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2022 Vol. 19, No. 27 Published: 2022-09-25

	7	Study of the synergistic effect of air temperature and PM2.5 on the death of respiratory diseases
		ZHANG Weining SUN Yuanyuan SHEN Xifeng LI Meiting NAN Jiale GAO Dongping
		DOI: 10.20047/j.issn1673-7210.2022.27.01
		Objective To study the effect of the synergistic effect of PM2.5 and air temperature on the death population of residents with respiratory diseases. Methods A generalized additive model based on time series was used to explore the health effects of PM2.5 concentration and air temperature on the population in this area, and a bivariate response surface was established to evaluate the interaction between PM2.5 and air temperature on the death of residents from respiratory diseases. Results From 2014 to 2018, there were 25 971 deaths of residents in the area due to respiratory diseases, with an average daily death toll of 14 cases. The effect of PM2.5 on the death of residents’ respiratory diseases had a lag effect, and the effect was the largest when the lag was 2 d, with every increase of 10 μg/m3. Residents’ daily risk of death from respiratory diseases was increased by 0.36% (95%CI: 0, 0.72%). Under the conditions of low temperature and high concentration of PM2.5, the mortality risk of respiratory diseases was the highest, and low temperature and PM2.5 had a synergistic effect on the mortality risk of respiratory diseases. Conclusion Atmospheric PM2.5 exposure can increase the risk of death from respiratory diseases in residents, and low air temperature has a synergistic effect.
		2022 Vol. 19 (27): 7-11 [Abstract] ( 14 ) HTML (1 KB) PDF (1260 KB) ( 109 )

	12	Analysis of domestic chronic disease management literature based on bibliometrics
		DING Liping1 ZHANG Rong2 LIU Feng1 FAN Xinrong1 XU Fen1
		DOI: 10.20047/j.issn1673-7210.2022.27.02
		Objective To analyze the current research status of domestic chronic disease management based on bibliometrics, so as to provide a basis for further related research. Methods Literatures related to chronic disease management from January 2016 to December 2020 were retrieved from CNKI database. The articles that met the inclusion and exclusion criteria were imported into the bibliographic co-occurrence analysis system software, CiteSpace and SPSS 20.0 software for bibliometric analysis of publication volume, time, authors and institutions, journals and high-frequency words. Results A total of 2 865 literatures were obtained. Literature volume increased from 423 articles/year to a maximum of 742 articles/year. The overall trend showed a slow growth year by year, published in 682 kinds of journals, statistics institutions and authors of the top 10, a wide geographical distribution, between the authors and institutions have not formed a fixed cooperative relationship. Co-occurrence cluster analysis of high-frequency keywords in the literature showed three hotspots of chronic disease management research: chronic disease management-related nursing intervention; community chronic disease management model; and hierarchical diagnosis and treatment for chronic disease management. Conclusion According to the results of high-frequency word cluster analysis, the research content of chronic disease management and hierarchical diagnosis and treatment in community can become the direction of chronic disease management research in China in the near future, and provide a theoretical basis for clarifying the future research direction.
		2022 Vol. 19 (27): 12-15,29 [Abstract] ( 14 ) HTML (1 KB) PDF (2186 KB) ( 98 )

	16	Effect of Tangluoning regulating miR-211 on apoptosis of dorsal root ganglion neurons in diabetic peripheral neuropathy rats
		ZHANG Chen1 CHEN Feng1 XIN Jingyan1 ZHU Yufei1 LI Jin1 WU Changjiang1 XIE Wenying1 ZHANG Taojing2
		DOI: 10.20047/j.issn1673-7210.2022.27.03
		Objective To investigate the effect of Tangluoning regulating miR-211 on apoptosis of dorsal root ganglion neurons (DRGn) in diabetic peripheral neuropathy rats. Methods Neonatal rat DRGn cells were used as research objects.They were divided into normal group, high glucose group, Tangluoning group, miR-211 inhibitor negative group, and miR-211 inhibitor group. The normal group was treated with special medium for neurons, while the high glucose group, the Tangluoning group, the miR-211 inhibitor negative group, and the miR-211 inhibitor group were treated with special medium for high glucose neurons (containing 50 mmol/L glucose). miR-211 inhibitor negative group and miR-211 inhibitor group were transfected with empty vector and miR-211 inhibitor vector, respectively. The normal group, the high glucose group, the miR-211 inhibitor negative group and the miR-211 inhibitor group were given 10% blank serum intervention, and the Tangluoning group was given 10% Tangluoning containing serum intervention. After 24 hours of intervention, the cells in each group were collected to detect the apoptosis rate, miR-211, and the expression levels of apoptosis pathway related protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2α (eIF2α), activator of transcription 4 (ATF4), and C/EBP homologous protein (CHOP). Results There was no significant difference in every indexes between high glucose group and miR-211 inhibitor negative group (P ＞ 0.05). The apoptosis rate, miR-211 gene expression, and protein expression levels of PERK, eIF2α, ATF4, and CHOP in the high glucose group were higher than those in the normal group, the apoptosis rate, miR-211 gene expression, and protein expression levels of PERK, eIF2α, ATF4, and CHOP in Tangluoning group and miR-211 inhibitor group were lower than those in high glucose group, and the differences were statistically significant (P ＜ 0.05). Conclusion Tangluoning can attenuate DRGn apoptosis induced by high glucose by inhibiting miR-211 regulating apoptosis pathway.
		2022 Vol. 19 (27): 16-20 [Abstract] ( 12 ) HTML (1 KB) PDF (1361 KB) ( 30 )

	21	Determination of content and microscopical indentification of Mongolian medicine Ganluyangxin Pills
		BAO Shunru NA Rentuya WU Yunsuode GAO Lei HAN Tana
		DOI: 10.20047/j.issn1673-7210.2022.27.04
		Objective To establish a method for the determination and microscopic identification of crocin-Ⅰ and crocin-Ⅱ in Ganluyangxin Pills. Methods The content of crocin-Ⅰ and crocin-Ⅱ in Stigma Croci was determined by high performance liquid chromatography. The column was Waters XBridge C18 (250 mm×4.6 mm, 5 μm), the mobile phase was methanol-water(45∶55), the detection wavelength was 440 nm, the flow rate was 1.0 ml/min, and the column temperature was 30℃. Microscopic identification method was used to study microscopic characteristics of Ganluyangxin Pills. Results Crocin-Ⅰ and crocin-Ⅱ showed good linear relationships within the rage of 5.184-51.837, 2.015-20.154 μg/ml (r = 1.000 0), whose average recovery were 102.32% and 102.40%, the RSD was 1.45% and 1.47%, respectively. Unique characteristics in Spora Lygodii, Fructus Hippophae, Semen Descurainiae, Radix Astragali seu Hedysari, Crab, Mallow flos, Croci stigma L., Ramulus syringae were screened out as microscopic identification basis of Ganluyangxin Pills. Conclusion The method is scientific, reasonable and accurate, and can be used for the quality control of the Ganluyangxin Pills.
		2022 Vol. 19 (27): 21-24,34 [Abstract] ( 13 ) HTML (1 KB) PDF (1903 KB) ( 21 )

	25	Construction and verification of nomogram prediction model of risk for perineal laceration in primiparas
		ZHANG Han1 DUAN Xia1 PANG Qiying2 MAO Yanli3 ZHONG Minhui1 YU Chan1 YAN Xiaoxue1
		DOI: 10.20047/j.issn1673-7210.2022.27.05
		Objective To construct the nomogram prediction model of risk for perineal laceration in primiparas. Methods A total of 932 primiparas from the First Maternity and Infant Hospital, Tongji University from December 2020 to September 2021 were selected as research objects. A total of 746 primiparas were used as the modeling group to construct the model, and they were divided into laceration group (506 cases) and non-laceration group (240 cases) according to whether perineal laceration occurred; 186 primiparas were included in validation group to validate the model. Logistic regression model was used to construct the model, Hosmer-Lemeshow goodness of fit, calibration curve, and receiver operating characteristic curve were used to evaluate the model. Results The first labor time, second labor time, and total labor time in laceration group were longer than those in non-laceration group, and the differences were statistically significant (P < 0.05). The proportion of full-term birth, suspected macrosomia, epidural analgesia, midwife outpatient service, fetal distress, and hypertension of pregnancy in laceration group was higher than that in non-laceration group, and the difference was statistically significant (P < 0.05); there were significant differences in perineal elasticity, length of perineal body, degree of puerperal cooperation, seniority of midwife, mode of induced labor, free position, delivery position, degree of fear of childbirth, and physical activity level during pregnancy between two groups (P < 0.05). Gestational age， suspected macrosomia, second labor time, degree of fear of childbirth, seniority of midwives, and physical activity level during pregnancy were the influencing factors of perineal lacerations in primiparas (P < 0.05). The Hosmer-Lemeshow goodness of fit and calibration curve indicated that the model fit was good. The area under the curve of the modeling group and the verification group were 0.822 and 0.799, respectively， and the prediction performance of the model was good. Conclusion The prediction model of risk for perineal laceration in this study has good differentiation and calibration, which can provide an efficient and convenient evaluation tool for clinical practice.
		2022 Vol. 19 (27): 25-29 [Abstract] ( 16 ) HTML (1 KB) PDF (912 KB) ( 60 )

