Professor Zhang Peitong’s experience in differentiation and treatment of pancreatic cancer from disease-syndrome-symptom mode
		ZHANG Ruoqi1 ZANG Xiaotong2 ZHANG Zheng1 MIAO Rui1 WANG Jing1 HUANG Rong1 ZHANG Peitong2
		DOI: 10.20047/j.issn1673-72102023.25.26
		This article mainly introduces Professor Zhang Peitong’s experience in the differentiation and treatment of pancreatic cancer from disease-syndrome-symptom mode. Professor Zhang believes that the pathogenesis of pancreatic cancer is based on root deficiency and branch excess. The deficiency should be distinguished the difference between qi, blood, yin, and yang, and the excess should be discriminated between primary and secondary among phlegm, blood stasis, qi stagnation, heat, and toxicity. The treatment focus should be adjusted according to specific situation. The disease location is mainly in spleen, which is closely related to liver. In the disease-syndrome-symptom mode, using self-prescripted Liujun Ermu Decoction can play the functions of strengthening the spleen and removing phlegm, clearing heat and detoxify, promoting blood and qi, which is corresponding to the pathogenesis of pancreatic cancer to achieve early curettage of disease progression. According to the rules of disease progression, the common three stages and six syndromes and corresponding prescriptions are summarized. Accurate differentiation of syndroms is the prerequisite and key to obtain curative effect. For the symptoms and signs that seriously affect the quality of life of patients, timely intervention should be conducted and treatment according to the symptoms can create conditions for subsequent treatment. In clinical practice, the disease-syndrome-symptom mode should be flexibly applied in the whole process of treatment in order to improve the clinical effect of pancreatic cancer.
		2023 Vol. 20 (25): 120-123,142 [Abstract] ( 12 ) HTML (1 KB) PDF (877 KB) ( 19 )

	124	Jiao Yongzheng’s experience in treating erectile dysfunction combined with insomnia from “disharmony between yin and yang”
		LUO Chenglong1 CAO Yan2 SU Liang1 CHENG Haoyang1 ZHANG Sizheng1 JIAO Yongzheng3
		DOI: 10.20047/j.issn1673-72102023.25.27
		This article mainly summarizes the experience of researcher Jiao Yongzheng in the treatment of erectile dysfunction combined with insomnia. Erectile dysfunction and insomnia are common clinical diseases, and they are closely related and often affect each other, which seriously endangers men’s health. Researcher Jiao Yongzheng based on the theory of yin and yang of traditional Chinese medicine, combined with many years of clinical experience, believes that the disharmony between yin and yang is the core pathogenesis of this disease, secondary pathological transformation such as phlegm turbidness, blood stasis, collateral damage, and intermingled deficiency and excess. The four therapeutic principles of clinical diagnosis were put forward, the first is to tonify kidney and calm the mind, harmonize yin and yang; the seconnd is to invigorate spleen and eliminate phlegm, activate blood and clear collaterals; the third is to fill the essence and nourish collaterals, and moisten convergent tendon; the fourth is to move in order to start the static, and to lead the medicine to the penile. Keep the pathogenesis, play a harmonizing yin and yang, invigorate impotence, and attached a representative test case, in order to provide clinical ideas for reference.
		2023 Vol. 20 (25): 124-128 [Abstract] ( 15 ) HTML (1 KB) PDF (797 KB) ( 26 )

	129	Professor Zhao Haibin’s experience in treating chronic heart failure combined with depression based on “yang qi, essence nourishes the spirit, and gentleness nourishes the tendons” theory
		LI Dongfang1 WANG Chao1 ZHAO Haibin1 HOU Jiqiu1 DING Wanli2 SHI Jinyu2 GAO Yaru1
		DOI: 10.20047/j.issn1673-72102023.25.28
		Chronic heart failure combined with depression is a common dual heart disease in clinical practice, and the treatment effect of traditional Chinese medicine is significant. “Yang qi, essence nourishes the spirit, and gentleness nourishes the tendons” is from Suwen·Shengqi Tongtian Lun. Based on the theory, Professor Zhao Haibin thinks that the core pathogenesis of chronic heart failure combined with depression is root deficiency empty and manifestation excess. “Insufficient heart yang” is the root and initial factor of the disease. “Blood stasis”, “retained fluid”, and “depression” are the symptoms and key pathological factors. In terms of treatment, Professor Zhao Haibin advocates “warming yang and benefiting the heart” to treat its root cause, “removing blood stasis and promoting water circulation, nourishing the heart and calming the mind” to heal its manifestation, and the clinical application of Linggui Zhugan Shuangxin Fang has a good therapeutic effect.
		2023 Vol. 20 (25): 129-133 [Abstract] ( 14 ) HTML (1 KB) PDF (797 KB) ( 14 )

