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2023 Vol. 20, No. 19 Published: 2023-07-05

	4	Proteomics analysis of diacetylmorphine-induced rhythm abnormalities in cardiac muscle cells interfered with by the inhibitor KN-93
		JI Min1 SU Liping2 LIU Li2 GUAN Yalin1 XIAO Jinling1 PU Hongwei3
		DOI: 10.20047/j.issn1673-7210.2023.19.01
		Objective To analysis the role of the inhibitor KN-93 to intervene in diacetylmorphine-induced rhythm abnormalities in cardiac muscle cells. Methods Myocardial tissue was extracted from 60 SPF-grade SD rats, regardless of male or female. Primary myocardial cells of SD rats were cultured in vitro and divided into the control group and the experimental group. The control group was treated with 100 μmol/L diacetylmorphine for 24 h, and the experimental group was treated with 100 μmol/L diacetylmorphine +1 μmol/L KN-93 for 24 h. The TMT relative quantitative protein technique was used to screen out the proteins with significant expression difference between the control group and the experimental group. The screening criteria were: up-regulation of expression ploidy ＞ 1.2-fold or down-regulation of expression ploidy ＜ 0.83-fold and P＜0.05. The main functions, cellular localization, and biological processes involved in differentially expressed proteins were analyzed by GO functional enrichment. The possible metabolic or signaling pathways involved in differentially expressed proteins were analyzed by KEGG pathway enrichment. Protein interaction network was used to analyze the binding or interaction between proteins. Results Compared with the control group, the phosphorylation level of Ca2+/Calmodulin-dependent protein kinaseⅡ (CaMKⅡ) in the experimental group was decreased, and the difference was statistically significant (P＜0.05). A total of 346 differentially expressed proteins were screened by TMT technology, which were mainly involved in the reaction to cytokines and cell response to cytokine stimulation and other processes, and affected molecular functions such as the same protein binding and signal receptor binding, as well as cellular component proteins such as extracellular regions and extracellular regions. It is mainly concentrated in cancer pathway, PI3K-Akt signaling pathway, human papillomavirus infection, Alzheimer disease, and other signaling pathways. The protein interaction network showed that MSH6, NFkB1, and CaMKⅡ might have protein interaction relationship. Compared with the control group, the protein expressions of ADCY7, NFkB1, MSH6, MMP2, MMP9, NQO1, and TXNRD1 in the experimental group were significantly decreased, with statistical significance (P＜0.05). Conclusion CaMKⅡ may regulate cardiomyocyte apoptosis through cancer pathway signaling pathway by regulating the changes of NFkB, MSH6 and other proteins, and participate in the abnormal rhythm of cardiac muscle cells induced by diacetylmorphine
		2023 Vol. 20 (19): 4-9 [Abstract] ( 16 ) HTML (1 KB) PDF (1647 KB) ( 68 )

	10	Study of optimization and activity of extraction process of fermented mulberry leaf glycoprotein
		SUN Dandan SUN Yinling ZHENG Hongyu DING Chunjie ZHAO Han SONG Jipeng CHEN Liyan
		DOI: 10.20047/j.issn1673-7210.2023.19.02
		Objective To determine the optimal extraction process of fermented mulberry leaf glycoprotein (FMLGP), and to evaluate the activity of glycoprotein. Methods Taking protein concentration as index, the extraction process of FMLGP was optimized by single factor combined with response surface method. Fibrinolytic activity was detected by agarose fibrin plate method. Macrophage RAW264.7 foam was induced by ox-LDL. The experiment was divided into blank group, model group, and FMLGP high-dose, medium-dose, and low-dose groups (the final concentration was 15, 10, and 5 mg/ml, respectively). The cells were cultured for 24 h and the degree of lipid accumulation in each group was investigated by Oil red staining. Results The optimal extraction conditions of FMLGP were PBS buffer solution, solid-liquid ratio of 1∶6 g/ml, extraction at 25℃ for 4 h, protein concentration of (57.92±1.14) mg/ml, fibrinolytic activity of (1 780.66±76.49) IU/ml, and 15 mg/ml FMLGP could significantly promote lipid excretion in macrophage foam cells. Conclusion In this study, the optimal extraction process of FMLGP is determined, and the fibrinolytic activity and macrophage foaming experiments shows that FMLGP had potential anti-atherosclerosis effects.
		2023 Vol. 20 (19): 10-13,34 [Abstract] ( 15 ) HTML (1 KB) PDF (1448 KB) ( 30 )

	14	Patent analysis of CAR-NK cell therapy technology
		LIANG Yaru1 LI Liyuan2
		DOI: 10.20047/j.issn1673-7210.2023.19.03
		Objective To reveal the research progress of CAR-NK cell therapy from the perspective of patents, in order to provide useful references for further research of innovative entities in our country. Methods CAR-NK related patents are searched through the database of China Patent Search and Service System, and the development trend, regional distribution and the research and development route of main applicants in the field were analyzed. Results The number of CAR-NK patent applications was growing steadily. At present, many domestic and foreign companies were accelerating their deployment in this field. The research of domestic companies mainly focused on the design of CAR-NK with different targets, and involves less combination drugs and upstream and downstream technologies. The technical direction of patent application distribution was relatively simple and was in the relatively initial stage of research and development, while the patent applications of foreign large pharmaceutical companies, focused on multi-angle layout, involving all aspects of the industrial chain. Conclusion The number of high-value patents in the field of CAR-NK in our country is relatively small, and more attention needs to be paid to patent layout and achievement transformation in the future.
		2023 Vol. 20 (19): 14-18 [Abstract] ( 20 ) HTML (1 KB) PDF (1822 KB) ( 184 )

	19	Study on the mechanism of intervention of Shenyuan Granules in diabetic nephropathy based on IRE-1α/NF-κB pathway
		ZHOU Yikun WANG Xiaoqin
		DOI: 10.20047/j.issn1673-7210.2023.19.04
		Objective To investigate the mechanism of intervention of Shenyuan Granules in diabetic nephropathy (DN) based on IRE-1α/NF-κB pathway. Methods Forty SPF grade 7-week-old db/db male mice with body weight of (40±2) g were selected and divided into model group and Shenyuan Granules low-dose, medium-dose, and high-dose groups with ten mice in each group according to random number table method. Ten 7-week-old wild-type WT male mice of the same strain with SPF grade and body weight of (20±2) g were selected as blank control group. After one week of adaptive feeding, fasting blood glucose was detected in model group and Shenyuan Granules low-dose, medium-dose, and high-dose groups, and DN was determined by fasting blood glucose ≥16.7 mmol/L for three consecutive times, urine volume ＞150% of blank control group, and continuous proteinuria. Subsequently, Shenyuan Granules low-dose, medium-dose, and high-dose groups were given 1.5, 3.0, and 6.0 g/(kg·d) Shenyuan Granules intragastrically, respectively, while model group and blank control group were given the same amount of double steam water intragastrically, all five groups were given continuous intragastrically for 12 weeks. After the experiment, five kidney tissues of groups were collected and stained with hematoxylin-eosin to observe the pathological changes of kidney. Real-time polymerase chain reaction was used to detect the mRNA expression of GRP78, XBP-1S, IRE-1α, and NF-κB in the five groups, and the protein expressions of GRP78 and XBP-1S, and the phosphorylation levels of IRE-1α and NF-κB in the five groups were detected by Western blot. Results No obvious lesions were observed in the blank control group, while the model group had abnormal renal tissue structure, glomerular atrophy, and partial renal tubule dilatation. Compared with the model group, Shenyuan Granules low-dose, medium-dose, and high-dose groups showed some improvements. The mRNA expression of GRP78, XBP-1S, IRE-1α, NF-κB, and the protein expression of GRP78, XBP-1S in model group were higher than those in blank control group, and the levels of p-IRE-1α /IRE-1α and p-NF-κB /NF-κB were higher than those in blank control group, the differences were highly statistically significant (P＜0.01). The mRNA expression of GRP78, XBP-1S, IRE-1α, NF-κB, and the protein expression of GRP78, XBP-1S in Shenyuan Granules low-dose, medium-dose, and high-dose groups were lower than those in model group, and the levels of p-IRE-1α/IRE-1α and p-NF-κB/NF-κB were lower than those in model group, the differences were statistically significant (P＜0.05 or P＜0.01). The mRNA expression of GRP78, XBP-1S, IRE-1α, NF-κB, and the protein expression of XBP-1S in Shenyuan Granules high-dose group were lower than those in Shenyuan Granules medium-dose and low-dose groups, and the levels of p-IRE-1α/IRE-1α and p-NF-κB/NF-κB were lower than those in Shenyuan Granules medium-dose and low-dose groups, the protein expression of GRP78 in Shenyuan Granules high-dose group was lower than that in Shenyuan Granules low-dose group; the levels of IRE-1α mRNA, GRP78 protein, XBP-1S protein, and p-IRE-1α/IRE-1α in Shenyuan Granules medium-dose group were lower than those in Shenyuan Granules low-dose group, and the differences were statistically significant (P＜0.05 or P＜0.01). Conclusion Shenyuan Granules may inhibit excessive endoplasmic reticulum stress response through IRE-1α/NF-κB pathway to reduce renal inflammation, improve renal function, and inhibit the progression of DN.
		2023 Vol. 20 (19): 19-23,29 [Abstract] ( 19 ) HTML (1 KB) PDF (1524 KB) ( 28 )

