兰州市中老年居民的血清肝酶与2型糖尿病发病的相关性分析

doi:10.20047/j.issn1673-7210.2023.19.06

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (684 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (GGT) and type 2 diabetes mellitus (T2DM) in middle-aged and elderly residents in Lanzhou. Methods In 2011, a cluster of 5 135 residents aged 40 to 75 years old from three communities in Lanzhou were randomly sampled, and 3 832 residents meeting the exclusion criteria were eventually included. They were divided into four groups according to ALT, AST, and GGT quartile (group Q1 to Q4). Non-interventional follow-up ≥three years of T2DM events. Logistic regression analysis of the correlation between serum liver enzymes and T2DM. The predictive value of serum liver enzymes for T2DM was analyzed by receiver operating characteristic (ROC) curve. Results Non-interventional follow-up ≥three years, the incidence of T2DM was 6.99% (268/3 832). The number of fasting blood glucose, 2-hour post-meal blood glucose, glycosylated hemoglobin, ALT, GGT, triglyceride, and rate of fatty liver in T2DM group were higher than that in non-T2DM group, and the differences were statistically significant (P＜0.05); high density lipoprotein cholesterol (HDL-C) was lower than that in non-T2DM group, and the difference was statistically significant (P＜0.05). The incidence of T2DM in ALT group Q4 was higher than that in ALT group Q1 and Q2, and the differences were statistically significant (P＜0.05). The incidence of T2DM in GGT group Q3 and Q4 was higher than that in GGT group Q1 and Q2, and the differences were statistically significant (P＜0.05). Logistic regression analysis showed that elevated ALT and GGT were independent risk factors for T2DM (OR＞1, P＜0.05). ROC curve showed that ALT predicted the critical value, area under the curve, sensitivity and specificity of T2DM to be 18.5 U/L, 0.593, 0.519, and 0.634, while GGT to be 20.5 U/L, 0.614, 0.616, and 0.572, respectively. Conclusion The elevation of ALT and GGT in middle-aged and elderly residents in Lanzhou may be associated with the onset of T2DM.

Key words： Type 2 diabetes mellitus Alanine aminotransferase Aspartate aminotransferase γ-glutamyl transferase Middle aged and elderly

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	DING Yulu1 ZHANG Di1 YANG Mengdi1 WANG Yujie1 SUN Linnan1 HE Fengying1 ZHEN Donghu2

Cite this article:

DING Yulu1 ZHANG Di1 YANG Mengdi1 WANG Yujie1 SUN Linnan1 HE Fengying1 ZHEN Donghu2. Analysis on the correlation between serum liver enzymes and the incidence of type 2 diabetes mellitus in middle-aged and elderly residents in Lanzhou[J]. 中国医药导报, 2023, 20(19): 30-34.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.19.06 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I19/30