	30	Discussion on the medication rules of traditional Chinese medicine in treating cardiorenal syndrome based on data mining technology
		PAN Zhiyu1 ZHANG Yifan1 ZHANG Qi2 ZHANG Yu2
		DOI: 10.20047/j.issn1673-7210.2022.27.06
		Objective To explore the medication rules of modern doctors in the treatment of cardiorenal syndrome based on the data mining technology. Methods Prescriptions for the treatment of cardiorenal syndrome were collected from CNKI, Wanfang data and VIP Chinese journal database from inception to August 2021. The clinical treatment database of cardiorenal syndrome was constructed, and the rules of its medication composition by using the traditional Chinese medicine inheritance computing platform (V3.0) was explored. Results A total of 59 effective prescriptions were included, including 114 kinds of drugs, and 21 kinds of drugs were used more than ten times. The four nature of drugs were mainly warm and cold, the five flavours were mainly sweet and bitter, and the channel tropism were mainly spleen, heart, lung and kidney channels. Five groups of core drugs used more than 25 times and three new prescriptions were excavated. Conclusion Modern doctors treat cardiorenal syndrome mainly from the perspective of “warming yang，benefiting qi and water”, and with drugs for nourishing yin and promoting blood circulation, they play the function of “yang into yin for diuresis”.
		2022 Vol. 19 (27): 30-34 [Abstract] ( 14 ) HTML (1 KB) PDF (1272 KB) ( 32 )

	35	Effect of diabetes mellitus on aging changes of dental pulp tissue
		CHEN Xiaoqian1 GAO Shiqi1 ZHANG Yi1 TIAN Qinglu1 ZHENG Liwei1 ZHOU Yachuan2
		DOI: 10.20047/j.issn1673-7210.2022.27.07
		Diabetes mellitus can affect the structure and function of cardiovascular and nervous organs by microvascular disorder and peripheral neuropathy caused by hyperglycemia. Diabetes mellitus is also a risk factor for many oral diseases. Recent studies have found that diabetes mellitus can accelerate the aging changes of dental pulp tissue, it may be related to the stimulated oxidative stress response and inflammatory immune response. Drugs with anti-inflammatory and antioxidant properties may relieve aging changes of dental pulp resulting from diabetes mellitus. Therefore, this article aims to review the aging changes of dental pulp tissue caused by diabetes mellitus, related mechanisms and potential treatment methods, in order to provide a theoretical basis for clinical treatment of diabetic mellitus patients with dental pulp disease.
		2022 Vol. 19 (27): 35-38,46 [Abstract] ( 18 ) HTML (1 KB) PDF (537 KB) ( 126 )

	39	Regulation mechanism of adipocyte transdifferentiation on puberby sexual development and bone growth
		DUAN Juan1 LIU Lailai2
		DOI: 10.20047/j.issn1673-7210.2022.27.08
		Puberty sexual development is accompanied by rapid bone formation and fat remodeling, estrogen regulates bone growth at the global level, sexual initiation is controlled by the hypothalamic-pituitary-gonadal axis (HPGA) and is related to body fat. Recent studies have found that leptin can stimulate hypothalamic gonadotropin-releasing hormone (GnRH) to stimulate HPGA, thus promoting the onset of puberty, but leptin is not an essential initiator. Peroxisome proliferator-activated receptor γ (PPARγ) is an important link between energy metabolism and reproductive axis. The activation of PPARγ triggers leptin signal, which can stimulate the hypothalamic GnRH to stimulate HPGA. As an endocrine organ, bone can inhibit the formation of adipocytes, which in turn can inhibit the proliferation and differentiation of osteoblasts and antagonize bone formation. PPARγ is a key factor regulating adipogenic and osteogenic differentiation. Therefore, adipocyte transdifferentiation is an important mechanism regulating puberty sexual development and bone growth. This paper expands the new understanding of adipocyte transdifferentiation on the regulation of children’s sexual development and bone metabolism, and provides a new idea for clinical multi-target and multi-way intervention of children’s precocious puberty and improvement of lifelong high.
		2022 Vol. 19 (27): 39-42 [Abstract] ( 13 ) HTML (1 KB) PDF (519 KB) ( 44 )

	43	Research progress of Gremlin 1 in glucolipid metabolic and related diseases
		GU Tian ZHAO Li DENG Xia YANG Ling YUAN Guoyue▲
		DOI: 10.20047/j.issn1673-7210.2022.27.09
		Gremlin 1 is a member of the transforming growth factor-β superfamily. Early studies have found that it participates in the formation, development, and differentiation of embryos and inhibits the formation of bone and cartilage. In glucose metabolism, Gremlin 1 can antagonize insulin action; in lipid metabolism, Gremlin 1 can regulate the formation and differentiation of human adipocytes and inhibit browning of white adipocytes. This article reviews the research progress of Gremlin 1 in glucolipid metabolism and related diseases in recent years, in order to provide theoretical basis for the treatment of glucolipid metabolism related diseases.
		2022 Vol. 19 (27): 43-46 [Abstract] ( 9 ) HTML (1 KB) PDF (442 KB) ( 41 )

	47	Research progress of long non-coding RNA in acute kidney injury
		XIE Anni YU Yanting WANG Xiaoyan
		DOI: 10.20047/j.issn1673-7210.2022.27.10
		Acute kidney injury (AKI) is characterized by rapid loss of renal function in a short period of time. Sepsis, ischemia-reperfusion, and nephrotoxic substances are the main causes of AKI. The mechanism of AKI is still unclear and there is a lack of effective diagnosis and treatment. With the novel development of sequencing technology, more and more long non-coding RNAs (lncRNAs) have been identified to abnormally expressed in AKI patients and animal and cell models. Studies have shown that lncRNA may play an important role in the occurrence, development, and prognosis of AKI by targeting inflammation, oxidation, and apoptosis signaling pathways through sponge adsorption of miRNA. This article reviews the mechanism and potential application of lncRNA in AKI.
		2022 Vol. 19 (27): 47-49 [Abstract] ( 12 ) HTML (1 KB) PDF (339 KB) ( 35 )

	50	Correlation between dietary habits, lifestyle, and dyslipidemia in the elderly
		WANG Lijie LIU Yuxiang LI Yu
		DOI: 10.20047/j.issn1673-7210.2022.27.11
		Objective To explore the influence of dietary habits and lifestyle on dyslipidemia in the elderly. Methods A total of 119 elderly patients who were treated in Jinqiu Hospital of Liaoning Province from June 2020 to June 2021 were selected as the research subjects, and questionnaires, physical examinations, and biochemical tests were carried out. Logistic regression and multiple linear regression were used to explore the relationship between dietary habits, lifestyle, and dyslipidemia, respectively. Results Among the 119 elderly, 75 (63.03%) had normal blood lipids, and 44 (36.97%) had dyslipidemia. The proportions of current smoking, current drinking, daily carbohydrate intake, and no daily protein intake in the dyslipidemia group were higher than those in the normal blood lipid group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that the risk of dyslipidemia in the elderly who smoked was 2.727 times that of non-smokers (OR = 2.727, 95%CI: 1.048 to 7.096); the risk of dyslipidemia in the elderly who ate protein intermittently or never was 2.927 times higher than that of those who ate protein daily (OR = 2.927, 95%CI: 1.140 to 7.515). After removing the influencing factors of age, gender, sleep situation, and eating pattern, multiple linear regression analysis showed that plasma triglyceride level was the relevant factor affecting the lifestyle score (P ＜ 0.05). Conclusion Smoking, intermittent or never eating protein are risk factors for dyslipidemia in older adults. Active lifestyle improvements and improved lifestyle scores can reduce triglyceride levels in older adults.
		2022 Vol. 19 (27): 50-53 [Abstract] ( 12 ) HTML (1 KB) PDF (564 KB) ( 145 )

	54	Study on the comprehensive health assessment of empty-nest elderly in Hunan Province
		WANG Min SHE Jinwen ZHOU Liping HUANG Ling HU Ziyan
		DOI: 10.20047/j.issn1673-7210.2022.27.12
		Objective To explore the comprehensive health status and its influencing factors of empty-nest in Hunan Province. Methods From December 2020 to August 2021, a total of 158 empty-nest elderly people in 29 urban communities and 21 villages in Hunan Province were comprehensively evaluated by using the multi-dimensional functional assessment questionnaire in the older American resource and service (OARS) scale. Regression analysis was used to explore the influencing factors of comprehensive health status. Results A total of 167 questionnaires were distributed, and 158 valid questionnaires were recovered, with an effective recovery rate of 94.6%. There were statistically significant differences in the social health scores of the elderly with different empty-nest types and marital status (P ＜ 0.05); there were statistically significant differences in the economic status scores of the elderly with different genders and empty-nest types (P ＜ 0.05). The comprehensive health status of empty nesters was 22.78%, 41.13% was average, and 36.08% was poor. The excellent and good rates of physical health and social health were 24.05% and 31.01%, respectively. The logistic regression results showed that the type of empty-nest and the number of diseased species were the influencing factors of physical health; the type of empty nest was the influencing factor of social health (P ＜ 0.05). Multiple regression analysis found that age and the number of diseases were also influencing factors of comprehensive health status (P ＜ 0.05). Conclusion The comprehensive health status of empty-nest elderly is not optimistic. Attention should be paid to absolute empty-nest elderly who coexist with old age and multiple diseases, and help them establish a positive social support network to promote the construction of healthy aging.
		2022 Vol. 19 (27): 54-57,67 [Abstract] ( 17 ) HTML (1 KB) PDF (628 KB) ( 125 )

