|
|
Effect of transcranial direct current stimulation in the treatment of central post-stroke pain |
YANG Jian1 LIANG Guisheng1 XU Shuiying1 ZHOU Guanghui1 LIAO Chengju2 CHEN Yuzhuan1 LIANG Pingping1 |
1.Department of Rehabilitation Medicine, Dongguan Shilong People’s Hospital Affiliated to Southern Medical University Dongguan Songshan Lake Central Hospital the Third People’s Hospital of Dongguan, Guangdong Province, Dongguan 523326, China;
2.Department of Neurology, Dongguan Shilong People’s Hospital Affiliated to Southern Medical University Dongguan Songshan Lake Central Hospital the Third People’s Hospital of Dongguan, Guangdong Province, Dongguan 523326, China
|
|
|
Abstract Objective To investigate the effect of transcranial direct current stimulation(tDCS) in the treatment of central post-stroke pain (CPSP). Methods A total of 66 patients with CPSP admitted to Dongguan Songshan Lake Central Hospital, Guangdong Province from March 2019 to March 2022 were selected, and they were divided into control group and tDCS group according to the random number table method, with 33 cases in each group. Control group received conventional drugs and rehabilitation treatment, and tDCS group was treated with tDCS on the basis of control group, the treatment continued for two weeks. The scores of visual analogue scale (VAS), modified Barthel index (MBI), and function independence measure (FIM) of two groups were compared before and after treatment, and the pain efficacy of two groups was compared. Results In the control group, one case fell off due to recurrent stroke during treatment, and a total of 65 cases were included in the final statistics. After treatment, the VAS scores of two groups were lower than those before treatment, and tDCS group was lower than control group, and the differences were statistically significant (P<0.05). After treatment, MBI score and FIM score of two groups were higher than those before treatment, and tDCS group was higher than control group, and the differences were statistically significant (P<0.05). The pain effect of tDCS group was better than that of control group, and the difference was statistically significant (P<0.05). Conclusion tDCS can relieve the degree of CPSP, and improve the pain effect and the ability of daily living of patients.
|
|
|
|
|
[1] Liampas A,Velidakis N,Georgiou T,et al. Prevalence and management challenges in central post-stroke neuropathic pain:A systematic review and meta-analysis [J]. Adv Ther,2020,37(7):3278-3291.
[2] Barbosa LM,da Silva VA,de Lima Rodrigues AL,et al. Dissecting central post-stroke pain:A controlled symptom-psychophysical characterization [J]. Brain Commun,2022,4(3): fcac90.
[3] Angstadt R,Esperti S,Mangano A,et al. Palliative ketamine:the use of ketamine in central post-stroke pain syndrome-a case report [J]. Ann Palliat Med,2021,10(6):6974-6978.
[4] Hirato M,Miyagishima T,Takahashi A,et al. Thalamic anterior part of the ventral posterolateral nucleus and central lateral nucleus in the genesis of central post-stroke pain [J]. Acta Neurochir(Wien),2021,163(8):2121-2133.
[5] Choi HR,Aktas A,Bottros MM. Pharmacotherapy to manage central post-stroke pain [J]. CNS Drugs,2021,35(2):151- 160.
[6] Hosomi K,Kishima H,Oshino S,et al. Cortical excitability changes after high-frequency repetitive transcranial magnetic stimulation for central poststroke pain [J]. Pain,2013,154(8):1352-1357.
[7] Zhao CG,Sun W,Ju F,et al. Analgesic effects of navigated repetitive transcranial magnetic stimulation in patients with acute central poststroke pain [J]. Pain Ther,2021,10(2):1085-1100.
[8] Zheng L,Li XY,Huang FZ,et al. Effect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus [J]. Brain Res,2020,1733(3):146680.
[9] Choi YH,Kim DH,Paik NJ,et al. Long-term analgesic effects of peripheral nerve block in patients with central post- stroke pain:A retrospective series [J]. Pain Pract,2021,21(8):843-849.
[10] Liu Q,Zhong Q,Tang G,et al. Ultrasound-guided stellate ganglion block for central post-stroke pain:A case report and review [J]. J Pain Res,2020,13:461-464.