	24	Study on chemical constituents of different parts of Andrographis paniculata based on UPLC fingerprint
		FANG Chaozuan HE Rongrong GAN Lifan WANG Yuting CHEN Shiyan DENG Guihai WANG Kaidong SUN Dongmei
		DOI: 10.20047/j.issn1673-7210.2023.19.05
		Objective To establish UPLC fingerprint to compare the differences of chemical constituents in the main stem, lateral stem, and leaf of Andrographis paniculata, so as to provide a basis for the quality evaluation of Andrographis paniculata. Methods CORTECS UPLC T3 column (100 mm×2.1 mm, 1.6 μm ) was used; gradient elution was performed with acetonitrile-0.1 % phosphoric acid solution as mobile phase. The UPLC fingerprints of 14 batches (S1-S14) of main stem, lateral stem, and leaf of Andrographis paniculata were studied by similarity evaluation, heat map cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis. Results In the established UPLC fingerprint, 13 common peaks were identified in the main stem, lateral stem, and leaf of Andrographis paniculata, and identified five characteristic peaks of luteolin-7-O-β-D glucuronide, andrographolide, neoandrographolide, 14-deoxyandrographolide, and anhydroandrographolide; except for S3, S7, and S9, the similarity between the UPLC fingerprints of main stem, lateral stem, and leaf of Andrographis paniculata and the corresponding control fingerprints was greater than 0.900; the results of heat map cluster analysis and principal component analysis could distinguish the main stem, lateral stem, and leaves; the orthogonal partial least squares discriminant analysis screened out four different components with VIP value＞1, P＜0.05. Conclusion This study reflects the differences of chemical constituents in different parts of Andrographis paniculata as a whole, comprehensively and truly, and is of great significance to the quality control and evaluation of Andrographis paniculata.
		2023 Vol. 20 (19): 24-29 [Abstract] ( 17 ) HTML (1 KB) PDF (1335 KB) ( 32 )

	30	Analysis on the correlation between serum liver enzymes and the incidence of type 2 diabetes mellitus in middle-aged and elderly residents in Lanzhou
		DING Yulu1 ZHANG Di1 YANG Mengdi1 WANG Yujie1 SUN Linnan1 HE Fengying1 ZHEN Donghu2
		DOI: 10.20047/j.issn1673-7210.2023.19.06
		Objective To investigate the relationship between alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (GGT) and type 2 diabetes mellitus (T2DM) in middle-aged and elderly residents in Lanzhou. Methods In 2011, a cluster of 5 135 residents aged 40 to 75 years old from three communities in Lanzhou were randomly sampled, and 3 832 residents meeting the exclusion criteria were eventually included. They were divided into four groups according to ALT, AST, and GGT quartile (group Q1 to Q4). Non-interventional follow-up ≥three years of T2DM events. Logistic regression analysis of the correlation between serum liver enzymes and T2DM. The predictive value of serum liver enzymes for T2DM was analyzed by receiver operating characteristic (ROC) curve. Results Non-interventional follow-up ≥three years, the incidence of T2DM was 6.99% (268/3 832). The number of fasting blood glucose, 2-hour post-meal blood glucose, glycosylated hemoglobin, ALT, GGT, triglyceride, and rate of fatty liver in T2DM group were higher than that in non-T2DM group, and the differences were statistically significant (P＜0.05); high density lipoprotein cholesterol (HDL-C) was lower than that in non-T2DM group, and the difference was statistically significant (P＜0.05). The incidence of T2DM in ALT group Q4 was higher than that in ALT group Q1 and Q2, and the differences were statistically significant (P＜0.05). The incidence of T2DM in GGT group Q3 and Q4 was higher than that in GGT group Q1 and Q2, and the differences were statistically significant (P＜0.05). Logistic regression analysis showed that elevated ALT and GGT were independent risk factors for T2DM (OR＞1, P＜0.05). ROC curve showed that ALT predicted the critical value, area under the curve, sensitivity and specificity of T2DM to be 18.5 U/L, 0.593, 0.519, and 0.634, while GGT to be 20.5 U/L, 0.614, 0.616, and 0.572, respectively. Conclusion The elevation of ALT and GGT in middle-aged and elderly residents in Lanzhou may be associated with the onset of T2DM.
		2023 Vol. 20 (19): 30-34 [Abstract] ( 15 ) HTML (1 KB) PDF (684 KB) ( 28 )

	35	Study on stability of Compound Camphor Cream
		REN Jie YAN Xiaolan XIE Liusheng
		DOI: 10.20047/j.issn1673-7210.2023.19.07
		Objective To study the stability of Compound Camphor Cream. Methods Triamcinolone acetate in Compound Camphor Cream was determined by high performance liquid chromatography with methanol∶ 0.2% aqueous phosphate∶ ether (60∶38∶2) as mobile phase, shvmadzu chromatographic column (4.6 mm×150 mm, 5 μm) at a wavelength of 239 nm. High temperature, strong light, acceleration, and long-term tests were carried out under the same chromatographic conditions according to the Chinese pharmacopoeia standards. Thin layer chromatography was used to identify camphor and menthol in compound camphor cream. Results Triamcinolone acetate showed a good linear relationship (r=0.999) between 0.23-1.15 μg, RSD of precision were 0.19 %, RSD of stability were 0.12 %, RSD of repeatability were 0.09 %, average recovery was 100.05%, RSD of 0.95 % (n=9). The thin layer chromatographic spots of camphor and menthol in the cream were clear, Rf value was moderate, negative without interference. The product was placed at high temperature (40±2)℃ and strong light (4 500±500) Lx for ten days. The appearance, character and content of the preparation all met the regulations. The quality of the preparation was stable after accelerated test and long-term test. Conclusion Compound Camphor Cream has good stability.
		2023 Vol. 20 (19): 35-39 [Abstract] ( 13 ) HTML (1 KB) PDF (1006 KB) ( 110 )

	40	Overview of pathogenesis and treatment of vertigo in Chinese and western medicine
		YAN Yong* ZHU Jingjing* ZHAI Liang LI Jingmin WAN Qianhui ZUO Qi CHEN Ying WU Shuhui
		DOI: 10.20047/j.issn1673-7210.2023.19.08
		Vertigo is a comprehensive symptom of many clinical diseases, the incidence of which is increasing year by year, seriously affecting patients’ physical and mental health and daily life. Chinese and western medicine have their own advantages in the pathogenesis analysis and comprehensive treatment of vertigo. Western medicine divided vertigo into vestibular vertigo and non-vestibular vertigo according to different etiology, and according to the severity of the condition are given to improve cerebral blood circulation, vestibular inhibitors, neuroprotective agents and other drugs, surgery, vestibular rehabilitation, and other cause and symptomatic treatment. The treatment of vertigo by traditional Chinese medicine is based on the etiology and pathogenesis of patients, with deficiency and solid as the key line, which can be divided into no wind no glare, no fire no glare, no deficiency no glare, no phlegm no glare, no blood stasis no glare. The treatment adopts traditional Chinese medicine decoction for syndrome differentiation, acupuncture and acupoint massage, and other internal and external treatment methods. In this paper, the latest understanding of the pathogenesis of vertigo in Chinese and western medicine is summarized, and the related progress of traditional Chinese and western medicine treatment of vertigo is summarized, in order to provide the direction for the clinical treatment of vertigo.
		2023 Vol. 20 (19): 40-44 [Abstract] ( 22 ) HTML (1 KB) PDF (789 KB) ( 270 )

	45	Research progress in the treatment of non-alcoholic fatty liver disease by fecal microbiota transplantation
		LIU Yincong MA Xiuying ZHANG Yuting LUO Jinbo XIAO An WANG Wenxue GENG Jiawei
		DOI: 10.20047/j.issn1673-7210.2023.19.09
		Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, and the prevalence rate is increasing year by year worldwide, and there is no specific treatment. Recent years’ studies have shown that intestinal flora imbalance can promote the occurrence and development of non-alcoholic fatty liver disease through the enteric-liver axis, and fecal microbiota transplantation can reconstruct intestinal flora in patients with non-alcoholic fatty liver disease, improve hepatocyte steatosis, and reduce liver inflammation. In this paper, the possible mechanism of fecal microbiota transplantation in the treatment of non-alcoholic fatty liver disease, the current domestic and foreign preclinical, and clinical research progress and existing problems are summarized, to provide reference for the future clinical treatment of fecal microbiota transplantation in non-alcoholic fatty liver disease.
		2023 Vol. 20 (19): 45-48 [Abstract] ( 19 ) HTML (1 KB) PDF (564 KB) ( 122 )

	49	Advances in the diagnosis and treatment of multiple myeloma after renal transplantation
		PENG Yue LI Jinke ZHOU Jiangqiao
		DOI: 10.20047/j.issn1673-7210.2023.19.10
		Multiple myeloma (MM) is a malignant proliferative disease caused by abnormal hyperplasia of plasma cells in bone marrow. It is characterized by the secretion of monoclonal immunoglobulin and light chain, which can lead to the damage of multiple organs and tissues throughout the body. The kidney is one of the most commonly affected target organs. MM after renal transplantation can cause kidney function impairment in the short term. The mechanism of MM leading to kidney damage is mainly related to the direct toxicity of light chain protein, the deposition of uromodulin, inflammatory reaction fibrosis, and other factors. At present, immunoregulatory drugs and proteasome inhibitors are the main treatment of the disease. Blood purification and autologous hematopoietic stem cell transplantation can also be used. Timely and effective intervention measures are helpful to improve the prognosis. In this paper, the mechanism and diagnosis of kidney injury caused by MM after kidney transplantation is elaborated, the latest clinical strategies and existing problems for the treatment of kidney injury are analyzed, and further research directions are put forward to provide theoretical basis for clinical work.
		2023 Vol. 20 (19): 49-52 [Abstract] ( 33 ) HTML (1 KB) PDF (553 KB) ( 105 )