	134	Influence of cognitive behavioral therapy intervention combined with yin and yang regulating moxibustion on menopausal obese patients
		HUANG Bei ZHANG Lihua WANG Yun LIU Zhi LUO Xiang LI Caihong ZHOU Zhongyu▲
		DOI: 10.20047/j.issn1673-72102023.25.29
		Objective To explore the influence of cognitive behavioral therapy intervention combined with yin and yang regulating moxibustion on menopausal obese patients. Methods A total of 80 menopausal obese patients admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from January 2021 to June 2022 were selected as research subjects and they were divided into the control group and the observation group according to the random paper method, with 40 cases in each group. The control group was given cognitive behavioral therapy intervention combined with moxibustion. The observation group was given cognitive behavioral therapy intervention combined with yin and yang regulating moxibustion. The body mass index (BMI), hip circumference, the waist circumference, qi deficiency symptom score, and the impact of weight on quality of life-life(IWQOL-Lite) score were compared. Results Before intervention, there were no significant differences in BMI, hip circumference, waist circumference, qi-deficiency symptom score and IWQOL-Lite score between the two groups (P＞0.05). After intervention, BMI, hip circumference, waist circumference, qi-deficiency symptom score, and IWQOL-Lite score in two groups were lower than before intervention, and observation group was lower than control group, the differences were statistically significant (P＜0.05). Conclusion Cognitive behavior therapy intervention combined with yin-yang conditioning moxibustion can improve menopausal obesity symptoms, improve qi deficiency symptom and IWQOL-Lite score, it is worth to be used.
		2023 Vol. 20 (25): 134-137 [Abstract] ( 10 ) HTML (1 KB) PDF (632 KB) ( 31 )

	138	Clinical effect of Tiaoshen acupuncture in patients with refractory sudden deafness
		SUN Lianzhu1 DING Dingming1 PAN Meng1 LI Sikang1 YU Lijun1 MA Ruijie2
		DOI: 10.20047/j.issn1673-72102023.25.30
		Objective To investigate the clinical effect of Tiaoshen acupuncture in patients with refractory sudden deafness. Methods Patients with refractory sudden deafness treated in Department of Acupuncture and Moxibustion, Wuhu Municipal Hospital of Traditional Chinese Medicine, Anhui Province from January 2021 to December 2022 were selected as the study objects, and they were divided into control group and treatment group according to random number table method, with 30 cases in each group. The control group was treated with electric nape needles, and the treatment group was treated with Tiaoshen acupuncture (acupoints: bǎihuì, běnshén, nèiguān, shénmén, sānyīnjiāo) on this basis. Both groups were treated once a day, five times a week. Hearing threshold level, Pittsburgh sleep quality index (PSQI) and self-rating anxiety scale (SAS) scores were performed before treatment, one, two, and four weeks after treatment, respectively, and clinical efficacy was evaluated four weeks after treatment. Results Overall analysis showed that comparison between groups, comparison at time points and interaction of PSQI scores and SAS scores between the two groups were statistically significant (P＜0.05). Intra-group comparison: there was statistical significance in PSQI scores of the treatment group at all times (P＜0.05). The PSQI score of the control group after two and four weeks of treatment was lower than that before and after one week of treatment, and the PSQI score after four weeks of treatment was lower than that after two weeks of treatment, the differences were statistically significant (P＜0.05). The SAS scores of the two groups after two and four weeks of treatment were lower than those before and after one week of treatment, and the SAS scores after four weeks of treatment were lower than those after two weeks of treatment, the differences were statistically significant (P＜0.05). Inter-group comparison: After one, two, and four weeks of treatment, PSQI scores in the treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05). After two and four weeks of treatment, SAS scores in the treatment group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Overall analysis showed that comparison between groups, comparison at time points and interaction of the average hearing threshold value between the two groups were statistically significant (P＜0.05). Intra-group comparison: after two and four weeks of treatment, the average hearing threshold value of the two groups was lower than that before and after one week of treatment, and the average hearing threshold value after four weeks of treatment was lower than that after two weeks of treatment, the differences were statistically significant (P＜0.05). Inter-group comparison: after two weeks and four weeks of treatment, the average hearing threshold value in the treatment group was lower than that in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in clinical efficacy between the two groups (P＞0.05). Conclusion Tiaoshen acupuncture combined with electric nape needles improved the average hearing threshold of patients with refractory sudden deafness more significantly than that of the simple electric nape needles group, which was related to the improvement of sleep quality and anxiety state of patients with Tiaoshen acupuncture, and the two had a synergistic effect.
		2023 Vol. 20 (25): 138-142 [Abstract] ( 20 ) HTML (1 KB) PDF (699 KB) ( 11 )