[11] 杨健,梁桂生,廖成钜,等.经颅直流电刺激配合认知训练治疗卒中后认知障碍的疗效[J].中国实用神经疾病杂志,2022,25(2):160-165.
[12] Gregoret L,Zamorano AM,Graven-Nielsen T. Effects of multifocal transcranial direct current stimulation targeting the motor network during prolonged experimental pain [J]. Eur J Pain,2021,25(6):1241-1253.
[13] Kang JH,Choi SE,Park DJ,et al. Effects of add-on transcranial direct current stimulation on pain in Korean patients with fibromyalgia [J]. Sci Rep,2020,10(1):12114.
[14] Houde F,Harvey MP,Tremblay Labrecque PF,et al. Combining transcranial direct current stimulation and transcutaneous electrical nerve stimulation to relieve persistent pain in a patient suffering from complex regional pain syndrome:A case report [J]. J Pain Res,2020,13:467-473.
[15] Alwardat M,Pisani A,Etoom M,et al. Is transcranial direct current stimulation(tDCS)effective for chronic low back pain? A systematic review and meta-analysis [J]. J Neural Transm(Vienna),2020,127(9):1257-1270.
[16] Vukojevic Z,Dominovic Kovacevic A,Peric S,et al. Frequency and features of the central poststroke pain[J]. J Neurol Sci,2018,391:100-103.
[17] Gift AG. Visual analogue scales:measurement of subjective phenomena [J]. Nurs Res,1989,38(5):286-288.
[18] Bae SH,Kim GD,Kim KY. Analgesic effect of transcranial direct current stimulation on central post-stroke pain [J]. Tohoku J Exp Med,2014,234(3):189-195.
[19] Leung SO,Chan CC,Shah S. Development of a Chinese version of the modified barthel index-- validity and reliability [J]. Clin Rehabil,2007,21(10):912-922.
[20] Desrosiers J,Rochette A,Noreau L,et al. Comparison of two functional independence scales with a participation measure in post-stroke rehabilitation [J]. Arch Gerontol Geriatr,2003,37(2):157-172.
[21] Elias GJB,De Vloo P,Germann J,et al. Mapping the network underpinnings of central poststroke pain and analgesic neuromodulation [J]. Pain,2020,161(12):2805-2819.
[22] Ngernyam N,Jensen MP,Arayawichanon P,et al. The effects of transcranial direct current stimulation in patients with neuropathic pain from spinal cord injury [J]. Clin Neurophysiol,2015,126(2):382-390.
[23] 谭娟,李晓敏,苟晨,等.经颅直流电刺激对脑卒中后中枢性疼痛患者的镇痛效果研究[J].川北医学院学报,2021,36(6):753-756.
[24] Tavares DRB,Okazaki JEF,Santana MVA,et al. Motor cor- tex transcranial direct current stimulation effects on knee osteoarthritis pain in elderly subjects with dysfunctional descending pain inhibitory system:A randomized controlled trial [J]. Brain Stimul,2021,14(3):477-487.
[25] Mencarelli L,Menardi A,Neri F,et al. Impact of network-targeted multichannel transcranial direct current stimulation on intrinsic and network-to-network functional connectivity [J]. J Neurosci Res,2020,98(10):1843-1856.
[26] Das N,Spence JS,Aslan S,et al. Cognitive training and tra- nscranial direct current stimulation in mild cognitive impairment:A randomized pilot trial [J]. Front Neurosci,2019, 13:307.
[27] Wang J,Luo H,Schülke R,et al. Is transcranial direct cur- rent stimulation,alone or in combination with antidepressant medications or psychotherapies,effective in treating major depressive disorder? A systematic review and meta- analysis [J]. BMC Med,2021,19(1):319.
[28] Stagg CJ,Best JG,Stephenson MC,et al. Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation [J]. J Neurosci,2009,29(16):5202-5206.
[29] Liebetanz D,Nitsche MA,Tergau F,et al. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability [J]. Brain,2002,125(10):2238-2247. |
|
|
|