	53	Research progress in the application of artificial intelligence in the assisted reproduction field
		XIE Yanpeng YANG Huan LIU Jianrong
		DOI: 10.20047/j.issn1673-7210.2023.19.11
		Artificial intelligence has been often used in assisted reproductive technology in recent years. Semen quality, endometrial thickness, tubal patency, embryo selection and transfer, uterine cavity microenvironment, and other factors will affect assisted reproductive technology. Artificial intelligence can be applied to the diagnosis and treatment of reproductive diseases through processing images, data analysis, predictive models, embryo grading, robotic surgery, and other emerging technologies, so as to achieve accurate diagnosis and personalized treatment, but the pros and cons of some operations are still controversial. Although artificial intelligence has made great progress in the medical field, but there are still few relevant literature reports in China. This paper reviews the research progress of artificial intelligence in the assisted reproduction field in recent years, and discusses the development prospects of artificial intelligence in reproductive medicine in the future.
		2023 Vol. 20 (19): 53-56 [Abstract] ( 22 ) HTML (1 KB) PDF (529 KB) ( 345 )

	57	Pathogenesis and treatment of hepatic encephalopathy based on intestinal microbiota
		ZHOU Jianbo1 FU Weiqiang1 WU Xiongjian2
		DOI: 10.20047/j.issn1673-7210.2023.19.12
		Hepatic encephalopathy is a common complication of liver cirrhosis. Cognitive dysfunction and abnormal signs of nervous system are the main clinical manifestations, and the fatality rate is relatively high. Currently, the pathogenesis of hepatic encephalopathy is still unclear and specific treatment is lacking. The intestinal microecosystem of patients with hepatic encephalopathy is dysfunctional, and it may induce hepatic encephalopathy by promoting the production of blood ammonia, releasing inflammatory factors, affecting the production of neurotransmitters, and reducing the synthesis of bile acids and short-chain fatty acids. Therefore, the treatment of hepatic encephalopathy based on intestinal flora has become a new entry point, including the use of probiotics, prebiotics, and antibiotics and fecal microbiota transplantation. This review summarizes the main mechanism of action of intestinal flora in hepatic encephalopathy and related treatments based on intestinal flora, in order to provide a new theoretical basis for clinical treatment of hepatic encephalopathy.
		2023 Vol. 20 (19): 57-60,68 [Abstract] ( 13 ) HTML (1 KB) PDF (700 KB) ( 98 )

	61	Research progress on possible mechanism of exercise intervention in chronic constipation based on intestinal flora
		AN Jingwen1 CHANG Yi1 LIU Jing1 XU Yuting1 ZHANG Xiangan2
		DOI: 10.20047/j.issn1673-7210.2023.19.13
		The pathogenesis of chronic constipation (CC) is still not yet clearly established, and with the deepening of intestinal microecology research, the imbalance of intestinal flora and its metabolites is considered to be the potential predisposing factor of CC. Exercise as one of the basic measures of CC treatment, it can participate in metabolism, anti-inflammatory, oxidative stress, and other processes by regulating the composition of intestinal microorganisms, it is suggested that there is some internal relationship between intestinal flora, exercise, and CC. This paper summarizes and reviews the potential mechanism of exercise to improve CC based on intestinal flora, in order to provide new ideas for further exploration of exercise, prevention and treatment in CC.
		2023 Vol. 20 (19): 61-64,129 [Abstract] ( 9 ) HTML (1 KB) PDF (744 KB) ( 86 )

	65	Effects of catch-up growth of very preterm and extremely preterm infants on physical and neuropsychological behavior development
		ZHANG Di LI Lihua▲
		DOI: 10.20047/j.issn1673-7210.2023.19.14
		With the opening up and implementation of the comprehensive “two child”“three child” policy, China’s birth population will continue to increase, and the birth rate and survival rate of extremely premature and ultra premature infants will also increase year by year. Due to their small age, low birth weight, disability and high mortality, the physical, neuropsychological, and behavioral development of premature infants at small gestational age has become the focus of public health undertakings. Postnatal physical catch-up growth is not parallel to neuropsychological development. Good physical growth does not mean premature infants are ahead in adaptability, movement, language, cognition, and social interaction. This article mainly summarizes the definition and mechanism of postnatal catch-up growth of premature infants, and summarizes the impact of postnatal catch-up growth of ultra early/extremely premature infants on later neuropsychological and behavioral development.
		2023 Vol. 20 (19): 65-68 [Abstract] ( 13 ) HTML (1 KB) PDF (541 KB) ( 55 )

	69	Exploration of characteristic position and reform practices of management majors in Chinese medical colleges based on new humanity concept
		HE Chang YU Qinming
		DOI: 10.20047/j.issn1673-7210.2023.19.15
		New humanity is a new idea, new direction and new practice of the innovation and development of humanity higher education. Based on the concept of new humanity, the management majors of Chinese medical colleges have some problems. The characteristic position has lagged behind the rapid changes of social demands, the attention and the practices of interdisciplinary integration are insufficient, the ideological education has not been deeply integrated into the whole process of professional education, and the teaching reforms and innovations of digital technology enabled education are insufficient. The management majors of Chinese medical colleges should be professional reformed and practical explored by making clear the characteristic position on the background of the traditional Chinese medicine, taking the construction of new humanity as an opportunity, taking the market demands as a guide, taking the information technology as a means and taking the students’ post competency improvement as a objective. With the goal of improving students’ job competence, the management majors of Chinese medical colleges aim to enhance the effectiveness of practical teaching, promote interdisciplinary resource sharing and integration in response to social needs and practices, focus on creating ideological and political education with industry and professional characteristics, use modern information technology to optimize and integrate teaching resources, and construct a collaborative education mechanism and training model for new humanities, realizing the goal of improving the construction level of management majors in traditional Chinese medicine colleges under the guidance of new humanity concept.
		2023 Vol. 20 (19): 69-72,90 [Abstract] ( 5 ) HTML (1 KB) PDF (769 KB) ( 49 )

	73	Exploration and practice of blending teaching of exercise physiology course based on capability-oriented
		SHI Kaixuan1 HOU Lijuan2
		DOI: 10.20047/j.issn1673-7210.2023.19.16
		Exercise physiology is one of the main courses of sports science and sports medicine. It is difficult to learn because the course content includes a lot of basic medical knowledge and practical operation content. The traditional teaching mode based on teacher teaching has the problems of teaching evaluation and single method, students have no problems and so on, which limits the internalization and mastering of students’ knowledge, is not conducive to promoting the practice and application of sports as good medicine, and can not meet the requirements of “Healthy China” strategy for the cultivation of talents for the integration of compound medicine. In this paper, a capability-oriented assessment system is constructed. Meanwhile, the rain classroom platform is used to apply the problem based learning flipped classroom model of learning to the teaching of exercise physiology. Through online high-quality resources push and offline interaction integration, students can enrich their knowledge vision, improve their scientific research literacy, and achieve the purpose of training comprehensive exercise physiology talents.
		2023 Vol. 20 (19): 73-76 [Abstract] ( 10 ) HTML (1 KB) PDF (833 KB) ( 76 )

	77	Research on the path of strengthening medical humanities education under the background of new medical science
		LI Jun1 WU Yonggang1 LI Yajun2
		DOI: 10.20047/j.issn1673-7210.2023.19.17
		Medical education is an important part of the whole education system, and also a bridge linking the strategy of “education first development” and the strategy of “healthy China”. The proposal of new medical science reflects the new requirements of the new era of socialism with Chinese characteristics for the training of talents in higher medical education. The construction of new medical science will greatly improve the humanistic quality of medical students. However, at present, medical colleges and universities lack effective recognition of the rich connotation of new medical science, and lack consensus understanding of the status and significance of medical humanistic education in the construction of new medical science, which leads to the slow pace and poor construction results of new medical science. This article will start from the background and rich connotation of new medical science, this article will analyze the currentt situation and value implication of medical humanistic education. On this basis, it will propose a realistic path to strengthen medical humanistic education under the background of new medical science.
		2023 Vol. 20 (19): 77-80 [Abstract] ( 9 ) HTML (1 KB) PDF (676 KB) ( 92 )