	58	Investigation and analysis of pre-job training needs of new employees in tumor specialized hospitals
		JI Shuming1 GAO Ya1 SHEN Rui2 ZHENG Da2 LIU Xiaolin2 CHANG Sheng1
		DOI: 10.20047/j.issn1673-7210.2022.27.13
		Objective To understand the pre-job training needs of new employees in tumor specialized hospitals, and to provide reference and basis for the development of scientific and reasonable pre-job training plans in a targeted manner. Methods From July to August 2021, the cluster sampling method was used to select 352 new employees from the Cancer Hospital of the Chinese Academy of Medical Sciences and the Cancer Hospital of the Chinese Academy of Medical Sciences of Hebei Province, and a questionnaire survey on pre-job training needs was conducted. 12 statistical items including basic information of the survey respondents and pre-job training needs were included in observation items. Results A total of 352 questionnaires were distributed and 352 were effectively recovered, with a recovery rate of 100%. New employees of tumor specialized hospitals generally believe that the ideal training period was one week or two to three days. The results showed that there was a statistically significant difference between the ideal training cycle demand indicators of different ages, whether it was a freshman, work experience, educational background of new employee (P ＜ 0.05). There was a statistically significant difference in the training content demand indicators of different departments of new employee (P ＜ 0.05). There was a statistically significant difference in the demand indicators of training assessment methods with different educational backgrounds of new employee (P ＜ 0.05). Conclusion Guided by the pre-job training needs of new employees, formulate a pre-job training program for new employees in the oncology specialist hospital with a moderately efficient period, rich and practical content, and scientific and reasonable assessment. It will help to improve the pertinence and practicality of training and ensure the effect of pre-job training.
		2022 Vol. 19 (27): 58-62 [Abstract] ( 12 ) HTML (1 KB) PDF (589 KB) ( 32 )

	63	Effect of serum Glypican-4 factor on diabetic kidney disease in obese patients with type 2 diabetic mellitus
		ZHAO Jiaxuan GAO Jing Ilinur Adair FAN Huimin
		DOI: 10.20047/j.issn1673-7210.2022.27.14
		Objective To investigate the effect of serum Glypican-4 factor on diabetic kidney disease (DKD) in obese patients with type 2 diabetic mellitus. Methods A total of 128 obese patients with type 2 diabetes mellitus diagnosed and treated in Fifth Affiliated Hospital of Xinjiang Medical University from September 2020 to April 2021 were selected. According to the Chinese Clinical Guidelines for the Prevention and Treatment of Diabetic Kidney Disease, the patients were divided into diabetes group and DKD group. The influence factor of DKD in obese patients with type 2 diabetes mellitus were analyzed; Spearman correlation coefficient was used to analyze the correlation between related indexes and urinary albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR); the value of Glypican-4 factor in the diagnosis of DKD in obese patients with type 2 diabetes mellitus was determined by receiver operating characteristic curve. Results There were significant differences in hypertension, course of disease, urinary microalbumin, eGFR, UACR, serum creatinine, triglyceride (TG), glycosylated hemoglobin (HBA1c), fasting blood glucose (FBG), 2h postprandial blood glucose (2hPG), and Glypican-4 between two groups (P < 0.05). Glypican-4, FBG, 2hPG, course of disease, hypertension, and TG were the influencing factors of DKD in obese patients with type 2 diabetes mellitus (OR > 1, P < 0.05). Glypican-4, HBA1c, FBG, 2hPG, course of disease, hypertension, and TG were positively correlated with UACR (r > 0, P < 0.05), and negatively correlated with eGFR (r < 0, P < 0.05). The cut-off value of Glypican-4 for DKD in obese patients with type 2 diabetes mellitus was 0.76 ng/ml, the area under the curve was 0.693, the sensitivity was 69.0%, and the specificity was 65.7%. Conclusion There is a correlation between serum Glypican-4 and DKD in obese patients with type 2 diabetes mellitus. Glypican-4 is a risk factor for DKD and has certain value in the diagnosis of DKD.
		2022 Vol. 19 (27): 63-67 [Abstract] ( 12 ) HTML (1 KB) PDF (668 KB) ( 53 )

	68	Application of absorbable gelatin sponge in pediatric circumcision aged 5 to 12 years
		WANG Ni1* ZHANG Jiayu2* CUI Yingdong1 YANG Chao1▲
		Objective To investigate the application effect of absorbable gelatin sponge in pediatric circumcision aged 5 to 12 years. Methods From May to August 2020, a total of 120 children who from the urology clinic of the National Hospital of Enshi Tujia and Miao Autonomous Prefecture were selected and divided into two groups according to the random number table method, with 60 cases in each group. The incision in observation group was covered with absorbent gelatin sponge and self-adhesive bandage, while the incision in the control group were covered with gauze and self-adhesive bandage the operation time, surgical blood loss, and ease of dressing removal on the third day after operation, visual analogue scale (VAS) score when dressing removal, incision bleeding after dressing removal, wound edema time, titanium nail complete shedding time, complete healing time, family satisfaction, and complications were compared between the two groups. Results There were no significant differences in operation time, surgical blood loss, titanium nail complete shedding time, and complete healing time between the two groups (P ＞ 0.05). Compared with the control group, the observation group was easier to remove the dressing on the third day after operation was decreased, the VAS pain score when dressing removal and the bleeding rate of incision after dressing removal were decreased in the observation group, and the differences were statistically significant (P ＜ 0.05). The postoperative wound edema time in the observation group was shorter than that in the control group, and the differences were statistically significant (P ＜ 0.05). The postoperative satisfaction of observation group was higher than that of control group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the number of postoperative complications between the two groups, and the differences were statistically significant (P ＞ 0.05). Conclusion Absorbable gelatin sponge can greatly reduce the pain of dressing change after circumcision in children, and it is easier to remove dressings during dressing change, reduce incision tears and bleeding caused by adhesions during dressing change, and increase the satisfaction of children’s families, which is worthy of clinical promotion.
		2022 Vol. 19 (27): 68-71,87 [Abstract] ( 11 ) HTML (1 KB) PDF (914 KB) ( 151 )

	72	Analysis of etiology and risk factors of postoperative urinary tract infection for non-muscular invasive bladder cancer
		YNAG Liu1 NI Wei2 PENG Li1
		DOI: 10.20047/j.issn1673-7210.2022.27.16
		Objective To investigate the pathogenic bacteria detected and the influencing factors of urinary tract infection (UTI) in patients with non-muscle invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor (TURBT), to provide an important basis for clinical prevention and integrated treatment of traditional Chinese and western medicine. Methods The clinical data of 318 patients with NMIBC treated by TURBT in Hubei Provincial Hospital of Traditional Chinese Medicine from January 2011 to December 2020 were retrospectively investigated. The distribution characteristics of pathogenic bacteria in patients with UTI were observed, and the influencing factors of postoperative UTI were analyzed by logistic regression. Results UTI occurred in 38 of 318 patients, and the infection rate was 11.95%; 51 strains of pathogenic bacteria were detected in 38 UTI patients, among which 35 strains of Gram negative bacilli accounted for 68.63%, and 13 strains of Gram positive coccus accounted for 25.49%, three strains of fungus accounted for 5.88%. There were significant differences in age, tumor site, diabetes, hypertension, postoperative indwelling catheter, spleen and kidney deficiency syndrome between the two groups (P ＜ 0.05). Age ≥65 years, multiple tumor sites, diabetes mellitus, hypertension, postoperative induration catheter ≥7 days, and spleen and kidney deficiency syndrome type were independent risk factors for postoperative UTI (OR ＞ 1，P ＜ 0.05). Conclusion Patients after TURBT with high probability of postoperative UTI, the influencing factors are complex, and effective clinical intervention measures of integrated traditional Chinese and western medicine should be proposed based on the distribution and influencing factors of pathogenic bacteria to improve the prognosis of patients.
		2022 Vol. 19 (27): 72-75 [Abstract] ( 16 ) HTML (1 KB) PDF (610 KB) ( 43 )

	76	Analysis of influencing factor of urinary sepsis in patients undergoing retrograde intrarenal surgery under flexible ureteroscope
		MA Shimin HUANG Yasheng YANG Mei
		DOI: 10.20047/j.issn1673-7210.2022.27.17
		Objective To explore influencing factor of urinary sepsis in patients undergoing retrograde intrarenal surgery under flexible ureteroscope. Methods A total of 400 ureteral calculi patients in Hangzhou Hospital of Traditional Chinese Medicine from February 2019 to March 2020 were selected as objects, they were divided into non-occurrence group (310 cases), occurrence group (90 cases) by complicating urinary sepsis or not. The sex, age, hypertension, body mass index, triglyceride, high density liptein cholesterol, fasting blood glucose, operation time, calculi number, diameter, serum creatinine, blood urea nitrogen, C-reactive protein, procalcitonin of patients were compared. Logistic regression analysis was used to analyze the influencing factors of urinary sepsis in patients after flexible ureteroscopic holmium laser lithotripsy. Results There were significant differences in age, gender, number of stones, stone diameter, operation time, serum creatinine, urea nitrogen, C-reactive protein, and procalcitonin between the two groups (P ＜ 0.05). Multiple stones, stone diameter ≥20 mm, serum creatinine, urea nitrogen, C-reactive protein, and procalcitonin were the influencing factors of urinary sepsis after flexible ureteroscopic holmium laser lithotripsy (OR ＞ 1, P ＜ 0.05). Conclusion The multiple calculi, calculi diameter ≥20 mm, serum creatinine abnormity, blood urea nitrogen abnormity, C-reactive protein abnormity, procalcitonin abnormity of patients were influencing factors of urinary sepsis, actively intervention has positive significance in reducing postoperative complications of urinary sepsis.
		2022 Vol. 19 (27): 76-79 [Abstract] ( 13 ) HTML (1 KB) PDF (519 KB) ( 46 )