	143	Clinical effect of acupuncture and massage along meridians on children with spastic cerebral palsy
		LI Xiaomeng GUAN Xia ZHENG Hong
		DOI: 10.20047/j.issn1673-72102023.25.31
		Objective To explore the clinical effect of acupuncture and massage along the meridian in the treatment of spastic cerebral palsy in children. Methods A total of 90 children with spastic cerebral palsy admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from January 2020 to April 2022 were selected and they were divided into the control group and the study group according to the random number table, with 45 cases in each group. Both groups were treated with routine rehabilitation. The control group was treated with Botulinum Toxin A on this basis, and the study group was treated with acupuncture and massage along meridians on the basis of the control group. After three months of treatment, the clinical efficacy of the two groups was evaluated, and the clinical spasticity index (CSI), fine motor development motor scale-fine motor (PDMS-FM), gross motor function (GMFM), and modified Ashworth scale (MAS) scores before and after treatment were compared. Results The clinical efficacy of the study group was better than that of the control group (P＜0.05). After treatment, the scores of PDMS-FM and GMFM in the two groups were higher than those before treatment, and the study group were higher than those in the control group (P＜0.05). After treatment, the upper and lower limb MAS scores in the two groups were lower than before treatment, and the study group were lower than those in the control group (P＜0.05). After treatment, the scores of clonus, muscle tension, tendon reflex, and CSI in the two groups were lower than those before treatment, and the study group were lower than those in the control group (P＜0.05). Conclusion Acupuncture and massage along meridians has a better therapeutic effect on children with spastic cerebral palsy, which can effectively alleviate the muscle spasticity and improve the motor function of children.
		2023 Vol. 20 (25): 143-146,151 [Abstract] ( 14 ) HTML (1 KB) PDF (718 KB) ( 45 )

	147	Visual analysis of acupoint massage for chemotherapy induced nausea and vomiting based on CiteSpace
		HU Xiaowei1 FANG Haiyan1▲ WANG Xiang1 MA Guiyue1 XU Hongxia2 GAO Mingzhu2
		DOI: 10.20047/j.issn1673-72102023.25.32
		Objective To explore the research hotspot and development trend of acupoint massage (AM) in the treatment of chemotherapy-induced nausea and vomiting (CINV) by using CiteSpace software. Methods The relevant literatures on AM treatment of CINV from CNKI database were retrieved from the establishment of the database to December 31, 2021 and visualized by CiteSpace 6.1.R2 software. Results A total of 176 related literatures were included, and the number of publications showed an increasing trend. Zhang Yali published the most articles. The main research institutions were Jiangsu Province Hospital of Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Jiangsu Provincial Subei People’s Hospital and other institutions. The main keywords were chemotherapy, acupoint massage, vomiting and there were 10 types of keywords cluster; the research focus was mainly on the effect of acupoint massage on gastrointestinal function and immune function. Conclusion The research on AM treatment of CINV is heating up gradually, and high-quality research is still needed to explore the standard treatment regimen, objective evaluation indicators, and internal mechanism of action
		2023 Vol. 20 (25): 147-151 [Abstract] ( 14 ) HTML (1 KB) PDF (1593 KB) ( 135 )