	81	Construction and practice of the teaching mode of “ideology and politics + wisdom” in the introduction course of nursing from the perspective of “three whole education”
		WANG Shurong1 YU Jin2 ZOU Xiangni3▲ WANG Dongmei4 YU Qingxia1 HAN Yali1
		DOI: 10.20047/j.issn1673-7210.2023.19.18
		Objective To explore the construction and practice of the teaching mode of “ideology and politics + wisdom” in the introduction course of nursing from the perspective of “three whole education”. Methods The Nursing undergraduates of Heilongjiang University of Chinese Medicine in 2021 were selected as the research object, and students from Class 1 and 2 were selected as the experimental group (67 students), and students from Class 3 and 4 were selected as the control group (65 students). The experimental group adopted the teaching mode of “ideology and politics + wisdom” in the introduction course of nursing from the perspective of “three whole education”, while the control group adopted the traditional teaching mode. The teaching effect of the two groups was evaluated through the nursing introduction examination and questionnaire survey. Results The peacetime scores, final scores and comprehensive scores of the test group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The score of autonomous learning ability scale of the test group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The score of moral sense scale of experimental group was higher than that of control group, and the difference was statistically significant (P＜0.05). Conclusion The construction and practice of the teaching mode of “ideology and politics + wisdom” in the introduction course of nursing from the perspective of “three whole education” can improve the teaching effect of the introduction course of nursing and provide a reference for higher nursing education.
		2023 Vol. 20 (19): 81-85 [Abstract] ( 9 ) HTML (1 KB) PDF (969 KB) ( 157 )

	86	Exploration of online and offline hybrid curriculum teaching reform of fermentation engineering for the cultivation of application-oriented talents in the biomedical industry
		HONG Xuan LI Hebin CHEN Zhongwei XIONG Weide HE Ruonan CAI Wenkai
		DOI: 10.20047/j.issn1673-7210.2023.19.19
		In the cultivation of applied talents in the biomedical industry, the traditional fermentation engineering course has some shortcomings, such as inadequate applicability of the teaching content, poor grasp of the operation and fault analysis of the fermentation tank, insufficient students' willingness to learn actively and ability to learn independently, and inadequate systematization of the curriculum ideology and politics. Therefore, this paper discusses the teaching reform of the online and offline hybrid curriculum system of fermentation engineering for the cultivation of applied talents in the biomedical industry from the aspects of teaching content design, teaching resource construction, online and offline hybrid teaching process based on virtual simulation experiments, and curriculum ideological and political integration. The teaching reform can improve the teaching effect of fermentation engineering, improve the quality of application-oriented talent training, and provide a reference for solving the shortage of application-oriented talent training in the biomedical industry.
		2023 Vol. 20 (19): 86-90 [Abstract] ( 6 ) HTML (1 KB) PDF (1131 KB) ( 79 )

	91	Research on moral education of medical students and quality improvement strategy based on Durkheim’s moral education theory
		YE Guancheng1 JIANG Zhe2 ZHANG Shaohui3 CHEN Jiaqi4 YUAN Hejing2
		DOI: 10.20047/j.issn1673-7210.2023.19.20
		With the promotion of healthy China strategy and the need of medical education innovation, it is an important task for medical colleges to cultivate medical talents with excellent medical skills and noble medical ethics. Taking Durkheim’s moral education theory as an analytical perspective, this paper objectively examines a series of problems existing in the current moral education of medical students, and explores ways to improve the quality of medical students’ moral education based on the combination of Durkheim’s moral education concept and social environment in the new era. It mainly includes internalizing moral ideas, establishing effective moral punishment, and carrying out socialized moral education, so as to provide ideas for theoretical research and policy formulation of moral education for medical students.
		2023 Vol. 20 (19): 91-94,128 [Abstract] ( 7 ) HTML (1 KB) PDF (864 KB) ( 46 )

	95	Meta-analysis of efficacy and safety of Xiaozhiling Injection combined with meridian operation in the treatment of rectal prolapse
		LAI Suyu1 CHEN Mingjie2 RUAN Mengyi1 ZENG Yixian1 ZHAO Ziting1 REN Bing1 JIA Fei1 WANG Xiaofeng1
		DOI: 10.20047/j.issn1673-7210.2023.19.21
		Objective To evaluate the efficacy and safety of Xiaozhiling injection combined with meridian surg in the treatment of rectal prolapse. Methods Using RevMan 5.4 software, the databases of CNKI, VIP, Wanfang, China Biomedical Literature Service System, Cochrane Library, PubMed, EMbase, and Web of Science were systematically searched, and screened out relevant randomized controlled trial (RCT). Results Eleven RCTs were included, including 710 patients. The data showed that compared with perineal operation alone, Xiaozhiling Injection could improve the cure rate （RR[95%CI]= 1.49[1.16, 1.91], P=0.002; RR[95%CI]=1.58[1.20, 2.08], P=0.001）, improved the total response rate （RR[95%CI]=1.17[1.09,1.26], P＜0.000 1）, reduced the bleeding rate （RR[95%CI]=0.16[0.05, 0.47], P=0.000 9）, and decreased the recurrence rate at 6 and 12 months after surgery （RR[95%CI]=0.27[0.10, 0.74], P=0.01; RR[95%CI]=0.10[0.02, 0.53], P=0.007）. Conclusion Xiaozhiling Injection can improve the clinical effect of meridian operation in the treatment of rectal prolapse, improve postoperative bleeding and reduce recurrence, and no serious adverse reactions have been seen in clinical use. The above conclusions need to be further demonstrated.
		2023 Vol. 20 (19): 95-99 [Abstract] ( 10 ) HTML (1 KB) PDF (1816 KB) ( 55 )

	100	Effect of resistance movement combined with nutrition intervention on senile patients with sarcopenia
		ZHOU Yanyan ZHAO Xulan ZHANG Shiyang XIA Song ZHANG Junhui LIANG Fang▲
		DOI: 10.20047/j.issn1673-7210.2023.19.22
		Objective To explore the effect of resistance movement combined with nutrition intervention on senile patients with sarcopenia. Methods A total of 500 elderly patients with sarcopenia admitted to Shijiazhuang People’s Hospital from May 2016 to May 2021 were selected and divided into two groups with 250 patients each by simple random sampling method. The control group received conventional intervention combined with nutrition intervention, while based on the control group, the observation group was combined with resistance exercise. The levels and changes of body weight, grip strength, walking speed, and skeletal muscle density at each stage were compared between the two groups, as well as the relevant indexes of oxidative stress response before and after treatment. Results At six months after treatment, grip, pace, skeletal muscle density, and limb skeletal muscle mass in two groups were higher than before treatment, while those of observation group were higher than those of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in muscle mass index between the two groups (P＞0.05). At six months after treatment, the contents of homocysteine, interferon-γ, and malondialdehyde in both groups were lower than those before treatment, while those of the observation group were lower than those of the control group; the content of superoxide dismutase in the two groups was higher than that before treatment, while the observation group was higher than the control group, and the differences were statistically significant (P＜0.05). Conclusion Resistance movement combined with nutritional intervention can effectively improve the level of grip, pace, skeletal muscle density, and other related indicators in elderly patients with sarcopenia, stabilize oxidative stress indicators, and thus improve prognosis and quality of life.
		2023 Vol. 20 (19): 100-103 [Abstract] ( 8 ) HTML (1 KB) PDF (603 KB) ( 213 )

	104	Influence and predictive value of serum 25-hydroxyvitamin D3 and chemokine on the occurrence of coronary artery lesion in children with Kawasaki disease
		LI Nana WANG Hongqun▲
		DOI: 10.20047/j.issn1673-7210.2023.19.23
		Objective To analyze the influence and prognostic value of serum 25-hydroxyvitamin D3 [25(OH)D3] and chemokine on the occurrence of coronary artery lesion (CAL) in children with Kawasaki disease (KD). Methods A total of 86 KD children admitted to the Second People’s Hospital of Wuhu City, Anhui Province from July 2018 to November 2022 were selected as the study objects. After two weeks of treatment, the patients were divided into the occurrence group (21 cases) and the non-occurrence group (65 cases) according to the occurrence of CAL. The clinical data, serum levels of 25(OH)D3, and lipid-derived cytokines were compared between the two groups, and the influencing factors of the occurrence of CAL in KD children were analyzed, and the predictive value of the combined detection of serum 25(OH)D3 and lipid-derived cytokines on the occurrence of CAL in KD children was further analyzed. Results The proportion of KD in acute phase, the proportion of intravenous immunoglobulin (IVIg) resistance, and the levels of procalcitonin, omentin-1, and chemokine before treatment in the occurrence group were higher than those in the non-occurrence group, the duration of fever before IVIg was longer than that in the non-occurrence group, and the serum 25(OH)D3 was lower than that in the non-occurrence group (P＜0.05). The results of multivariate logistic regression analysis showed that procalcitonin (OR= 2.759, 95%CI: 1.053-4.185), serum 25(OH)D3 (OR=0.310, 95%CI: 0.128-0.754), and chemokine (OR=3.364, 95%CI: 2.063-7.125) were the influencing factors of CAL occurrence in KD children (P＜0.05). The analysis of the receiver operation characteristic curve showed that the area under the curve of serum 25(OH)D3 combined with chemokine predicted CAL development in KD children was higher than those predicted by the two alone (P＜0.05). Conclusion Procalcitonin, serum 25(OH)D3, and chemokine are all related factors affecting the occurrence of CAL in KD children, and the combination of serum 25(OH)D3 and chemokine has a higher predictive effect on the occurrence of CAL in KD children.
		2023 Vol. 20 (19): 104-107 [Abstract] ( 8 ) HTML (1 KB) PDF (649 KB) ( 14 )