	80	Analysis of the influencing factors of Zhang-Hou’s fracture
		LIAO Wei WANG Guang ZHANG Youqiang CHEN Xiaoheng YAN Ling
		Objective To analyze the influencing factors of Zhang-Hou’s fractures, and to provide reference value for clinical diagnosis. Methods From January 2016 to December 2021, 196 patients with spiral fractures of the middle and lower 1/3 of tibia admitted to the Department of Orthopedics, the Third Affiliated Hospital of Zunyi Medical University were selected. They were divided into posterior malleolus group and non-posterior malleolus group according to the presence or obsence of posterior malleolus fracture. The general information and imaging data of two groups were recorded and analyzed, logistic regression was used to analyze the influencing factors of spiral fracture of the middle and lower 1/3 of the tibia combined with posterior malleolus fracture. Results The length of the tibia fracture line, the distance from the lowest point of the tibial fracture line to the tibial-talar surface, the distance from the lowest point of the tibial fracture line to the tibial-talar surface accounted for the proportion of the tibial total length (hereinafter referred to as “distance ratio”) in posterior malleolus group were greater than those in non-posterior malleolus group, and the differences were statistically significant (P < 0.05). The length of the tibia fracture line and distance ratio were independent risk factors for the middle and lower 1/3 tibial spiral fracture combined with posterior malleolus fracture (OR > 1, P < 0.05). Conclusion The middle and lower 1/3 tibial spiral fracture complicated posterior malleolus fractures may be affected by various factors. Clinicians can pay close attention to the length of the tibial fracture line and distance ratio. If the above indicators are large, it is necessary to be alert to the occurrence of posterior malleolus fracture to avoid clinical missed diagnosis and bury hidden dangers for later treatment.
		2022 Vol. 19 (27): 80-83 [Abstract] ( 8 ) HTML (1 KB) PDF (656 KB) ( 20 )

	84	Effect of acromioclavicular ligament combined with modified double TightRope loop plate to reconstruction of coracoclavicular ligament on Rockwood Ⅲ acromioclavicular joint dislocation
		LIU Weifeng WU Jiyun JIA Jun CHEN Weinan
		DOI: 10.20047/j.issn1673-7210.2022.27.19
		Objective To investigate the effect of acromioclavicular ligament combined with modified double TightRope loop plate to reconstruct coracoclavicular ligament on Rockwood Ⅲ acromioclavicular joint dislocation. Methods A total of 82 patients with acromioclavicular joint dislocation from April 2018 to June 2020 in Wuxi Taihu Hospital of Jiangsu Province were selected. They were divided into control group (41 cases, who received modified double TightRope loop plate to reconstruction of coracoclavicular ligament) and study group (41 cases, combined with acromioclavicular ligament treatment on the basis of control group). The related rehabilitation indicators between two groups were compared, Constant-Murley scores and visual analogue scale (VAS) scores before and after operation were compared between two groups, and the incidence of complications was observed. Results The operation time of study group was longer than that of control group, the intraoperative blood loss was higher than that of control group, while the postoperative drainage volume was shorter than that of control group (P < 0.05). One year after operation, the Constant-Murley scores of two groups were higher than those before operation, and those of study group was higher than those of control group (P < 0.05). At six months after operation, the VAS scores of two groups were lower than those before operation, and those of study group was lower than those of control group (P < 0.05). There was no significant difference in the incidence of complications between two groups (P > 0.05). Conclusion The treatment of Rockwood type Ⅲ acromioclavicular joint dislocation by acromioclavicular ligament combined with modified double TightRope loop plate to reconstruction of coracoclavicular ligament is effective, can reduce shoulder pain, and is safe and reliable.
		2022 Vol. 19 (27): 84-87 [Abstract] ( 18 ) HTML (1 KB) PDF (569 KB) ( 189 )

	88	Effect of Mulligan dynamic joint mobilization combined with shock wave on hip joint function recovery and hemorheology in patients with osteonecrosis of the femoral head
		LI Zhigang1 LU Haiyan2 LIU Zhu1 WANG Hongxu1 LIU Xuzhuo1 ZHAO Na2 ZHANG Jie1
		DOI: 10.20047/j.issn1673-7210.2022.27.20
		Objective To investigate the effect of Mulligan dynamic joint mobilization combined with shock wave on hip joint function recovery and hemorheology in patients with osteonecrosis of the femoral head (ONFH). Methods From September 2019 to August 2021, 60 patients with early ONFH treated in the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine were selected, they were divided into study group (Mulligan dynamic joint mobilization combined with shock wave) and control group (shock wave) according to the random number table method, with 30 caese in each group. Hip joint mobility, hemorheology indicators, and clinical efficacy were compared between two groups before and after treatment. Results After treatment, hip joint mobility in study group was higher than that before treatment, while the flexion, internal rotation, external rotation, and adductionmobility in control group were higher than those before treatment, and the differences were statistically significant (P < 0.05); the hip joint mobility in study group was higher than that in control group, and the difference was statistically significant (P < 0.05). After treatment, the plasma viscosity, whole blood low-cut reduced viscosity and whole blood high-cut reduced viscosity of two groups were lower than those before treatment, and study group was lower than control group, and the differences were statistically significant (P < 0.05). The excellent and good rate of study group was higher than that of control group, and the difference was statistically significant (P < 0.05). Conclusion Mulligan dynamic joint mobilization combined with shock wave treatment of ONFH can effectively improve hip joint mobility. It also has a significant improvement in hemorheology indicators, and is beneficial to the recovery of hip joint function.
		2022 Vol. 19 (27): 88-91 [Abstract] ( 13 ) HTML (1 KB) PDF (578 KB) ( 65 )

	92	Meta analysis on prevalence of anxiety and depression of patients with polycystic ovary syndromen in China
		YAN Xin WANG Lianhong GUO Yunmei LIU Ying DING Rui
		DOI: 10.20047/j.issn1673-7210.2022.27.21
		Objective To understand the anxiety and depression of patients with polycystic ovary syndrome (PCOS) in China. Methods The databases includes CNKI, Wanfang Data Knowledge Service Platform, VIP, CBM, PubMed, EMbase, The Cochrane Library, and Web of Science core collection were searched by computer, the retrieval time was from the database construction to September 2021. The investigation and research on the anxiety and depression of PCOS patients in China were collected. The prevalence of anxiety and depression was analyzed using Stata 12.0 software. Results A total of nine literatures were included. Meta analysis showed that the prevalence of anxiety in PCOS patients in China was 22% (95%CI: 20%-24%), and the prevalence of depression was 30% (95%CI: 28%-32%). Subgroup analysis showed that the prevalence of PCOS anxiety was 24% (95%CI: 21%-27%) and the prevalence of depression depression was 28% (95%CI: 26%-31%) in recent five years; the prevalence of PCOS anxiety and depression was 16% (95%CI: 11%-21%) and the prevalence of depression was 30% (95%CI: 24%-36%) in recent five to ten years; the prevalence of PCOS anxiety was 23% (95%CI: 19%-27%), and the prevalence of depression was 37% (95%CI: 32%-42%) over ten years. The prevalence of anxiety was 30% (95%CI: 25%-36%) and the prevalence of depression was 29% (95%CI: 23%-34%) in South China; the prevalence of anxiety was 27% (95%CI: 22%-32%) and the prevalence of depression was 38% (95%CI: 33%-42%) in North China; the prevalence of anxiety was 16% (95%CI: 13%-20%) and the prevalence of depression was 33% (95%CI: 29%-38%) in East China; the prevalence of anxiety was 22% (95%CI: 19%-26%) and the prevalence of depression was 24% (95%CI: 21%-28%) in Southwest China. Conclusion Anxiety and depression in PCOS patients in China are in a high incidence trend. Therefore, it is necessary to strengthen the management of PCOS patients’ adverse emotions to explore effective emotional management means by both prevention and intervention.
		2022 Vol. 19 (27): 92-96 [Abstract] ( 11 ) HTML (1 KB) PDF (2774 KB) ( 165 )

	97	Effects of stored autologous component transfusion and whole blood transfusion on immune function and hemorheology of Rh(D)-negative perinatal pregnant women
		JIANG Hui GU Xiaowen WANG Yue▲
		DOI: 10.20047/j.issn1673-7210.2022.27.22
		Objective To investigate the effects of stored autologous component transfusion and whole blood transfusion on immune function and hemorheology of Rh(D)-negative perinatal pregnant women. Methods A total of 98 Rh(D）-negative perinatal pregnant women who were treated in the Affiliated Huaian NO.1 Hospital of Nanjing Medical University from August 2016 to August 2021 were selected. They were divided into study group and conventional group by random number table method, with 49 cases in each group. The conventional group was treated with stored autologous whole blood transfusion, and study group was treated with stored autologous component transfusion. Immune function index, erythrocyte deformed index (EDI), low blood viscosity (LBV), mean blood viscosity, red blood cell count, hematocrit (HCT), and erythrocyte aggregation index (EAI) before blood transfusion and three days after blood transfusion between two groups were compared; pregnancy outcomes and adverse reactions between two groups were observed. Results Three days after transfusion, CD4+ and CD4+/CD8+ in two groups were lower than those before blood transfusion, and those of study group were higher than those of conventional group (P < 0.05); CD8+ was higher than that before blood transfusion, and that of study group was higher than that of conventional group (P < 0.05). Three days after transfusion, LBV and average blood viscosity in two groups were lower than those before transfusion, and those in study group were lower than those in conventional group (P < 0.05); EDI of two groups was higher than that before blood transfusion, and that of study group was lower than that of conventional group (P < 0.05). Three days after transfusion, red blood cell count, HCT, and EAI in two groups were lower than those before blood transfusion, and those in study group were lower than those in conventional group (P < 0.05). There were no significant differences in blood loss at 24 h after delivery, Apgar score at five minutes, and length of hospital stay between two groups (P > 0.05). No allergic reaction occurred in both groups. There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Compared with stored autologous whole blood transfusion, stored autologous component transfusion has better effects on immune function indexes and hemorheology of Rh(D）-negative perinatal pregnant women, can improve blood indexes, and is safe and reliable.
		2022 Vol. 19 (27): 97-100,105 [Abstract] ( 25 ) HTML (1 KB) PDF (652 KB) ( 20 )

