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2021 Vol. 18, No. 29 Published: 2021-10-15

	4	Immune-related predicted genes of prognosis in non-small cell lung cancer
		LIU Shu ZHANG Xin XU Shun
		Objective To study immune-related predicted genes of prognosis in non-small cell lung cancer (NSCLC). Methods After the data were obtained from the cancer genome atlas, standardized processing was carried out, and immune-related differentially expressed genes were screened out. Cox regression analysis was conducted to establish the best risk model, and gene expression omnibus data were used for external verification. Results A total of 336 genes were identified as immune-related differentially expressed genes of NSCLC, and a prognostic risk model of NSCLC with an area under the curve of 0.703 composed of seven genes was obtained by Cox regression analysis. After evaluation and validation, this model can predict prognostic risk of NSCLC, and all seven genes constructed in the model affect prognosis. Conclusion In this study, a prognostic model based on immune-related differentially expressed genes was constructed to provide a new strategy for the prognostic study of NSCLC.
		2021 Vol. 18 (29): 4-7 [Abstract] ( 76 ) HTML (1 KB) PDF (937 KB) ( 149 )

	8	Study on the mechanism of Shenqi Dihuang Decoction in the treatment of IgA nephropathy by network pharmacology
		LI Ming1 LI Liang1 LI Weinan2 BA Yuanming3
		Objective To investigate the mechanism of Shenqi Dihuang Decoction in the treatment of IgA nephropathy by network pharmacology. Methods The effective active components of Shenqi Dihuang Decoction were obtained and their targets were predicted by using traditional Chinese medicine systems pharmacology database and analysis platform. At the same time, IgA nephropathy disease targets were screened by online Mendelian inheritance in man database, GWAS database, and GeneCards database, and drug targets and disease targets were mapped to obtain common targets. Proteinprotein interaction (PPI) networks were constructed from common targets and analyzed for GO and KEGG functional enrichment. Results In this study, 68 active components of Shenqi Dihuang Decoction were screened out, 200 potential targets were predicted, and 2038 targets of IgA nephropathy were screened out. Among them, 96 targets of Shenqi Dihuang Decoction were involved in IgA nephropathy. A 96-node, 1985-edge PPI network model was constructed, in which the key targets were MAPK1, CXCL8, Akt1, IL-6, JUN, TP53, VEGFA, TNF, MMP9, and PTGS2. GO enrichment analysis involved positive transcriptional regulation of RNA polymerase negative regulation of apoptotic process and hypoxia response. In addition, KEGG enrichment analysis results involved various pathogenic microbial infection signaling pathways and TNF signaling pathway. Conclusion Shenqi Dihuang Decoction has synergistic effects on IgA nephropathy through multiple components, multiple targets and multiple pathways, providing certain reference and support for the clinical application of Shenqi Dihuang Decoction.
		2021 Vol. 18 (29): 8-13 [Abstract] ( 83 ) HTML (1 KB) PDF (2072 KB) ( 115 )

	14	Visualization analysis the theory of “liver and kidney homology” research map based on CiteSpace
		LIU Yulian1 LIU Zheng2 JI Bo2
		Objective To make a visual analysis on the traditional Chinese medicine visceral manifestations theory of “homogeny of liver and kidney ” based on the CiteSpace software. Methods Citespace 5.7.R3 software was used to make data statistics and visual analysis on the authors, institutions and keywords of related research on the theory of “homogeny of liver and kidney ” published in CNKI journal databose from incoption to December 2020. Results A total of 729 Chinese literatures were included in the study, and the annual number of published articles showed an upward trend; through the econometric analysis, found out the high-yielding institutions and representative researchers and their teams in this field were found out. The key words analysis results showed that the main research direction and trend was “famous doctor experience”. Conclusion The atlas directly shows the research course, research hotspot and frontier trend in this field, and points out the direction for the further development of the theory of homogeny of liver and kidney in the future.
		2021 Vol. 18 (29): 14-17,24 [Abstract] ( 94 ) HTML (1 KB) PDF (1268 KB) ( 243 )

	18	Study on the medication law and action mechanism of tic disorder patent compound based on data mining and network pharmacology
		WANG Xiaoran1 ZHENG Pan2 SUN Shijie1
		Objective To explore the medication rule and action mechanism of tic disorder patent compound based on data mining and network pharmacology. Methods The patent compound prescription for the treatment of tic disorder in the China National Knowledge Infrastructure and the China National Intellectual Property Administration Patent Datebase was searched by computer, and the time limit was to build the database until December 31, 2020. The regularity of drug use was analyzed by SPSS 21.0 and SPSS Modeler 18.0 software. The active components of core drugs and the effective targets of the interaction between drug targets and disease targets were screened by traditional Chinese medicine systems pharmacology database and analysis platform, GeneCards, DrugBank and OMIM database, and the target protein names were standardized with the help of Uniprot database. The “drug-active ingredient-target” network was screened and constructed by Cytoscape 3.7.0 software, and the effective targets were introduced into STRING platform to draw PPI network. GO enrichment analysis and KEGG signal pathway analysis of intersection target were carried out by Metascape. Results A total of 93 patented prescriptions were collected, involving 243 traditional Chinese medicines, mainly using drugs for calming the liver and relieving wind and tonifying deficiency, and the top five core drugs were Rhizoma Gastrodia, Radix Paeoniae Alba, gambir plant nod, Poria and Rhizoma Aoori Tatarinowii. A total of 16 core drug pairs were obtained by correlation analysis. Five kinds of drug combinations were obtained by systematic clustering. A total of 79 active components and 372 action targets of the core drug, 1259 disease targets and 137 effective targets were screened. GO analysis showed 20 biological processes such as chemical synaptic transmission and ion transport, six cellular components such as presynaptic membrane and vesicle lumen, 12 molecular functions such as G protein coupled receptor binding and receptor ligand activity, and 12 signal pathways such as neuroactive ligand-receptor interaction and cAMP signal pathway by KEGG analysis. Conclusion The treatment of tic disorder with traditional Chinese medicine patent compound prescription takes calming the liver and extinguishing wind as the core, taking into account the deficiency of liver and kidney, and the core drugs can treat tic disorders through multi-components, multi-targets and multi-pathways.
		2021 Vol. 18 (29): 18-24 [Abstract] ( 128 ) HTML (1 KB) PDF (2120 KB) ( 118 )

