Nd∶YAG脉冲式激光联合重组人碱性成纤维细胞生长因子治疗复发性唇疱疹的效果

doi:10.20047/j.issn1673-72102023.25.21

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Abstract Objective To evaluate the effect of Nd∶YAG pulsed laser combined with recombinant human basic fibroblast growth factor (rh-bFGF) on recurrent herpes labialis. Methods A total of 94 patients with recurrent herpes labialis who were treated in Shijiazhuang Second Hospital from January 2020 to February 2021 were selected, and they were divided into control group and observation group by random number table method, with 47 cases in each group. The control group was treated with simple Nd∶YAG pulsed laser, while observation group was treated with Nd∶YAG pulsed laser combined with rh-bFGF. The clinical effect and wound healing status (Vancouver scar scale [VSS] score, herpes disappearance time, wound healing time, and scab shedding time] between two groups were compared; the levels of plasma transforming growth factor-β1(TGF-β1), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), macrophage inflammatory protein-1 (MIP-1), monocyte chemoattractant protein-1 (MCP-1), Toll-like receptor (TLR) 2, and TLR9 before and after treatment between two groups were compared. Results The efficacy of observation group was better than that of control group, and the difference was statistically significant (P＜0.05). The VSS score of observation group was lower than that of control group, and the herpes disappearance time, wound healing time, and scab shedding time of observation group were shorter than those of control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of plasma TGF-β1, bFGF, and VEGF between two groups were higher than those before treatment, and observation group was higher than control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of plasma of MIP-1, MCP-1, TLR2, and TLR9 of two groups were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P＜0.05). Conclusion Nd∶YAG pulsed laser combined with rh-bFGF is effective in the treatment of recurrent herpes labialis, which can promote wound healing, and its mechanism is related to promoting the generation of TGF-β1, bFGF, and VEGF, inhibiting the generation of MIP-1, MCP-1, TLR2, and TLR9, thus eliminating local inflammation.

Key words： Nd∶YAG pulsed laser Recombinant human basic fibroblast growth factor Recurrent herpes labialis

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	ZHOU Lijing DAI Dongxiao SHI Yahong

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ZHOU Lijing DAI Dongxiao SHI Yahong. Effect of Nd∶YAG pulsed laser combined with recombinant human basic fibroblast growth factor on recurrent herpes labialis[J]. 中国医药导报, 2023, 20(25): 99-102.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-72102023.25.21 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I25/99

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