	108	Effect of compound polyethylene glycol electrolyte combined with Lin-alotide on bowel preparation before colonoscopy in patients with functional constipation
		WU Zhenxing LIN Ying
		DOI: 10.20047/j.issn1673-7210.2023.19.24
		Objective To analyze the effect of combined application of compound polyethylene glycol electrolyte and Linalotide on bowel preparation before colonoscopy in patients with functional constipation. Methods A total of 155 patients with functional constipation underwent colonoscopy in Taizhou First People’s Hospital of Zhejiang Province from October 2020 to October 2021 were selected and divided into control group (77 cases) and study group (78 cases) according to random number table method. The control group used compound polyethylene glycol electrolyte for intestinal preparation. The study group used compound polyethylene glycol electrolyte combined with Linalotide for intestinal preparation. Gastrointestinal symptom grading scale scores, bowel sound time, and anal exhaust time of the two groups were compared two days before examination and one day after examination, and intestinal cleanliness, subjective tolerance, and adverse reactions of the two groups were recorded. Results After one day of examination, the scores of gastrointestinal symptom rating scale in both groups were lower than those at two days before examination, and those in the study group were lower than those in the control group (P＜0.05). After one day of examination, the bowel sound time and anal exhaust time of the two groups were shorter than those at two days before examination, and those in the study group were shorter than those in the control group (P＜0.05). The subjective tolerance and intestinal cleanliness of the study group were better than those of the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The combination of compound polyethylene glycol electrolyte and Linalotide for intestinal preparation before colonoscopy effectively improve the peristaltic function of the patients, and significantly increase the intestinal cleaning ability, achieve the effect of improving the degree of subjective tolerance of patients.
		2023 Vol. 20 (19): 108-111 [Abstract] ( 9 ) HTML (1 KB) PDF (587 KB) ( 88 )

	112	Clinicopathologic analysis of 27 cases of cellular angiofibroma
		ZHANG Kang1 LI Xiangli2 JIANG Guoqing1
		DOI: 10.20047/j.issn1673-7210.2023.19.25
		Objective To investigate the clinical features, pathology, immunohistochemistry of cellular angiofibroma. Methods Clinical data of 26 cases reported in China from January 2000 to June 2022 in CNKI and Wanfang Data, and one case of cellular angiofibroma admitted to the First Hospital of Tsinghua University (hereinafter referred to as “our hospital”) on February 18, 2022 were collected. The characteristics of clinical, pathological, and immunohistochemical of the case were analyzed. Results The patient in our hospital was 44 years old, and was diagnosed with vulvar mass for three months, enlargement accompanied by tenderness for two weeks. The mass was located in the right medial lip of the minora, with a size of 9 cm. Pathologically, it showed short spindle cells with uniform distribution, more mitotic images, and large cell atypia. Small and medium blood vessels can be seen in the interstitium, and some blood vessels have thicker walls, accompanied by hyaline degeneration. Immunohistochemistry: CD34 (vessel +), Desimn (vessel +), Vimentin (+), SATA6 (-), S-100 (-), Ki-67 index (30%), SMA (vessel +), ER (+), PR (+). A total of 26 patients aged 16-78 years were reported, including 18 females and eight males. There were 21 cases with no pain and five cases with mild pain. The growth sites were the labia majora in 13 cases, the scrotum in four cases, the middle finger in two cases, the groin in two cases, the pubic mound in one case, the vulva in one case, the spermatocele in one case, the labia minora in one case, and the cervix in one case. The course of disease ranges from one week to ten years. The pathological features were composed of short spindle cells with the same morphology and abundant blood vessels. Immunohistochemistry showed that Vimentin was diffusion-positive, CD34, ER, PR, SMA were positive or partially positive, and Desimin, HMB45, S-100 were mostly negative. In the literatures, among the 26 patients who received surgical treatment, two patients were suspected to have relapsed, and one patient in our hospital did not have recurrence after surgery. Conclusion Cellular angiofibroma is a rare mesenchymal tumor, most common in the bisexual genital area. It is characterized by dense short spindle cells and abundant blood vessels under microscope. Surgical resection is the main treatment, and the patient has a good prognosis.
		2023 Vol. 20 (19): 112-116 [Abstract] ( 9 ) HTML (1 KB) PDF (1074 KB) ( 177 )

	117	Effect of Metformin on glycolipid metabolism and homocysteine levels in patients with schizophrenia treated with Risperidone
		YAN Zhen WU Yanhai TAN Chenchen SUN Longlong LI Yexin
		DOI: 10.20047/j.issn1673-7210.2023.19.26
		Objective To explore the effect of Metformin on glycolipid metabolism and homocysteine levels in patients with schizophrenia treated with Risperidone. Methods A total of 102 schizophrenic patients treated with Risperidone in Fuyang Third People’s Hospital, Anhui Province from July 2021 to July 2022 were selected and divided into control group and study group by random number table method, with 51 cases in each group. On the basis of maintaining Risperidone treatment, the control group was given placebo and the study group was given Metformin. Both groups were treated for three months. The clinical efficacy, waist-to-hip ratio, glucose, and lipid metabolism indexes (fasting blood glucose [FPG], 2 h postmeal blood glucose [2hPG], fasting insulin [FINS], total cholesterol [TC]), and homocysteine (Hcy) levels were compared between the two groups before and after treatment. The occurrence of adverse reactions during treatment was recorded in both groups. Results There was no significant difference in clinical efficacy between the two groups (P＞0.05). After treatment, the levels of waist-to-hip ratio, FPG, 2hPG, FINS, and TC in the study group were not significantly different from those before treatment (P＞0.05), while the levels of waist-to-hip ratio, FPG, 2hPG, FINS, and TC in the control group were higher than those before treatment (P＜0.05). The levels of waist-to-hip ratio, FPG, 2hPG, FINS, and TC in the study group were lower than those in the control group (P＜0.05). After treatment, the Hcy level in both groups was lower than before treatment, and the study group was lower than the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion In the treatment of schizophrenia with Risperidone, the addition of Metformin can prevent the increase of waist-to-hip ratio, abnormal glucose, and lipid metabolism, regulate the level of Hcy, and will not affect the therapeutic effect of Risperidone, and is safe and reliable.
		2023 Vol. 20 (19): 117-120 [Abstract] ( 5 ) HTML (1 KB) PDF (548 KB) ( 27 )

	121	Effect of transcranial direct current stimulation in the treatment of central post-stroke pain
		YANG Jian1 LIANG Guisheng1 XU Shuiying1 ZHOU Guanghui1 LIAO Chengju2 CHEN Yuzhuan1 LIANG Pingping1
		DOI: 10.20047/j.issn1673-7210.2023.19.27
		Objective To investigate the effect of transcranial direct current stimulation（tDCS） in the treatment of central post-stroke pain (CPSP). Methods A total of 66 patients with CPSP admitted to Dongguan Songshan Lake Central Hospital, Guangdong Province from March 2019 to March 2022 were selected, and they were divided into control group and tDCS group according to the random number table method, with 33 cases in each group. Control group received conventional drugs and rehabilitation treatment, and tDCS group was treated with tDCS on the basis of control group, the treatment continued for two weeks. The scores of visual analogue scale (VAS), modified Barthel index (MBI), and function independence measure (FIM) of two groups were compared before and after treatment, and the pain efficacy of two groups was compared. Results In the control group, one case fell off due to recurrent stroke during treatment, and a total of 65 cases were included in the final statistics. After treatment, the VAS scores of two groups were lower than those before treatment, and tDCS group was lower than control group, and the differences were statistically significant (P＜0.05). After treatment, MBI score and FIM score of two groups were higher than those before treatment, and tDCS group was higher than control group, and the differences were statistically significant (P＜0.05). The pain effect of tDCS group was better than that of control group, and the difference was statistically significant (P＜0.05). Conclusion tDCS can relieve the degree of CPSP, and improve the pain effect and the ability of daily living of patients.
		2023 Vol. 20 (19): 121-124 [Abstract] ( 9 ) HTML (1 KB) PDF (496 KB) ( 16 )

	125	Experience summary of traditional Chinese medicine master Professor Lu Fang in the treatment of tic disorders with self-designed Xifeng Zhidong Prescription
		MA Rui1 WANG Xiaorui2 SUN Qi3 ZHU Jingxin1 CHAI Zekun1 CHEN Zijia4 WANG Le5
		DOI: 10.20047/j.issn1673-7210.2023.19.28
		Tic disorder is a common neuropsychiatric disease in clinical practice. The incidence of tic disorder has increased year by year in recent years. Professor Lu Fang, a traditional Chinese medicine master, has achieved good results in the diagnosis and treatment of tic disorder by using traditional Chinese medicine theory. Professor Lu Fang believes that the core disease of this disease is in the liver, which can extend to the heart, lung, and spleen. The core pathogenesis is the internal stirring of liver wind, wind-phlegm invading upward, and the disorder of form and spirit. The main treatment is to suppress hyperactive liver for calming endogenous wind, dissipate phlegm and relieve spasm, and regulate both form and spirit. Professor Lu Fang uses the self-designed Xifeng Zhidong Prescription as the basic prescription of the disease, and according to the characteristics of the disease and syndrome, treatment based on classification differentiation, and finally according to the specific disease and specific prescription, add or change, at the same time emphasizing the importance of life protection in the treatment of disease. This paper summarizes the clinical experience of Professor Lu Fang, a traditional Chinese medicine master, in the treatment of tic disorders with self-designed Xifeng Zhidong Prescription. Case one is attached for proof.
		2023 Vol. 20 (19): 125-129 [Abstract] ( 17 ) HTML (1 KB) PDF (850 KB) ( 42 )

