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2022 Vol. 19, No. 10
Published: 2022-04-05
 
 
5 Acupuncture point specificity study on the treatment of stress incontinence model rats by electroacupuncture at the cìliáo point#br#
ZHANG Weiwei1 CAI Mingxing1 MO Qian1 YANG Dan2
Objective To investigate the acupuncture point specificity of electroacupuncture at the cìliáo point in rats with stress incontinence. Methods Fifty 8-week-old female SD rats, weighing 180 - 220 g, were divided into normal group, model group, cìliáo point group, sānyīnjiāo group, and non-channel point group according to random number table method, with ten rats in each group. The normal group was only tested, and the other four groups were treated with bilateral ovariectomy first, followed by vaginal dilation to establish the model of stress incontinence. After modeling, urine flow dynamics was detected before and after electroacupuncture intervention, and the changes of abdominal leak point pressure (ALPP) and maximal bladder capacity (MBC) were observed. Immunohistochemistry was used to detect the expression levels of type Ⅰ collagen (collagen Ⅰ) and connective tissue growth factor (CTGF) in the tissues of caudal gluteus muscle and bladder cervical urethral sphincter. Results The results of urine flow dynamics showed that MBC and ALPP values of model group were significantly decreased after intervention compared with normal group (P ＜ 0.05). Compared with model group, MBC and ALPP values of cìliáo point group, sānyīnjiāo group, and non-channel point group were increased after intervention (P ＜ 0.05). Compared with cìliáo point group, MBC and ALPP values of sānyīnjiāo group and non-channel point group were decreased (P ＜ 0.05). Immunohistochemical results showed that compared with normal group, the expression levels of collagen Ⅰ and CTGF in model group were significantly decreased (P ＜ 0.01). Compared with model group, the expression levels of collagen Ⅰ and CTGF in cìliáo point group, sānyīnjiāo group, and non-channel point group were significantly increased (P ＜ 0.05). Compared with the cìliáo point group, the expression levels of collagen Ⅰ and CTGF in sānyīnjiāo group and non-channel point group were decreased (P ＜ 0.05). Conclusion Electroacupuncture on cìliáo point can effectively improve the symptoms of stress urinary incontinence and repair the pelvic floor tissue damage, and the bladder regulation effect has acupoint specificity.
2022 Vol. 19 (10): 5-8,13 [Abstract] ( 20 ) HTML (1 KB)  PDF (1191 KB)  ( 87 )
9 Analysis of knowledge graph of akupotomye in the treatment of knee osteoarthritis based on CiteSpace#br#
ZHANG Liangzhi1 ZHANG Renpan2 LIU Hong1 ZHANG Zesheng1 JI Ziqian2 LIU Jing1 XIU Zhongbiao1
Objective To measure and visualize the literature on akupotomye in the treatment of knee osteoarthritis by using CiteSpace knowledge graph software, and to explore the research status, hot spots, and frontier of this field in the past 20 years. Methods Literature on akupotomye in the treatment of knee osteoarthritis in China National Knowledge Infrastructure was searched as data source from January 2000 to December 2019. Excel was used to conduct preliminary statistics on the included literature, and CiteSpace was used to conduct co-occurrence analysis on the authors, institutions, and keywords in the literatures to draw the relevant knowledge graphs. Results The number of related research papers was generally increasing. A total of 81 institutions were included in the graph, of which 8 institutions published≥5 papers. A total of 322 authors were included in the graph, and there were 40 authors who had published≥5 papers. A total of 183 keywords were included, among them, 22 key words had published≥10 papers in this field. Twelve key words appeared emergent, and the most recent emergent time was “muscle region theory and musculoskeletal ultrasound”, which lasted from 2014 to 2019 and from 2016 to 2019, respectively. Conclusion The related research on akupotomye in the treatment of knee osteoarthritis can be divided into three stages: basic stage, development stage, and flourishing stage, and the hot spots tend to be related to musculoskeletal ultrasound and muscle region theory. However, there are also problems such as lack of cross-organization and cross-team cooperation and communication and lack of innovation.
2022 Vol. 19 (10): 9-13 [Abstract] ( 122 ) HTML (1 KB)  PDF (1480 KB)  ( 22 )
14 Diagnostic value assessment of seven noninvasive diagnostic models in liver fibrosis and cirrhosis of patients with chronic hepatitis B#br#
WU Xiaoxi WANG Tao DU Shengnan JIANG Yuanye▲ CAO Qin▲
Objective To explore the diagnostic value of liver fibrosis and cirrhosis in patients with chronic hepatitis B (CHB) among the aspartate aminotransferase / platelet ratio (APRI), cirrhosis discriminant score (CDS), and fibrosis index based on the four factors (FIB-4), Forns index, glutamyltransferase / platelet ratio (GPR), King’s score, S index model for chronic. Methods From January 2019 to December 2020, a total of 166 patients with CHB who were admitted to Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine and underwent liver biopsy and blood biochemical coagulation tests were selected. According to the liver fibrosis stage (S) of the liver biopsy results, there were 55 cases in the non-obvious liver fibrosis group (S0-1), 97 cases in the significant liver fibrosis group (S2-3), and 14 cases in the early-stage cirrhosis group (S4). The APRI, CDS, FIB-4, Forns index, GPR, King’s score, and S index according to the formula were calculate. At the same time, the receiver operating characteristic (ROC) curves of the above seven models were drawn, and the area under the ROC curve (AUC), sensitivity, and specificity were calculated to evaluate the value of each model in the diagnosis of liver fibrosis. Results Compared with the three groups of model scores, and the difference was highly statistically significant (P ＜ 0.01). Except for the CDS model, each model index was positively correlated with the inflammation grade (r ＞ 0, P ＜ 0.05); the scores of each model were positively correlated with liver fibrosis stage (r ＞ 0, P ＜ 0.05). The AUC of S index, APRI, GPR, and King’s score for the diagnosis of significant liver fibrosis＞0.7. The AUC for the diagnosis of early liver cirrhosis from high to low as GPR, S index, APRI, Forns index, King’s score, CDS, and FIB-4. The AUC analysis of the seven models showed that there was a statistically significant difference between APRI and King’s score in the significant liver fibrosis group (Z = 2.197, P ＜ 0.05); there was no significant difference between the other models (P ＞ 0.05). Conclusion APRI, GPR, King’s score, and S index can better diagnose significant liver fibrosis and early cirrhosis in CHB patients. CDS, FIB-4, Forns index have certain diagnostic value for early liver cirrhosis, but the diagnostic accuracy for significant liver fibrosis is low. APRI and GPR models are simple to calculate, serological indicators are readily available, and the cost is low. It can be recommended as a detection method for liver fibrosis in patients with CHB in the grassroots and areas with limited medical resources, so that some patients can avoid invasive liver biopsy and reduce medical costs.
2022 Vol. 19 (10): 14-19 [Abstract] ( 56 ) HTML (1 KB)  PDF (824 KB)  ( 84 )
20 Discussion on the molecular mechanism of Xiaoqinglong Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease based on integrative pharmacology and molecular docking technology#br#
HAN Dongwei YANG Qinqin WANG Lifang LIANG Xin ZHANG Hongbo ZHANG Weijun
Objective To explore the molecular mechanism of Xiaoqinglong Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) by integrating pharmacology and molecular docking technology. Methods Components and targets of Xiaoqinglong Decoction were retrieved by integrative pharmacology-based research platform of traditional Chinese medicine V2.0 database, and the targets related to AECOPD were queried by using GeneCards and OMIM databases. Protein-protein interaction network was performed by using STRING database. The multidimensional network diagram of “prescription-active ingredient-core target-phenotype-disease” was constructed by using Cytoscape 3.7.2 software. The active ingredients and the core targets were performed to molecular docking by using AutoDock software. Results A total of 41 components and 23 core targets of Xiaoqinglong Decoction were retrieved. Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis indicated that core targets were mostly involved in biological processes such as inflammation and immunity, oxidative stress, and energy metabolism. Molecular docking showed that paeoniflorin dione, isoglycyrrhizin, and 2，4，4’-trihydroxychalcone had high affinity with epidermal growth factor, Akt kinase 1, and tumor necrosis factor. Conclusion The potential active components and targets of Xiaoqinglong Decoction in the treatment of AECOPD are initially screened, its multi-component and multi-target effects mainly improve AECOPD process through biological processes such as inflammation and immunity, oxidative stress, and energy metabolism.
