|
|
Predictive value of enhanced dual-phase CT imaging parameters combined with serum carcinoembryonic antigen for benign and malignant pulmonary subcentimeter nodules |
LI Lu WANG Jing ZHANG Xiejun |
Department of Imaging, Xuancheng Central Hospital, Anhui Province, Xuancheng 242000, China
|
|
|
Abstract Objective To investigate the value of enhanced dual-phase CT imaging parameters combined with serum carcinoembryonic antigen (CEA) expression in predicting benign and malignant pulmonary subcentimeter nodules. Methods The clinical data of 69 patients with pulmonary subcentimeter nodules admitted to Xuancheng Central Hospital of Anhui Province from March 2018 to May 2022 were retrospectively analyzed. According to pathological results, they were divided into benign group (46 cases) and malignant group (23 cases). The enhanced dual-phase CT imaging parameters and the serum CEA expression level at admission were compared between two groups; and the influencing factors of benign and malignant pulmonary subcentimeter nodules were analyzed; predictive value of enhanced dual-phase CT imaging parameters combined with serum CEA expression in the diagnosis of benign and malignant pulmonary subcentimeter nodules by receiver operating characteristic curve. Results The proportion of clear tubercle boundary in malignant group was lower than that in benign group; the proportion of foliation sign, thymus sag sign, ground glass density, burr, upper lobe, vascular cluster sign, and vacuole were higher than those in benign group (P<0.05). The positive expression rate of CEA in malignant group was higher than that in benign group (P<0.05). The nodular boundary, foliation, ground glass density, and burr were the factors affecting the malignant pulmonary subcentimeter nodules (OR>1, P<0.05). The benign and malignant model of pulmonary subcentimeter nodules predicted by enhanced dual-phase CT imaging parameters was Log(P) =1.325+1.543×nodular boundary+1.265×foliation+1.421×ground glass density+1.172× burr. The value of area under the curve of malignant pulmonary subcentimeter nodules predicted by enhanced dual-phase CT imaging parameter prediction model and serum CEA expression was higher than that of each single test. Conclusion Enhanced dual-phase CT imaging parameters and serum CEA expression have important value in predicting benign and malignant pulmonary subcentimeter nodules, and their combination has higher value.
|
|
|
|
|
[1] 童伦兵,伍兵.CT引导下空针导航联合平静呼吸法在肺亚厘米结节穿刺活检中的应用价值[J].武警医学,2020, 31(7):592-594,600.
[2] 王亚洲,窦允龙,王道清,等.CT引导下肺亚厘米小结节穿刺活检的临床研究[J].医学影像学杂志,2019,29(10):1725-1728.
[3] 李永皎,杜诗霖,付立武,等.18F-FDG PET-CT对不同密度孤立性肺结节的诊断价值[J].中国中西医结合影像学杂志,2021,19(3):229-233.
[4] 黄定品,傅钢泽,蔡蒙婷,等.亚厘米纯磨玻璃密度结节肺腺癌的CT特征对其浸润性的预测价值[J].温州医科大学学报,2019,49(11):837-841.
[5] 苏蕾,董军强,胡丽丽,等.优化CT引导下穿刺活检技术在肺部亚厘米结节中的应用[J].医学影像学杂志,2019, 29(3):410-413.
[6] 傅文悦,朱广辉.Revolution CT能谱成像技术对不同性质肺结节鉴别诊断价值的应用研究[J].中国CT和MRI杂志,2021,19(6):58-61.
[7] 韩萍萍,富丽萍,张凌,等.原发性肺黏液腺癌18F-FDG PET/CT与增强CT影像特征分析[J].协和医学杂志,2022, 13(2):270-276.
[8] 万辉,高美玲,林洁,等.不同类型的肺部磨玻璃结节患者术前免疫炎症指标和癌胚抗原的比较[J].温州医科大学学报,2022,52(7):557-561.
[9] 卢高俊,王若天,田笑如,等.叶酸受体阳性循环肿瘤细胞检测对肺部亚厘米结节的诊断价值[J].肿瘤研究与临床,2020,32(1):1-5.
[10] 单国际.不同方法在孤立性肺结节胸腔镜术前定位中的应用分析[J].中国医师进修杂志,2021,44(6):574-576.
[11] 张艳.双源CT双能量技术在孤立性肺结节患者胸腔镜术前诊治中的应用[J].中国CT和MRI杂志,2020,18(1):57-60.
[12] 伍勇勇,何忠良,叶中瑞,等.两种术前定位方式行胸腔镜孤立性肺结节切除的疗效对比分析[J].浙江医学,2021, 43(21):2353-2356.
[13] 乔理华,王琳,娄加陶.循环肿瘤细胞在良恶性肺部孤立性结节鉴别诊断中的应用价值[J].中华检验医学杂志,2016,39(12):941-945.
[14] 金鑫,钱坤,卢高俊,等.肿瘤相关自身抗体对良恶性亚厘米肺结节的鉴别诊断价值研究[J].实用心脑肺血管病杂志,2020,28(7):83-87.
[15] 苏雷,支修益,张毅,等.56例循环肿瘤细胞检测阳性的亚厘米肺结节患者术后病理分析[J].医学研究杂志,2019, 48(5):51-54.
[16] 张楼乾,蒋峰,李明,等.无创三维重建在肺部亚厘米结节定位中应用[J].南京医科大学学报(自然科学版),2019,39(10):1491-1493.
[17] 高鹏,董志辉,莫哲恒,等.亚厘米纯磨玻璃密度肺腺癌的计算机断层扫描特征及临床意义[J].癌症进展,2020, 18(7):728-730,755.
[18] 向科旭,汪真辉,瞿颖,等.100例亚厘米肺结节手术患者中医证型与病理分析[J].广州中医药大学学报,2022, 39(8):1732-1738.
[19] 张云峰,于磊,柯冀.CT表现为磨玻璃样亚厘米孤立性肺结节的影像及相关临床特征分析[J].中华全科医师杂志,2022,21(7):656-661.
[20] 陈跃,杜坤,沈蕾.亚厘米磨玻璃结节CT特点与临床病理的关系[J].中国CT和MRI杂志,2022,20(5):92-95.
[21] 徐建平,李会方,叶伟,等.178例肺亚厘米结节(直径≤8 mm)影像学与临床病理分析[J].临床与实验病理学杂志,2020,36(3):290-294.
[22] 林芮羽,吕发金,付彬洁,等.灶周肺组织密度改变在亚厘米肺实性结节鉴别诊断中的价值[J].临床放射学杂志,2022,41(3):474-478.
[23] 曹芹,李雪冰,张丽,等.孤立性肺结节危险因素及良恶性预测模型[J].中华肺部疾病杂志(电子版),2019,12(4):463-468.
[24] 陈珮,胡海洋,韩玉栋,等.孤立型肺结节术前良恶性预测模型的建立[J].局解手术学杂志,2018,27(7):481- 485.
[25] 张王鹏,王晋君,乔英.基于增强双期CT成像的肺亚厘米结节良恶性预测模型[J].分子影像学杂志,2022,45(1):76-80.
[26] 何伟荣,连永伟,王海,等.高分辨CT对亚厘米肺结节微小浸润型肺癌的诊断价值研究[J].中国医药科学,2022,12(3):149-152. |
|
|
|