	25	Survey on the status quo of social support, burden and coping style of the main caregivers of elderly chronic disease patients at home
		DING Rulei1 HUANG Lifang2 TANG Sanhui3 ZHOU Jing1 GONG Fanghua3
		Objective To investigate the current status of the main caregivers’ social support, the burden of the main caregivers, and coping styles of elderly patients with chronic diseases at home and to explore the mechanisms of action of the three. Methods From January 2018 to December 2019, 226 cases of main caregivers of elderly patients with chronic diseases at home in Hunan Province People’s Hospital were selected, and they were investigated by self-made general questionnaire, social support rating scale, Zarit caregiver burden scale and characteristic coping styles. Data were analyzed by IBM SPSS Statistics 19.0 and Amos 22.0. Results The total score of social support for main caregivers of elderly patients with chronic diseases at home was (38.65±2.72) points, and the total score of care burden was (51.27±3.11) points, both of which were at a moderate level, and passive coping styles were more active. The total score of caregiver burden was negatively correlated with positive coping (r = -0.604, P ＜ 0.01), positively correlated with negative coping (r = 0.206, P ＜ 0.01), and negatively correlated with social support (r = -0.647, P ＜ 0.01). Positive coping was positively correlated with social support (r = 0.641, P ＜ 0.01), and negative coping was negatively correlated with social support (r = -0.227, P ＜ 0.01). The total effect of social support on the burden of caregivers was 0.336, of which the direct effect was 0.041. Conclusion Strengthen research on the main caregivers of elderly patients with chronic diseases at home, optimize the social support structure, establish positive coping styles, reduce the burden of care, and further improve the quality of life of caregivers of elderly patients with chronic diseases at home.
		2021 Vol. 18 (29): 25-30 [Abstract] ( 118 ) HTML (1 KB) PDF (1505 KB) ( 127 )

	31	High-risk factors of lymph node metastasis of endometrial cancer and the construction of prediction model#br#
		CHEN Silu1,2 SONG Kairong1,2 LIU Yuan1,2 YANG Yongxiu1,2,3
		Objective To study the relationship between clinicopathological factors and endometrial cancer (EC) lymph node metastasis, to explore the risk factors of lymph node metastasis, and to construct its risk nomogram prediction model. Methods Retrospectively collected the clinical data of 268 patients who were diagnosed with EC and undergo a full staging operation from January 2015 to August 2020 in the First Hospital of Lanzhou University. According to the presence or absence of lymph node metastasis, they were divided into metastatic group and non-metastatic group. Among them, there were 247 cases in the metastatic group and 21 cases in the non-metastatic group. Single-factor and multi-factor logistic regression analysis were used to screen the risk factors of lymph node metastasis, and R software was used to construct a nomogram model for predicting the risk of lymph node metastasis, and to evaluate the prediction model. The total score of the nomogram model to draw the receiver operating characteristic curve was used, and the lymph node metastasis of different risk strata in patients with EC was analyzed. Results The proportion of carbohydrate antigen 125 (CA125), pathological type, histological grade, depth of myometrial invasion, cervical interstitial invasion, adnexal metastasis and tumor size were compared between the two groups, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that preoperative CA125＞35 U/ml (OR = 3.288), non-endometrioid adenocarcinoma (OR = 4.795), poorly differentiated (OR = 3.617), and depth of muscle invasion ≥ 1/2 (OR = 4.588) were independent risk factors for EC lymph node metastasis (P ＜ 0.05). The prediction model had been internally verified to obtain a consistency index of 0.88, and the calibration curve showed an average absolute error of 0.022. The total score of the nomogram model was less than 130 as low risk, and the total score was more than 130 as high risk. There was a statistically significant difference in lymph node metastasis in patients with different risk strata (P ＜ 0.05). Conclusion The risk nomogram model established by preoperative CA125 level, pathological type, histological grade, and depth of muscle invasion can be used to predict the risk of EC lymph node metastasis. At the same time, the risk stratification of patients allows clinicians to identify low-risk and high-risk patients early, guide clinicians to formulate more precise and individualized treatment plans, and at the same time guide follow-up adjuvant treatment for patients who are accidentally diagnosed with EC due to postoperative medical examinations.
		2021 Vol. 18 (29): 31-35 [Abstract] ( 68 ) HTML (1 KB) PDF (744 KB) ( 43 )

	36	Research progress of HUCMSCs in spinal cord injury cell transplantation#br#
		PAN Zhipeng LI Sicheng TANG Long YAO Liqing
		Human umbilical cord mesenchymal stem cells (HUCMSCs) is a kind of totipotent stem cells with continuous self-renewal, which have strong ability to delay and transplant and less ethical controversy. Therefore, HUCMSCs have been widely promoted and applied. In the treatment of spinal cord injury, the use of HUCMSCs is a new biological therapy for spinal cord injury, which shows better therapeutic potential compared with conventional methods such as surgery, drugs, and rehabilitation. However, the therapeutic mechanism, optimal transplantation approach, and timing of HUCMSCs in spinal cord injury are still controversial. Therefore, based on the latest research progress of HUCMSCs in the treatment of spinal cord injury, this paper systematically summarizes the characteristics of HUCMSCs and the potential neural repair mechanism and application of HUCMSCs in spinal cord injury, providing a basis for the clinical transformation research of HUCMSCs transplantation in the future.
		2021 Vol. 18 (29): 36-40 [Abstract] ( 137 ) HTML (1 KB) PDF (514 KB) ( 150 )

	41	The prognostic role of inflammatory markers in patiens with nasopharyngeal carcinoma#br#
		LI Qian HU Qinyong
		Inflammation plays an important role in the occurrence and development of various cancers. Inflammatory markers have the characteristics of low cost, stable results and convenience, which have been widely used in lung cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and other malignant tumors to predict the prognosis of patients. Inflammation markers have been a hot spot in cancer research in recent years. However, there are relatively few studies on inflammatory markers in nasopharyngeal carcinoma and the conclusions are different. Therefore, this article reviews the widely studied inflammatory markers, such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lymphocyte-to-monocyte ratio, as well as the recent development of emerging inflammatory markers such as systemic immune inflammation index, systemic inflammation response index, prognostic nutritional index, Glasgow prognostic score and C-reactive protein/albumin ratio in nasopharyngeal carcinoma. It aims to supplement the traditional prognostic factors of nasopharyngeal carcinoma and help to provide better personalized treatment plans for cancer patients.
		2021 Vol. 18 (29): 41-44,55 [Abstract] ( 97 ) HTML (1 KB) PDF (863 KB) ( 203 )

	45	Pathogenesis of idiopathic pulmonary fibrosis and progress in drug treatment#br#
		FENG Xinli1 ZHUANG Pan1 LIU Junquan1,2▲
		Idiopathic pulmonary fibrosis is an interstitial lung disease that can cause progressive damage to lung function. Studies have found that the cause of idiopathic pulmonary fibrosis is that the appearance of fibroblast foci leads to a large amount of extracellular matrix deposition, collagen accumulation, lung matrix destruction, alveolar structure damage, and alveolar epithelial cells cannot perform normal repair. Eventually lead to the damage of normal lung tissue structure and so on. Clinically, mesenchymal stem cells and their secreted exosomes or cytokines have a certain effect on the pathogenesis of idiopathic pulmonary fibrosis, and can reduce inflammation, reducing oxidative stress, and regulate extracellular matrix. This review summarizes the pathogenesis of idiopathic pulmonary fibrosis and the research progress of its drug therapy.
		2021 Vol. 18 (29): 45-48 [Abstract] ( 152 ) HTML (1 KB) PDF (502 KB) ( 171 )

