脂肪细胞转分化对青春期性发育及骨生长的调控机制

doi:10.20047/j.issn1673-7210.2022.27.08

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Abstract Puberty sexual development is accompanied by rapid bone formation and fat remodeling, estrogen regulates bone growth at the global level, sexual initiation is controlled by the hypothalamic-pituitary-gonadal axis (HPGA) and is related to body fat. Recent studies have found that leptin can stimulate hypothalamic gonadotropin-releasing hormone (GnRH) to stimulate HPGA, thus promoting the onset of puberty, but leptin is not an essential initiator. Peroxisome proliferator-activated receptor γ (PPARγ) is an important link between energy metabolism and reproductive axis. The activation of PPARγ triggers leptin signal, which can stimulate the hypothalamic GnRH to stimulate HPGA. As an endocrine organ, bone can inhibit the formation of adipocytes, which in turn can inhibit the proliferation and differentiation of osteoblasts and antagonize bone formation. PPARγ is a key factor regulating adipogenic and osteogenic differentiation. Therefore, adipocyte transdifferentiation is an important mechanism regulating puberty sexual development and bone growth. This paper expands the new understanding of adipocyte transdifferentiation on the regulation of children’s sexual development and bone metabolism, and provides a new idea for clinical multi-target and multi-way intervention of children’s precocious puberty and improvement of lifelong high.

Key words： Adipocytes Bone growth Leptin Sexual precosity

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	DUAN Juan1 LIU Lailai2

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DUAN Juan1 LIU Lailai2. Regulation mechanism of adipocyte transdifferentiation on puberby sexual development and bone growth[J]. 中国医药导报, 2022, 19(27): 39-42.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.27.08 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I27/39

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