	101	Effect of intracavitary interventional therapy instrument on cytokines in patients with pelvic inflammatory mass
		ZHENG Zaihong YU Xianbo ZHAO Lixia LI Chengcheng ZHU Ping
		DOI: 10.20047/j.issn1673-7210.2022.27.23
		Objective To investigate the effect of intracavitary interventional therapy instrument on cytokines in patients with pelvic inflammatory mass. Methods A total of 130 patients with pelvic inflammatory mass admitted to the Department of Gynecology, Cangzhou People’s Hospital of Hebei Province from October 2018 to June 2020 were selected as the research objects, according to the random number table method, they were divided into medication group and treatment instrument group, with 65 ceses in each group. The medication group was treated with Metronidazole combined with Doxycycline, while the treatment instrument group was treated with luminal interventional therapy instrument. The levels of cytokines (granulocyte-macrophage colony-stimulating factor [GM-CSF], C-reactive protein [CRP], tumor necrosis factor-α [TNF-α], and interleukin-6 [IL-6]), hemorheology, pelvic mass diameter, and pain degree were observed before and after treatment, the clinical efficacy and adverse reactions of the two groups were statistically analyzed. Results After treatment, the levels of GM-CSF, CRP, TNF-α, and IL-6 in the two groups were lower than those before treatment, and the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the hemorheological indexes of the two groups were lower than those before treatment, and the hemorheological indexes of the study group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the pelvic mass diameter and visual analogue scales score of the two groups were lower than those before treatment, and the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the clinical effect of the therapeutic apparatus group was better than that of the drug group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in adverse reactions between the two groups (P ＞ 0.05). Conclusion The treatment of patients with pelvic inflammatory mass by cavity interventional therapy device is effective and can reduce cytokines, which is worthy of clinical promotion.
		2022 Vol. 19 (27): 101-105 [Abstract] ( 19 ) HTML (1 KB) PDF (674 KB) ( 34 )

	106	Predictive value of nasal polyps tissues’ eosinophilic cationic protein/myeloperoxidase, chemokine ligand 4, and immunoglobulin E in the recurrence of patients with chronic rhinosinusitis with nasal polyps after surgery
		LIN Qiuhong XIAO Xiang ZHANG Shujia HAN Jiahui DONG Chunguang▲
		DOI: 10.20047/j.issn1673-7210.2022.27.24
		Objective To investigate the predictive value of nasal polyps tissues’ eosinophilic cationic protein (ECP)/myeloperoxidase (MPO), chemokine ligand 4 (CCL4), and immunoglobulin E (IgE) in the recurrence of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) after surgery. Methods A total of 189 patients with CRSwNP who underwent endoscopic nasal surgery in the First People’s Hospital of Lianyungang City, Jiangsu Province from January 2017 to December 2019 were selected as the research objects. According to the recurrence within two years after surgery, they were divided into recurrence group (26 cases) and non-recurrence group (163 cases). The clinical data and the levels of ECP/MPO, CCL4, and IgE in nasal polyps tissues were compared between the two groups, and the influencing factors of CRSwNP recurrence and the clinical value of ECP/MPO, CCL4, and IgE levels in CRSwNP recurrence were further analyzed. Results The nasal polyps Davos score, the proportion of smoking history, the proportion of postoperative infection, and the levels of ECP/MPO, CCL4, and IgE in the recurrence group were higher than those in the non-recurrence group, and the differences were statistically significant (P ＜ 0.05). The results of multivariate analysis showed that smoking, postoperative infection, ECP/MPO, CCL4, and IgE were the influencing factors of recurrence in patients with CRSwNP within two years after surgery (P ＜ 0.05). ECP/MPO, CCL4, and IgE levels alone and in combination had certain predictive value for recurrence in patients with CRSwNP within two years after surgery (area under the curve > 0.5, P < 0.05). Conclusion ECP/MPO, CCL4, and IgE in nasal polyps tissues alone and in combination have clinical value in predicting CRSwNP recurrence within two years after surgery, which is worthy of further analysis and discussion.
		2022 Vol. 19 (27): 106-109,118 [Abstract] ( 13 ) HTML (1 KB) PDF (850 KB) ( 202 )

	110	Effects of periodontal reconstruction assisted oral prosthodontics on the efficacy and periodontal indexes of patients
		DU Lingchen YAN Zhigang
		DOI: 10.20047/j.issn1673-7210.2022.27.25
		Objective To analyze the effects of periodontal reconstruction assisted oral prosthodontics on the efficacy and periodontal indexes of patients. Methods From January 2018 to September 2020, 150 patients with dentition and tooth defects who underwent oral restoration in the Department of Stomatology, Luoyang North Enterprise Group Staff Hospital were selected as the research objects, according to the random number table method, they were divided into group A (75 cases) and group B (75 cases). Group A received periodontal reconstruction assisted oral prosthodontic treatment, and group B received conventional oral prosthodontic treatment. Both groups were followed up for six months. The efficacy and satisfaction rate of the two groups were observed at six months after restoration. The dental function score, periodontal indexes and cytokine levels of gingival crevicular fluid were compared between the two groups before and six months after restoration. Results At six months after restoration, the efficiency and special satisfaction of repair in group A were better than those in group B (P ＜ 0.05). The scores of comfort, chewing function, language function, and dental aesthetics in the two groups were higher than those before restoration, and those in group A were higher than those in group B (P ＜ 0.05). At six months after restoration, the probing depth, clinical attachment loss, sulcus crevicular bleeding index and the levels of metallomatrix proteinase-8 (MMP-8), hyper sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) in gingival crevicular fluid in the two groups were lower than those before restoration, and those in group A were lower than those in group B (P ＜ 0.05). Conclusion Periodontal reconstruction assisted oral restoration can reduce the levels of MMP-8, hs-CRP, and TNF-α in gingival crevicular fluid of patients, effectively inhibit local inflammatory reaction, and then improve the periodontal indicators, promote the recovery of dental function, which is helpful to improve the clinical efficacy and the satisfaction rate of patients with restoration.
		2022 Vol. 19 (27): 110-113 [Abstract] ( 14 ) HTML (1 KB) PDF (578 KB) ( 21 )

	114	Analysis of Professor Lü Wenliang’s thinking of diagnosis and treatment of jaundice
		XU Lei1 QIANG Rui2 ZHANG Lili2 YAO Ziang1 LYU Wenliang2
		DOI: 10.20047/j.issn1673-7210.2022.27.26
		Jaundice is a common clinical disease of liver diseases in traditional Chinese medicine, with yellow eyes, yellow body and yellow urine as the typical manifestations. Professor Lü Wenliang, based on Zhong Jing’s theory that “Huang family, get it from dampness”, combined with the comments of medical experts and clinical experience in the past dynasties, believes that jaundice, exogenous six climatic exopathogens, and internal injuries and miscellaneous diseases can be the cause of jaundice, but the evil of “dampness” is the most important. Although there is a change from cold to heat, most of them are heat. And dampness evil has been living for a long time, accumulating stagnation in the liver and spleen. The liver regulates qi and stores blood, and the spleen regulates dampness and regulates blood. If it is qi stagnation and blood injury and heat trapping blood tier, it can cause blood stasis, heat and yellowing. Therefore, in the treatment of clinical syndromes, it is often to strengthen vital qi to eliminate pathogenic factor as the key link, mainly to clear the dampness-heat, cool the blood and remove blood stasis, supplemented by nourishing the liver and spleen, regulating qi and blood. And combined with the patient’s actual situation, attention and syndrome change, and to consider the profit and loss.
		2022 Vol. 19 (27): 114-118 [Abstract] ( 15 ) HTML (1 KB) PDF (783 KB) ( 28 )

	119	Relationship between traditional knowledge protection of traditional Chinese medicine and intellectual property system
		LI Yu1 LIU Qian1 GUO Hua2 AN Hong1 ZHAO Zhupei1 SHI Xueqin1 ZHANG Fengxia1 LIU Jianfeng1
		DOI: 10.20047/j.issn1673-7210.2022.27.27
		The traditional knowledge protection of traditional Chinese medicine and the intellectual property system are relatively independent and cross each other. The existing intellectual property system in China protects traditional knowledge of traditional Chinese medicine in four aspects: patent, trademark right, copyright and trade secret. However, due to the particularity of differences in protection purpose, right object and protection mode, relying only on the intellectual property system cannot improve and effectively protect traditional knowledge of traditional Chinese medicine. The intellectual property system and traditional knowledge protection will complement and integrate each other, and a special protection mode of traditional Chinese medicine knowledge will be set up on the basis of intellectual property protection, so as to build a comprehensive protection system of traditional Chinese medicine knowledge in line with the characteristics of traditional Chinese medicine.
		2022 Vol. 19 (27): 119-122,131 [Abstract] ( 18 ) HTML (1 KB) PDF (696 KB) ( 154 )

	123	Qin Bowei’s theory of diagnosis and treatment of epidemic diseases and its academic inheritance experience
		MAN Tian1 JI Yongkuan2 LI Yan3 ZHAI Zhiguang4 YU Huiyong1
		DOI: 10.20047/j.issn1673-7210.2022.27.28
		As a famous modern Chinese medicine expert, Qin Bowei has his own characteristic theory in the diagnosis and treatment of epidemic diseases. According to the pathogenic nature of the epidemic diseases, cold and temperature manifestations, whether the disease is wet or not and so on, combined with the disease stage and transmission characteristics of weifen，qifen，yingfen and xuefen, the syndrome differentiation is carried out, and the treatment methods such as dehumidification, eliminating turbidity, clearing, resuscitation, eliminating erythema, cooling blood are given accordingly. The students of professor Qin Bowei inherited and developed Qin Bowei’s experience in treating epidemic diseasess, and emphasized the use of strengthening vital qi to eliminate pathogenic factor methed in the treatment of exogenous fever during the recovery period method. They enriched the theory of epidemic diseases differentiation and treatment.
		2022 Vol. 19 (27): 123-126 [Abstract] ( 13 ) HTML (1 KB) PDF (696 KB) ( 84 )