	152	Application of buccal acupuncture therapy in patients with dysphagia after simultaneous radiochemotherapy of nasopharyngeal carcinoma
		YANG Xinzhu1 CHEN Qing2▲
		DOI: 10.20047/j.issn1673-72102023.25.33
		Objective To explore the application of buccal acupuncture therapy in patients with dysphagia after simultaneous radiochemotherapy of nasopharyngeal carcinoma. Methods A total of 180 patients with dysphagia after simultaneous radiochemotherapy of nasopharyngeal carcinoma admitted in the First Affiliated Hospital of Hunan University of Chinese Medicine from January 2020 to January 2022 were selected and they were divided into rehabilitation group and combination group according to the random number table method, with 90 cases in each group. The rehabilitation group was treated with perioral rehabilitation training, and the combination group was treated with buccal acupuncture on the basis of the rehabilitation group, the treatment lasted for two months. The efficacy and satisfaction of the two groups after two months of treatment were compared, and the gugging swallowing function (GUSS) score and swallowing-quality of life (SWAL-QOL) score in Chinese version of the two groups before and after treatment were compared. Results After two months of treatment, the curative effect of the combination group was better than that of the rehabilitation group (P＜0.05); the GUSS score and SWAL-QOL score in both groups increased compared with before treatment, and the combination group was higher than the rehabilitation group (P＜0.05); the satisfaction of the combination group was higher than that of the rehabilitation group (P＜0.05). Conclusion The effect of buccal acupuncture therapy combined with perioral rehabilitation training on dysphagia patients with nasopharyngeal carcinoma after simultaneous radiochemotherapy is better, which can improve the swallowing function and the quality of life, and improve the treatment satisfaction of patients.
		2023 Vol. 20 (25): 152-155 [Abstract] ( 13 ) HTML (1 KB) PDF (546 KB) ( 35 )

	156	Study of ultrasound parameters and clinical value of stellate ganglion block based on C6 and C7 pathway
		CHU Xiaoai1 WANG Junli1 HU Aili1 LU Dasheng2 XIA Qinzhong2▲
		DOI: 10.20047/j.issn1673-72102023.25.34
		Objective To investigate the clinical application value of stellate ganglion block (SGB) based on C6 and C7 transverse process approach. Methods A total of 108 healthy subjects who underwent cervical ultrasound examination in Wuhu Hospital Affiliated to East China Normal University from June 2021 to November 2022 were selected, ultrasonic data of C6 and C7 transverse process simulated puncture were recorded. Forty-five patients with ultrasound-guided SGB in the Second Affiliated Hospital of Wannan Medical College from August 2021 to October 2022 were selected as the study objects, the patient received SGB based on C6 and C7 transversal process approach. The puncture success rate, SGB success rate, visual analog scale (VAS) score, and related complications of different approaches were compared. Results There were no significant differences between the left and right of C6 transverse process in the distance from anterior tubercle to carotid artery, the distance from anterior tubercle to jugular vein, and the distance from longus cervical muscle to vagus nerve (P＞0.05). There was no significant difference between the left and right of C7 transverse process in the distance from vertebral vein to carotid artery, the distance from vertebral vein to jugular vein, and the distance from longus cervical muscle to vagus nerve (P＞0.05). The width of the artery window, the width of the vein window, and the distance from longus cervical muscle to vagus nerve in C7 transversal process approach were longer than those in C6 transversal process approach; the proportion of arterial window width＜5 mm and venous window width ＜5 mm on C7 transversal process approach were lower than those on C6 transversal process approach, and the differences were statistically significant (P＜0.05). Successful puncture through different approaches and Horner’s syndrome was occurred. The puncture success rate of C7 transversal process was higher than that of C6 transversal process, and the VAS score was lower than that of C6 transversal process, and the differences were statistically significant (P＜0.05). There was no significant difference in hoarseness rate among different approaches (P＞0.05). Conclusion Ultrasound-guided SGB through C7 transverse process approach is more valuable than C6 transverse process approach, and is worth popularizing.
		2023 Vol. 20 (25): 156-159,163 [Abstract] ( 14 ) HTML (1 KB) PDF (934 KB) ( 142 )

