Gremlin 1在糖脂代谢及其相关疾病中的研究进展

doi:10.20047/j.issn1673-7210.2022.27.09

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Abstract Gremlin 1 is a member of the transforming growth factor-β superfamily. Early studies have found that it participates in the formation, development, and differentiation of embryos and inhibits the formation of bone and cartilage. In glucose metabolism, Gremlin 1 can antagonize insulin action; in lipid metabolism, Gremlin 1 can regulate the formation and differentiation of human adipocytes and inhibit browning of white adipocytes. This article reviews the research progress of Gremlin 1 in glucolipid metabolism and related diseases in recent years, in order to provide theoretical basis for the treatment of glucolipid metabolism related diseases.

Key words： Gremlin 1 Glucose metabolism Lipid metabolism Type 2 diabetes mellitus Complication

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	GU Tian ZHAO Li DENG Xia YANG Ling YUAN Guoyue▲

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GU Tian ZHAO Li DENG Xia YANG Ling YUAN Guoyue▲. Research progress of Gremlin 1 in glucolipid metabolic and related diseases[J]. 中国医药导报, 2022, 19(27): 43-46.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2022.27.09 OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I27/43

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