	130	Analysis of clinical application of in vitro fertilization-embryo transfer acupuncture stage adjuvant treatment based on “nourishing kidney and blood”
		WU Jiaman1 MA Fei1 LI Yitong1 TAN Liya2 LIN Yanting1 NING Yan1
		DOI: 10.20047/j.issn1673-7210.2023.19.29
		Assisted reproductive technology is one of the modern mainstream diagnosis and treatment methods for the infertility. However, its success rate is low and there are also many complications in the process of follicle extraction and transplantation. Multidisciplinary integration is the trend of current medical development. In this paper, starting from the perspective of acupuncture and moxibustion assisted treatment, according to the reproductive physiological characteristics of in vitro fertilization-embryo transfer at different time nodes, it is divided into six stages: pre-in vitro fertilization conditioning period, pituitary down-regulation period, controlled superovulation period, ovulation period, pre-embryo transfer period, and post-transplantation period. In this paper, staging and syndrome differentiation treatment of traditional Chinese and western medicine is adopted, and a unique set of acupuncture and moxibustion auxiliary treatment program of “nourishing kidney and blood” is constructed from the perspective of acupuncture and moxibustion auxiliary treatment program, in order to provide a relatively safe and effective treatment method to improve the rate of fertilization, embryo implantation rate and pregnancy rate of clinical in vitro fertilization-embryo transfer patients, while reducing the amount of drugs and toxic side effects.
		2023 Vol. 20 (19): 130-134,138 [Abstract] ( 19 ) HTML (1 KB) PDF (1335 KB) ( 38 )

	135	Image schema analysis of conceptual metaphor in Shanghan Zabing Lun
		XIE Jing1 WANG Ding2 MA Cuilan3
		DOI: 10.20047/j.issn1673-7210.2023.19.30
		This paper takes Shanghan Zabing Lun, one of the four classics of traditional Chinese medicine, as an example to analyze its concept, language, and theory of traditional Chinese medicine from the perspective of conceptual metaphor and image schema theory in cognitive linguistics. The research holds that ancient people unknowingly took the familiar and simple things or phenomena in the brain as the original domain, and the abstract and complex traditional Chinese medicine theory as the target domain, and carried out psychological mapping with the help of basic human image schema-container schema, up-middle-down schema, original-path-end schema, center-to-edge schema, and so on-to form a series of conceptual metaphors which makes the latter easier to describe and understand.
		2023 Vol. 20 (19): 135-138 [Abstract] ( 18 ) HTML (1 KB) PDF (596 KB) ( 22 )

	139	Visual analysis of the mechanism of traditional Chinese medicine for renal fibrosisi based on CiteSpace
		ZHAO Yingkun1 LIU Lanying2 ZHAO Zongjiang3 TIAN Zhejing2 YAO Wenjing1 YAN Yingrui1 JIANG Hao1 TUO Wei1
		DOI: 10.20047/j.issn1673-7210.2023.19.31
		Objective To visual analysis of the mechanism of traditional Chinese medicine intervention in renal fibrosis based on CiteSpace, and to explore research hotspots in this field. Methods The literatures on the mechanism of traditional Chinese medicine treatment of renal fibrosis collected on CNKI from January 2001 to October 2022 were retrieved. The authors, institutions, and keywords were analyzed by CiteSpace and generated a series of maps. Results After manual screening and software removal, 371 literatures were included, and the annual publication volume showed an overall rising trend. Among the 13 core authors, Yan Ziyou’s team published the most papers, and Beijing University of Chinese Medicine published the most papers. The use of qi-enhancing and blood-activating drugs to remove blood stasis and the mechanism of oxidative stress, inflammation, and autophagy were hot topics of research. Conclusion Through the statistical atlases, the evolution process of research hotspots about the mechanism of intervention of traditional Chinese medicine on renal fibrosisi is visually displayed. The current work will provide some reference for future scientific research in this field.
		2023 Vol. 20 (19): 139-142 [Abstract] ( 19 ) HTML (1 KB) PDF (1367 KB) ( 59 )

	143	Clinical effect of Yishen Huoxue Jiedu Decoction combined with press-needle on peripheral neuropathy in patients with multiple myeloma of kidney deficiency and blood stasis type
		GAO Erchao LI Yingqiao PANG Hongcui ZHOU Zhenhuan WANG Maosheng
		DOI: 10.20047/j.issn1673-7210.2023.19.32
		Objective To investigate the clinical effect of Yishen Huoxue Jiedu Decoction combined with press-needle on peripheral neuropathy in patients with multiple myeloma of kidney deficiency and blood stasis type. Methods A total of 80 peripheral neuropathy patients with multiple myeloma of kidney deficiency and blood stasis type in Langfang Traditional Chinese Medicine Hospital of Hebei Province from October 2019 to August 2022 were selected and divided into control group and study group according to random number table method, with 40 cases in each group. The control group was given the western medicine Mecobalamin and Folic acid nutritional nerve treatment, and the study group was treated with Yishen Huoxue Jiedu Decoction combined with press-needle on the basis of oral nutritional nerve treatment. Both groups were treated for two courses. The improvement of peripheral neuropathy grading, immune function, quality of life (Karnofsky performance status [KPS], pain degree numerical rating scale [NRS], Pittsburgh sleep quality index scale [PSQI], Hamilton anxiety scale [HAMA]), and traditional Chinese medicine symptom score of the two groups were compared before and after treatment. Results After treatment, the grade of peripheral neuropathy in the two groups was better than before treatment, and the study group was better than the control group (P＜0.05). After treatment, CD4+ and CD4+/CD8+ in the study group were higher than before treatment, and those in the study group were higher than those in the control group (P＜0.05). CD8+ in the study group was lower than that before treatment, and that in the study group was lower than that in the control group (P＜0.05). After treatment, the KPS score of the two groups was higher than before treatment, and that of the study group was higher than that of the control group (P＜0.05). NRS, PSQI, and HAMA scores of the two groups were lower than before treatment, and those of the study group were lower than those of the control group (P＜0.05). After treatment, the scores of hand and foot numbness, sensory disturbance, limb pain, and cold aggravation in both groups were lower than before treatment, and those in the study group were lower than those in the control group (P＜0.05). Conclusion Yishen Huoxue Jiedu Decoction combined with press-needle has good clinical efficacy on peripheral neuropathy in patients with multiple myeloma of kidney deficiency and blood stasis type, improving peripheral neuropathy, regulating immune function, improving sleep quality and anxiety, and improving patients’ quality of life.
		2023 Vol. 20 (19): 143-148 [Abstract] ( 18 ) HTML (1 KB) PDF (942 KB) ( 117 )

	149	Clinical effect of Self-made Shugan Jianzhong Decoction on the treatment of Helicobacter pylori positive chronic atrophic gastritis with syndrome of heat stagnation in liver and stomach
		XIONG Li1 WANG Mei2 LUO Xilin3 YANG Yingjie3
		DOI: 10.20047/j.issn1673-7210.2023.19.33
		Objective To investigate the clinical effect of Self-made Shugan Jianzhong Decoction on the treatment of Helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) with syndrome of heat stagnation in liver and stomach. Methods A total of 112 patients with Hp positive CAG with syndrome of heat stagnation in liver and stomach admitted to Nanchong Hospital of Traditional Chinese Medicine of Sichuan Province from September 2020 to September 2022 were selected as the research objects. The patients were divided into control group and observation group by computer random drawing method, with 56 cases in each group. The control group was treated with quadruple therapy, and the observation group was additionally given Self-made Shugan Jianzhong Decoction internally. Both groups were treated with 14 days as a course of treatment for two courses. The clinical efficacy, one-time eradication rate of Hp were compared between the two groups, the traditional Chinese medicine symptom score and gastric function indexes were compared between the two groups before and after treatment, and the safety of treatment was observed. Results The clinical efficacy of the observation group was better than that of the control group, and the one-time eradication rate of Hp was higher than that of the control group (P＜0.05). After treatment, the scores of stomach fullness, abdominal pain and distention, acid regurgitation and belching, tongue red and liver-yellow, and the levels of pepsinogen Ⅰ, pepsinogen Ⅱ, gastrin-17 in both groups were lower than those before treatment, and those of the observation group were lower than those of the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion In the treatment of Hp positive CAG with syndrome of heat stagnation in liver and stomach, Self-made Shugan Jianzhong Decoction can improve the symptoms of traditional Chinese medicine and stomach function of patients, and improve the effect and the rate of radical treatment of Hp, with good safety.
		2023 Vol. 20 (19): 149-152,157 [Abstract] ( 15 ) HTML (1 KB) PDF (803 KB) ( 20 )

	153	Summary of veteran doctors of traditional Chinese medicine Zhang Xi’s academic experience in orthopedics and traumatology
		JIN Tianxiang1 YUAN Jun1 CHANG Junjie1 GAO Jun2 ZHANG Xi2
		DOI: 10.20047/j.issn1673-7210.2023.19.34
		Zhang Xi, a veteran doctors of traditional Chinese medicine, has engaged in the clinical activities of orthopedics and traumatology for a long time. While mastering traditional Chinese medicine, Professor Zhang is also an expert on western medicine, and has formed the clinical thinking of integrating traditional Chinese medicine and western medicine with the former as the core, and summarizes many effective internal and external treatment methods. In terms of internal treatment, Professor Zhang pays particular attention to the dual treatment of qi and blood, the harmonization of Yin and Yang, and the consideration of spleen and stomach on the basis of syndrome differentiation treatment. In terms of external treatment, Professor Zhang emphasizes that delicate manipulation is the key to the rectification of fractures, dislocations and joint disorders, which is reflected in flexible bone setting ideas and delicate manipulation. Professor Zhang attaches great importance to the combined treatment of muscles and bones during and after bone-setting, combining dynamic and static to promote functional recovery. This paper explores and summarizes the clinical academic experience of Professor Zhang in bone injury in order to better serve the clinic.
		2023 Vol. 20 (19): 153-157 [Abstract] ( 19 ) HTML (1 KB) PDF (850 KB) ( 31 )