	160	Comparison of diagnostic efficiency of contrast-enhanced ultrasound and MRI-DWI in benign and malignant soft tissue tumors
		FENG Yingying ZHAO Si▲ ZONG Yuan
		DOI: 10.20047/j.issn1673-72102023.25.35
		Objective To compare the diagnostic efficiency of contrast-enhanced ultrasound and MRI-diffusion weighted imaging (DWI) in benign and malignant soft tissue tumors. Methods The clinical data of 189 patients with soft tissue tumors who received diagnosis and treatment in Shijiazhuang People’s Hospital from December 2020 to November 2021 were retrospectively analyzed. All patients underwent contrast-enhanced ultrasound and MRI-DWI examination before surgery. The diagnostic efficiency of contrast-enhanced ultrasound and MRI-DWI in benign and malignant soft tissue tumors was analyzed with pathological results as the gold standard; the apparent diffusion coefficient (ADC) and relative apparent diffusion coefficient (rADC) of benign and malignant soft tissue tumors were compared, and the correlation between the properties of soft tissue tumors and ADC and rADC was analyzed. Results Among 189 patients, 62 were malignant soft tissue tumors. The sensitivity, specificity, and accuracy of contrast-enhanced ultrasound in the diagnosis of malignant soft tissue tumor were 77.42%, 74.02%, and 75.13%; the sensitivity, specificity, and accuracy of MRI-DWI in the diagnosis of malignant soft tissue tumors were 88.71%, 97.64%, and 94.71%. ADC and rADC in benign soft tissue tumors were higher than those in malignant soft tissue tumors (P＜0.05). The properties of soft tissue tumors (benign=0, maliganant=1) were negatively correlated with ADC and rADC (r＜0, P＜0.05). Conclusion The diagnostic efficiency of mRI-DWI in the diagnosis of benign and malignant soft tissue tumors is higher than that of contrast-enhanced ultrasound, which can provide more reliable and effective objective data reference for clinical diagnosis.
		2023 Vol. 20 (25): 160-163 [Abstract] ( 12 ) HTML (1 KB) PDF (818 KB) ( 138 )

	164	Discussion on rational drug equipping scheme of hospital ward rescue vehicles
		WANG Fang1 LIU Qingxiang1 YANG Moyuan1 WANG Xinhui1 ZHENG Jun1 WANG Yawei1 MA Xuehua2▲
		DOI: 10.20047/j.issn1673-7210.2023.25.36
		Objective To analyze the use of the drug types and quantity of the rescue car in hospital ward, and to provide methods and suggestions for rational allocation of drugs in the rescue car. Methods Big data analysis method was used to extract and analyze the variety and quantity of drugs used in large and medium-sized rescue in a Grade-Ⅲ hospital from April 2021 to April 2022, and statistically calculate the utilization rate, convenient use frequency, the rate of meeting the rescue demand, and the use of varieties inside and outside the rescue vehicle. And the use of quartile method, according to 75% of the points to determine the number of varieties equipped with emergency vehicles, the use of Plato method to determine the rescue vehicle should be equipped with varieties. Statistics were made on the outside access of emergency vehicles after optimization, and the rationality of the optimization scheme was verified. Results The utilization rate of rescue vehicle was 62.22%, and that of outpatient medical technology department was 0. The rate of fully meeting the rescue demand was 30.65%. The dose of epinephrine was adjusted from 10 to 17, and the dose of Dopamine Hydrochloride Injection was adjusted from ten to nine. With the application of Plato analysis, it was concluded that in addition to keeping the drugs in the original fixed template, another seven drugs outside the list were equipped as unified equipment. Human blood albumin, and other varieties were added according to the drug characteristics of hepatobiliary surgery, geriatrics and other departments. The proportion of drugs was used outside emergency vehicles with optimized equipment decreased from 44% to 11%, which better met the needs of clinical first aid. Conclusion Using scientific statistical methods to optimize the emergency vehicle allocation scheme can accurately meet the emergency needs.
		2023 Vol. 20 (25): 164-167,181 [Abstract] ( 13 ) HTML (1 KB) PDF (804 KB) ( 48 )