	127	Clinical effect of traditional Chinese medicine foot bath combined with magnetic bead pressing on ear in the treatment of cough after lung infection of lingering pathogen due to deficient vital qi type
		HUANG Haifeng1 TANG Yanfen1 CAO Yahong1 ZHU Hui2
		DOI: 10.20047/j.issn1673-7210.2022.27.29
		Objective To investigate the clinical effect of traditional Chinese medicine foot bath combined with magnetic bead pressing on ear in the treatment of cough after lung infection of lingering pathogen due to deficient vital qi type. Methods A total of 105 patients with cough after lung infection of lingering pathogen due to deficient vital qi type admitted to Nantong Hospital of Traditional Chinese Medicine in Jiangsu Province from October 2018 to May 2021 were selected. According to the random number table method, the patients were divided into traditional Chinese medicine foot bath group, magnetic bead pressing on ear group and combination group (traditional Chinese medicine foot bath combined with magnetic bead pressing on ear), with 35 cases in each group. After two weeks of treatment, the efficacy, symptom relief time, traditional Chinese medicine syndrome score, cytokines and adverse reactions of the three groups were compared. Results After treatment, the overall efficacy of the combined group was better than that of the traditional Chinese medicine foot bath group and the magnetic bead pressing on ear group, and the differences were statistically significant(P ＜ 0.05). The scores of cough, expectoration, and pharyngeal itching in the three groups were significantly lower than those before treatment, and the scores in the combined group were lower than those in the magnetic bead pressing on ear group and the traditional Chinese medicine foot bath group, and the differences were statistically significant (P < 0.05). The relief time of cough, expectoration and pharyngeal itching in the combined group were shorter than those in the magnetic bead pressing on ear group and the traditional Chinese medicine foot bath group, and the differences were statistically significant (P < 0.05). The serum C-reactive protein and white blood cell counts of the three groups were lower than those before treatment, and those in the combined group were lower than those in the magnetic bead pressing on ear group and the traditional Chinese medicine foot bath group, the level of secretory immunoglobulin A in sputum was higher than that before treatment, and the level of combined group was higher than that of magnetic bead pressing on ear group and traditional Chinese medicine foot bath group, and the differences were statistically significant (P < 0.05). There were no obvious adverse reactions in the three groups. Conclusion The combination of traditional Chinese medicine foot bath and magnetic bead pressing on ear in the treatment of cough after lung infection of lingering pathogen due to deficient vital qi type can accelerate the relief and improvement of clinical symptoms, reduce serum inflammatory factors, and has significant effect.
		2022 Vol. 19 (27): 127-131 [Abstract] ( 16 ) HTML (1 KB) PDF (708 KB) ( 51 )

	132	Clinical effect of small akupotomye on the trigger points of the adductor femoral muscle group in the treatment of knee osteoarthritis
		LIU Na1 SUN Yindi1 JIANG Xiaofan2 XIANG Jie1 WANG Baohui1 LIANG Haohao1 CHEN Yingpu3 LI Yafeng1
		DOI: 10.20047/j.issn1673-7210.2022.27.30
		Objective To observe the clinical effect of small akupotomy therapy on knee osteoarthritis through stimulating trigger points of adductor femoral muscle group. Methods A total of 80 patients with knee osteoarthritis treated in the outpatient department of the Rehabilitation Hospital of the Honghui Hospital Affiliated to Xi’an Jiaotong University from October 2020 to October 2021 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group was treated with extracorporeal shock wave, and the observation group was treated with small akupotomy on the trigger points of adductor femoral muscle group on the basis of control group. Four weeks was as a course of treatment. The syndrome efficacy of traditional Chinese medicine, Wester Ontario and McMaster Universities osteoarthritis (WOMAC) index and the Lysholm knee rating scores were used to evaluated knee function. Results After treatment, the curative effect of traditional Chinese medicine syndrome in the observation group was better than the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the WOAMAC scores of the two groups were decreased, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, Lysholm scores of the two groups were increased, and the observation group was higher than the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The acupotomy of adductor femoral combined with extracorporeal shock wave can simultaneously deal with the internal and external muscles of the knee joint, improve the dynamic imbalance of the knee joint, effectively alleviate the pain of knee osteoarthritis, improve dysfunction, and improve the quality of life. It is better than the treatment of lateral femoral muscle with shock wave alone, and it is worth popularizing in clinical practice.
		2022 Vol. 19 (27): 132-136 [Abstract] ( 11 ) HTML (1 KB) PDF (788 KB) ( 105 )

	137	Clinical effect of akupotomy combined with Synovitis Granules in the treatment of knee osteoarthritis of damp heat obstruction type
		XUE Pengyu1 TIAN Yafeng2 DONG Junge2 YANG Mingshuai2 DONG Shaoyang1 ZHANG Yili1 CHEN Baosheng1 FAN Jinrui1
		DOI: 10.20047/j.issn1673-7210.2022.27.31
		Objective To explore the clinical efficacy of needle knife combined with Synovitis Granules in the treatment of damp heat obstruction type knee osteoarthritis. Methods A total of 180 patients with damp heat blocking knee osteoarthritis treated in the First Department of Orthopedics, Hebei Province Hospital of Traditional Chinese Medicine from March 2019 to may 2021 were selected, and they were divided into needle akupotomy group, traditional Chinese medicine group and combined group, with 60 cases in each group. They were treated with needle knife, oral Synovitis Granules and needle knife combined with Synovitis Granules, respectively. The patients in the three groups were treated for eight weeks. The visual analogue scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score and clinical efficacy were compared among the three groups before and after treatment, the levels of interleukin (IL)-1β and IL-6 were detected before and after treatment. Results After eight weeks of treatment, the VAS score and WOMAC score of the three groups were lower than those before treatment, and the combined group was lower than the akupotomy group and the traditional Chinese medicine group, and the differences were statistically significant (P ＜ 0.05). The levels of IL-1β and IL-6 in the three groups were decreased compared with those before treatment, and the levels of IL-1β and IL-6 in the combined group were lower than those in the akupotomy group and the traditional Chinese medicine group, and the differences were statistically significant (P ＜ 0.05). The clinical efficacy of combination group was higher than that of akupotomy group and traditional Chinese medicine group, and the differences were statistically significant (P ＜ 0.05). Conclusion Akupotmy combined with Synovitis Granules has a significant effect in the treatment of damp heat blocking knee osteoarthritis. It can significantly alleviate knee swelling and pain, improve knee function, reduce inflammatory reaction, and reduce levels of serum IL-1β, IL-6 and can restore the function of daily activities， and has certain clinical promotion and application value.
		2022 Vol. 19 (27): 137-140,153 [Abstract] ( 14 ) HTML (1 KB) PDF (775 KB) ( 22 )

	141	Clinical effect of akupotomy combined with fine silver needle in the treatment of knee osteoarthritis
		WEI Ye1 GE Hengqing1 LI Kaiping2
		DOI: 10.20047/j.issn1673-7210.2022.27.32
		Objective To observe the clinical effect of akupotomy combined with fine silver needle in the treatment of knee osteoarthritis. Methods Forty patients diagnosed with knee osteoarthritis in the Department of Akupotomy, Jiangsu Integrated Traditional Chinese and Western Medicine Hospital from January to December 2020 were selected as subjects, they were divided into observation group and control group by random number table method, with 20 cases in each group. The observation group was treated with akupotomy combined with fine silver needle, while the control group was treated with akupotomy only. Once a week, both groups were treated for four weeks. Lequesne, visual analogue scale score, knee circumference, and knee synovial thickness were observed before and after treatment. Results After treatment, the Lequesne index and VAS score of the two groups were lower than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the knee circumference and synovial thickness of the two groups were decreased than those before treatment, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Akupotomy combined with fine silver needle in the treatment of knee osteoarthritis can significantly improve joint swelling and pain, and reduce synovial thickness.
		2022 Vol. 19 (27): 141-144 [Abstract] ( 15 ) HTML (1 KB) PDF (609 KB) ( 87 )

	145	Comparison of therapeutic effects between muscle bone ultrasound-guided akupotomy and conventional akupotomy in the treatment of knee osteoarthritis
		HU Guoqiang LI Delong LIU Jishi
		DOI: 10.20047/j.issn1673-7210.2022.27.33
		Objective To compare the efficacy of muscle bone ultrasound-guided akupotomy and traditional akupotomy in the treatment of knee osteoarthritis (KOA). Methods A total of 100 patients with KOA in the Department of Rehabilitation, Shijiazhuang Hospital of Traditional Chinese Medicine from March 2019 to October 2021 were selected as the research object, they were divided into control group (50 cases) and study group (50 cases) according to the random number table method. The control group was treated with conventional akupotomy, and the study group was treated with akupotomy under the guidance of muscle bone ultrasound. The Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score, visual analog scale (VAS) score, quality of life score and clinical effects after treatment were compared between the two groups before and after treatment. Results After treatment, the WOMAC scores of the two groups were lower than those before treatment, and the study group was lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the VAS scores of the two groups were lower than those before treatment, and the study group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). The quality of life scores of the two groups were increased than those before treatment, and the study group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, the efficacy of the study group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The curative effect of muscle bone ultrasound-guided akupotomy in the treatment of KOA is better than that of conventional akupotomy. It can further improve the knee function, reduce the degree of knee pain and improve the quality of life, and avoid damaging healthy muscles and tendons.
		2022 Vol. 19 (27): 145-148,165 [Abstract] ( 14 ) HTML (1 KB) PDF (662 KB) ( 42 )