	158	Clinical effect of Zishen Runfei Liyan Decoction combined with press needle on chronic pharyngitis with syndrome of yin deficiency of lung and kidney
		HU Qiao1 PU Chunping2 CHEN Linfeng1 WU Yongping2
		DOI: 10.20047/j.issn1673-7210.2023.19.35
		Objective To explore the clinical effect of Zishen Runfei Liyan Decoction combined with press needle on chronic pharyngitis (CP) with syndrome of yin deficiency of lung and kidney. Methods A total of 135 patients with CP admitted to Nanchong Hospital of Traditional Chinese Medicine from January 2021 to July 2022 were selected and they were divided into three groups according to the random number table method. The decoction group was treated with Zishen Runfei Liyan Decoction, the press needle group was treated with press needle, and the combined group was treated with Zishen Runfei Liyan Decoction combined with press needle, all patients were treated for four weeks. The clinical efficacy, traditional Chinese medical syndrome scores, serum levels of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) were compared among the three groups before and after treatment, and the incidence rate of adverse reactions and recurrence were compared. Results The clinical effect of the combined group was better than that of the decoction group and the press needle group, the differences were statistically significant (P＜0.05). After treatment, the traditional Chinese medical symptom score and serum levels of IL-1β, IL-6, and TNF-α in combined group were lower than those in decoction group and press needle group, the differences were statistically significant (P＜0.05). No obvious adverse reactions occurred in the three groups. After three months of follow-up, the recurrence rate of combined group was lower than that of decoction group and press needle group, the difference was statistically significant (P＜0.05). Conclusion Zishen Runfei Liyan Decoction combined with press needle has a significant clinical effect on CP of lung-kidney yin deficiency type, which can effectively improve clinical symptoms, reduce the recurrence rate, and has high safety.
		2023 Vol. 20 (19): 158-161 [Abstract] ( 19 ) HTML (1 KB) PDF (641 KB) ( 84 )

	162	Predictive value of enhanced dual-phase CT imaging parameters combined with serum carcinoembryonic antigen for benign and malignant pulmonary subcentimeter nodules
		LI Lu WANG Jing ZHANG Xiejun
		DOI: 10.20047/j.issn1673-7210.2023.19.36
		Objective To investigate the value of enhanced dual-phase CT imaging parameters combined with serum carcinoembryonic antigen (CEA) expression in predicting benign and malignant pulmonary subcentimeter nodules. Methods The clinical data of 69 patients with pulmonary subcentimeter nodules admitted to Xuancheng Central Hospital of Anhui Province from March 2018 to May 2022 were retrospectively analyzed. According to pathological results, they were divided into benign group (46 cases) and malignant group (23 cases). The enhanced dual-phase CT imaging parameters and the serum CEA expression level at admission were compared between two groups; and the influencing factors of benign and malignant pulmonary subcentimeter nodules were analyzed; predictive value of enhanced dual-phase CT imaging parameters combined with serum CEA expression in the diagnosis of benign and malignant pulmonary subcentimeter nodules by receiver operating characteristic curve. Results The proportion of clear tubercle boundary in malignant group was lower than that in benign group; the proportion of foliation sign, thymus sag sign, ground glass density, burr, upper lobe, vascular cluster sign, and vacuole were higher than those in benign group (P＜0.05). The positive expression rate of CEA in malignant group was higher than that in benign group (P＜0.05). The nodular boundary, foliation, ground glass density, and burr were the factors affecting the malignant pulmonary subcentimeter nodules (OR＞1, P＜0.05). The benign and malignant model of pulmonary subcentimeter nodules predicted by enhanced dual-phase CT imaging parameters was Log(P) =1.325+1.543×nodular boundary+1.265×foliation+1.421×ground glass density+1.172× burr. The value of area under the curve of malignant pulmonary subcentimeter nodules predicted by enhanced dual-phase CT imaging parameter prediction model and serum CEA expression was higher than that of each single test. Conclusion Enhanced dual-phase CT imaging parameters and serum CEA expression have important value in predicting benign and malignant pulmonary subcentimeter nodules, and their combination has higher value.
		2023 Vol. 20 (19): 162-165 [Abstract] ( 16 ) HTML (1 KB) PDF (687 KB) ( 14 )

	166	Diagnostic value of musculoskeletal ultrasound imaging features combined with detection of anti-CCP antibody levels in rheumatoid arthritis
		YE Qing ZHU Congying WANG Xinru
		DOI: 10.20047/j.issn1673-7210.2023.19.37
		Objective To investigate the diagnostic value of musculoskeletal ultrasound imaging features combined with detection of anti-cyclic citrullinated peptide (CCP) antibody levels in rheumatoid arthritis. Methods A total of 81 patients with rheumatoid arthritis admitted to the Changzhou Wujin Hospital of Traditional Chinese Medicine, Jiangsu Province (“our hospital” for short) from April 2019 to March 2022 were selected as the research group, in addition, 45 healthy people with physical examination in our hospital during the same time were selected as the control group. According to 28 joint disease activity index scores, the research group was divided into high activity group (27 cases), moderate activity group (33 cases), and low activity group (21 cases). The research group underwent MRI and musculoskeletal ultrasonography. The detection rates of MRI and musculoskeletal ultrasonography for three typical pathological features (bone erosion, joint effusion, and synovial hyperplasia) were compared; the levels of anti-CCP antibodies between two groups were compared; the diagnostic value of musculoskeletal ultrasound imaging features combined with the level of anti-CCP antibody in rheumatoid arthritis was analyzed. Results There was no significant difference in the detection rate of bone erosion and synovial hyperplasia between MRI and musculoskeletal ultrasound (P＞0.05); the detection rate of joint effusion of musculoskeletal ultrasound was higher than that of MRI, and the difference was statistically significant (P＜0.05). The level of anti-CCP antibody in the research group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The level of anti-CCP antibody in high activity group was higher than that in low activity group and moderate activity group, the level of anti-CCP antibody in moderate activity group was higher than that in low activity group, and the differences were statistically significant (P＜0.05). The level of anti-CCP antibody was positively correlated with the severity of rheumatoid arthritis (r=0.573, P＜0.01). The area under curve value of joint effusion, synovial hyperplasia, and anti-CCP antibody combined diagnosis of rheumatoid arthritis was higher than that of the single diagnosis, and the difference was statistically significant (P＜0.05). Conclusion Musculoskeletal ultrasound imaging features (joint effusion, synovial hyperplasia) and anti-CCP antibody levels are of great value in the diagnosis of rheumatoid arthritis, and the combination of the three has a higher diagnostic value.
		2023 Vol. 20 (19): 166-169 [Abstract] ( 19 ) HTML (1 KB) PDF (688 KB) ( 32 )

	170	Imaging features and diagnostic value of enhanced CT and MRI in elderly patients with combined hepatocellular and cholangio carcinoma
		XIAO Zhifeng1 YANG Zhiyong1 QIAN Xiaojian1 SUN Rong1 JIANG Yanli1 XIAO Yichun2▲
		DOI: 10.20047/j.issn1673-7210.2023.19.38
		Objective To explore the imaging features and diagnostic value of liver enhanced CT and MRI in elderly patients with combined hepatocellular and cholangio carcinoma (cHCC-CC). Methods From October 2018 to September 2020, 98 elderly patients suspected to be cHCC-CC admitted to Rugao People’s Hospital, Jiangsu Province were selected as the research subjects, all patients underwent CT and MRI examinations. CT and MRI imaging features of elderly patients with cHCC-CC were analyzed. Pathological results as the gold standard, the diagnostic value of CT, MRI, and their combination in elderly patients with cHCC-CC was analyzed. Results Among the 98 elderly patients suspected to be cHCC-CC, 89 cases were cHCC-CC patients. CT plain scan showed that the liver contour was unstructured, wavy, with increased volume and uneven density, and the tumor presented mixed density or low density; plain MRI showed mosaic signs. The sensitivity of liver enhanced CT, MRI, and their combination in the diagnosis of elderly cHCC-CC was 77.53%, 92.13%, and 97.75%, respectively; the specificity was 66.67%, 77.78%, and 88.89%, respectively; the accuracy was 76.53%, 90.81%, and 96.94%, respectively. Conclusion The combination of enhanced CT and MRI in the diagnosis of cHCC-CC in the elderly is effective.
		2023 Vol. 20 (19): 170-173 [Abstract] ( 26 ) HTML (1 KB) PDF (650 KB) ( 14 )