2022 Vol. 19 (10): 20-24 [Abstract] ( 27 ) HTML (1 KB)  PDF (1838 KB)  ( 187 )
25 Diagnostic value of serum HDAC2 and SP-D in the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease combined with mild to moderate type Ⅱ respiratory failure treated by nasal highflow oxygen therapy#br#
LI Jiangtao WANG Yuan WANG Liang MENG Jing LI Yanjun
Objective To investigate the diagnostic value of serum histone deacetylase 2 (HDAC2) and pulmonary surfactant protein D (SP-D) in the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with mild to moderate type Ⅱ respiratory failure treated by nasal high flow oxygen therapy. Methods A total of 312 patients with AECOPD complicated with mild to moderate type Ⅱ respiratory failure admitted to the Department of Respiratory, Hebei Chest Hospital from January 2018 to December 2020 were selected. All patients received conventional treatment and nasal high flow oxygen therapy, and they were divided into stable group (224 cases) and recombination group (88 cases) according to the outcome after 14 days of treatment. General data, serum HDAC2, and SP-D levels before treatment were collected and compared to analyze the prognostic factors of patients with AECOPD complicated with mild to moderate type Ⅱ respiratory failure treated with nasal high flow oxygen therapy. Receiver operating characteristic curve and area under curve (AUC) were used to analyze the diagnostic value of serum HDAC2 and SP-D levels before treatment for prognosis of patients. Results The acute physiology and chronic health evaluationⅡ (APACHE Ⅱ) score, white blood cell count, neutrophil count, C-reactive protein, erythrocyte sedimentation rate, procalcitonin, serum HDAC2 before treatment, and serum SP-D before treatment in the recombination group were higher than those in the stable group, and the differences were statistically significant (P ＜ 0.05). The results of multivariate analysis showed that APACHE Ⅱ score, serum HDAC2 before treatment, and serum SP-D level before treatment were the influencing factors of the prognosis of AECOPD with mild to moderate type Ⅱ respiratory failure after 14 days of nasal high flow oxygen therapy (P ＜ 0.05). Serum HDAC2 and SP-D levels before treatment had certain diagnostic value for the prognosis of AECOPD patients with mild to moderate type Ⅱ respiratory failure after 14 days of nasal high flow oxygen therapy (AUC ＞ 0.5, P ＜ 0.05). Conclusion Serum HDAC2 and SP-D levels are correlated with the prognosis of AECOPD patients with mild to moderate type Ⅱ respiratory failure after 14 days of nasal high flow oxygen therapy, which has certain diagnostic value.
2022 Vol. 19 (10): 25-29 [Abstract] ( 33 ) HTML (1 KB)  PDF (854 KB)  ( 20 )
30 Effect of Tongqiao Yinao Prescription on learning and memory behavior in Scopolamine dementia model mice#br#
Alinuer Aimaier1 NIE Yunan1 Anaer Mahemuti2 GAO Li2
Objective To observe the effect of Tongqiao Yinao Prescription on learning and memory behavior in Scopolamine dementia model mice. Methods A total of 50 male Kunming mice were divided into blank control group, Scopolamine model group, Donepezil group, Tongqiao Yinao Prescription 0.41 g/kg group, and Tongqiao Yinao Prescription 0.82 g/kg group by random number table method, with ten mice in each group, continuously administrate drug for 29 d. Except blank control group, other groups were intraperitoneally injected with Scopolamine Hydrobromide 2 mg/kg 30 min before behavioral experiment to establish the model, blank control group was intraperitoneally injected with normal saline. The learning and memory ability of mice was tested by platform test, the contents of acetylcholine (ACh) and acetylcholinesterase (ChAT), and the activity of acetylcholinesterase (AChE) in hippocampus tissue of each group were determined by colorimetry and enzyme-linked immunosorbent assay. Results Compared with blank control group, the incubation period of stepping down in Scopolamine model group was shortened and the number of stepping down errors was increased during the training period and test period of platform test, and the differences were statistically significant (P < 0.05); compared with Scopolamine model group, the incubation period of stepping down in Tongqiao Yinao Prescription 0.41 g/kg and Tongqiao Yinao prescription 0.82 g/kg group were prolonged and the number of stepping down errors were reduced during the training period and test period of platform test, and the differences were statistically significant (P < 0.05). Compared with blank control group, the contents of ACh and ChAT of Scopolamine model group were decreased, and the activity of AChE was increased, and the differences were statistically significant (P < 0.05); compared with Scopolamine model group, the contents of ACh and ChAT of Tongqiao Yinao Prescription 0.41 g/kg and Tongqiao Yinao prescription 0.82 g/kg group were increased, and the activity of AChE were decreased, and the differences were statistically significant (P < 0.05). There were no statistically significant differences between Tongqiao Yinao Prescription 0.41 g/kg and Tongqiao Yinao prescription 0.82 g/kg group in incubation period of stepping down, the number of stepping down errors, ACh, ChAT content, and AChE activity (P > 0.05). Conclusion Tongqiao Yinao Prescription can improve the transient acquired learning and memory impairment caused by Scopolamine to a certain extent, and its mechanism is related to regulating the cholinergic function of Scopolamine mouse model.
2022 Vol. 19 (10): 30-33 [Abstract] ( 27 ) HTML (1 KB)  PDF (761 KB)  ( 191 )
34 Application of injection therapy for rectal prolapse abroad#br#
LI Yingqian LI Huashan
Injection therapy is an important method for the treatment of rectal prolapse. At present, this method is mainly used in children with incomplete rectal prolapse abroad, and it is also recommended for elderly patients who do not tolerate surgical treatment. For a long time, there are many injectable drugs available in clinic, each of them has its own advantages and disadvantages, none of them has absolute advantages, and there is no unified standard for the concentration and dosage of drugs. Therefore, more rigorous and comprehensive clinical and basic research is needed in the future work to realize the precise application of injection therapy.
2022 Vol. 19 (10): 34-37,50 [Abstract] ( 92 ) HTML (1 KB)  PDF (628 KB)  ( 23 )
38 Research progress on the interaction between sepsis and intestinal microbe#br#
BAI Yuanyuan DONG Beibei YU Yonghao▲
The gut microbiome is involved in the regulation of a variety of homeostatic mechanisms in the healthy host including immune function and gut barrier, etc. Recent studies have confirmed the important linkages between the gut microbiome and sepsis. This paper focuses on the potential mechanisms of intestinal microbes involved in the occurrence and development of sepsis from the following three aspects: Firstly, the activation of pathogenic intestinal flora, activation of the immune system and inflammatory response, as well as the reduction of beneficial microbial products, and other pathological changes affect the susceptibility of the host to sepsis; the second, sepsis leads to the destruction of intestinal microbiota and induces and aggravates terminal organ dysfunction; the third, microbial-based treatment strategies, such as selective intestinal decontamination and fecal microbiological transplantation, may reduce the incidence of sepsis and improve the prognosis of patients with sepsis. Intervention in the pathophysiological process of sepsis from the perspective of intestinal microorganisms may be a new target for the prevention or treatment of sepsis.
2022 Vol. 19 (10): 38-41,76 [Abstract] ( 64 ) HTML (1 KB)  PDF (603 KB)  ( 85 )
42 Research progress of m6A modification in gastric cancer#br#
XIE Shengmao1 ZHANG Zhilong2 LI Chunhui3 SHI Fei4
Gastric cancer is the most common gastrointestinal tumor in China, and its therapeutic effect is not good. More than 150 kinds of RNA modifications have been discovered, and the dynamic modification of m6A is the most abundant one in RNA modification. m6A modification plays an important role in RNA metabolism and is involved in many biological processes such as cell proliferation, differentiation, and apoptosis. m6A modification imbalance also plays an important role in the occurrence and development of gastric cancer, in-depth study of the molecular mechanism of gastric cancer can provide a new strategy for the treatment of gastric cancer.
2022 Vol. 19 (10): 42-45 [Abstract] ( 86 ) HTML (1 KB)  PDF (442 KB)  ( 37 )
46 Research progress of pulmonary rehabilitation in early rehabilitation of stroke#br#
LI Xin1 HU Luanjiao2 QUAN Fengying1
Pulmonary dysfunction in acute stage of stroke patients is one of the common complications, which affects the follow-up treatment and rehabilitation effect of patients. The application of pulmonary rehabilitation technology in patients with acute stroke can effectively improve their cardiopulmonary function, increase the rehabilitation effect of activity endurance, and nerve function, and comprehensively improve the prognosis of patients. This article reviews the pathogenesis of acute pulmonary dysfunction in post-stroke patients, the evidence-based basis of acute pulmonary rehabilitation of stroke and its clinical application in early rehabilitation of stroke, analyzes and summarizes the problems still exist in the clinical application, and puts forward further research direction to provide scientific guidance for the practical application of the clinical workers and theoretical basis.
2022 Vol. 19 (10): 46-50 [Abstract] ( 74 ) HTML (1 KB)  PDF (603 KB)  ( 107 )
51 Research progress on the influencing factors of unscheduled taking off the machine of continuous renal replacement therapy#br#
NIE Anliu SU Xiangfen GUAN Wenjie
Continuous renal replacement therapy (CRRT) has been widely used in the treatment of critically ill patients. In clinical practice, a variety of factors may lead to substandard treatment times or taking off the machine in advance due to trigger the indications of taking off the machine. This study reviewes the influencing factors of unscheduled taking off the machine of CRRT, it is expected that the result could help medical staffs to recognize the risk factors of the unscheduled taking off the machine, and take some effective measures. Through reviewing of domestic and foreign literatures, combined with the actual clinical situation, it is found that the rate of unscheduled taking off the machine of CRRT is as high as 17.14% to 74.51%, mainly occurring in the first eight hours, and most of them have no direct cause, it is mainly affected with the aspects of patients themselves, vascular access, treatment schemes, and operation staffs, etc.