	149	Effect of multidisciplinary nursing system for patients with gestational diabetes mellitus under quality control circle mode
		HU Yunxia1 LIN Juan2 YANG Lingyuan1▲
		DOI: 10.20047/j.issn1673-7210.2022.27.34
		Objective To explore the effect of multidisciplinary nursing system for patients with gestational diabetes mellitus under quality control circle mode. Methods A total of 98 patients with gestational diabetes mellitus treated in Huaian First People’s Hospital of Jiangsu Province from May 2018 to May 2021 were selected as the research objects. They were divided into control group and study group by random number table method, with 49 cases in each group. The control group received routine nursing guidance, while the study group received multidisciplinary nursing under quality control circle mode on the basis of the control group. The self-care ability, blood glucose level indicators, and adverse pregnancy outcomes were compared before nursing and after four weeks of nursing. Results After four weeks of nursing, the self-care ability scores of the two groups were higher than those before nursing, and the study group was higher than the control group (P ＜ 0.05). The levels of fasting blood glucose and 2 h blood glucose in the two groups were lower than those before intervention, and the study group was lower than the control group (P ＜ 0.05). The total incidence of adverse pregnancy outcomes in the study group was lower than that in the control group (P ＜ 0.05). Conclusion The application of multidisciplinary nursing under quality control circle mode in patients with gestational diabetes mellitus can improve their self-care ability, maintain the stable state of blood glucose level, and reduce the occurrence of adverse pregnancy outcomes.
		2022 Vol. 19 (27): 149-153 [Abstract] ( 18 ) HTML (1 KB) PDF (968 KB) ( 54 )

	154	Influence of clinical care path scheme on psychological state and prognosis of patients with gallbladder stones after laparoscopic cholecystectomy
		LIU Jing1 WANG Jian2 LUO Yan1 YANG Jiling1
		DOI: 10.20047/j.issn1673-7210.2022.27.35
		Objective To explore the influence of clinical care path scheme on psychological state and prognosis of patients with gallbladder stones after laparoscopic cholecystectomy. Methods Eighty patients with gallbladder stones who underwent laparoscopic cholecystectomy from January 2019 to January 2021 in Xuancheng People’s Hospital of Anhui Province were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group was given routine nursing, while the observation group was given clinical nursing pathway. The psychological status and clinical indicators were compared between the two groups. Results After the intervention, the anxiety and depression scores of the two groups were lower than those before the intervention, and those of the observation group were lower than the control group, and the differences were statistically significant (P ＜ 0.05); the white blood cell count, alanine aminotransferase in the two groups were higher than those befone intorvention, and albumin level in the two groups were lower than those before intervention, and the white blood cell count and alanine aminotransferase in the observation group were lower than those in the control group, and the albnmin level was higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of clinical care pathway program intervention for patients with gallbladder stones undergoing laparoscopic cholecystectomy can improve the psychological state of patients, improve clinical indicators, and facilitate the rapid prognosis of patients, which is worthy of reference and adoption by various departments.
		2022 Vol. 19 (27): 154-157 [Abstract] ( 13 ) HTML (1 KB) PDF (613 KB) ( 58 )

	158	Effect of “internet +” cognitive behavior intervention on exclusive breastfeeding rate of primiparas for six months after delivery
		GUAN Huiming GOU Baohua▲ YANG Jie LIU Guifen JIA Nan
		DOI: 10.20047/j.issn1673-7210.2022.27.36
		Objective To explore the effect of “internet +” cognitive behavior intervention on rate of exclusive breastfeeding of primiparas for six months after delivery. Methods From March to December 2020, puerpera who were registered in the Department of Obstetrics, Beijing Friendship Hospital, Capital Medical University were selected as the research objects. They were divided into control group and intervention group by random number table. The control group received routine nursing, the intervention group received “internet +” cognitive behavior intervention until six months postpartum. Six months after delivery, a questionnaire survey was conducted to investigate the cognition of exclusive breastfeeding among primiparas, breastfeeding status and breast complications of lactating mothers. Results A total of 248 patients were included, including 121 in the control group and 127 in the intervention group. There was no significant difference in the breastfeeding cognition of “bobies shonld be breastfed for six month” and “breastfecding on demand” between the two groups (P ＞ 0.05), however, there were statistically significant differences in other cognition (P ＞ 0.05). There were statistically significant differences in exclusive breastfeeding rate between the two groups at 1, 3, 6 months after delivery (P ＜ 0.05). There were significant differences in breast pain, chapped nipple and mastitis between the two groups (P ＜ 0.05). Conclusion “Internet +” cognitive behavior intervention for primiparas can improve breastfeeding cognition and increase the rate of exclusive breastfeeding for six months after delivery, and reduce the incidence of lactation complications.
		2022 Vol. 19 (27): 158-161 [Abstract] ( 16 ) HTML (1 KB) PDF (533 KB) ( 72 )

	162	Effect of cluster nursing on prevention of ventilator-associated pneumonia in patients with mechanical ventilation in emergency intensive care unit
		YU Xiuqin ZHAO Yang▲ SHI Chunyan
		DOI: 10.20047/j.issn1673-7210.2022.27.37
		Objective To observe the effect of cluster nursing on prevention of ventilator-associated pneumonia (VAP) in patients with mechanical ventilation in emergency intensive care unit (EICU). Methods A total of 96 patients who received mechanical ventilation in EICU of Fuyang People’s Hospital of Anhui Province from February 2020 to October 2021 were selected as the research objects. According to the random number table method, the patients were divided into control group and study group, with 48 cases in each group. The control group received routine nursing, while the study group received cluster nursing on the basis of the control group. The incidence of VAP after intervention, and pulmonary infection index score, blood gas analysis indexes before and after intervention, and treatment differences between the two groups were observed. Results After intervention, the incidence of VAP in the study group was lower than that in the control group (P ＜ 0.05); the pulmonary infection index score values of the two groups were lower than those before intervention, and the study group was lower than the control group (P ＜ 0.05); the arterial partial pressure of oxygen (PaO2) in the two groups was higher than that before intervention, and the partial pressure of carbon dioxide (PaCO2) was lower than that before intervention, the PaO2 in the study group was higher than that in the control group, and the PaCO2 score was lower than that in the control group (P ＜ 0.05). The mechanical ventilation time, EICU stay time, and total hospital stay time in the study group were shorter than those in the control group (P ＜ 0.05). Conclusion Cluster nursing measures for patients with mechanical ventilation in EICU can reduce the incidence of ventilator-associated pneumonia, improve blood gas indexes, help patients to be weaned as early as possible and shorten the length of hospital stay.
		2022 Vol. 19 (27): 162-165 [Abstract] ( 13 ) HTML (1 KB) PDF (590 KB) ( 8 )

	166	Effect of team stratified nursing combined with intra-aortic balloon pump postoperative nursing in patients with acute exacerbation of chronic heart failure
		YU Min FAN Xiaoying▲ LI Huihui YAO Ying
		DOI: 10.20047/j.issn1673-7210.2022.27.38
		Objective To analyze the application effect of team stratified nursing combined with intra-aortic balloon pump (IABP) postoperative nursing in patients with acute exacerbation of chronic heart failure. Methods A total of 150 patients with acute exacerbation of chronic heart failure who underwent IABP in the First Affiliated Hospital of Air Force Medical University from January 2020 to January 2022 were selected as the research objects. They were divided into experimental group and control group by random number table method, with 75 cases in each group. The control group received IABP postoperative nursing, while the experimental group received team stratified nursing combined with IABP postoperative nursing. The cardiac function indexes before and after intervention were compared between the two groups, and the nursing satisfaction and adverse reactions were compared between the two groups after intervention. Results After intervention, N-terminal pro-brain natriuretic peptide, and ghrelin in the two groups were lower than those before intervention, and the experimental group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After intervention, the cardiac output, stroke volume, and percutaneous arterial oxygen saturation of the two groups were higher than those before intervention, and the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The nursing satisfaction of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). No serious adverse reactions occurred in the two groups during the intervention. Conclusion The application of team stratified nursing combined with IABP postoperative nursing in patients with acute exacerbation of chronic heart failure can significantly improve their cardiac function, improve the quality of nursing services in all aspects, and has high safety, which is worthy of promotion.
		2022 Vol. 19 (27): 166-169 [Abstract] ( 16 ) HTML (1 KB) PDF (596 KB) ( 23 )

	170	Mediating effect of resilience between expected sadness and coping style in patients with multiple myeloma
		LI Xiaoyin CAI Hua YE Huirong WANG Huiling▲ LIAN Xiaoyan CHEN Yingying HUANG Qingqing
		DOI: 10.20047/j.issn1673-7210.2022.27.39
		Objective To analyze the relationship among resilience, expected sadness, and coping style in patients with multiple myeloma (MM), and to explore the mediating effect of resilience between expected sadness and coping styles. Methods A total of 100 MM patients hospitalized in 910th Hospital of PLA Joint Logistic Support Force from March 2019 to March 2021 were selected. Connor-Davidson resilience scale (CD-RISC), preparatory grief in advanced cancer patients scale (PGAC), and simple coping style questionnaire (SCSQ) were used to evaluate their resilience, anticipatory grief, and coping style, respectively, and The mediating effect of resilience between expected sadness and coping style were analyzed. Results The CD-RISC and PGAC scores of 100 MM patients included in this study were at a medium level. The score of positive coping was (20.34±2.52) points, and the score of negative coping was (13.13±1.53) points. CD-RISC score in MM patients was positively correlated with positive coping (r ＞ 0, P ＜ 0.05), and negatively correlated with negative coping (r ＜ 0, P ＜ 0.05). PGAC score of MM patients was negatively correlated with positive coping and CD-RISC score (r ＜ 0, P ＜ 0.05), and positively correlated with negative coping (r ＞ 0, P ＜ 0.05). Linear regression showed that resilience played a partial mediating effect on expected sadness and positive coping, expected sadness and negative coping in MM patients, and the contribution rate of mediating effect to the total effect was 15.11% and 54.62%, respectively (P ＜ 0.05). Conclusion There is a certain relationship between the resilience, coping style, and expected sadness in MM patients, and the resilience plays a partial mediating effect between expected sadness and coping style in MM patients.
		2022 Vol. 19 (27): 170-173,193 [Abstract] ( 11 ) HTML (1 KB) PDF (1011 KB) ( 108 )