	174	Thinking on the construction of public health prevention and control capacity of specialized hospitals based on grounded theory
		LYU Kainan YUAN Shuangqiu▲
		DOI: 10.20047/j.issn1673-7210.2023.19.39
		Objective To analyze the difficulties and challenges of public health prevention and control ability of specialized hospitals, and to put forward countermeasures and suggestions, using by the principles and methods of grounded theory. Methods From June to August 2022, 12 experts from four Grade-A hospitals in Beijing (Peking Union Medical College Hospital, Fuwai Hospital, Tumor Hospital, and Plastic Surgery Hospital Affiliated to Chinese Academy of Medical Sciences) were interviewed in a semi-structured manner about the challenges and suggestions of public health prevention and control capacity building of specialized hospitals, and the interview data were summarized and extracted by using grounded theory. Results Twelve initial categories, six main categories, and three core categories were summarized to form an analysis model of difficulties and challenges in the prevention and control ability of public health in specialized hospitals from three aspects: population risk, discipline construction and resource allocation. Conclusion It is suggested to improve the daily prevention and control level and emergency handling capacity of specialized hospitals from three aspects: improving emergency response mechanism, strengthening discipline construction, and personnel training, and optimizing material reserve strategy.
		2023 Vol. 20 (19): 174-177 [Abstract] ( 13 ) HTML (1 KB) PDF (463 KB) ( 62 )

	178	Study on nursing intervention of elderly burn patients based on Roy’s adaptation model
		ZHENG Chundong1 HUANG Qiuhuan2▲ HUANG Fen3 LU Liuxue2 WANG Shuxian3 LI Qingyun4 TANG Qiang3 QIN Mei3
		DOI: 10.20047/j.issn1673-7210.2023.19.40
		Objective To explore the study on nursing intervention of elderly burn patients based on Roy’s adaptation model. Methods A total of 84 elderly burn patients with burn plastic surgery and wound repair in the Department of Burn Plastic Surgery and Wound Repair, Affiliated Hospital of Youjiang Medical College for Nationalities from January 2020 to December 2021 were selected. They were divided into group A and group B by random number table method, with 42 cases in each group. Group A received routine care, and group B received care based on Roy’s adaptation model on the basis of group A. Serum inflammatory factor levels, emotional state, pain degree, sleep quality, and complications were compared between the two groups. Results After nursing, the levels of procalcitonin and C-reactive protein in two groups were lower than before nursing, and those of the group B were lower than group A (P＜0.05); the scores of self-rating anxiety scale and self-rating depression scale in two groups were lower than before nursing, and those of the group B was lower than group A (P＜0.05). The scores of visual simulation of pain and Pittsburgh sleep quality index in two groups were lower than before nursing, and group B was lower than group A (P＜0.05); the score of simple quality of life scale in two groups was higher than that before nursing, and group B was higher than group A (P＜0.05); the total incidence rate of adverse effect of group B was lower than that of group A (P＜0.05). Conclusion The nursing intervention based on Roy’ adaptation model is applied to the elderly burn patients, and the effect is ideal.
		2023 Vol. 20 (19): 178-181 [Abstract] ( 13 ) HTML (1 KB) PDF (624 KB) ( 79 )

	182	Effect of group sandtable game on rehabilitation effect of patients with cerebral infarction
		XU Xiaohong1 SHEN Min1 WEI Jurui2
		DOI: 10.20047/j.issn1673-7210.2023.19.41
		Objective To study the rehabilitation effect of group sandtable game on rehabilitation effect of patients with cerebral infarction. Methods A total of 268 patients with cerebral infarction who received treatment in Hangzhou Medical College Affiliated Lin’an People’s Hospital from September 2021 to August 2022 were selected as study subjects. They were randomly divided into control group and observation group, with 134 cases in each group. The patients in the control group received routine rehabilitation, and the patients in the observation group received group sandtable game on the basis of the control group. The hand function score, Barthel index score, self-rating anxiety scale score, self-rating depression scale score, and compliance were compared between the two groups before and after treatment for three months. Results After treatment, the hand function score of the two groups was higher than that before treatment, and the observation group was higher than the control group (P＜0.05); after treatment, Barthel index scores in both groups were higher than before treatment, and that of the observation group was higher than control group (P＜0.05); the scores of self-rating anxiety scale and self-rating depression scale in both groups were lower than before treatment, and that of the the observation group was lower than the control group (P＜0.05); the compliance of observation group was better than that of control group (P＜0.05). Conclusion Group sandtable game for patients with cerebral infarction can effectively improve the effect of rehabilitation training and is worthy of promotion.
		2023 Vol. 20 (19): 182-185 [Abstract] ( 15 ) HTML (1 KB) PDF (550 KB) ( 24 )

	186	Application effect of IMB model combined with Teach-back health education in patients with coronary heart disease after percutaneous coronary intervention
		SUN Xueli WANG Juanjuan MAO Wan
		DOI: 10.20047/j.issn1673-7210.2023.19.42
		Objective To observe the application effect of IMB model combined with Teach-back health education in patients with coronary heart disease after percutaneous coronary intervention. Methods Sixty patients with coronary heart disease who underwent percutaneous coronary intervention in Fuyang People’s Hospital, Anhui Province from April 2019 to December 2020 were selected as the study objects. The patients were divided into control group and study group, with 30 cases in each group. The control group received conventional and Teach-back health education, while the research group received IMB model health education based on the control group. After three months of intervention, the medical compliance of the two groups after intervention was compared, and the health knowledge cognition status and quality of life of the two groups before and after intervention were analyzed. Results The compliance of the study group was better than that of the control group, and the difference was statistically significant (P＜0.05); after intervention, the scores of disease inducement, first aid treatment, intervention drugs, matters needing attention after surgery, complications, exercise management, and diet management in two groups were higher than before intervention, and those in the study group were higher than those in the control group (P＜0.05); after intervention, angina attack degree, disease cognition degree, physical restriction degree, angina stability, and treatment satisfaction score of the two groups were higher than before intervention, and those in the study group were higher than those the control group (P＜0.05). Conclusion The application of Teach-back combined with IMB model intervention in patients with coronary heart disease after percutaneous coronary intervention can significantly improve their compliance and health knowledge, as well as improve their quality of life, which is worthy of promotion and application.
		2023 Vol. 20 (19): 186-189 [Abstract] ( 20 ) HTML (1 KB) PDF (598 KB) ( 13 )

	190	Application effect of interactive education system nursing in self-management of adolescent patients with depression
		GUAN Chunlan1 XU Chunhua2 BU Yangying3
		DOI: 10.20047/j.issn1673-7210.2023.19.43
		Objective To explore the application effect of interactive education system nursing in self-management of adolescent patients with depression. Methods A total of 106 adolescents with depression in the Fourth People’s Hospital of Wuhu, Anhui Province from January 2020 to June 2022 were selected as the research objects, according to random number table method, they were divided into control group and observation group, with 53 cases in each group. The control group took routine nursing, and the observation group added interactive education system nursing on the basis of the control group. The scores of anxiety, depression, self-efficacy scale, and medical coping style were compared between the two groups before intervention and one month after nursing. Results After nursing, the negative emotion scores of both groups were lower than those before intervention, and those of the observation group were lower than the control group (P＜0.05); after nursing, the self-care ability scale scores were higher in both groups than those before intervention, and those of the observation group were higher than those the control group (P＜0.05); the scores of help-seeking, rationalization and problem solving in the two groups were higher than those before nursing, and the observation group was higher than the control group, the scores of self-blame, fantasy, and withdrawal in the two groups were lower than those before nursing, and the observation group was lower than the control group (P＜0.05). Conclusion Interactive education system nursing for adolescents with depression can effectively reduce patients’ anxiety and depression, improve patients’ self-efficacy scores, and enhance patients’ courage to deal with the disease, which is worthy of reference and adoption by various departments.
		2023 Vol. 20 (19): 190-193 [Abstract] ( 9 ) HTML (1 KB) PDF (605 KB) ( 1804 )

	194	Application value of incentive psychological nursing combined with health education in patients undergoing intrauterine device placement
		YANG Jiping QUAN Peiqing DA Yuting YANG Lan▲
		DOI: 10.20047/j.issn1673-7210.2023.19.44
		Objective To explore the application value of incentive psychological nursing combined with health education in patients undergoing intrauterine device placement. Methods A total of 78 patients with intrapalace intrauterine device placement admitted to Obstetrics and Gynecology Hospital of Fudan University from May 2019 to February 2022 were selected, they were divided into control group and study group by random number table method, with 39 cases in each group. The control group received routine nursing combined with health education, and the study group received incentive psychological nursing on the basis of the control group. Adverse mood, coping style, quality of life, self-care ability, and nursing satisfaction were compared between the two groups before and after intervention. Results After intervention, the scores of depressive symptom group scale and generalized anxiety scale were lower in the two groups than those before intervention, and those of the study group were lower than the control group (P＜0.05); the face score of the two groups was higher than those before intervention, and the study group was higher than the control group (P＜0.05). The avoidance score and yield score of the two groups were lower than before intervention, and the study group was lower than the control group (P＜0.05); after intervention, the health survey scale scores of the two groups were higher than those before intervention, and the study group was higher than the control group (P＜0.05). The self-care ability scale scores of the two groups were higher than those before intervention, and the study group was higher than the control group (P＜0.05); the nursing satisfaction of study group was better than that of control group (P＜0.05). Conclusion The incentive psychological nursing combined with health education can improve the bad mood of patients undergoing intrauterine device placement, improve the quality of life, nursing satisfaction and self-care ability of patients, and deal with the operation in a positive way.
		2023 Vol. 20 (19): 194-封三 [Abstract] ( 7 ) HTML (1 KB) PDF (554 KB) ( 14 )

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