脓毒症与肠道微生物相互作用的研究进展

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Abstract The gut microbiome is involved in the regulation of a variety of homeostatic mechanisms in the healthy host including immune function and gut barrier, etc. Recent studies have confirmed the important linkages between the gut microbiome and sepsis. This paper focuses on the potential mechanisms of intestinal microbes involved in the occurrence and development of sepsis from the following three aspects: Firstly, the activation of pathogenic intestinal flora, activation of the immune system and inflammatory response, as well as the reduction of beneficial microbial products, and other pathological changes affect the susceptibility of the host to sepsis; the second, sepsis leads to the destruction of intestinal microbiota and induces and aggravates terminal organ dysfunction; the third, microbial-based treatment strategies, such as selective intestinal decontamination and fecal microbiological transplantation, may reduce the incidence of sepsis and improve the prognosis of patients with sepsis. Intervention in the pathophysiological process of sepsis from the perspective of intestinal microorganisms may be a new target for the prevention or treatment of sepsis.

Key words： Sepsis Gut microbiome Gut-organ axes Probiotics Fecal microbiota transplant

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	BAI Yuanyuan DONG Beibei YU Yonghao▲

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BAI Yuanyuan DONG Beibei YU Yonghao▲. Research progress on the interaction between sepsis and intestinal microbe#br#[J]. 中国医药导报, 2022, 19(10): 38-41,76.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I10/38

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