	174	Effect of ear tip blood-letting in patients with syndrome of upper hyperactivity of liver yang in acute cerebral infarction
		DONG Hongmei LU Nan HE Ning▲
		DOI: 10.20047/j.issn1673-7210.2022.27.40
		Objective To explore the effect of ear tip blood-letting in patients with syndrome of upper hyperactivity of liver yang in acute cerebral infarction. Methods A total of 182 patients with syndrome of upper hyperactivity of liver yang in acute cerebral infarction treated in Bozhou Hospital of Traditional Chinese Medicine, Anhui Province from March to December 2021 were selected and divided into control group and observation group by envelope method, with 91 cases in each group. Both groups received routine intervention for acute cerebral infarction, and the observation group received ear tip blood-letting on the basis of the control group. The course of treatment was two weeks. The main symptom score of syndrome of upper hyperactivity of liver yang in acute cerebral infarction, cranial nerve function, and limb motor function before and after intervention were observed and compared. Results After intervention, the main symptom scores of syndrome of upper hyperactivity of liver yang in acute cerebral infarction and the scores of National Institutes of Health stroke scale in the two groups were lower than those before intervention, and the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). After intervention, the Fugel-meyer assessment scores of the two groups were higher than those before intervention, and the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of ear tip blood-letting in the treatment of patients with syndrome of upper hyperactivity of liver yang in acute cerebral infarction can reduce the main symptom score, promote the recovery of cranial nerve function, improve the limb motor function of patients, which is worthy of clinical application.
		2022 Vol. 19 (27): 174-177 [Abstract] ( 15 ) HTML (1 KB) PDF (567 KB) ( 20 )

	178	Effect of comprehensive intervention under Maslow’s hierarchy of needs on disease knowledge and self-burden in patients with herpes zoster and pruritus
		WANG Huimin GE Shaoli LI Furong▲
		DOI: 10.20047/j.issn1673-7210.2022.27.41
		Objective To study the effect of comprehensive intervention based on Maslow’s hierarchy of needs in nursing care of patients with herpes zoster and pruritus on disease knowledge and self-burden. Methods A total of 80 patients with herpes zoster with pruritus admitted to Qingdao Municipal Hospital from February 2019 to January 2021 were selected and divided into control group and study group according to the random number table method, with 40 cases in each group. The control group was given routine intervention, while the study group was given comprehensive intervention under Maslow’s hierarchy of needs on the basis of the control group. The knowledge and self-burden of herpes zoster with pruritus before and after the intervention were compared between the two groups. Results After the intervention, the disease knowledge mastery scores of the two groups were higher than those before the intervention, while the study group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the scores of care, economy, emotion, and treatment burden in the two groups were lower than those before treatment, while those of the study group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The intervention satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of comprehensive intervention under Maslow’s hierarchy of needs in the treatment and nursing of patients with herpes zoster and pruritus can effectively improve the patient’s knowledge of herpes zoster and pruritus, and reduce the patient’s self-burden. It is worthy of clinical promotion and application.
		2022 Vol. 19 (27): 178-181 [Abstract] ( 16 ) HTML (1 KB) PDF (606 KB) ( 29 )

	182	Effect of nursing intervention based on Peplo interpersonal relationship theory on liver function, psychological state, and quality of life of patients with autoimmune hepatiti
		CHEN Chunhua LIU Jun HAN Ying JIA Gui▲
		DOI: 10.20047/j.issn1673-7210.2022.27.42
		Objective To explore the effect of nursing intervention based on Peplo interpersonal relationship theory on liver function, psychological state, and quality of life of patients with autoimmune hepatitis. Methods A total of 200 patients with autoimmune hepatitis admitted to the Department of Gastroenterology of the First Affiliated Hospital of Air Force Military Medical University from January 2019 to January 2021 were selected and divided into control group and observation group by random number table method, with 100 cases in each. The control group was given routine nursing intervention, while the observation group was given nursing intervention based on Peplo interpersonal relationship theory. The liver function, psychological state, and quality of life were compared between the two groups. Results After the intervention, the alanine aminotransferase and total bilirubin in the two groups were lower than before the intervention, while those of the observation group were lower than those of the control group; the albumin was higher than before the intervention, and the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the anxiety and depression self-rating scale scores in the two groups were lower than those before the intervention, while those of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). After the intervention, the physical, physiological, psychological, and social function scores of the two groups were higher than those before the intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Nursing intervention based on Peplo interpersonal relationship theory can help improve liver function in patients with autoimmune hepatitis, and improve their mental health and quality of life.
		2022 Vol. 19 (27): 182-185 [Abstract] ( 14 ) HTML (1 KB) PDF (573 KB) ( 32 )

	186	Bibliometric analysis of integrative medicine research in China
		ZHANG Zhixuan1 LIU Peinan1 ZHANG Hanzhi2 ZHAO Xuyan2 GUO Chendong2 MA Feng3 LYU Yi1 YAN Xiaopeng1
		DOI: 10.20047/j.issn1673-7210.2022.27.43
		Objective To understand the current situation of integrated medicine research in China, and to explore the research hotspot and development trend of holistic integrative medicine research in China. Methods With “integrative medicine” as the main topic or key word, the literatures related to integrative medicine were searched in CNKI, Wanfang Data, and VIP from the inception to December 2019. The literatures related to integrative medicine were statistically analyzed in terms of year, journal, region, author, institution, department distribution, and fund support. Results The 291 literatures included in this study were published in 137 journals, involving 223 authors from 187 research institutions in 32 provinces, autonomous regions, centrally administered municipalities, and special administrative regions in China. The author with the largest number of publications was Fan Daiming, the province with the largest number was Shaanxi Province, and the institution with the largest number was Xijing Digestive Disease Hospital of Fourth Military Medical University. A total of 104 literatures were supported by provincial and ministerial funds. Conclusion In recent years, the research of integrative medicine in China has developed rapidly and its geographical distribution is relatively concentrated. However, the overall number of publications is small and the research institutions are relatively scattered, which still has broad space for development.
		2022 Vol. 19 (27): 186-189,197 [Abstract] ( 11 ) HTML (1 KB) PDF (770 KB) ( 39 )

	189	Value of double-balloon enteroscopy in diagnosis and treatment of obscure lower gastrointestinal bleeding in children
		ZHANG Zhenqiang ZHOU Yuliang PAN Zhubin JU junjun QI Shiqin
		DOI: 10.20047/j.issn1673-7210.2022.27.44
		Objective To evaluate the value of double-balloon enteroscopy (DBE) in the diagnosis and treatment of obscure lower gastrointestinal bleeding (OGIB) in children. Methods Thirty-one children with OGIB in Anhui Provincial Children’s Hospital from June 2014 to September 2021 were selected. After admission, symptomatic treatment such as hemostasis, blood transfusion, acid inhibition， and fluid replenishment were given as appropriate. The children with negative colonoscopy and imaging examination were selected for DBE examination. The causes and distribution of bleeding in children with OGIB were observed, DBE examination time, laparoscopic operation time, and hospital stay were counted. All children were revisited regularly to observe the treatment effect. Results There were 31 children, including 21 males and 10 females; the average age was (9.13±3.11) years; the average hemoglobin at admission was (86.90±19.31) g/L. The DBE of 26 children was positive, among which 25 patients were confirmed to have Mecker diverticulum (MD) by laparoscopic exploration, and 1 patient was found to have flake mucosal erosion in the intestinal lumen by DBE examination but was negative by laparoscopic exploration; DBE examination was negative in 5 children, and 1 patient with negative DBE examination was confirmed as MD after laparoscopic exploration. The average examination time of DBE was (148.65±44.47) min; the average operation time was (176.58±34.62) min; the average hospital stay was (5.90±1.51) days. No postoperative complications occurred. Postoperative pathology revealed ectopic gastric mucosa in 2 cases. There was no recurrence of lower gastrointestinal bleeding in 26 cases diagnosed with MD and 1 case with negative laparoscopic exploration but positive for DBE. However, in the 4 cases of negative DBE exploration without laparoscopic exploration, one of them showed recurrent hematochezia at 7 months, and the result was still negative after laparoscopic exploration, no gastrointestinal bleeding symptom has occurred again. Conclusion DBE examination is safe, intuitive, and effective. It is suitable for the clinical diagnosis and treatment of MD children with unexplained lower gastrointestinal bleeding as the main manifestation. Combined with laparoscopic exploration, it can effectively complete the minimally invasive treatment of MD.
		2022 Vol. 19 (27): 189-193 [Abstract] ( 16 ) HTML (1 KB) PDF (847 KB) ( 35 )

	194	Systemic retroversion for development of tumorous treatment
		PENG Jianqiao Matthew1 LIN Yepeng2 YANG Weiwen3
		DOI: 10.20047/j.issn1673-7210.2022.27.45
		Previously, temperature check only reaches a body surface but not organic scope, and temperature is controlled only by vista but not intelligent quantization. Harmless temperature measurement is minimal or none invasive in advantage, how to monitor thermotherapy control by examining temperature accurately as to take advantage of thermotherapy is a hot topic. This paper summarizes some ideas and methods of tumor hyperthermia by reviewing the latest literature on tumor hyperthermia. Precise hyperthermia for tumors, for example, can be planned through advanced technologies such as proton resonance frequency shift-magnetic resonance thermal imaging, magnetic resonance-guided, laser-induced thermal therapy, and Sigma-HyperPlan. This panper depicts the natural regulation of thermal treatment is by historically reviewing the developing procedure about thermal treatment, the principle and solution of thermal treatment in past is well learnt, and critical thinking is provided by now.
		2022 Vol. 19 (27): 194-封三 [Abstract] ( 14 ) HTML (1 KB) PDF (1019 KB) ( 187 )

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