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| Influence and predictive value of serum 25-hydroxyvitamin D3 and chemokine on the occurrence of coronary artery lesion in children with Kawasaki disease |
| LI Nana WANG Hongqun▲ |
Department of Pediatrics, the Second People’s Hospital of Wuhu City, Anhui Province, Wuhu 241000, China
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Abstract Objective To analyze the influence and prognostic value of serum 25-hydroxyvitamin D3 [25(OH)D3] and chemokine on the occurrence of coronary artery lesion (CAL) in children with Kawasaki disease (KD). Methods A total of 86 KD children admitted to the Second People’s Hospital of Wuhu City, Anhui Province from July 2018 to November 2022 were selected as the study objects. After two weeks of treatment, the patients were divided into the occurrence group (21 cases) and the non-occurrence group (65 cases) according to the occurrence of CAL. The clinical data, serum levels of 25(OH)D3, and lipid-derived cytokines were compared between the two groups, and the influencing factors of the occurrence of CAL in KD children were analyzed, and the predictive value of the combined detection of serum 25(OH)D3 and lipid-derived cytokines on the occurrence of CAL in KD children was further analyzed. Results The proportion of KD in acute phase, the proportion of intravenous immunoglobulin (IVIg) resistance, and the levels of procalcitonin, omentin-1, and chemokine before treatment in the occurrence group were higher than those in the non-occurrence group, the duration of fever before IVIg was longer than that in the non-occurrence group, and the serum 25(OH)D3 was lower than that in the non-occurrence group (P＜0.05). The results of multivariate logistic regression analysis showed that procalcitonin (OR= 2.759, 95%CI: 1.053-4.185), serum 25(OH)D3 (OR=0.310, 95%CI: 0.128-0.754), and chemokine (OR=3.364, 95%CI: 2.063-7.125) were the influencing factors of CAL occurrence in KD children (P＜0.05). The analysis of the receiver operation characteristic curve showed that the area under the curve of serum 25(OH)D3 combined with chemokine predicted CAL development in KD children was higher than those predicted by the two alone (P＜0.05). Conclusion Procalcitonin, serum 25(OH)D3, and chemokine are all related factors affecting the occurrence of CAL in KD children, and the combination of serum 25(OH)D3 and chemokine has a higher predictive effect on the occurrence of CAL in KD children.
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[1] Akimoto K，Harada M，Oda H，et al. Coronary Revascularization of Giant Aneurysms in Children With Kawasaki Disease：A Report of Two Cases [J]. Front Pediatr，2020，8（2）：54-59.
[2] Zhang Y，Wang Y，Zhang L，et al. Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRbeta Vascular Smooth Muscle Cell Axis [J]. Circ Res，2020，127（7）：855- 873.
[3] Tsuchihashi T，Kakimoto N，Takeuchi T，et al. Intimal thickening and disruption of the media occur in the arterial walls of coronary arteries not associated with coronary arterial aneurysms in patients with Kawasaki disease [J]. BMC Cardiovasc Disord，2021，21（1）：278.
[4] 邵东，陈洁.川崎病患儿血清中25（OH）D3、NT-proBNP和IL-6表达水平及诊断价值[J].中国地方病防治杂志，2019，34（6）：92-93.
[5] 相虹，常明，王秋霞，等.川崎病患儿治疗前后血清脂源性细胞因子的变化及意义[J].中国当代儿科杂志，2020， 22（1）：64-68.
[6] 董焱，宋靖荣.脂源性细胞因子Omentin-1、Chemerin对川崎病患儿冠状动脉损伤的预测价值[J].医学综述，2020，26（21）：4349-4353.
[7] McCrindle BW，Rowley AH，Newburger JW，et al. Diagnosis, treatment, and long-term management of Kawasaki disease：A scientific statement for health professionals from the American Heart Association [J]. Circulation，2017，135（17）：927-999.
[8] 刘亚黎.川崎病的冠状动脉损害[J].中华实用儿科临床杂志，2001，16（5）：337-338.
[9] 焦富勇.川崎病[M].北京：人民卫生出版社，2014：21-23.
[10] 高文珺，范晓晨.丙球无反应性川崎病的诊断及治疗进展[J].安徽医学，2017，38（7）：951-954.
[11] 卢松建，靳晶晶，董坤，等.淀粉样蛋白A、D-二聚体、肌酸激酶同工酶联合检测对川崎病患儿冠状动脉损伤的诊断价值分析[J].现代生物医学进展，2022，22（4）：757-760.