2022 Vol. 19 (10): 51-54 [Abstract] ( 46 ) HTML (1 KB)  PDF (542 KB)  ( 39 )
55 Research progress on the relationship between selenium and Hashimoto thyroiditis#br#
GENG Wenqian QI Shuo CHEN Xiaoheng LI Zhe LI Huilong LIU Meijun GE Yaxue DING Zhiguo
In recent years, the incidence of Hashimoto thyroiditis (HT) has been increasing year by year. Selenium, as an essential trace element, is related to the pathogenesis of HT. Most studies attribute the immunomodulatory effects of selenium to its antioxidant properties. Glutathione peroxidase system, thioredoxin reductase system and iodothyronine deiodase system together constitute the selenoprotein family, which not only directly participate in the synthesis of thyroid hormones, but also regulate the internal REDOX state of the thyroid gland and protect the thyroid gland from oxidative stress damage. At present, many studies have supported the efficacy of selenium in reducing thyroid auto-antibody titers in HT patients, but there is still a lack of sufficient evidence to confirm the clear efficacy of selenium in the treating of HT. Whether selenium supplementation can become the standard treatment for HT remains to be discussed.
2022 Vol. 19 (10): 55-58 [Abstract] ( 23 ) HTML (1 KB)  PDF (490 KB)  ( 247 )
59 Research and practice in the course of Chinese materia medica based on the blending learning model#br#
CHEN Yuhang
In recent years, large-scale online teaching has brought unprecedented challenges to universities, and how to realize the integration of offline teaching and online teaching to increase efficiency is a theme of concern in the education reform of universities. Chinese materia medica is a discipline closely combined with the basic theory of traditional Chinese medicine, and its clinical application. At present, there are problems of passive learning process, fragmentation of teaching contents, and differentiation of teaching effects in the teaching of Chinese materia medica course. In this paper, the existing teaching mode of Chinese materia medica course in Chendu Medical College is reformed, a blending teaching mode of “pre-class, in-class, and after-class” is built, a whole process assessment and evaluation system is established, and the problems and solutions of this teaching mode are proposed. The blending teaching mode is effective in improving the teaching quality of Chinese materia medica course, and it is worth to promote the teaching.
2022 Vol. 19 (10): 59-63 [Abstract] ( 58 ) HTML (1 KB)  PDF (1507 KB)  ( 48 )
64 Examples and analysis of application of ideological and political elements in the course of Neijing#br#
QIAN Huinan LU Ying ZHAI Shuangqing HAN Jingjie CHANG Liguo HAO Yu WANG Weiguang
How to strengthen ideological and political curriculum and curriculum ideological and political cooperation education work is an urgent proposition of ideological and political education in colleges and universities. Neijing is the earliest existing medical literature in China. Its publication constructs the framework of traditional Chinese medicine (TCM) theory system. The book comprehensively discusses the thinking methods, theoretical principles and academic thoughts of TCM. The extensive and profound medical theories in Neijing also reflect a variety of thoughts such as “putting people first”, “medicine being humane art”, “harmony of man with nature”, “harmonizing yin and yang to achieve moderation”, “virtues of great physician”, etc., which contain abundant ideological and political elements. To reveal the ideological connotation of professional theory in Neijing, this paper in-depth minings the ideological elements in Neijing course, integrates the professional theories of Neijing into ideological and political elements, focus on chapters in the classroom teaching on the combination of “point and face”, tries to make the teaching of Nejing and ideological and political thinking go together to form a synergistic effect, forms a synergistic effect, make the course education “to detail the liquor”, achieves the goal of political cooperation education work moistens everything silently.
2022 Vol. 19 (10): 64-67 [Abstract] ( 29 ) HTML (1 KB)  PDF (632 KB)  ( 96 )
68 Practical study on integration of aesthetic education discourse with Chinese characteristics into English teaching in traditional Chinese medicine colleges and universities#br#
LI Yanwei1 BAO Lei2
The study of aesthetic education discourse with Chinese characteristics is of great significance to the reorganization of traditional ideological resources and the promotion of Chinese fine culture, it is inevitable route in the course of deepening the transformation and development of traditional Chinese medicine (TCM) colleges and universities and cultivating interdisciplinary applied talents. On the basis of sorting out the generation, development and inheritance of the aesthetic education discourse with Chinese characteristics, this paper proposes the guiding, spreading and influencing power of the aesthetic education discourse with Chinese characteristics in English teaching in TCM colleges and universities, and finally expounds the practical strategies of the aesthetic education discourse with Chinese characteristics in English teaching in TCM colleges and universities from teaching method, content and interaction. In the hope of implementing aesthetic education discourse with Chinese characteristics is practical, promoting the coordinated development of aesthetic discourse and language teaching in TCM colleges and universities, improving talents’ training quality in TCM colleges and universities.
2022 Vol. 19 (10): 68-71 [Abstract] ( 27 ) HTML (1 KB)  PDF (610 KB)  ( 243 )
72 Teaching mode of improving clinical thinking ability at surgery clinical practice stage for medical students#br#
ZHENG Yamin LIANG Kuo WANG Yuehua LIU Dongbin WANG Yajun YU Zhihao
Objective To explore the effectiveness of Web-based case-based learning problem based learning (CBL-PBL) teaching model in clinical practice teaching activities of hepatobiliary surgery. Methods From September 2020 to April 2021, 50 fifth grade medical students from the Department of Clinical Medicine, the First Clinical Medical College of Capital Medical University were divided into study group and control group by random number table method, with 25 students in each group. The study group adopted the network assisted CBL-PBL teaching mode, including network organization and management, CBL-based teaching plan design, PBL-centered teaching implementation and network after-school management. The control group used the traditional teaching mode. The students’ interest and satisfaction in clinical thinking ability were compared between the two groups. The clinical thinking teaching effect was evaluated by the general scale of clinical thinking ability teaching assessment. Results The students’ satisfaction of teaching clinical thinking ability in study group was higher than that in control group (P ＜ 0.05). The total scores and critical thinking, systematic thinking, evidence-based thinking, and clinical thinking in the study group were significantly higher than those in the control group (P ＜ 0.01). Conclusion The application of Web-based CBL-PBL teaching mode in clinical medical students’ practice of hepatobiliary surgery can improve students’ satisfaction and learning interest, and obviously improve the teaching effect of clinical thinking ability, which is worthy of further study, improvement and promotion.
2022 Vol. 19 (10): 72-76 [Abstract] ( 53 ) HTML (1 KB)  PDF (1460 KB)  ( 205 )
77 Building and practice of an innovative and practical ability-oriented triad training todel for applied medical laboratory technology professionals#br#
ZHAO Liping1 WU Qian1 WANG Li2 Li Yankui1 QUAN Zhibo1 MA Yanxia2
To meet the needs of social development, Shaanxi University of Chinese Medicine focusing on the training of applied medical laboratory technology professionals, has carried out reform and practice from three aspects: revising the talent training plan, constructing a new practical teaching model, and  reinforcing quality education, paying attention to the training of students’ practical ability and innovative spirit, and built a triad training todel for applied medical laboratory technology professionals.
2022 Vol. 19 (10): 77-80 [Abstract] ( 58 ) HTML (1 KB)  PDF (610 KB)  ( 205 )
81 Application effect of blended learning in “Medical Genetics” for training of rural order oriented medical students#br#
ZHANG Ni MI Yajing LIU Jie GOU Xingchun JING Xiaohong
Objective To explore the application effect of blended learning in ‘medical genetics’ for training of rural order-oriented medical students. Methods The study period was from February to July 2021, a total of 139 rural order-oriented general medicine students from Xi’an Medical University in Grade 2019 were divided into blended learning group (70 students) and control group (69 students) through the random number table method. The control group was taught with the traditional teaching method and blended learning group carried out various teaching methods, such as case teaching, micro-lectures. The teaching effect was evaluated by the combination of test score analysis and questionnaire. Results The middle term exam scores, the final test scores, and the total exam scores of the blended learning group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The results of the questionnaire showed that blended learning group was better than the control group in terms of doctor-patient communication ability, comprehensive problem analysis ability, and clinical thinking, the differences were statistically significant (P ＜ 0.05). Conclusion The blended teaching improves the quality of teaching and strengthens the job adaptability of rural order-oriented medical students. This research may provide a reference for further optimizing the training mode of rural order-oriented medical students.
2022 Vol. 19 (10): 81-83,88 [Abstract] ( 27 ) HTML (1 KB)  PDF (581 KB)  ( 89 )
84 Application effect of the “happy teaching method” in the teaching of periodontology for undergraduates #br#
HE Xiaotao1,2,3 AN Ying1,2,3 MIAO Hui1,2,3 RUAN Bai4 CHEN Fang1,2,3 CHEN Faming1,2,3 TIAN Beimin1,2,3
Objective To investigate the application effect of “happy teaching method” in periodontology education for undergraduates majoring in stomatology. Methods A total of 38 four-year undergraduate students majoring in stomatology in the Fourth Military Medical University in 2019 and 2020 were divided into experimental group (19 students) and control group (19 students) by random number table method. Five lessons namely “gingivitis”,“periodontitis”,“periodontitis-associated diseases”,“multidisciplinary team treatment”, and “case discussion on periodontal diseases” were selected for group teaching. The control group adopted traditional teaching method and the experimental group adopted “happy teaching method”. The implementation effects of the two teaching methods were evaluated comprehensively from three levels of student questionnaire survey scores, teacher scores and final theoretical examinations. Results There were no significant differences in scores of theoretical knowledge and inductive analysis ability between the two groups (P ＞ 0.05), the scores of learning initiative and efficiency of classroom learning, clinical thinking ability cultivation, doctor-patient communication skills, team cooperation ability training, the overall teaching satisfaction, and total score of the experimental group were higher than the control groups and the differences were statistically significant (P ＜ 0.05). The scores of independent learning ability, clinical thinking ability, classroom activity, problem finding, solving ability, and total score of students in the experimental group were higher than those in the control group, the differences were statistically significant (P ＜ 0.05). There were no statistically significant differences in the scores of objective type questions between the two groups (P ＞ 0.05), but the scores of case analysis questions and total scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion “Happy teaching tethod” can improve the teaching efficiency of classroom learning and appears to be a useful teaching method in Periodontology education for undergraduates.
