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| Research progress on prevention and treatment of ventricular remodeling by regulating relevant signaling pathways with traditional Chinese medi- cine |
| XU Cun1 WANG Baohe2 |
1.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;
2.Division of Cardiovascular Medicine, the First Hospital of Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
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Abstract Ventricular remodeling (VR) is a complex pathological process, which is a key factor leading to increased morbidity and mortality of heart failure, and its mechanism involves a variety of cytokines involved in signal regulation. The prevention and treatment of VR by traditional Chinese medicine is closely related to the regulation of TGF-β/Smad, NF-κB, MAPK, NLRP3 inflammatome, PI3K/Akt/mTOR, Ca2+, and VEGF/VEGFR2 signaling pathways. In this paper, the pathological changes of VR and the mechanism of Chinese medicine monomer and compound regulation related signal pathway to prevent and treatment VR were reviewed, and the regulation related signal pathway intervention in VR treatment of heart failure has a positive effect, aiming to provide a reference for clinical prevention and treatment of VR.
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