	168	Effect of follow-up management based on 4R model on rehabilitation effect and quality of life of patients after total knee arthroplasty
		ZHONG Wei SUN Wenlin▲ SHEN Xiaowen
		DOI: 10.20047/j.issn1673-72102023.25.37
		Objective To explore the effect of follow-up management based on 4R model on the rehabilitation effect and quality of life of patients after total knee arthroplasty. Methods A total of 94 patients undergoing total knee arthroplasty were selected from the Rehabilitation Center, Huaian First People’s Hospital, Jiangsu Province from October 2018 to October 2021. According to random number table method, the patients were divided into control group and observation group, with 47 cases in each group. The control group was followed up by routine management, and the observation group was followed up by 4R model follow-up management. After discharge, the two groups were followed up by telephone once a week and outpatient once a month for a total of three months. Scores of visual analogue scale (VAS), hospital for special surgery (HSS), 36-item short form health surrey, short form 36, SF-36) quality of life score, and self-efficacy for rehabilition (SER) score were calculated before intervention, 1 and 3 months, respectively. Results There were significant differences in pain VAS between groups, time, and interaction between the two groups (P＜0.05). Further pound-for-pair comparison, intra-group comparison: VAS scores at 1 and 3 months of intervention in both groups were lower than before intervention, VAS scores at three months of intervention in both groups were lower than that at one month of intervention (P＜0.05). Comparison between groups: VAS scores of the observation group at 1 and 3 months of intervention were lower than those of the control group (P＜0.05). There were significant differences in HSS between groups, time, and interaction between the two groups (P＜0.05). Further pairwise comparison, intra-group comparison: HSS scores at 1 and 3 months of intervention in both groups were lower than those before intervention, and HSS scores at three months of intervention in both groups were lower than that at one month of intervention (P＜0.05). Inter-group comparison: the HSS scores of the observation group at 1 and 3 months of intervention were lower than those of the control group (P＜0.05). There were significant differences among groups, time, and interaction in SF-36 evaluation (P＜0.05). Further pairwise comparison, intra-group comparison: the scores of all dimensions in both groups at 1 and 3 months of intervention were higher than before intervention, and the scores of all dimensions in both groups at three months of intervention were higher than that at one month of intervention (P＜0.05). Inter-group comparison: the scores of all dimensions in the observation group were higher than those in the control group at 1 and 3 months after intervention (P＜0.05). There were significant differences in coping self-efficacy and task self-efficacy between groups, time, and interaction (P＜0.05). Further pairwise comparison, intra-group comparison: the scores of coping self- efficacy and task self-efficacy of both groups at 1 and 3 months of intervention were higher than those before intervention, and the scores of coping self-efficacy and task self-efficacy of both groups at three months of intervention were higher than those at one month of intervention (P＜0.05). Inter-group comparison: the coping self-efficacy and task self-efficacy scores of the observation group were higher than those of the control group after 1 and 3 months of intervention (P＜0.05). Conclusion 4R mode of follow-up management can effectively improve the rehabilitation effect of patients with total knee arthroplasty, reduce postoperative pain, and better improve the quality of life of patients, which can be popularized.
		2023 Vol. 20 (25): 168-172 [Abstract] ( 10 ) HTML (1 KB) PDF (652 KB) ( 15 )

	173	Influence of standardized communication combined with early warning mode on the prevention of complications and quality of life in patients with lung cancer chemotherapy
		LYU Yun YIN Yue▲
		DOI: 10.20047/j.issn1673-72102023.25.38
		Objective To explore the influence of standardized communication combined with early warning mode (EWM) on the prevention of complications and quality of life in patients with lung cancer chemotherapy. Methods A total of 100 patients with lung cancer treated by chemotherapy in the Department of Oncology, Jiangsu Provincial People’s Hospital from April 2019 to August 2021 were selected as the study object. According random number table method, the patients were divided into control group and observation group, with 50 cases in each group. The control group received routine nursing, on this basis the observation group conducted standardized communication and EWM. The incidence of complications and the quality of life at the time of admission （before intervention） and after eight weeks of intervention （after intervention） were observed. Results The incidence of nausea, vomiting, and leukopenia in observation group were lower than those in control group (P＜0.05); after intervention, the total score of quality of life instruments for cancer patients-lung cancer in both groups was higher than before intervention, and the observation group was higher than the control group (P＜0.05). Conclusion Standardized communication combined with EWM can help reduce the incidence of complications in patients with lung cancer undergoing chemotherapy, and has a positive role in promoting the effective improvement of their quality of life.
		2023 Vol. 20 (25): 173-176 [Abstract] ( 17 ) HTML (1 KB) PDF (692 KB) ( 15 )