2022 Vol. 19 (10): 84-88 [Abstract] ( 26 ) HTML (1 KB)  PDF (681 KB)  ( 52 )
89 Evaluate of the effect of two hemodialysis methods on the overall left ventricular systolic function in patients with uremia by three-dimensional speckle tracking technology#br#
ZHANG Bingyi CHEN Xiaorong CHEN Hongmin WANG Ting CHEN Lu DONG Meng PING Jie
Objective To evaluate the effects of different hemodialysis methods on the overall systolic function of the left ventricle in patients with uremia by using 3D spot tracking technique (3D-STI). Methods Thirty-five uremic dialysis patients with stable condition in the People’s Hospital of China Three Gorges University from January 2019 to December 2020 were selected. Hemodialysis and hemofiltration were performed on the above patients according to different dialysis methods. Cardiac ultrasonography was performed once before dialysis and within 30 minutes after dialysis. Comparison of cardiac ultrasound parameters (left ventricular global peak systolic strain [LVGPSL], left ventricular global longitudinal strain [LVGLS], left ventricular global circumferential strain [LVGCS], left ventricular global area strain [LVGAS], left ventricular global radial strain [LVGRS], left ventricular ejection fraction [LVEF], left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume [LVESV]) and patient-related clinical and blood biochemical indicators. The correlation between the changes of serum β2-microglobulin (β2-MG) concentrations and the changes of 3D-STI in the two groups was analyzed. Results The measured values of left ventricular end-diastolic diameter, left atrium diamete, left ventricular volumes index in hemodialysis and hemofiltration after dialysis were significantly lower than those before dialysis, and the differences were statistically significant (P ＜ 0.05); however, there was no significant difference in Sm between the two methods before and after dialysis (P > 0.05). After a single dialysis, the measured values of LVGPSL, LVGLS, LVGCS, LVGAS, LVGRS, LVEDV, and LVESV in the hemodialysis methods were lower than those before dialysis, and the differences were highly statistically significant (P ＜ 0.01); there was no significant difference in LVEF before and after dialysis (P ＞ 0.05). After a single dialysis, the LVESV in the hemofiltration methods was significantly lower than that before dialysis, and the difference was statistically significant (P ＜ 0.05). The serum urea and serum creatinine after a single dialysis in the two methods were lower than those before dialysis, and the differences were statistically significant (P ＜ 0.01). In the hemodialysis methods, the serum β2-MG after dialysis was higher than that before dialysis, and the difference was highly statistically significant (P ＜ 0.01). The serum β2-MG in the hemofiltration methods after dialysis was lower than that before dialysis, and the difference was highly statistically significant (P ＜ 0.01). The changes of serum β2-MG concentration before and after dialysis in the hemofiltration methods were negatively correlated with LVGLS (r = -0.45, P ＜ 0.05). Conclusion Hemodialysis has a certain damage to the overall systolic function of the left ventricle, while hemofiltration has a protective effect on the overall systolic function of the left ventricle. The possible mechanism is through filtering out macromolecular substances.
2022 Vol. 19 (10): 89-93 [Abstract] ( 67 ) HTML (1 KB)  PDF (1080 KB)  ( 10 )
94 Effects of adrenaline hydrochloride in painless gastroscopy on acute non-varices upper gastrointestinal bleeding#br#
HE Hua SUN Lili PANG Na
Objective To explore the clinical effect of different use of drugs under painless gastroscope in the treatment of acute non-variceal upper gastrointestinal bleeding. Methods A total of 92 patients with acute non-variceal upper gastrointestinal bleeding who were treated in Union Hospital of Tangshan City, Hebei Province from March 2019 to January 2020 were selected and randomly divided into groups, with 46 cases in each group. The spray group was treated with hemocoagulase under gastroscope, while the injection group was treated with adrenaline hydrochloride under gastroscope. The clinical efficacy, bleeding stop time, bleeding stop rate within five minutes, rebleeding rate within a week, serum lipopolysaccharide (LPS) content, serum C-reactive protein (CRP) content, and occurrence of adverse reactions were compared between the two groups. Results The efficacy of the injection group was significantly better than that of the spray group, and the difference was statistically significant (P ＜ 0.05). The bleeding stop time in the injection group was shorter than that in the spray group, and the difference was statistically significant (P ＜ 0.05). The bleeding stop rate within five minutes in the injection group was higher than that in the spray group, and the difference was statistically significant (P ＜ 0.05). The rebleeding rate within a week in the injection group was lower than that in the spray group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of serum LPS and CRP in the two groups were lower than those before treatment, while the serum levels of the injection group were lower than those of the spray group, and the differences were statistically significant (P ＜ 0.05). The incidence of adverse reactions in the injection group was lower than that in the spray group, and the difference was statistically significant (P ＜ 0.05). Conclusion The injection of adrenaline hydrochloride under painless gastroscopy has a better hemostatic effect than spraying hemocoagulase in the treatment of patients with acute non-varices upper gastrointestinal bleeding. It helps to reduce serum endotoxin and inflammatory factor content, thereby improving treatment safety.
2022 Vol. 19 (10): 94-97,102 [Abstract] ( 16 ) HTML (1 KB)  PDF (683 KB)  ( 39 )
98 Effects of ultrasound-guided catheter thrombolysis combined with AngioJet thrombus suction in the treatment of deep venous thrombosis of lower extremities#br#
WANG Qiang WANG Tao LIANG Siyuan ZHOU Long
Objective To investigate the effect of ultrasound-guided catheter thrombolysis combined with AngioJet thrombus suction in the treatment of deep venous thrombosis (DVT) of lower extremities. Methods A total of 73 patients with DVT in lower extremities admitted to the Department of Vascular Surgery, Taizhou Municipal Hospital of Zhejiang Province from January 2017 to January 2020 were selected and they were divided into the observation group (37 cases) and the control group (36 cases) according to the random number table method. The control group was treated with ultrasound-guided catheter thrombolysis, and the observation group was treated with ultrasound-guided catheter thrombolysis combined with AngioJet thrombus suction. Clinical efficacy, thrombus removal effect, Villalta scores, and incidence of complications were compared between the two groups. Results The clinical efficacy and thrombus removal effect of the observation group were better than those of the control group, the average times of thrombolysis and hospitalization were shorter than those of the control group, and the dosage of urokinase was less than that of the control group, the differences were statistically significant (P ＜ 0.05). Overall comparison: there were statistically significant differences in Villalta score between the two groups, time points, and interactions (P ＜ 0.05). Intra-group comparison: Villalta score was increased in both groups at 6 and 12 months after surgery compared with 3 months after surgery, Villalta score was increased in both groups at 12 months after surgery compared with 6 months after surgery, the differences were statistically significant (P ＜ 0.05). Comparison between groups: Villalta score in the observation group was significantly lower than that in the control group at 3, 6, and 12 months after surgery, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion Ultrasonic-guided catheter thrombolysis combined with AngioJet thrombus suction can rapidly clear DVT of lower extremities, reduce urokinase dosage and lower Villalta score.
2022 Vol. 19 (10): 98-102 [Abstract] ( 48 ) HTML (1 KB)  PDF (664 KB)  ( 41 )
103 Clinical effect of Molian Qubai Decoction combined with Tachlimus Ointment in the treatment of vitiligo at stable stage of kidney deficiency and blood stasis type#br#
DU Kaiqing1 GUO Wen1 GONG Ke1 GUO Jianhui2 SHEN Yana3
Objective To investigate the clinical effect of Molian Qubai Decoction combined with Taclimus Ointment in the treatment of vitiligo at stable stage of kidney deficiency and blood stasis type. Methods A total of 56 patients with vitiligo at stable stage of kidney deficiency and blood stasis type admitted to Department of Dermatology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province from September 2020 to June 2021 were selected and they were divided into treatment group and control group according to random number table method, with 28 patients in each group. The treatment group was treated with Molian Qubai Decoction combined with Taclimus Ointment, and the control group was treated with Taclimus Ointment. The two groups were routinely given Compound Glycyrrhizin Tablets, and the two groups were treated for three consecutive courses. The results of treatment and dermatology life quality index (DLQI) were compared between the two groups, and the levels of tumor necrosis factor-α (TNF-α) in peripheral blood of the two groups were compared. Results The clinical effect of treatment group was better than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the DLQI and TNF-α level in two groups were decreased compared with before treatment, and those in treatment group were lower than those in control group, the differences were statistically significant (P ＜ 0.05). Conclusion Molian Qubai Decoction combined with Taclimus Ointment can improve the quality of life of patients with vitiligo in stable stage of kidney deficiency and blood stasis type, reduce the inflammatory state and improve the curative effect.