	49	Application of Hall technique in the treatment of molar caries of deciduous teeth#br#
		GAO Shiqi YU Sihan ZHOU Yuan ZHENG Liwei ZHOU Xin
		West China Hospital of Stomatology of Sichuan University, Sichuan Province, Chengdu 610041, China [Abstract] The Hall technique is a more convenient method for the treatment of molar caries of deciduous teeth based on the traditional metal preformed crown restorations. The Hall technique does not require local anesthesia, caries removal, and tooth preparation. It can be used to fix the metal precrown directly on the affected tooth, and can be used to close the caries tissue and prevent the development of caries. Several studies have shown that the clinical efficacy of the Hall technique is more comparable than traditional metal preformed crown restorations, and the success rate is higher than that of traditional filling techniques and non-restorative treatments. Hall technology embodies the concept of minimally invasive and comfortable treatment in children’s stomatology, which is helpful to reduce the occurrence of dental fear in children. However, due to the absence of tooth preparation, the Hall technique is controversial in the aspects of occlusal relationship, edge closeness, and influence on periodontal tissue. In this paper, the basic principles, indications and contraindients, clinical efficacy and related clinical issues of Hall technology are summarized.
		2021 Vol. 18 (29): 49-51 [Abstract] ( 55 ) HTML (1 KB) PDF (508 KB) ( 72 )

	52	Analysis of related risk factors of hypertensive nephropathy in the elderly#br#
		HUANG Huacui KE Xiao XIE Guangsu LIU Liping
		Objective To study the risk-related factors of elderly hypertensive nephropathy in Xindu District, and further provide basis for the early prevention and treatment of elderly hypertensive nephropathy. Methods Elderly hypertensive patients admitted to the People’s Hospital of Xindu District were selected from January 2018 to December 2019. Combined with clinical diagnosis and laboratory examinations, a total of 93 patients with hypertensive nephropathy were established as the study group, while a total of 93 patients with simple hypertension as the control group. The levels of items such as liver function, kidney function, and blood lipids in the serum of the two groups were detected and compared. Multivariate logistic regression analysis was used to evaluate the influencing factors of elderly hypertensive nephropathy. Results Glucose (Glu), triglycerides (TG), cystatin C (CysC), homocysteine (Hcy), urea, creatinine (Cr), and uric acid (UA) in the study group were higher than those in the control group, while high-density lipoprotein cholesterol (HDL-C) and low-density protein cholesterol (LDL-C) were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Urea, Cr, UA, HDL-C, TG, CysC, and Hcy were correlated with elderly hypertensive nephropathy (P ＜ 0.05). TG, CysC, and Hcy were the influencing factors of hypertensive nephropathy (P ＜ 0.05). The incidence of hypertensive nephropathy in patients with high TG, CysC, and Hcy were 60.128, 58.486 and 0.897 times of those with simple hypertension, respectively. Conclusion Increases in serum TG, CysC, and Hcy in elderly hypertensive patients are related factors for hypertensive kidney damage. Elderly hypertensive patients should be paid great attention, regular physical examinations to monitor changes in serum indicators, and timely intervention measures should be taken.
		2021 Vol. 18 (29): 52-55 [Abstract] ( 420 ) HTML (1 KB) PDF (531 KB) ( 75 )

	56	Investigation and analysis of the status quo of knowledge, attitude, and practice of traditional Chinese medicine health preservation of nurses in hospitals of traditional Chinese medicine#br#
		DENG Siqi PAN Xiaoyan XIAO Ziwei LI Fang
		Objective To investigate the status quo of knowledge, attitude, and practice traditional Chinese medicine health preservation of nurses in traditional Chinese medicine hospitals, and to explore their influencing factors, so as to provide a reference for the promotion of traditional Chinese medicine health preservation knowledge. Methods From August 14th to 26th, 2020, a total of 1132 nursing staff from 13 traditional Chinese hospitals were randomly selected to conduct surveys by filling out online questionnaires, while their general information, knowledge, attitude, and practice scores, and application attitudes were analyzed. Results A total of 1183 questionnaires were distributed in this survey, and 1132 valid questionnaires were returned, the effective response rate was 95.5%. There were statistically significant differences in the scores of traditional Chinese medicine health preservation knowledge, attitude, and practice of nurses in traditional Chinese medicine hospitals of different ages, working years, and provinces where the hospital was located (P ＜ 0.05). The linear regression results showed that, age, working years, and the province where the hospital was located were related factors that affect the knowledge, attitude, and practice of traditional Chinese medicine health preservation among nurses in traditional Chinese medicine hospitals (P ＜ 0.05). Attitude surveys showed that due to lack of knowledge (82.4%), lack of time and energy (61.6%) among nursing staff, the clinical application rate of traditional Chinese medicine health preservation knowledge was not high. Conclusion Nursing staff in traditional Chinese medicine hospitals have a high level of knowledge and attitude about traditional Chinese medicine health preservation, but their implementation level of traditional Chinese medicine health preservation practice is low, and their working years and management methods affect the behaviors of traditional Chinese medicine hospital nurses. Relevant departments should coordinate to take measures to increase the enthusiasm of nurses to promote the knowledge of traditional Chinese medicine, meet the needs of patients for knowledge of traditional Chinese medicine, and give full play to the unique advantages of traditional Chinese medicine.
		2021 Vol. 18 (29): 56-59 [Abstract] ( 147 ) HTML (1 KB) PDF (555 KB) ( 83 )

	60	Correlation analysis of sleep quality and traditional Chinese medicine constitution of Miao nationality perimenopausal women in Guizhou Province#br#
		CHEN Yitao1 ZHU Hong2 ZHU Zhusheng3 RAN Limei4
		Objective To explore the correlation between sleep quality of perimenopausal women of Miao nationality in Guizhou Province and the constitution of traditional Chinese medicine, and to provide new ideas and methods for clinical prevention and treatment of perimenopausal insomnia. Methods From March 2019 to June 2020, a multi-stage random sampling method was used to select 1827 Miao nationality women aged 40 to 60 in Guizhou Province for a questionnaire survey. Education level, marital status, menopause, number of births, number of pregnancy, sleep status, age at menarche, age at first birth, etc. were understood. The fitness tendency was judged by the traditional Chinese medicine body mass scale, and the Pittsburgh sleep quality index (PSQI) was used to judge the quality of sleep. Results There were statistically significant differences in the subjective perception of sleep quality, sleep persistence, sleep disturbance, and daytime dysfunction scores of different traditional Chinese medicine constitution types (P ＜ 0.05).Peace quality was negatively correlated with subjective perception of sleep quality, sleep persistence, sleep efficiency, sleep disturbance and daytime dysfunction scores (r ＜ 0, P ＜ 0.05). In addition to the time to fall asleep and sleep efficiency, qi deficiency, yang deficiency, yin deficiency, phlegm-dampness, damp-heat and idiosyncratic qualities were positively correlated with other PSQI scores (r ＞ 0, P ＜ 0.05). Except for time to fall asleep, blood stasis quality was positively correlated with the scores of other dimensions of PSQI (r ＞ 0, P ＜ 0.05). In addition to sleep efficiency, qi depression was positively correlated with the scores of other dimensions of PSQI (r ＞ 0, P ＜ 0.05). Conclusion The sleep problems of Miao nationality women in Guizhou Province are more prominent. Miao nationality women of different physiques have different symptoms of sleep disorders. The quality of sleep can be improved in a targeted manner by conditioning their physique.
		2021 Vol. 18 (29): 60-63 [Abstract] ( 112 ) HTML (1 KB) PDF (528 KB) ( 86 )