	177	Influence of multidimensional intervention mode based on personality characteristic classification on the mental state and nutritional status of maintenance hemofiltration dialysis patients
		ZHAO Jun YANG Hongmei LI Nan ZHAO Shuangshuang ZHAO Hui ZHANG Zhiyong▲
		DOI: 10.20047/j.issn1673-72102023.25.39
		Objective To explore the influence of multidimensional intervention mode based on personality characteristic classification on the mental state and nutritional status of maintenance hemofiltration dialysis patients. Methods A total of 100 patients receiving maintenance hemofiltration dialysis in the Department of Nephrology, Sixth Medical Center, Chinese People’s Liberation Army General Hospital from June 2019 to July 2022 were selected as subjects. According to random number table method, the patients were divided into reference group and research group, with 50 cases in each group. The reference group was given routine nursing, and the research group was given multidimensional intervention mode based on personality characteristic classification. The changes of mental state and nutritional state of the two groups were observed after 28 d of intervention. Results After intervention, the scores of self-rating anxiety scale and self-rating depression scale in both groups were lower than those before intervention, and those of the study group were lower than those of the reference group, the differences were statistically significant (P＜0.05); after intervention, the levels of pre-albumin, total albumin, and albumin in both groups were higher than those before intervention, and those of the study group were higher than those of the reference group, the differences were statistically significant (P＜0.05). Conclusion During the treatment of patients with maintenance hemofiltration dialysis, multidimensional nursing intervention based on personality characteristics classification can help patients effectively improve their psychological state, improve the therapeutic effect and improve the nutritional status of the body.
		2023 Vol. 20 (25): 177-181 [Abstract] ( 10 ) HTML (1 KB) PDF (722 KB) ( 15 )

	182	Application effect of psychological resilience support combined with humanized nursing in perioperative period of endoscopic retrograde cholangiopancreatography
		SHI Xiaohong
		DOI: 10.20047/j.issn1673-72102023.25.40
		Objective To investigate the application effect of psychological resilience support combined with humanized nursing in the perioperative period of endoscopic retrograde cholangiopancreatography (ERCP). Methods A total of 80 patients who received ERCP treatment in Fuyang People’s Hospital of Fuyang City, Anhui Province from June 2020 to July 2022 were selected for the study and divided into study group (40 cases) and control group (40 cases) according to random number table method. The control group received routine nursing, and the study group received psychological resilience support combined with humanized nursing. After seven days of nursing, the scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS), Conner-Davideson resilience scale (CD-RIS) and Pittsburgh sleep quality index (PSQI) before and after nursing were compared between the two groups, and the hospitalization time and hospital cost were recorded and compared between the two groups. Results After nursing, SAS and SDS scores of the two groups were lower than those before nursing, while those of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The score of CD-RIS in the two groups was higher than that before nursing, and the study group was higher than the control group, and the differences were statistically significant (P＜0.05). The hospitalization time of the study group was shorter than that of the control group, and the hospitalization cost was lower, and the differences were statistically significant (P＜0.05). After nursing, the scores of sleep quality, sleep time, sleep time, sleep efficiency, sleep disorders, hypnotic drugs, and daytime function in the two groups were lower than before nursing, while those of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion The application of psychological resilience support combined with humanized nursing in perioperative period of ERCP can effectively reduce patients’ depression and anxiety, improve patients’ sleep quality, and is worth promoting.
		2023 Vol. 20 (25): 182-185 [Abstract] ( 13 ) HTML (1 KB) PDF (563 KB) ( 10 )