[12] 刘凡，丁艳，唐红霞，等.川崎病患儿冠状动脉损伤与血浆sFKN水平的关系探讨[J].中西医结合心脑血管病杂志，2020，18（17）：2889-2891.
[13] 牟静飞，潘宣任，覃敏.川崎病致冠状动脉损害的诊断和急性期治疗新进展[J].中国医药科学，2023，13（7）：45-48，57.
[14] 黄丽，温雪风，唐小燕，等.小儿川崎病并发冠状动脉损伤的特点及危险因素分析[J].中国当代医药，2022，29（24）：5-8，13.
[15] 罗洁，李晓忠，闵月，等.川崎病患儿心率变异性与PCT的相关性及其预测冠状动脉损伤的价值[J].河北医学，2021，27（7）：1215-1219.
[16] 袁时健，孔玉洁，董湘玉.川崎病及所致冠状动脉病变病因与发病机制研究进展[J].中国医药，2022，17（9）：1431-1434.
[17] Wang Y，Xu Y，Huang P，et al. Homozygous of MRP4 Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease [J]. Front Genet，2021，12（3）：50-54.
[18] 胡慧敏，陈笑征，张永兰，等.川崎病急性期肝损害与冠状动脉损伤和免疫球蛋白无反应的关系[J].中国当代儿科杂志，2022，24（6）：681-686.
[19] 王茹，周莉蓉，戚昌丽.双嘧达莫联合丙种球蛋白及阿司匹林治疗川崎病疗效及对患儿免疫功能和凝血功能的影响[J].河北医学，2021，27（2）：317-321.
[20] 陈幼萍，孔璐丹.急性期川崎病患儿T细胞亚群，25-（OH）D3水平与冠脉损害的关系[J].中国妇幼保健，2020，35（14）：2614-2616.
[21] 许阳琼，刘国桥.丙种球蛋白与阿司匹林对川崎病患儿的效果及安全性观察[J].中国医药科学，2021，11（22）：86-88，100.
[22] 郝京霞，张英谦，李博，等.细胞因子对川崎病患儿发生冠状动脉病变及静脉用丙种球蛋白抵抗的预测价值[J].中国医药，2022，17（2）：175-178.
[23] 朱再富，范晓晨.川崎病患儿红细胞分布宽度变化及意义[J].临床儿科杂志，2020，38（3）：182-185.
[24] 陈小红，罗晓明，马晓慧，等.25-羟维生素D3预测川崎病冠状动脉病变的价值[J].中国妇幼健康研究，2019， 30（5）：558-561.
[25] 韦美玉，张广利，杨建国，等.血清25-羟基维生素D3水平、基质金属蛋白酶-9与冠心病的相关性研究[J].中西医结合心脑血管病杂志，2020，18（15）：2480-2483.
[26] 阙学俊，吕少剑，卢业佳，等.血清PA、NT-proBNP与25（OH）D3水平对川崎病患儿冠状动脉病变风险的预测价值[J].川北医学院学报，2022，37（6）：768-771.
[27] 程诚，王鑫.冠状动脉狭窄程度与血清25（OH）D3的关系探讨[J].中西医结合心脑血管病杂志，2019，17（4）：575-577.
[28] 蒋华芳，高健，韩文宁.川崎病儿童血清维生素D水平及其受体FokⅠ基因多态性研究[J].中国妇幼保健，2020，35（3）：459-462.
[29] 陈艳丽.川崎病患儿血清25（OH）D3水平的变化及意义[J].重庆医学，2022，34（8）：1230-1232.
[30] 任倩，吴新.血清中25（OH）D3、NT-proBNP和IL-6在川崎病患儿中的早期诊断价值[J].中国妇幼健康研究，32（5）：4349-4353.
[31] Morita S，Sato S，Maruyama S，et al. Prevalence and whole- genome sequence analysis of Campylobacter spp. strains isolated from wild deer and boar in Japan [J]. Comp Immunol Microbiol Infect Dis，2022，82（32）：766-769.
[32] Fukushima Y，Nishiyama K，Kataoka H，et al. RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells [J]. EMBO J，2020，39（12）：930-936.
[33] 董焱，宋靖荣.脂源性细胞因子Omentin-1、Chemerin对川崎病患儿冠状动脉损伤的预测价值[J].医学综述，2020，32（5）：740-743. |
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