	64	Research on the relationship between teachers’ job burnout and mental health in Beijing colleges and universities from the perspective of psychological capital#br#
		LI Yachao1 HUANG Ziwei2 CHANG Kuo1 LI Xue1 ZHANG Hui1▲
		Objective To investigate the status quo of teachers’ mental health in Beijing colleges and universities, and on the basis of verifying the relationship between the level of college teachers’ mental health and job burnout, further explore the mediating role of psychological capital. Methods Using the cross-sectional survey design, a total of 318 college teachers were conveniently sampled in nine colleges and universities in Beijing from November 2018 to March 2019. The “Beijing residents mental health scale”, “psychological capital questionnaire”, and “occupational burnout scale china version” were used to conduct an on-site anonymous survey, in order to messure the level of mental health, psychological capital and job burnout of college teachers. Results A total of 331 questionnaires were sent out in this survey, and 318 valid questionnaires were obtained, and the effective response rate was 96.07%. The various dimensions and total scores of the mental health of teachers in colleges and universities in Beijing were at an intermediate level. There were statistically significant differences in the scores of college teachers of different genders, marital status, and ages in various dimensions of mental health (P ＜ 0.05). Mental health level was positively correlated with mental capital (r = 0.51, P ＜ 0.01), while job burnout was negatively correlated with mental health level and mental capital (r = -0.70, -0.41, P ＜ 0.01). The level of mental health could not directly predict job burnout, but it predicted job burnout through the complete mediating effect of psychological capital. Conclusion Teachers in Beijing colleges and universities have relatively good mental health, while their psychological capital is at the upper-middle level, while job burnout is relatively mild. Psychological capital plays a complete mediating role in mental health and job burnout.
		2021 Vol. 18 (29): 64-67 [Abstract] ( 43 ) HTML (1 KB) PDF (552 KB) ( 119 )

	68	Effect of acupuncture on patients with stable angina pectoris with syndrome of blockade of phlegm-turbidity#br#
		SUN Yan1 LI Bohui2 WANG Zelin3
		Objective To investigate the clinical effect of acupuncture on patients with stable angina pectoris with syndrome of blockade of phlegm-turbidity and its effect on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level. Methods A total of 116 patients with stable angina pectoris with syndrome of blockade of phlegm-turbidity admitted to the Department of Cardiology, the Second Affiliated Hospital of Shenyang Medical College from October 2018 to June 2020 were selected as the research objects. They were divided into Western medicine control group and acupuncture treatment group by random number table method, with 58 patients in each group. The Western medicine control group was treated with conventional Western medicine such as coronary artery dilation, anti-platelet aggregation and reducing lipid to stabilize plaque, while the acupuncture treatment group was treated with acupuncture on the basis of the Western medicine control group. Both groups received continuous treatment for 12 weeks. The changes of traditional Chinese medicine syndrome score, Seattle angina questionnaire score, electrocardiogram treadmill exercise test, serum lipid and Lp-PLA2 levels were compared between the two groups. Results The clinical effective rate of traditional Chinese medicine syndrome in acupuncture treatment group was higher than that in Western medicine control group (P ＜ 0.05). After treatment, Seattle angina questionnaire score and electrocardiogram treadmill exercise test index were significantly higher than before treatment (P ＜ 0.05). Traditional Chinese medicine syndrome score and serum levels of triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and Lp-PLA2 were significantly decreased compared with those before treatment (P ＜ 0.05). Compared with the Western control group, the Seattle angina questionnaire score and electrocardiogram treadmill exercise test index in the acupuncture treatment group after treatment were significantly increased (P ＜ 0.05), and the traditional Chinese medicine syndrome score and levels of serum TAG, TC, LDL-C, and Lp-PLA2 were significantly decreased (P ＜ 0.05). Conclusion The clinical effect of acupuncture on patients with stable angina pectoris with syndrome of blockade of phlegm-turbidity is significant, which can effectively improve the clinical symptoms, improve the quality of life and heart function, and reduce the levels of serum lipid and Lp-PLA2.
		2021 Vol. 18 (29): 68-72 [Abstract] ( 389 ) HTML (1 KB) PDF (509 KB) ( 77 )

	73	Effect of blood purification on cardiac function in patients with acute heart failure and peripheral edema
		ZHAO Chunli1 DONG Zhiyang1▲ CAO Changmeng1 LIU Ying1 LIU Fei2 NING Shuwei1
		Objective To analyze the effect of blood purification on cardiac function in patients with acute heart failure and peripheral edema. Methods A total of 68 patients with acute heart failure and peripheral edema in Dalian Friendship Hospital, Liaoning Province from January 2018 to September 2020 were selected, and divided into group A and group B according to different treatment methods, with 34 cases in each group. Group A was treated with conventional drugs, and group B was treated with conventional drugs combined with blood purification. The clinical efficacy, heart failure markers (B-type natriuretic peptide), cardiac function (left ventricular end diastolic diameter, the left ventricular end systolic diameter, left ventricular ejection fraction) and blood gas analysis indicators (arterial partial pressure of carbon dioxide, arterial partial pressure of oxygen, oxygen saturation) of the two groups were compared. Results The total effective rate in group B was higher than that in group A (P ＜ 0.05); after treatment, the level of B-type natriuretic peptide in the two groups was lower than that before treatment, the level of B-type natriuretic peptide in group B after treatment was lower than that in group A (P ＜ 0.05). After treatment, the left ventricular end diastolic diameter and the left ventricular end systolic diameter of the two groups were lower than before treatment, left ventricular ejection fraction was higher than before treatment (P ＜ 0.05), and the left ventricular end diastolic diameter and left ventricular end systolic diameter of group B were lower than those of group A, the left ventricular ejection fraction was higher than that of group A (P ＜ 0.05); after treatment, arterial blood carbon dioxide was lower than before treatment, arterial blood oxygen partial pressure and oxygen saturation were higher than before treatment, and arterial blood carbon dioxide in group B was lower than that in group A, arterial blood oxygen partial pressure and oxygen saturation were higher than those in group A (P ＜ 0.05). Conclusion Blood purification is effective in the treatment of acute heart failure and peripheral edema, and the total effective rate is high. It can significantly improve the heart failure markers, cardiac function indexes and blood gas analysis indexes, which is worthy of promotion.
		2021 Vol. 18 (29): 73-76,85 [Abstract] ( 102 ) HTML (1 KB) PDF (809 KB) ( 46 )