[1] 周小琦，刘新会，张微，等.老年人丙氨酸氨基转移酶、天冬氨酸氨基转移酶/丙氨酸氨基转移酶与2型糖尿病及代谢综合征的相关性研究[J/OL].中国全科医学：1-6[2023-04-28].
[2] 焦彦林，吕亚林，周羽.利拉鲁肽对2型糖尿病合并NAFLD患者肝酶活性、抗氧化反应能力及血清肝纤维化指标的影响[J].社区医学杂志，2022，20（9）：495-499.
[3] 王晶璞，卢燕，王会.利拉鲁肽治疗初诊肥胖2型糖尿病的效果及对FGF-21、调节性T细胞及血清肝酶的影响[J].河北医药，2021，43（7）：1066-1068，1072.
[4] 王诗佳，徐茂晟，占小梅，等.2型糖尿病患者肝脏硬度与功能的相关性研究[J].医学研究杂志，2021，50（10）：146- 150，154.
[5] 朱荔，丘红梅，刘开平，等.血清肝酶与血脂正常2型糖尿病患者代谢指标的相关性[J].实用糖尿病杂志，2020， 16（5）：98-99.
[6] Yan Q，Sun D，Li X，et al. Neck circumference and incidence of type 2 diabetes in chinese elderly individuals：A community-based cohort study [J]. Obes Facts，2021，14（5）：450- 455
[7] 苑东敏，崔静，任杰，等.青岛成年居民血清肝酶与新诊断2型糖尿病关联研究[J].中国慢性病预防与控制，2020，28（3）：187-190，194.
[8] 缪莹，万沁.2型糖尿病合并高血压患者血清肝酶水平[J].中国老年学杂志，2019，39（16）：3921-3924.
[9] 卢燕，王晶璞，刘莉红，等.利拉鲁肽对初诊肥胖2型糖尿病患者成纤维细胞生长因子21和调节性T细胞及血清肝酶的影响[J].中国临床保健杂志，2019，22（4）：492- 495.
[10] 周小海，马华林，汤杰印.2型糖尿病患者HbA1c水平与尿蛋白、血脂及肝酶的关系[J].湖北科技学院学报（医学版），2017，31（5）：375-377.
[11] 侯庆宁，周海燕.2型糖尿病一级亲属血清肝酶水平与空腹血糖、胰岛素抵抗的相关性分析[J].宁夏医学杂志，2017，39（6）：503-505.
[12] 王丛丛，董砚虎，张磊.2型糖尿病患者血清肝酶水平与代谢综合征的关系[J].川北医学院学报，2017，32（2）：242-245.
[13] 程俊文，盛永齐，何军儒，等.肝酶水平与2型糖尿病合并微血管病变的相关性[J].西部中医药，2016，29（10）：136-138.
[14] 赵建宇，杨杰，刘学亮，等.2型糖尿病合并肥胖症患者胰岛素抵抗与血清肝酶及胆汁酸的关系[J].中国实验诊断学，2016，20（8）：1356-1357.
[15] Hatano Y，Inoue K，Kashima S，et al. Serum alanine transaminase as a predictor of type 2 diabetes incidence：The yuport prospective cohort study [J]. Tohoku J Exp Med，2020，251（3）：183-191.
[16] 留菁菁.2型糖尿病合并非酒精性脂肪肝血清肝酶与糖脂代谢指标的相关性研究[J].现代实用医学，2015，27（6）：781-782，803.
[17] 中华医学会糖尿病学分会.中国2型糖尿病防治指南（2020年版）[J].国际内分泌代谢杂志，2021，41（5）：482- 548.
[18] 国家基层高血压管理专家委员会.国家基层高血压防治管理指南2020版[J].中国医学前沿杂志（电子版），2021，13（4）：26-37.
[19] 余倩，乔虹.血清肝酶与2型糖尿病及空腹血糖受损的相关性研究[J].中国医刊，2014，49（12）：36-38.
[20] Hua S，Qi Q，Kizer JR，et al. Association of liver enzymes with incident diabetes in us hispanic/latino adults [J]. Diabet Med，2021，38（8）：e14522.
[21] Kim CH，Park JY，Lee KU，et al. Association of serum gamma-glutamyltransferase and alanine aminotransferase activities with risk of type 2 diabetes mellitus independent of fatty liver [J]. Diabetes Metab Res Rev，2009，25（1）：64-69.
[22] Park JY，Han K，Kim HS，et al. Cumulative exposure to high γ-glutamyl transferase level and risk of diabetes：A nationwide population-based study [J]. Endocrinol Metab （Seoul）， 2022，37（2）：272-280.
[23] Lin V，Hamby T，Das S，et al. Prevalence of elevated liver enzymes and their association with type 2 diabetes risk factors in children [J]. J Pediatr Endocrinol Metab，2021，34（6）：707-711.
[24] 张玉琴.糖尿病伴肝酶异常72例临床分析[J].四川医学，2002（3）：314-315.
[25] Meyh?觟fer S，Eckert AJ，Hummel M，et al. Elevated liver enzymes and comorbidities in type 2 diabetes：A multicentre analysis of 51 645 patients from the diabetes prospective follow-up （dpv） database [J]. Diabetes Obes Metab，2022， 24（4）：727-732.