	186	Effect of photon therapy on perianal edema after hemorrhoid surgery
		KONG Lingmei LIAO Lifang HU Kaibing
		DOI: 10.20047/j.issn1673-72102023.25.41
		Objective To explore the effect of photon therapy on perianal edema after hemorrhoid surgery. Methods A total of 80 patients with mixed hemorrhoids undergoing procedure for prolapse and hemorrhoids(PPH) and external hemorrhoidectomy were selected from the Hefei Second People’s Hospital, Anhui Province from January 2020 to December 2021. According to random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group was treated with routine wound disinfection, dressing and nursing, and the observation group was treated with photon therapy on the basis of the control group. Perianal edema, bleeding, pain, wound seepage, wound healing, and hospital stay of the two groups were observed. Results After seven days of intervention, perianal edema, bleeding, pain, and wound seepage scores in both groups were lower than before intervention, while those of observation group were lower than those of control group, and the differences, were statistically significant (P＜0.05); incision healing in the observation group was better than that in the control group, the difference was statistically significant (P＜0.05); there was no significant difference in hospitalization days between the two groups (P＞0.05). Conclusion Photon therapy can relieve perianal edema and bleeding in patients with hemorrhoids, improve postoperative pain and wound seepage, and promote postoperative incision healing.
		2023 Vol. 20 (25): 186-189 [Abstract] ( 14 ) HTML (1 KB) PDF (658 KB) ( 12 )

	190	Application of humanistic care service based on Kano model during chemotherapy for esophageal cancer
		QIAN Aixin YANG Yan▲ LIU Jiangli
		DOI: 10.20047/j.issn1673-72102023.25.42
		Objective To explore the application effect of humanistic care service based on Kano model (KANO) during esophageal cancer chemotherapy. Methods The nursing status of 82 patients undergoing chemotherapy for esophageal cancer in the Department of Oncology, Anqing Municipal Hospital, Anhui Province from January 2020 to July 2022 was studied. According to random number table method, they were divided into control group (41 cases) and observation group (41 cases). The control group was treated with routine nursing, and the observation group was treated with humanistic care service based on KANO model. From the beginning of patient admission, nursing to discharge, the self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score and spitzer simple quality of life scale (SQLI) score of the two groups were compared and analyzed after the end of nursing, and the incidence of adverse reactions and patients’ satisfaction with nursing were compared and analyzed. Results After nursing, SAS and SDS scores of the two groups were lower than those before nursing, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After nursing, the scores of daily life, life experience, health experience, activity ability, and family support in the two groups were higher than those before nursing, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). The nursing satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Humanistic care service based on KANO model can improve the quality of life of patients during the chemotherapy of esophageal cancer, and it is worth promoting.
		2023 Vol. 20 (25): 190-193 [Abstract] ( 16 ) HTML (1 KB) PDF (551 KB) ( 58 )

	194	Application value of health literacy intervention based on knowledge, belief and practice model in hemodialysis patients
		WANG Hongcui WANG Yuanyuan
		DOI: 10.20047/j.issn1673-72102023.25.43
		Objective To explore the application value of health literacy intervention based on knowledge attitude belief practice (KABP) model in hemodialysis patients. Methods A total of 90 hemodialysis patients admitted to Anhui Medical University Affiliated Chaohu Hospital from January 2021 to December 2022 were selected, they were divided into control group and observation group according to random number table method, with 45 cases in each group. The control group received routine health education, and the observation group received health literacy intervention based on KABP theory. After three months of intervention, the levels of health literacy, disease uncertainty, exercise self-efficacy and self-management ability of the two groups were observed. Results After intervention, the scores of health literacy, exercise self-efficacy (ESE) scale and self-management scale of the two groups were higher than before intervention, the scores of Mishel disease uncertainty (MUIS) scale were lower than before intervention, and the scores of health literacy, ESE scale and self-management scale of the observation group were higher than those of the control group, the score of MUIS was lower than that of control group (P＜0.05). Conclusion Health literacy intervention based on KABP theory can improve health literacy, disease uncertainty, exercise self-efficacy, and self-management ability of hemodialysis patients.
		2023 Vol. 20 (25): 194-198 [Abstract] ( 17 ) HTML (1 KB) PDF (545 KB) ( 31 )

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