|
|
|
| Study on the medication rules of traditional Chinese medicine in the treatment of chronic atrophic gastritis with the syndrome of qi deficiency and blood stasis based on data mining#br# |
| YANG Ruiping1 LIN Xiaojing1 TAO Chunhui2 JIANG Ruixue1 |
1.School of Basic Medicine, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China;
2.Clinicial College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China |
|
|
|
Abstract Objective To explore the medication rules of traditional Chinese medicine in the treatment of chronic atrophic gastritis (CAG) with the syndrome of qi deficiency and blood stasis by using traditional Chinese medicine inheritance auxiliary platform. Methods The literature in the treatment of CAG with the syndrome of qi deficiency and blood stasis from January 1990 to December 2020 were collected through the CNKI, Wanfang, and VIP databases, and prescriptions were extracted from the screened literatures. The traditional Chinese medicine inheritance auxiliary platform was used to perform frequency analysis, association rule analysis, and cluster analysis on the drugs. Results A total of 166 prescriptions were selected, involving 155 kinds of Chinese herbs, among them, the drug properties was mainly warm, the drug taste was mainly sweet, and the meridian tropism was mainly spleen meridian. There were 20 Chinese herbs with frequency more than 30. A total of 63 drug combinations and 10 drug compatibility rules were obtained by association rule analysis, association rule diagram showed that the drug combination was modified Liujunzi Decoction. A total of 16 core drug combinations and eight new prescriptions were obtained by cluster analysis. Conclusion The treatment of CAG with the syndrome of qi deficiency and blood stasis is based on replenishing qi and invigorating spleen, with the core of activating blood and removing stasis, combining with learing heat and removing toxicity; the new prescription is mainly based on tonifying deficiency and strengthening vital qi, removing stasis and removing toxicity, supplemented by regulating qi and digesting food.
|
|
|
|
|
|
[1] 李军祥，陈誩，吕宾，等.慢性萎缩性胃炎中西医结合诊疗共识意见（2017年）[J].中国中西医结合消化杂志，2018， 26（2）：121-131.
[2] Adamu MA，Weck MN，Gao L，et al. Incidence of chronic atrophic gastritis：systematic review and meta-analysis of follow-up studies [J]. Eur J Epidemiol，2010，25（7）：439-448.
[3] Strong VE，Russo A，Yoon SS，et al. Comparison of Young Patients with Gastric Cancer in the United States and China [J]. Ann Surg Oncol，2017，24（13）：3964-3971.
[4] 魏玮，杨洋.慢性萎缩性胃炎诊治现状及中医药治疗优势[J].中医杂志，2016，57（1）：36-40.
[5] 马丽，王静滨.谢晶日教授治疗慢性萎缩性胃炎的经验[J].中国医药导报，2015，12（25）：90-92.
[6] 饶淑华，杨光华.张镜人与萎缩性胃炎证治规律发现[J].中医研究，2002（2）：38-40.
[7] 刘赓，丁洋，张声生.张声生从“虚”、“毒”、“瘀”论治慢性萎缩性胃炎[J].中国中医基础医学杂志，2012，18（10）：1098-1099.
[8] 国家药典委员会.中华人民共和国药典[S].一部.北京：中国医药科技出版社，2015：3-384.
[9] 钟赣生.中药学[M].北京：中国中医药出版社，2012：59-454.
[10] 卢朋，李健，唐仕欢，等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志，2012，18（9）：1-4.
[11] 张露，沈洪，周晓波，等.从气虚血瘀论治慢性萎缩性胃炎癌前病变[J].北京中医药大学学报：中医临床版，2013， 20（1）：16-20.
[12] 李多，于永强，高会斌，等.白术内酯Ⅰ对慢性萎缩性胃炎大鼠胃黏膜保护作用[J].河北中医药学报，2016，31（3）：5-8.
[13] 李祎群，谢建群，龚雨萍，等.黄芪甲苷对慢性萎缩性胃炎大鼠的影响[J].复旦学报（医学版），2015，42（5）：601-606.
[14] 王茵萍，范刚启，孙茂峰，等.穴注黄芪、当归注射液对实验性慢性萎缩性胃炎胃粘膜屏障的影响[J].广州中医药大学学报，2002（3）：195-198.
[15] 刘良，王建华，侯宁，等.党参及其有效成分抗胃粘膜损伤作用与机制研究——Ⅵ、党参部位提取物Ⅶ-Ⅱ对胃分泌、胃血流与胃肠运动的影响[J].中药药理与临床，1990（4）：20-23.
[16] 郑君，林晓春，陈育尧，等.甘草总黄酮抑制慢性萎缩性胃炎大鼠胃黏膜腺体萎缩及机制研究[J].中国药理学通报，2014，30（1）：113-117.
[17] 吴时胜.丹参对萎缩性胃炎伴异型增生的逆转治疗研究[J].时珍国医国药，2002（12）：751-752.
[18] 朱诗国，许政旭，罗俊，等.黔产莪术油对人直肠癌细胞血管生成因子表达的影响[J].中国实验方剂学杂志，2017， 23（4）：152-158.
[19] 张子理，陈蔚文.黄芪和白术对胃粘膜损伤药理作用的初步研究[J].中华实用中西医杂志，2006，19（4）：470-471.
[20] 汤秋芳，廖郁文，沈智理.加味六君子汤治疗气虚血瘀型慢性萎缩性胃炎临床观察[J].山西中医，2020，36（7）：7-9.
[21] 崔力.六君子汤加减治疗慢性萎缩性胃炎（脾胃虚弱证）对患者症状改善、胃肠功能及疗效影响分析[J].中医临床研究，2019，11（8）：42-44.
[22] 浦飞飞，陈凤霞，夏平.白花蛇舌草抗肿瘤化学成分和作用机制的研究进展[J].癌症进展，2019，17（17）：1985-1988.
[23] 杨雪竹，张浩，崔西玉，等.川陈皮素抑制胃癌SGC-7901细胞侵袭能力的机制探讨[J].现代肿瘤医学，2020， 28（18）：3099-3104.
[24] 吴晓龙，崔思远，王琰，等.中药半枝莲有效成分抗肿瘤作用机制研究进展[J].中华中医药杂志，2018，33（4）：1459-1462.
[25] 林丽霞，薛银萍，陈燕，等.茯苓多糖对人胃癌裸鼠移植瘤的抑制效应研究[J].解放军医药杂志，2015，27（11）：60-63. |
|
|
|