2022 Vol. 19 (10): 103-106 [Abstract] ( 70 ) HTML (1 KB)  PDF (626 KB)  ( 35 )
107 Influencing factors of bone mineral density in male patients with diabetes mellitus type 2#br#
WEN Juanjuan1 MENG Tao1 BU Jia1 HAN Lixin1 LI Zhuo2
Objective To investigate the influencing factors of bone mineral density (BMD) in male patients with diabetes mellitus type 2 (T2DM). Methods A total of 171 male T2DM patients admitted to Affiliated Hospital of Shanxi Datong University from July 2018 to August 2020 were divided into normal bone mass group (67 cases) and abnormal bone mass group (104 cases) according to BMD value. Age, course of disease, body mass index (BMI), with or without the history of diabetic peripheral neuropathy (DPN), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), fasting C peptide (FCP), postprandial 2hC peptide (2hCP), homocysteine (Hcy), uric acid (UA), high density lipoprotein-cholesterol (HDL-C), triglyceride (TG), total cholesterol (TC), and low density lipoprotein-cholesterol (LDL-C) were compared between the two groups, and the risk of abnormal bone mass in T2DM was analyzed by binary logistics regression. Results Age, course of disease, TC, LDL-C, HDL-C, Hcy levels, and the proportion of DPN history in abnormal bone mass group were significantly higher than those in normal bone mass group, while BMI, 2hCP, and UA levels were lower than those in normal bone mass group, the differences were statistically significant (P ＜ 0.05). There were no significant differences in FCP, HbA1c, FBG, and TG levels between the two groups (P ＞ 0.05). Binary logistic regression analysis showed high LDL-C level (OR = 3.399, 95%CI: 1.293-8.936, P = 0.013) and a history of DPN (OR = 6.689, 95%CI: 1.733-25.816, P = 0.006) were risk factors for bone abnormalities in T2DM patients, and high UA level (OR = 0.975, 95%CI: 0.964-0.986, P = 0.000) was a protective factor for bone abnormalities in T2DM patients. Conclusion Maintaining a slightly higher serum UA level may have a protective effect on BMD, while high LDL-C level and a history of DPN may lead to abnormal bone mass in T2DM patients.
2022 Vol. 19 (10): 107-110 [Abstract] ( 56 ) HTML (1 KB)  PDF (526 KB)  ( 17 )
111 Effect of epidural labor analgesia on neonatal lactation behavior and breastfeeding#br#
XU Yang1 TENG Ping2 ZHOU Yun1 WANG Aihua1▲ ZHANG Yuanyuan1 LIU Yi2 MA Xiaoyan3
Objective To explore the effect of epidural labor analgesia on neonatal lactation behavior and breastfeeding, and to provide data support for optimizing the prescription of epidural analgesics. Methods A total of 80 cases of parturient women who delivered naturally in Weifang Maternal and Child Health Hospital of Shandong Province from August 2020 to March 2021 were selected as the research objects. According to maternal wishes, they were divided into two groups, with 40 cases in each group. The experimental group received epidural analgesia, while the control group did not. The time of expression of lactation behavior and action was observed in the two groups, and the start time of lactation, the lactation initiation rate within 72 h and the times of exclusive breastfeeding 24 and 48 hours after delivery were compared between the two groups. Results The duration of neonate’s first cry in experimental group was shorter than that in control group, and it took longer to reach crawing, familiarity, and sucking stage than that in cotrol group (P ＜ 0.05); there were no significant differences in relaxation duration, awakening, activity, and sleep stage between two groups (P > 0.05). The start time of lactation in experimental group was earlier than that in control group (P < 0.05); there was no significant difference in the lactation initiation rate within 72 h between two groups (P > 0.05). There was no significant difference in the times of exclusive breastfeeding 24 and 48 hours after delivery between two groups (P > 0.05). Conclusion Labor analgesia may affect the expression of neonatal lactation behavior, which requires further optimization of analgesic drug prescription to minimize maternal and infant effects.
2022 Vol. 19 (10): 111-114,118 [Abstract] ( 29 ) HTML (1 KB)  PDF (705 KB)  ( 43 )
115 Clinical observation of nèiguān point pressing combined with Dexmedetomidine in preventing nausea and vomiting after strabismus correction surgery in children#br#
LIU Yang WU Hao TAN Lei▲
Objective To observe the effect of nèiguān point pressing combined with Dexmedetomidine in preventing nausea and vomiting after strabismus correction surgery in children. Methods A total of 90 cases of strabismus correction surgery under general anesthesia in the Affiliated Suqian First People’s Hospital of Nanjing Medical University from January 2018 to July 2021 were selected as research objects. According to the random number table method, they were divided into three groups, with 30 cases in each group. In group A, Dexmedetomidine was given nasal drops in the operating room 10 min before induction of anesthesia; in group B, acupressure wrist bands were placed at nèiguān point on both forearms immediately after anesthesia induction until 24 h after surgery; in group C, Dexmedetomidine was given nasal drops in the operating room 10 min before anesthesia induction, and acupressure wrist bands were placed at nèiguān point on both forearms immediately after anesthesia induction until 24 h after surgery. The incidence of intraoperative ocardial reflex, Atropine use and traction cessation were observed; operation time was recorded; the incidence of nausea and vomiting 24 h after surgery and the duration of postanesthesia care unit (PACU) were recorded. Results There were no significant differences in the incidence of intraoperative ocardial reflex, Atropine use and traction cessation among three groups (P > 0.05). There were no significant differences in operation time and the duration of PACU among three groups (P > 0.05). The incidence of nausea and vomiting in group C were lower than that in group A and B, and the differences were statistically significant (P < 0.017). Conclusion Nèiguān point pressing combined with Dexmedetomidine pretreatment can effectively reduce the incidence of postoperative nausea and vomiting and provide safe and comfortable medical guarantee for strabismus children.
2022 Vol. 19 (10): 115-118 [Abstract] ( 19 ) HTML (1 KB)  PDF (569 KB)  ( 30 )
119 Formation and characteristics of Qing Dynasty royal manipulate school Zang Fuke’s academic thoughts on injured soft tissue massage #br#
HAN Siyu GAN Yena ZHANG Tongtong CHENG Luyao YUAN Yi WANG Bin LIU Changxin LI Duoduo
As one of the representative heirs and inheritors of Qing Dynasty royal manipulate school, Zang Fuke is the founder of massage department in Dongzhimen Hospital, Beijing University of Chinese Medicine. On the basis of clinical experience, classical theory of traditional Chinese medicine and the frontier of modern medicine of his teacher Liu Shoushan, combined with his own perception, his academic thoughts on injured soft tissue massage has gradually formed, which has become an important theoretical basis for the modern system of diagnosis and treatment of Qing Dynasty royal manipulate. By examining the evolution of the relationship between orthopedics department and massage department in Dongzhimen Hospital, Beijing University of Chinese Medicine, exploring theorietical source of the formation of this academic thoughts, this paper mainly introduces the academic connotation of “dacheng” of Zang Fuke injured soft tissue massage and the characteristic concept of the key techniques of twelve character manipulation, in order to provide reference for the inheritance and development of traditional Chinese medicine massage.
2022 Vol. 19 (10): 119-122 [Abstract] ( 16 ) HTML (1 KB)  PDF (745 KB)  ( 53 )
123 Analysis on medication rule of compound Chinese medicine in the external treatment of uremic pruritus#br#
ZHAO Li JIN Qiying QU Jianhua
Objective To explore the medication rule of Chinese medicine in the external treatment of uremic pruritus based on data mining. Methods The literatures on Chinese medicine in the external treatment of uremic pruritus published in PubMed, CNKI, VIP Chinese periodical service platform, Wanfang data knowledge service platform, China biomedical literature service system and other databases from the establishment of the database to December 2020 were collected and sort outed. The frequency of Chinese medicine, drug properties, drug taste and menstruation were counted. Association rule analysis and cluster analysis were carried out for high-frequency drugs. Results A total of 77 prescriptions of Chinese medicine and 105 drugs were included in the study. The most frequently used drug was Kochiae Fructus. The highest support of association rules was Chuanxiong Rhizoma→Angelicae Sinensis Radix. Five cluster prescriptions were obtained. Conclusion The core of Chinese medicine in the external treatment of uremic pruritus is nourishing yin and tonifying blood. Pay attention to clearing heat and draining dampness, promoting blood circulation and removing blood stasis, and give consideration to detoxification.
