长链非编码RNA在急性肾损伤中的研究进展

doi:10.20047/j.issn1673-7210.2022.27.10

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Abstract Acute kidney injury (AKI) is characterized by rapid loss of renal function in a short period of time. Sepsis, ischemia-reperfusion, and nephrotoxic substances are the main causes of AKI. The mechanism of AKI is still unclear and there is a lack of effective diagnosis and treatment. With the novel development of sequencing technology, more and more long non-coding RNAs (lncRNAs) have been identified to abnormally expressed in AKI patients and animal and cell models. Studies have shown that lncRNA may play an important role in the occurrence, development, and prognosis of AKI by targeting inflammation, oxidation, and apoptosis signaling pathways through sponge adsorption of miRNA. This article reviews the mechanism and potential application of lncRNA in AKI.

Key words： Long non-coding RNA Acute kidney injury Biomarker Sepsis Ischemia-reperfusion

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	XIE Anni YU Yanting WANG Xiaoyan

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XIE Anni YU Yanting WANG Xiaoyan. Research progress of long non-coding RNA in acute kidney injury[J]. 中国医药导报, 2022, 19(27): 47-49.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.27.10 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I27/47

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