	77	Meta-analysis of the efficacy and safety of Oxiracetam in the treatment of cognitive impairment after intracerebral hemorrhage#br#
		XUE Daojin1 YIN Lianjun1,2 MENG Jinyuan1,2 ZHEN Zheng1,2 ZHAN Jie1 SHEN Youbi1 PENG Zizhuang1 HUANG Tao1,2
		Objective To systematically evaluate the efficacy and safety of Oxiracetam in the treatment of cognitive impairment after intracerebral hemorrhage. Methods Randomized controlled trials of Oxiracetam for cognitive impairment after intracerebral hemorrhage were searched in CNKI, Wanfang Data, VIP, CBM, EMbase, PubMed, and the Cochrane Library. The retrieval period is from inception to November 2020. Meta-analysis was performed using RevMan 5.3 software. Results A total of 616 patients were included in eight literatures, 310 in experimental group and 306 in control group. The mini mental status examination (MMSE) score (MD = 8.85, 95%CI: 4.82-12.87, P ＜ 0.0001) and Barthel index (MD = 17.21, 95%CI: 15.29-19.14, P ＜ 0.0001) in experimental group were higher than those in control group. Further subgroup analysis showed that the MMSE score (MD = 12.33, 95%CI: 8.54-16.11, P ＜ 0.000 01) and Barthel index (MD = 20.44, 95%CI: 17.77-23.11, P ＜ 0.000 01) of static drops group, the MMSE score (MD = 4.19, 95%CI: 2.20-6.18, P ＜ 0.0001), and Barthel index (MD = 13.73, 95%CI: 10.95-16.50, P ＜ 0.000 01) of oral group were higher than those in control group. Hasegawa dementia scale score in the experimental group was higher than that in the control group (MD = 3.84, 95%CI: 1.65-6.03, P = 0.0006), and National Institutes of Health stroke scale score was lower than that in the control group (MD = -4.31, 95%CI: -6.37 to -2.25, P ＜ 0.0001). There was no significant difference in the incidence of adverse reactions between the two groups (RR = 1.18, 95%CI: 0.62-2.22, P = 0.62). Conclusion Oxiracetam has significant effect in improving cognitive function, activities of daily living and neurological deficit symptoms of patients with intracerebral hemorrhage.
		2021 Vol. 18 (29): 77-81 [Abstract] ( 177 ) HTML (1 KB) PDF (1384 KB) ( 191 )

	82	Effects of glucagon-like peptide-1 combined with Compound Levodopa on Parkinson disease with diabetes mellitus patients
		FAN Lei LIU Xingliang LOU Zhan WANG Ying WANG Yuejuan
		Objective To study the effect of glucagon-like peptide-1 (GLP-1) combined with Compound Levodopa on Parkinson disease (PD) with diabetes mellitus (DM) patients. Methods A total of 158 PD with DM patients admitted to the First Affiliated Hospital of Hebei North University from January 2018 to June 2020 were selected as the research objects. They were divided into control group (79 cases) and research group (79 cases) according to the random number table method. The control group was given subcutaneous injection of insulin and oral Compound Levodopa Tablets, and the research group was given subcutaneous injection of GLP-1 and oral Compound Levodopa Tablets. The treatment time for both groups was six months. Before and after treatment, the changes of Montreal cognitive assessment scale (MoCA), unified Parkinson disease rating scale (UPDRS)Ⅱ (activity of daily living) and UPDRS Ⅲ (exercise ability) scores in UPDRS were compared. Results During the treatment, two patients in the research group dropped out, and 156 patients were eventually enrolled in the study. After treatment, MoCA score was higher than before treatment, UPDRS Ⅱ and Ⅲ scores were lower than before treatment, and the MoCA score of the research group was higher than that of the control group, and the UPDRS Ⅱ and Ⅲ scores were lower than that of the control group, with statistical significance (P ＜ 0.05). Conclusion GLP-1 combined with Compound Levodopa can not only improve the cognitive function of PD with DM patients, but also improve the quality of life and exercise ability of these patients.
		2021 Vol. 18 (29): 82-85 [Abstract] ( 131 ) HTML (1 KB) PDF (516 KB) ( 82 )

	86	Effect of hot medicinal compress therapy by traditional Chinese medicine combined with eight winds and eight pathogens stagnation acupuncture on patients with severe craniocerebral injury with limb dysfunction
		CAO Wenping ZHANG Xiuwen▲
		Objective To analyze the application value of hot medicinal compress therapy by traditional Chinese medicine combined with eight winds and eight pathogens stagnation acupuncture in patients with severe craniocerebral injury and limb dysfunction. Methods A total of 100 patients with stable severe craniocerebral injury with limb dysfunction admitted to the First Affiliated Hospital of Air Force Military Medical University from January to December 2019 were selected as the research subjects. They were divided into control group and observation group, with 50 cases in each group by random number table method. The control group was treated with hot medicinal compress therapy by traditional Chinese medicine, and the observation group was treated with eight winds and eight pathogens stagnation acupuncture on the basis of the control group. The course of treatment was eight weeks. Muscle strength of upper and lower limbs, Holden walking function grade, functional independence measure, and 36-item short form health survey scores were compared between the two groups before and after treatment. Results After treatment, the scores of muscle strength of upper and lower limbs in the observation group were lower than that in the control group, and scores of Holden walking function grade, functional independence measure, and 36-item short form health survey were higher than those in the control group, with statistical significance (P ＜ 0.05). Conclusion Hot medicinal compress therapy by traditional Chinese medicine combined with eight winds and eight pathogens stagnation acupuncture can effectively improve the limb function of patients with stable severe craniocerebral injury accompanied by limb dysfunction and improve their quality of life, which is worthy of clinical promotion.
		2021 Vol. 18 (29): 86-89 [Abstract] ( 93 ) HTML (1 KB) PDF (542 KB) ( 104 )

	90	Expression and clinical significance of miR-204-5p and miR-1233-3p in hypertensive disorders complicating pregnancy women#br#
		WU Guimei LI Jiyun JIN Yan LIU Hongling WANG Wenjie XING Xiaohong CAO Yanmin
		Objective To investigate the diagnostic value of miR-204-5p and miR-1233-3p for hypertensive disorders complicating pregnancy (HDCP). Methods A total of 197 HDCP patients admitted to Cangzhou Central Hospital of Hebei Province (hereinafter referred to as “our hospital”) from December 2018 to June 2020 were selected as research subjects, among them, 102 patients with gestational hypertension were in gestational hypertension group, and 95 patients with preeclampsia were in preeclampsia group; in addition, 82 normal full-term single pregnancy pregnant women who were admitted hospital for labor and regular perinatal care in Department of Obstetrics of our hospital were randomly selected as control group. The expressions of miR-204-5p and miR-1233-3p, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in peripheral blood of the subjects were detected. The correlation between the expression of miR-204-5p and miR-1233-3p and the clinical parameters IL-6, and TNF-α of HDCP patients, and the diagnostic value of miR-204-5p and miR-1233-3p for HDCP were analyzed. Results The expressions of serum miR-204-5p and miR-1233-3p and the levels of IL-6 and TNF-α in preeclampsia group and gestational hypertension group were higher than those in control group (P < 0.05); the expressions of serum miR-204-5p and miR-1233-3p and the levels of IL-6 and TNF-α in preeclampsia group were higher than those in gestational hypertension group (P < 0.05). The expressions of miR-204-5p and miR-1233-3p in HDCP patients were negatively correlated with gestational age and neonatal weight (rmiR-204-5P = -0.403, -0.395, rmiR-1233-3p = -0.321, -0.354, P < 0.05); it was positively correlated with systolic blood pressure, diastolic blood pressure, 24 h urine protein, IL-6, and TNF-α (rmiR-204-5P = 0.653, 0.619, 0.597, 0.594, 0.601, rmiR-12333-3p = 0.624, 0.609, 0.543, 0.615, 0.631, P < 0.05). The area under curve value of HDCP diagnosed by miR-204-5p and miR-1233-3p was greater than that detected by miR-204-5p and miR-1233-3p alone (P < 0.05). Conclusion The high expressions of miR-204-5p and miR-1233-3p are related to gestational age, neonatal weight and inflammatory factors, which have high application value for the diagnosis of HDCP.
		2021 Vol. 18 (29): 90-93,111 [Abstract] ( 130 ) HTML (1 KB) PDF (872 KB) ( 216 )