2022 Vol. 19 (10): 123-126,135 [Abstract] ( 108 ) HTML (1 KB)  PDF (2023 KB)  ( 78 )
127 Discussion on medication rule of traditional Chinese medicine in treating postherpetic neuralgia based on data mining#br#
YAN Mingyue1 LI Yingjia1 CHEN Yuanyuan1 TAN Weiqiang1 LIU Xin1 LI Meichen1 ZHUANG Lixing2
Objective To explore the medication rule of traditional Chinese medicine in treating postherpetic neuralgia based on data mining. Methods CNKI, Wanfang database, VIP Chinese periodical service platform and China biomedical literature service system were searched. The relevant literatures on the treatment of postherpetic neuralgia with traditional Chinese medicine from the establishment of the database to April 2021 were collected and screened, the database was established. The medication rule was analyzed based on traditional Chinese medicine inheritance auxiliary platform (V3.0). Results A total of 386 prescriptions were selected, involving 273 herbs. The property of a medicine was mainly cold, warm, and flat. The herbal medicines in a prescription was mainly bitter, supplemented by spicy and sweet products. The meridians were mainly liver, heart, spleen, and lung meridians. The top five Chinese medicines in terms of medication frequency were Angelicae Sinensis Radix, Rhizoma Corydalis, Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba and Bupleuri Radix. Commonly used drug combinations included Angelicae Sinensis Radix-Rhizoma Corydalis, Angelicae Sinensis Radix-Bupleuri Radix, Carthami Flos-Persicae Semen, etc. Five drug association rules and six new prescriptions were excavated. Conclusion Traditional Chinese medicine pays equal attention to tonifying deficiency and removing blood stasis in the treatment of postherpetic neuralgia. It is treated from the perspectives of deficiency, depression and blood stasis. On the basis of drugs for promoting blood circulation and removing blood stasis, the drugs of benefiting qi and strengthening vital qi, dispersing stagnated liver qi and clearing heat are added.
2022 Vol. 19 (10): 127-130 [Abstract] ( 25 ) HTML (1 KB)  PDF (1054 KB)  ( 15 )
131 Experience of Professor Zhai Xiaofeng in diagnosing and treating liver cancer#br#
YU Song1 HONG Jing1 FENG Qiuting1 HU Jiajia1 ZHAI Xiaofeng2
Traditional Chinese medicine has unique advantages in treating liver cancer. Professor Zhai Xiaofeng has rich knowledge and experience, and has unique views on the pathogenesis and clinical treatment of liver cancer. Professor Zhai believes that it is necessary to understand the pathogenesis of liver cancer with an overall concept, pay attention to the influence of hepatitis B and cirrhosis on the characteristics of liver cancer. It is suggested that “liver depression and toxin accumulation” should be the core pathogenesis of hepatitis B related liver cancer. Liver cancer established, the course of disease often presents two main characteristic manifestations of “both ends of dampness and blood stasis”. The core of syndrome differentiation and treatment should be the liver and spleen, give consideration to “dampness”, “blood stasis”, “accumulation”, and “poison”. The basic principle is “soothing liver, strengthening spleen and nourishing health, removing toxin, eliminating accumulation and eliminating evil”. The main treatment methods are soothing liver and activating spleen, eliminating accumulation and removing toxin.
2022 Vol. 19 (10): 131-135 [Abstract] ( 26 ) HTML (1 KB)  PDF (816 KB)  ( 46 )
136 Study on the medication rules of traditional Chinese medicine in the treatment of chronic atrophic gastritis with the syndrome of qi deficiency and blood stasis based on data mining#br#
YANG Ruiping1 LIN Xiaojing1 TAO Chunhui2 JIANG Ruixue1
Objective To explore the medication rules of traditional Chinese medicine in the treatment of chronic atrophic gastritis (CAG) with the syndrome of qi deficiency and blood stasis by using traditional Chinese medicine inheritance auxiliary platform. Methods The literature in the treatment of CAG with the syndrome of qi deficiency and blood stasis from January 1990 to December 2020 were collected through the CNKI, Wanfang, and VIP databases, and prescriptions were extracted from the screened literatures. The traditional Chinese medicine inheritance auxiliary platform was used to perform frequency analysis, association rule analysis, and cluster analysis on the drugs. Results A total of 166 prescriptions were selected, involving 155 kinds of Chinese herbs, among them, the drug properties was mainly warm, the drug taste was mainly sweet, and the meridian tropism was mainly spleen meridian. There were 20 Chinese herbs with frequency more than 30. A total of 63 drug combinations and 10 drug compatibility rules were obtained by association rule analysis, association rule diagram showed that the drug combination was modified Liujunzi Decoction. A total of 16 core drug combinations and eight new prescriptions were obtained by cluster analysis. Conclusion The treatment of CAG with the syndrome of qi deficiency and blood stasis is based on replenishing qi and invigorating spleen, with the core of activating blood and removing stasis, combining with learing heat and removing toxicity; the new prescription is mainly based on tonifying deficiency and strengthening vital qi, removing stasis and removing toxicity, supplemented by regulating qi and digesting food.
2022 Vol. 19 (10): 136-139,154 [Abstract] ( 75 ) HTML (1 KB)  PDF (1193 KB)  ( 29 )
140 Research on the medication rule of Professor Xie Zuogang in the treatment of chronic prostatitis based on data mining#br#
FANG Yuekun XIE Zuogang
Objective To study the medication rule of Professor Xie Zuogang in the treatment of chronic prostatitis. Methods The medical records of Professor Xie Zuogang in the andrology clinic of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang Province from January 2019 to August 2020 were selected, the relevant database was established, and the relevant core drug combinations and drug compatibility laws hidden in the prescription were mined by frequency analysis, association rule analysis, and entropy cluster analysis. Results A total of 356 cases and 1015 prescriptions were included in this study, involving 267 kinds of drugs. The four Qi of medicine were mainly cold and warm, and the five flavours were mainly bitter and pungent. The commonly used channel tropism was mainly liver meridian. There were 23 drugs used more than 220 times, and the top five were Poria, Ramulus Cinnamomi, Radix Glycyrrhizae, Radix Scutellariae, and Radix Bupleuri. Core prescriptions were mined through association rule analysis. Based on entropy cluster analysis of complex system, 12 core combinations of traditional Chinese medicine and six new prescriptions were evolved. Conclusion Professor Xie Zuogang’s treatment of prostatitis with traditional Chinese medicine mainly focuses on “soothing liver and regulating qi”, “ activating blood and removing stasis”, “clearing heat and promoting diuresis”, and “tonifying kidney and benefiting qi”.
2022 Vol. 19 (10): 140-143,158 [Abstract] ( 77 ) HTML (1 KB)  PDF (991 KB)  ( 36 )
144 Effect of Jianpi Yiwei Formula in the treatment of peptic ulcer with the syndrome of deficiency of spleen and stomach#br#
JIANG Yuping1 LIU Weifeng2 WEN Zhixi2 WU Shanshan2 DUAN Guijiao3 LYU Yanhang3
Objective To explore the clinical effect of Jianpi Yiwei Formula in the treatment of peptic ulcer with the syndrome of deficiency of spleen and stomach. Methods A total of 90 patients of peptic ulcer with the syndrome of deficiency of spleen and stomach who were treated in Department of Spleen-stomach Liver Disease in the International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine from September 2019 to February 2021 were divided into the control group and the treatment group by random number table method, 45 cases in each group. The control group was given Omeprazole Enteric-coated Capsules. The treatment group was treated with Jianpi Yiwei Formula on the basis of the control group. The clinical efficacy was observed for four weeks. The changes situation of pepsinogen (PG)Ⅰ, PGⅡ, and the PGⅠ / PGⅡ before and after treatment, the adverse events in the two groups were observed and recorded. Results The clinical effect of the treatment group was better than that in the control group (P < 0.05). After treatment, PGⅠ in the two groups were lower than those before treatment, and the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, PG Ⅱ in the treatment group was lower than that before treatment, and PGⅡ in the treatment group was lower than that in the control group (P ＜ 0.05). There were no adverse reactions such as rash, nausea and vomiting, and needlesickness in the both groups. Conclusion Jianpi Yiwei Formula can effectively inhibit the expression of PGⅠ and PGⅡ, and improve the function of gastrointestinal peristalsis, and has definite effect of peptic ulcer with the syndrome of deficiency of spleen and stomach, there is no adverse reaction, it is worthy of reference, promotion, and application in clinic.
2022 Vol. 19 (10): 144-147,162 [Abstract] ( 23 ) HTML (1 KB)  PDF (589 KB)  ( 33 )
147 Analysis of common herbal pairs used by Professor Li Peiwen to prevent recurrence and metastasis of triple-negative breast cancer#br#
ZHANG Lei1 ZHANG Chenyang1 CHEN Dongmei2 WAN Donggui2
Triple-negative breast cancer (TNBC) is characterized by early age of onset, invasive strong, and high degree of malignancy, and how to prevent its recurrence and metastasis is the key to improve prognosis. Professor Li Peiwen has rich experience in traditional Chinese medicine intervention for TNBC during the “empty window period”, and believes that the main pathogenesis of recurrence and metastasis of TNBC is closely related to the spleen and kidney insufficiency, liver qi depression, and phlegm and stasis with toxin accumulation. This paper summarizes Professor Li’s common clinical herbal pairs based on the theory of prevention before disease onset, summarizes the herbal compatibility characteristics and clinical applications of Radix Astragali seu Hedysari-Herba Epimedii, Flos Rosae Rugosae-Cortex Albiziae, Pericarpium Trichosanthis-Pseudobulbus Cremastrae seu Pleiones, Concha Ostreae-Carapax Trionycis, Semen Citri Reticulatae-Radix Ranunculi Ternati, Herba Scutellariae Barbatae-Herba Duchesnea Indica, anf Flos Carthami-Hirudo, and attached a medical case, in order to help colleagues.
