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| Diagnostic value of musculoskeletal ultrasound imaging features combined with detection of anti-CCP antibody levels in rheumatoid arthritis |
| YE Qing ZHU Congying WANG Xinru |
Department of Ultrasound, Changzhou Wujin Hospital of Traditional Chinese Medicine, Jiangsu Province, Changzhou 213161, China
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Abstract Objective To investigate the diagnostic value of musculoskeletal ultrasound imaging features combined with detection of anti-cyclic citrullinated peptide (CCP) antibody levels in rheumatoid arthritis. Methods A total of 81 patients with rheumatoid arthritis admitted to the Changzhou Wujin Hospital of Traditional Chinese Medicine, Jiangsu Province (“our hospital” for short) from April 2019 to March 2022 were selected as the research group, in addition, 45 healthy people with physical examination in our hospital during the same time were selected as the control group. According to 28 joint disease activity index scores, the research group was divided into high activity group (27 cases), moderate activity group (33 cases), and low activity group (21 cases). The research group underwent MRI and musculoskeletal ultrasonography. The detection rates of MRI and musculoskeletal ultrasonography for three typical pathological features (bone erosion, joint effusion, and synovial hyperplasia) were compared; the levels of anti-CCP antibodies between two groups were compared; the diagnostic value of musculoskeletal ultrasound imaging features combined with the level of anti-CCP antibody in rheumatoid arthritis was analyzed. Results There was no significant difference in the detection rate of bone erosion and synovial hyperplasia between MRI and musculoskeletal ultrasound (P＞0.05); the detection rate of joint effusion of musculoskeletal ultrasound was higher than that of MRI, and the difference was statistically significant (P＜0.05). The level of anti-CCP antibody in the research group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The level of anti-CCP antibody in high activity group was higher than that in low activity group and moderate activity group, the level of anti-CCP antibody in moderate activity group was higher than that in low activity group, and the differences were statistically significant (P＜0.05). The level of anti-CCP antibody was positively correlated with the severity of rheumatoid arthritis (r=0.573, P＜0.01). The area under curve value of joint effusion, synovial hyperplasia, and anti-CCP antibody combined diagnosis of rheumatoid arthritis was higher than that of the single diagnosis, and the difference was statistically significant (P＜0.05). Conclusion Musculoskeletal ultrasound imaging features (joint effusion, synovial hyperplasia) and anti-CCP antibody levels are of great value in the diagnosis of rheumatoid arthritis, and the combination of the three has a higher diagnostic value.
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