	94	Establishment of risk factor scoring system for invasive fungal infection in children with PICU
		LI Qian1 DING Xiangyu1 JIA Lili2 ZHANG Guying1
		Objective To analyze the high risk factors of invasive fungal infection (IFI) in children with pediatric intensive care unit (PICU) and to establish a risk scoring system. Methods The clinical data of 65 hospitalized children with IFI diagnosis in PICU of Children’s Hospital of Hebei Province from January 2015 to June 2020 were analyzed and included in observation group; according to the principle of 1∶1 allocation, 65 cases of non-IFI hospitalized children with similar underlying diseases in the same period and ward were included in control group. The independent risk factors affecting the occurrence of IFI in children with PICU were analyzed and assigned, an IFI risk scoring system was established, and the ROC curve was drawn to verify the effectiveness of the scoring system. Results The length of hospitalization in observation group was longer than that of control group; and the proportion of indwelling gastric tube, indwelling urinary catheter, central venous catheter, mechanical ventilation >3 days, combination of two or more antibacterial drugs, hypoproteinemia, surgery of observation group were higher than those of control group, and the differences were statistically significant (P < 0.05). Hospitalization days (OR = 1.109, 95%CI: 1.048-1.174), central venous catheter (OR= 38.344, 95%CI: 5.354-274.609), combination of two or more antibacterial drugs (OR=6.194, 95%CI: 2.267-16.924) were independent risk factors for IFI in PICU children (P < 0.05). According to the regression coefficients of independent risk factors, the length of stay was 1, the central venous catheter was 36, and the combination of two or more antibacterial drugs was 18, and a scoring system was established. ROC curve showed that area under the curve was 0.875 (95%CI: 0.816-0.934, P < 0.001), the cut-off value was 0.615, corresponding to the critical value of 28, and the sensitivity was 0.754 and specificity was 0.862. Conclusion The scoring system has good excellent efficiency and good specificity, which is of certain significance for PICU in early identification of IFI high-risk children.
		2021 Vol. 18 (29): 94-97 [Abstract] ( 138 ) HTML (1 KB) PDF (507 KB) ( 102 )

	98	Effect of Methylprednisolone Sodium Succinate in the treatment of children with severe mycoplasma pneumonia and its effect on inflammatory factors#br#
		LIU Xiaomeng1 ZHANG Yanbei2 YU Haiming1 ZHANG He1 SUN Yuanyuan2
		Objective To investigate the effect of Methylprednisolone Sodium Succinate in the treatment of children with severe mycoplasma pneumonia and its effect on inflammatory factors. Methods A total of 100 children with severe mycoplasma pneumonia in Baoding Children’s Hospital of Heibei Province from October 2018 to September 2020 were selected as research objects，and they were divided into control group（conventional symptomatic treatment）and observation group（Methylprednisolone Sodium Succinate combined with conventional symptomatic treatment）, with 50 cases in each group according to the random number table method. The clinical total effective rate, improvement time of symptoms and signs (fever, cough and pulmonary ronal sound), the levels of serum proinflammatory factors (interleukin-1β [IL-1β], IL-6, and tumor necrosis factor-α [TNF-α]) and anti-inflammatory factors (IL-4 and γ interferon [IFN-γ]) before treatment, three and five days after treatment were compared between two groups. Results The clinical total effective rate of observation group were higher than those of control group， and the differences were statistically significant (P ＜ 0.05). The improvement time of symptoms and signs between two groups were statistically significant (P < 0.05). After three and five days of treatment, the levels of IL-1β, IL-6, TNF-α, IL-4, and IFN-γ in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). Conclusion Methylprednisolone Sodium Succinate combined with conventional symptomatic treatment has a good curative effect on children with severe mycoplasma pneumonia, and can effectively control the expression level of inflammatory factors in children, so the application value is relatively high.
		2021 Vol. 18 (29): 98-101 [Abstract] ( 400 ) HTML (1 KB) PDF (493 KB) ( 43 )

	102	Effect of Jianpi Yishen Huatan Formula combined with DP chemotherapy on middle-advanced stage lung squamous carcinoma
		CHEN Xinli WANG Zhiguang
		Objective To evaluate the effect of Jianpi Yishen Huatan Formula combined with Docetaxel+Cisplatin(DP) chemotherapy on middle-advanced stage lung squamous carcinoma. Methods A total of 80 middle-advanced stage lung squamous carcinoma patients admitted to the Department of Oncology, the First Affiliated Hospital of Guangxi University of Chinese Medicine from January 2018 to January 2020 were selected. According to the random number table method, they were divided into observation group and control group, with 40 case with each group. The control group was given DP chemotherapy, and the observation group was given Jianpi Yishen Huatan Formula combined with DP chemotherapy, 21 days was one cycle, and the treatment lasted for 4-6 consecutive cycles. The short-term effect, traditional Chinese medicine, syndrome score, immune function, and adverse reaction were compared between the two groups. Results The total effective rate and disease control rate of observation group were significantly higher than those of control group (P ＜ 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were significantly decreased compared with before treatment, and observation group was lower than control group (P ＜ 0.05). The CD3+, CD4+, and CD4+/CD8+ of two groups were significantly higher than before treatment, and observation group was higher than the control group (P ＜ 0.05). The CD8+ of two groups was significantly decreased compared with before treatment, and the observation group was significantly lower than the control group (P ＜ 0.05). Compared with control group, the rate of myelosuppression, liver and kidney damage, gastrointestinal reactions and cardiotoxicity in observation group were less than those of control group (P ＜ 0.05). Conclusion Jianpi Yishen Huatan Formula combined with DP chemotherapy treat with middle-advanced stage lung squamous carcinoma, can effectively control disease progression, reduce adverse reactions, and improve immune function.
		2021 Vol. 18 (29): 102-105 [Abstract] ( 94 ) HTML (1 KB) PDF (545 KB) ( 58 )