2022 Vol. 19 (10): 147-150 [Abstract] ( 72 ) HTML (1 KB)  PDF (713 KB)  ( 11 )
151 Comparative analysis of digital subtraction angiography and CT angiography imaging features and diagnostic value of intracranial artery stenosis in elderly patients with cerebral infarction#br#
CHEN Yufeng1 CHENG Ying1 QI Liang2▲
Objective To explore and compare the imaging features and diagnostic value of digital subtraction angiography (DSA) and CT angiography (CTA) of intracranial artery stenosis in elderly patients with cerebral infarction. Methods A total of 103 elderly patients with cerebral infarction admitted to the Xuzhou Renci Hospital, Jiangsu Province were selected as the research objects from May 2017 to December 2020. All patients were diagnosed with DSA and CTA, with DSA as the “gold standard”. DSA and CTA image characteristics of intracranial artery stenosis in elderly patients with cerebral infarction were recorded, and the consistency of diagnosis of intracranial artery stenosis was compared between them. Results DSA diagnosis showed normal intracranial artery in seven cases, mild stenosis in 58 cases, moderate stenosis in 23 cases, severe stenosis in 13 cases, and occlusion in two cases. CTA diagnosed normal intracranial artery in 13 cases, mild stenosis in 54 cases, moderate stenosis in 24 cases, severe stenosis in 11 cases, and occlusion in one case. DSA and CTA were highly consistent in the diagnosis of intracranial artery stenosis in elderly patients with cerebral infarction (Kappa=0.748, P ＜ 0.05). Conclusion CTA diagnosis has a high consistency with DSA examination, and CTA has certain value in the diagnosis of intracranial artery stenosis in elderly patients with cerebral infarction.
2022 Vol. 19 (10): 151-154 [Abstract] ( 36 ) HTML (1 KB)  PDF (743 KB)  ( 28 )
155 Analysis of the appearance of color Doppler ultrasonography in severe placental abruption#br#
WANG Lingling TIAN Yana YANG Shujiao
Objective To explore the appearance of color Doppler ultrasonography in severe placental abruption. Methods A total of 238 patients with suspected placental abruption admitted to Women and Children’s Hospital of Fuyang City, Anhui Province from April 2019 to February 2021 were selected as the study subjects. Color Doppler ultrasonography was performed within 24 h after admission, the pathological diagnosis and ultrasonic manifestations of the patients were recorded, and the diagnosis results of severe placental abruption by pathology and color Doppler ultrasonography were compared. Results Fifteen cases of severe placental abruption were diagnosed by color Doppler ultrasonography, of which three cases had irregular anechoic fluid dark area between uterine wall and placenta. In five cases, the solid echo between placenta and uterine wall was similar to that of placenta, and the boundary between tissue and placenta was not clear. In four cases, there were disorderly echo masses and irregular fluid dark area between uterine wall and placenta. In two cases, hyperechoic mass and no blood flow signal were observed behind the placental margin. There was no abnormal echo between uterine wall and placenta in one case, but high echo mass without blood flow signal could be seen in other parts of placenta outside the attachment point. Among the 15 cases of severe placental abruption detected by color Doppler ultrasonography, nine cases were pathologically confirmed as severe placental abruption. The sensitivity and specificity of color Doppler ultrasound in the diagnosis of severe placental abruption were 81.82% and 97.36%, respectively. The diagnosis of severe placental abruption by color Doppler ultrasound was highly consistent with pathological diagnosis (Kappa = 0.675, P ＜ 0.05). Conclusion Color Doppler ultrasonography can provide ultrasound data reference for clinical diagnosis of severe placental abruption, which is highly consistent with pathological results and worthy of clinical promotion.
2022 Vol. 19 (10): 155-158 [Abstract] ( 15 ) HTML (1 KB)  PDF (1058 KB)  ( 20 )
159 Efficacy and safety of Rabeprazole combined with itopride in the treatment of functional dyspepsia#br#
HU Yunfu
Objective To investigate the efficacy and safety of rabeprazole enteric-coated tablet combined with itopapride in the treatment of functional dyspepsia (FD). Methods A total of 108 FD patients in Maanshan Shiqiye Hospital, Anhui Province from April 2019 to March 2021 were selected as the research subjects, and according to random number table method, they were divided into control group and study group, with 54 cases in each group. The control group was treated with Itopride, and the research group was treated with Rabeprazole Sodium Enteric-Coated Tablets on the basis of the control group. Both groups were treated for two weeks. The treatment effect, symptom score before and after treatment (upper abdominal burning, upper abdominal pain, early satiety, fullness after meal), serum gastrin (GAS) and motilin (MTL) levels, and incidence of adverse reactions were compared between the two groups. Results The therapeutic effect of study group was better than control group (P ＜ 0.05); after treatment, the scores of upper abdominal burning sensation, upper abdominal pain, early satiety and postprandial fullness in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05); the levels of GAS and MTL in the two group were higher than those before treatment, and the study group were higher than those in the control group (P ＜ 0.05); there was no statistical significance in the rate of adverse reactions between the two groups (P ＞ 0.05). Conclusion Taking rabeprazole sodium enteric coated tablets and Itopride in the treatment of FD can improve the treatment effect of the disease, which may be related to the effective regulation of the contents of serum gas and MTL, and the safety is guaranteed, which is worth popularizing.
2022 Vol. 19 (10): 159-162 [Abstract] ( 23 ) HTML (1 KB)  PDF (571 KB)  ( 27 )
163 Application of loop-mediated isothermal amplification in detection of lower respiratory tract pathogens in patients with mechanical ventilation#br#
LIU Jiajia SUN Jingna YAN Haiyang HAN Zhengang CHEN Jing ZHAO Shuai▲
Objective To explore the application of loop-mediated isothermal amplification in the detection of lower respiratory tract pathogens in patients with mechanical ventilation. Methods From January to June 2021, a total of 90 patients with lower respiratory tract infection who were newly transferred to the Department of Respiratory Medicine and the Intensive Care Unit of the First Hospital of Hebei Medical University and underwent mechanical ventilation combined with ventilation through tracheal intubation were collected for bronchoalveolar lavage fluid samples for bacterial culture and drug sensitivity identification. At the same time, the loop-mediated isothermal amplification was used to detect the nucleic acid of pathogenic bacteria, and the samples of pathogenic bacteria were detected by drug resistance gene chip to analyze the detection of pathogens and drug resistance genes in patients. Results A total of 90 specimens were tested, among which 69 specimens were positive by the loop-mediated isothermal amplification, with a positive rate of 76.67%, and 31 were positive by bacterial culture, with a positive rate of 34.44%. The positive detection rate of the loop-mediated isothermal amplification was significantly higher than that of the bacterial culture method. The drug resistance test was carried out on the positive strains. Taking each sample as a separate whole, the loop-mediated isothermal amplification had a high detection rate in the detection of mecA, OXA-48, OXA-23, and other drug resistance genes, and was consistent with the detection rate of drug resistance genes. The compliance rate of the “gold standard” for drug resistance detection was high. Conclusion The detection rate of pathogens and drug resistance genes by the loop-mediated isothermal amplification is higher than that of traditional bacterial culture and drug susceptibility tests, and the detection rate of drug resistance genes is high, which has a good application prospect for guiding clinical medication.
2022 Vol. 19 (10): 163-166 [Abstract] ( 24 ) HTML (1 KB)  PDF (527 KB)  ( 30 )
167 Exploration of hospital comprehensive budget management based on the integration of industry and finance#br#
XU Lingqian1 DU Jun2 TONG Qun1 HUANG Juan1 WANG Jingyuan1 ZHENG Qing1 JING Jing1▲
The integration of hospital industry and finance needs to integrate business data and financial data through information means to realize the integration of industry and finance, and then realizes the optimal allocation of resources and improve the efficiency of economic operation. Taking ZL Hospital as an example, this paper summarizes the difficulties and difficulties encountered in the process of promoting the integration of industry and finance, and finds the breakthrough point for improvement based on the actual business process, so as to put forward the main ideas and relevant enlightenment of the informatization construction of hospital budget management under the integration of industry and finance. Suggested that the hospital from the system integration, business process optimization, to carry out the three-level organic combination under centralized management, budget targets and strategic targets, budget formulation adjustment, the classification of the budget items and straighten out the relationship between the accounting and management, intensify expert argumentation, strengthen budget control, mark moved forward the aspects such as promote the hospital comprehensive budget management in construction industry fiscal integration mode.
2022 Vol. 19 (10): 167-170,189 [Abstract] ( 35 ) HTML (1 KB)  PDF (769 KB)  ( 73 )
171 Influence of quality nursing service based on planned behavior theory on mood disorder and coping style of chronic renal failure hemodialysis patients#br#
ZHAO Hong YIN Jianhua XU Lili YANG Jing
Objective To explore the impact of quality nursing services based on planned behavior theory on mood disorders and coping styles in patients with chronic renal failure hemodialysis. Methods A total of 100 cases of chronic renal failure hemodialysis patients admitted in Hefei First People’s Hospital  from January 2017 to January 2020 were selected as the research objects, according to random number table method, they were divided into control group and observation group, with 50 cases in each group. The control group was given routine nursing intervention, and the observation group was given high-quality nursing services based on the planned behavior theory. The negative emotions, self-experience burden, coping style, self-management behavior and quality of life scores before and incidence of complications after nursing in the two groups were compared. Results After nursing, the scores of anxiety and depression in the two groups were lower than before nursing, and the observation group was lower than the control group (P ＜ 0.05); all dimensions and total score of self-perceived burden in both groups were lower than before nursing, and the observation group was lower than the control group (P ＜ 0.05); the coping style score of the two groups was higher than before nursing, and the score of avoidance and yield was lower than before nursing, and the score of the observation group was higher than the control group, and the score of avoidance and yield was lower than the control group (P ＜ 0.05); the dimensions and total score of self-management behavior in both groups were higher than before nursing, and the observation group was higher than the control group (P ＜ 0.05); quality of life scores of both groups were higher than before nursing, and the observation group was higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion The high-quality nursing service based on the planned behavior theory is applied to patients with chronic renal failure hemodialysis, which can relieve patients’ mood disorders, ease the burden of self-feeling, and improve coping styles, improve self-management behavior, and have a positive significance in reducing the occurrence of complications and improve the quality of life of patients.
