硒与桥本甲状腺炎的相关性研究进展

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Abstract In recent years, the incidence of Hashimoto thyroiditis (HT) has been increasing year by year. Selenium, as an essential trace element, is related to the pathogenesis of HT. Most studies attribute the immunomodulatory effects of selenium to its antioxidant properties. Glutathione peroxidase system, thioredoxin reductase system and iodothyronine deiodase system together constitute the selenoprotein family, which not only directly participate in the synthesis of thyroid hormones, but also regulate the internal REDOX state of the thyroid gland and protect the thyroid gland from oxidative stress damage. At present, many studies have supported the efficacy of selenium in reducing thyroid auto-antibody titers in HT patients, but there is still a lack of sufficient evidence to confirm the clear efficacy of selenium in the treating of HT. Whether selenium supplementation can become the standard treatment for HT remains to be discussed.

Key words： Selenium Selenoprotein Autoimmune thyroiditis Hashimoto thyroiditis Selenium supplement therapy

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	GENG Wenqian QI Shuo CHEN Xiaoheng LI Zhe LI Huilong LIU Meijun GE Yaxue DING Zhiguo

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GENG Wenqian QI Shuo CHEN Xiaoheng LI Zhe LI Huilong LIU Meijun GE Yaxue DING Zhiguo. Research progress on the relationship between selenium and Hashimoto thyroiditis#br#[J]. 中国医药导报, 2022, 19(10): 55-58.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I10/55

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