	106	Meta-analysis of the association between long Non-coding RNA-PVT1 expression and the prognosis and clinicopathology of digestive system malignant tumors #br#
		LIU Yingtao1 FANG Changzhong2 CHEN Wenliang2
		School, Shanxi Medical University, Shanxi Province, Taiyuan 030001, China; 2.Department of General Surgery, Second Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China [Abstract] Objective To study the relationship between long non coding RNA-plasmacytoma variant translocation 1 （PVT1) and the clinicopathological features and prognosis of digestive system malignancies. Methods The Web of Science, EMBASE, and PubMed were searched, the search ended on January 2021. According to the retrieval strategy and inclusion and exclusion criteria, the literatures were screened and the relevant data were extracted. RevMan v5.3 software was used for meta analysis. Results A total of 32 studies involving 2873 patients were included. The highly expressed PVT1 levels were potentially connected with poorer overall survival (HR = 1.71, 95%CI:1.54-1.89, P ＜ 0.000 01) and disease free survival (HR = 1.95, 95%CI:1.67-2.29, P ＜ 0.000 01). Highly expressed PVT1 levels were also positively correlated with diameter of tumor (OR = 2.02, 95%CI: 1.43-2.86, P ＜ 0.000 01)，TNM stage （OR = 3.42, 95%CI: 2.86-4.08, P ＜ 0.000 01), lymph node metastasis (OR = 3.04, 95%CI:2.41-3.84, P ＜ 0.000 01), tumor differentiation (OR = 1.81, 95%CI:1.21-2.72, P = 0.004), distant metastasis (OR = 2.91, 95%CI:2.06-4.11, P ＜ 0.000 01) and infiltration depth (OR = 5.19, 95%CI:3.52-7.66, P ＜ 0.000 01). Conclusion PVT1 can be used to gauge clinicopathological characteristics and outcomes in patients withdigestive system malignant tumors.
		2021 Vol. 18 (29): 106-111 [Abstract] ( 130 ) HTML (1 KB) PDF (977 KB) ( 89 )

	112	Systematic reevaluation of gene polymorphism and osteosarcoma occurrence and prognosis#br#
		GUO Jinrong1 MEI Qijie1 YUAN Changshen1 XU Wenfei2 YAO Hongyi3
		Objective To reevaluate the published systematic evaluation of gene polymorphism and osteosarcoma occurrence and prognosis. Methods PubMed, Embase, Web of Science, Cochrane Library, CBM, CNKI, VIP, and Wanfang Data were searched to screen the systematic evaluation of gene polymorphism and the occurrence and prognosis of osteosarcoma. The search period was from the establishment of inception to April 2020. After independent literature screening, data extraction, and quality evaluation, AMSTAR2 scale was used to evaluate the quality of the methodology included in the study. Results In the end, 23 articles were included in the systematic evaluation, and AMSTAR2 scale results showed that three articles were of medium quality, 11 articles were of low quality, and nine articles were of extremely low quality. Conclusion The overall quality of evidence included in the study is low, the current research results show that gene polymorphism is closely related to the occurrence and prognosis of osteosarcoma, which provides new methods and ideas for the treatment of osteosarcoma patients. Due to the impact of the quality of the included research, more high-quality research is needed for further verification.
		2021 Vol. 18 (29): 112-117 [Abstract] ( 105 ) HTML (1 KB) PDF (690 KB) ( 84 )

	118	Effect of Bevacizumab combined with chemotherapy in the treatment of non-small cell lung cancer and its influence on T cell subsets and immune function#br#
		PAN Enyuan1 XIA Qin2
		Objective To study the effect of Bevacizumab combined with chemotherapy in the treatment of non-small cell lung cancer (NSCLC) and its influence on T cell subsets and immune function. Methods Eighty NSCLC patients admitted to Anhui No.2 Provincal People’s Hospital from January 2018 to August 2020 were selected as the research subjects, they were divided into observation group and control group by random number table method, with 40 cases in each group. The control group was given Pemetrexed combined with platinum chemotherapy, and the observation group was combined with Bevacizumab on the basis of the chemotherapy. Both groups were given intravenous infusion on the first day, with a cycle of 21 days, and each cycle was given intravenous infusion on the first day for a total of two cycles. The clinical efficacy, the changes of the T cell subsets CD3+, CD4+, CD4+/CD8+, immunoglobulin IgA, IgG, and IgM before and after treatment were compared between the two groups, and the side reaction during the treatment were compared. Results After treatment, the total clinical effective rate of observation group was higher than control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+, IgA, IgG, and IgM in two groups were lower than those before trentment, and the observation group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of side reaction between two groups during treatment (P ＞ 0.05). Conclusion Bevacizumab combined with chemotherapy has a significant effect on the treatment of NSCLC patients, which can improve the expression of T cell subsets and immune function, and is worthy of application and promotion.
		2021 Vol. 18 (29): 118-121 [Abstract] ( 139 ) HTML (1 KB) PDF (549 KB) ( 98 )

	122	Effect of Biling Weitong Granules combined with quadruple therapy on chronic atrophic gastritis with positive Helicobacter pylori infection
		HONG Shanshan1 HUANG Jiahui1 XU Shaojun2
		Objective To investigate the effect of Biling Weitong Granules combined with quadruple therapy in the treatment of Helicobacter pylori (Hp) infection positive chronic atrophic gastritis. Methods A total of 110 Hp-positive patients with chronic atrophic gastritis admitted to Anhui No.2 Provincial People’s Hospital from March 2019 to March 2020 were selected, and the patients were divided into control group (quadruple therapy, 55 cases) and observation group (Biling Weitong Granules combined with quadruple therapy, 55 cases) by envelope lottery. Both groups were treated for four months. Efficacy, symptom score, Hp eradication rate and related serum indexes were compared between the two groups, and the safety of the two groups was recorded. Results The total clinical effective rate of observation group was higher than control group (P ＜ 0.05). The eradication rate of Hp in observation group was higher than that in control group (P ＜ 0.05). After treatment, the scores of epigastric pain, epigastric fullness, pulse string, belching and other symptoms, interleukin-4, tumor necrosis factor -α in the observation group were lower than those in the control group (P ＜ 0.05), and interferon γ was higher than that in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Biling Weitong Granules combined with quadruple therapy for the treatment of Hp-positive chronic atrophic gastritis has a definite effect, which can promote the improvement of symptoms, improve the eradication rate of Hp and improve the level of inflammation.
		2021 Vol. 18 (29): 122-125 [Abstract] ( 646 ) HTML (1 KB) PDF (386 KB) ( 97 )

	126	Exploration and analysis of Kang Shouyi’s abdominal diagnosis experience based on Shanghan Lun
		LI Panfei1,2 WANG Yan3 TAN Tianyang4 SU Qingmin5
		Scholars generally recognize the important position of Shanghan Lun in the history of abdominal diagnosis in traditional Chinese medicine, but there are still few doctors who apply Shanghan Lun in abdominal diagnosis nowadays. Doctor Kang Shouyi, the disciple of Mr. Liu Shaowu, the founder of the Three Departments and Six Diseases school, realizes the diagnostic and treatment value of abdominal diagnosis in Shanghan Lun. After years of practice, doctor Kang Shouyi formed a systematic understanding of abdominal diagnosis in Shanghan Lun. This article will comprehensively summarize and analyze the theory, method and application of doctor Kang Shouyi’s abdominal diagnosis from five parts: abdominal diagnosis technique, abdominal diagnosis preparation, abdominal observation, pressing and kneading, and deep pressing. It focuses on summarizing and explaining some of the abdominal diagnosis features, such as fullness and discomfort in chest and hypochondrium, hard distention, and hard pain in the upper abdomen, hyperpulsation of the abdominal aorta, vibration water sound, abdominal tenderness in the middle abdomen, and hypogastric pain in the lower abdomen. It also points out that the hyperpulsation of the abdominal aorta, fullness and discomfort in chest and hypochondrium, vibration water sound are indications for the application of Guizhi Prescriptions, Chaihu Prescriptions, and Lingui Prescriptions. These contents belong to the new results of the research of abdominal diagnosis in traditional Chinese medicine and Shanghan Lun.
		2021 Vol. 18 (29): 126-130 [Abstract] ( 97 ) HTML (1 KB) PDF (792 KB) ( 151 )