2022 Vol. 19 (10): 171-176 [Abstract] ( 67 ) HTML (1 KB)  PDF (823 KB)  ( 52 )
177 Application effect of clinical nursing pathway based on goal-orientation in patients with acute cholecystitis#br#
XU Jiajia ZHANG Lingling ZHOU Dandan
Objective To explore the application effect of goal-oriented clinical nursing path in patients with acute cholecystitis. Methods A total of 134 patients with acute cholecystitis treated in the Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical University from February 2020 to February 2021. They were randomly divided into control group and experimental group by random number table method, with 67 cases in each group. The control group was treated with routine nursing, and the experimental group was treated with clinical nursing pathway based on goal-orientation. Adverse reactions, total incidence of complications, negative emotions, nursing satisfaction and quality of life were compared between the two groups. Results The incidence of adverse reactions and complications in experimental group was lower than that in control group, and the difference was statistically significant (P ＜ 0.05). One week after nursing, scores of generalized anxiety disorder scale (GAD-7) and patient health questionnaire-9 (PHQ-9) in both groups were lower than those before nursing, and scores of GAD-7 and PHQ-9 in experimental group were lower than those in control group, and the difference were statistically significant (P ＜ 0.05). The scores of Newcastle service nursing satisfaction scale (NSNS) and generic quality of life inventory-74 (GQOL-74) in the two groups were higher than those before nursing, and the scores of NSNS and GQOL-74 in the experimental group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion In acute cholecystitis patients, the application of clinical nursing path based on goal guidance can reduce the occurrence of adverse reactions and complications, relieve the adverse psychological mood of patients, and improve the quality of life.
2022 Vol. 19 (10): 177-180 [Abstract] ( 21 ) HTML (1 KB)  PDF (571 KB)  ( 31 )
181 Preventive effect of graded nursing combined with AIDET communication on postpartum hemorrhage in high-risk women based on improved postpartum hemorrhage prediction score#br#
JIN Xing1 TIAN Yanjiao1 LIU Wenjuan1 LIU Jiayin2▲
Objective To explore the prevention effect of improved postpartum hemorrhage prediction score grading nursing combined with AIDET communication in high-risk puerpera with postpartum hemorrhage. Methods Seventy-six parturients who gave birth in Rugao People’s Hospital of Jiangsu Province from February 2018 to June 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 38 cases in each group. The control group received AIDET communication, and the observation group received graded nursing with improved prediction score of postpartum hemorrhage on the basis of the control group. Hemodynamic indexes, negative emotions, postpartum blood loss, labor duration and delivery outcomes were compared between the two groups before and after intervention. Results After intervention, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), percutaneous arterial oxygen saturation (SpO2) and other indexes in both groups were higher than before intervention, and SBP, DBP, HR and SpO2 indexes in observation group were higher than control group, the differences were statistically significant (P ＜ 0.05). The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the two groups were lower than before intervention, and the SAS and SDS scores in were lower than the control group, the differences were statistically significant (P ＜ 0.05). In the observation group, the 24 h postpartum blood loss was lower than the control group, and the time of the first labor stage, second labor stage and third labor stage was shorter than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion In the prevention of high-risk postpartum hemorrhage, the application of graded nursing with improved prediction score of postpartum hemorrhage combined with AIDET communication can maintain the stability of the condition, relieve the adverse psychological mood of puerpera, shorten the time of labor and improve the outcome of childbirth.
2022 Vol. 19 (10): 181-184 [Abstract] ( 88 ) HTML (1 KB)  PDF (564 KB)  ( 225 )
185 Data mining of nursing research hotspots of ventilator associated pneumonia in ICU#br#
DAI Qiuhong ZHANG Jiajia CHEN Xin▲
Objective To conduct data mining was performed on nursing literature of ventilator associated pneumonia (VAP) in ICU patients in China, explore its research hotspots. Methods CiteSpace software was used to analyze all VAP nursing literature of China HowNet from the establishment of the database to October 1, 2021. The time was divided into 2-year nodes, the types were institutions, authors, and keywords, the connection strength was Cosine, and the visual knowledge map was generated by the minimum spanning tree algorithm. Results At present, there were 2417 VAP nursing research literatures in China, the First Affiliated Hospital of Zhengzhou University had the largest number of papers, and a total of 32 studies have been supported by the fund. Zhang Yao of Shengjing Hospital Affiliated to China Medical University had the largest number of papers, the journal with the largest number of VAP nursing research papers was World Latest Medical Information Abstracts. The research hotspots are VAP cluster nursing, oral nursing risk factors. Conclusion The morbidity and mortality of VAP are high, and will greatly increase the medical cost and the length of hospital stay, so it is important to carry out effective nursing measures while actively treating VAP.
2022 Vol. 19 (10): 185-189 [Abstract] ( 102 ) HTML (1 KB)  PDF (1512 KB)  ( 56 )
190 Related factors of nursing dependence of patients with cataract after daytime surgery#br#
SHI Yan CAO Juan
Objective To observe the degree of nursing dependence of patients with cataract after daytime surgery, and to analyze its related influencing factors. Methods From January to May 2021, 200 patients with cataract who received daytime surgery in Jiangsu Provincial People’s Hospital were selected as the research subjects, on the day after operation, the family members of patients filled in the care dependency scale (CDS) on behalf of the patients, the degree of nursing dependence of patients was assessed, and the baseline data questionnaire was designed, the CDS score of patients with different data characteristics were compared; the family members of patients filled in to evaluate the uncertainty in illness of patients, self-care ability and social support level (assessed by medical uncertainty inventory scale [MUIS], exercise of self-care agency [ESCA] and social support rating scale [SSRS]), the influencing factors of nursing dependence of patients with cataract after daytime surgery were analyzed. Results Average CDS score of 200 patients with cataract after daytime surgery was (27.86±5.64) points; the CDS score of patients with education level of senior high school and below was higher than that of patients with education level of junior college and above (P ＜ 0.05); there was no statistical significant difference in CDS score of patients with different data characteristics (P ＞ 0.05); the scores of MUIS, ESCA and SSRS were (78.54±8.95), (72.44±8.36) points and (21.54±5.13) points respectively; the equation Y = 56.393+0.308X1 (education level)+0.060 X2 (scores of MUIS)-0.346X3 (scores of ESCA)-0.387X4 (scores of SSRS) was obtained by multiple linear regression analysis, F value of regression model was 3910.280, R2 was 0.988, R2 after adjustment was 0.987, the results showed that the education level of senior high school or below and high MUIS score were the risk factors of nursing dependence of patients with cataract after daytime surgery (P ＜ 0.05); high ESCA score and SSRS score were the protective factors of nursing dependence of patients with cataract after daytime surgery (P ＜ 0.05). Conclusion The nursing dependence of patients with cataract after daytime surgery may be affected by their education level, uncertainty in illness, self-care ability and social support.
2022 Vol. 19 (10): 190-193 [Abstract] ( 24 ) HTML (1 KB)  PDF (533 KB)  ( 95 )
194 Effects of multi-dimensional collaborative nursing on negative emotion, knowledge mastery and self-efficacy in patients with postherpetic neuralgia#br#
WANG Rui1 LI Li1 LUO Li1 LIU Qian1 LIU Huan1 XIE Wenjing2▲
Objective To explore the effects of multi-dimensional collaborative nursing on negative emotions, knowledge mastery and self-efficacy in patients with postherpetic neuralgia. Methods Eighty patients with postherpetic neuralgia admitted to the Department of Dermatology Xijing Hospital, the First Affiliated Hospital of Air Force Military Medical University from January 2020 to April 2021 were selected. They were divided into control group and observation group by random number table method, with 40 cases in each group. The control group received routine nursing, and the observation group received multi-dimensional collaborative nursing on this basis. Self-rating anxiety scale (SAS), self-rating depression scale (SDS), general self-efficacy scale (GSES), knowledge mastery and patient satisfaction were compared between the two groups. Results After intervention, SAS and SDS scores in both groups were lower than before intervention, and GSES scores were higher than before intervention, SAS and SDS scores in observation group were lower than control group, and GSES scores were higher than control group, and the differences were statistically significant  (P ＜ 0.05). The situation of knowledge mastery in observation group was better than that in control group, and the difference was statistically significant (P ＜ 0.05). The nursing satisfaction of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Multi-dimensional collaborative nursing can improve the negative emotions of patients with postherpetic neuralgia, improve their knowledge mastery and gain higher recognition from patients, which is worthy of extensive clinical promotion and application.
2022 Vol. 19 (10): 194-封三 [Abstract] ( 35 ) HTML (1 KB)  PDF (562 KB)  ( 37 )
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