	131	Discussion on the relationship between qi, blood and fluid lesions and toxin and evil#br#
		WANG Xueke1 CUI Yinglin2
		Qi, blood and fluid, as the material basis of human life activities, play the role of nourishing zang-fu viscera and nourishing meridians. If qi movement is smooth, essence and blood is full, fluid is not lack, channel is adjusted, vital qi is prosperous and anti-evil, body health can be guaranteed. If the evil qi becomes poisonous for a long time, the toxin will be so violent and will destroy the body, cause the disorder of qi, blood and fluid, and the pathological changes caused by deficiency and stagnation and stasis become real, then all diseases are born and the body is in danger. At present, the theory of qi, blood and fluid and the theory of toxin and evil have been continuously enriched and developed unilaterally, but the relationship between the two has not been discussed in detail. Therefore, the author discusses the relationship between qi, blood and fluid lesions and toxin and evil in order to better guide clinical treatment.
		2021 Vol. 18 (29): 131-133,141 [Abstract] ( 65 ) HTML (1 KB) PDF (791 KB) ( 90 )

	134	Practice and reflection on the inheritance and development of Pingle Guo’s bonesetting academic school #br#
		YE Yanrong GUO Yanxing GUO Jiayi
		Under the background of the new era, academic schools of traditional Chinese medicine are an important link to promote the vigorous development of traditional Chinese medicine. This paper briefly describes the historical evolution and development status of Pingle Guo’s bonesetting academic school, the first national academic school of traditional Chinese medicine, and summarizes its practical experience in academic system construction, school characteristic development, talent team construction and school brand construction in recent years, and combined with the development needs of traditional Chinese medicine, this paper further puts forward some thoughts and suggestions on the inheritance and development of traditional Chinese medicine academic schools, in order to provide reference for traditional Chinese medicine academic schools to help the prosperity and revival of traditional Chinese medicine.
		2021 Vol. 18 (29): 134-137 [Abstract] ( 86 ) HTML (1 KB) PDF (738 KB) ( 86 )

	138	Investigation on origin and development of frequent blinking#br#
		JIANG Deyou LIANG Lin XIE Ying CHANG Jiayi LI Fuzhen CHEN Fei LI Wenhao HAN Jieru
		The cognition of frequent blinking in traditional Chinese medicine can be traced back to the Song dynasty. Qian Yi first put forward the main cause of “liver wind into the eyes”, which was fully extended and developed in the Ming and Qing dynasties. This disease is a common clinical disease, mostly seen in children, but also in postpartum women, its self-healing possibility is very small, and even sustainable to life, affecting people’s normal life and appearance characteristics, belongs to the category of difficult diseases. It is concluded that most of the disease sites are liver and spleen. The etiology is caused by wind, fire, phlegm, deficiency and infantile convulsion, and the treatment is mainly to expelling remnant, invigorating and dingzhong method. This paper tries to identify the main idea for the treatment of this disease, so it traces back to the original source, so as to prove the ancient and determine the present.
		2021 Vol. 18 (29): 138-141 [Abstract] ( 56 ) HTML (1 KB) PDF (746 KB) ( 53 )

	142	Experience of Professor Ren Shunping in treating chronic atrophic gastritis by using the method of regulating qi-flowing and dredging and descending with the theory of ascending and descending#br#
		ZHAO Mengmeng1 MA Hongxue2 REN Shunping2
		The theory of ascending and descending has a long history. It is an important part of the theoretical system of traditional Chinese medicine and runs through the whole process of treatment based on syndrome differentiation of diseases of the spleen and stomach system. Professor Ren Shunping has used the theory of ascending and descending to diagnose and treat chronic atrophic gastritis for many years. He believes that the main characteristics of chronic atrophic gastritis are deficient root and excessive superficial, and intermingled cold and heat. Deficiency of spleen and stomach and impediments of qi movement are the pathological basis of this kind of disease. The treatment of chronic atrophic gastritis is to regulate qi movement, recover rise and fall, and restore physiological function of spleen and stomach. The three-pronged approaches of disease differentiation and syndrome differentiation, oral administration of traditional Chinese medicine, and the exercise adjustment are often used simultaneously. Professor Ren Shunping’s clinical thinking is clear, and he pays great attention to both manifestation and root cause, with accurate medication, and the effect is significant. The typical case is used to prove the academic experience of Professor Ren Shunping, so as to share with the people engaged in the same pursuit.
		2021 Vol. 18 (29): 142-145 [Abstract] ( 122 ) HTML (1 KB) PDF (741 KB) ( 72 )

	146	Clinical effect of Self-made Huatan Tongluo Prescription in the treatment of acute cerebral infarction with syndrome of wind-phlegm obstructing collateral#br#
		TONG Xiaoling1 CHENG Xiaojing2 ZHANG Lianwen3
		Objective To observe the clinical effect of Self-made Huatan Tongluo Prescription in the treatment of acute cerebral infarction patients with syndrome of wind-phlegm obstructing collateral. Methods From January 2019 to August 2020, a total of 60 patients with acute cerebral infarction admitted to Department of Encephalopathy in Beijing Hospital of Integrated Traditional Chinese and Western Medicine were selected as the research subject. They were divided into control group and treatment group according to the random number table method, with 30 cases in each group. Both groups were given conventional treatment, on the basis of the control group, the treatment group was added with Huatan Tongluo Prescription, the total course of both groups was four weeks. Traditional Chinese medicine (TCM) syndrome scores, National Institutes of Health stroke scale (NHISS) scores, Barthel index (BI) scores before and after treatment were observed in both groups, and the difference of clinical efficacy in both groups was compared. Results After treatment, TCM syndrome scores and NHISS scores in both groups were lower than those before treatment, BI scores were higher than those before treatment, and TCM syndrome score and NHISS score in the treatment group were significantly lower than those in the control group, BI score was significantly higher than that of the control group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy of the treatment group was significantly better than that of the control group (P ＜ 0.05). Conclusion The self-made Huatan Tongluo Prescription has a remarkable effect in the treatment of acute cerebral infarction with syndrome of wind-phlegm obstructing collateral, which can obviously improve the neurological deficit symptoms of acute cerebral infarction patients, relieve TCM syndrome, and increase the patients’ quality of life.
		2021 Vol. 18 (29): 146-149 [Abstract] ( 95 ) HTML (1 KB) PDF (742 KB) ( 80 )

	150	Analysis on the health maintenance concept of “preventive treatment of disease” in traditional Chinese medicine from the original meaning of “nourishing yang in spring and summer, nourishing yin in autumn and winter”#br#
		ZHAO Kaiwei ZHANG Yuhui LIU Lixiang ZHANG Min
		“Nourishing yang in spring and summer, nourishing yin in autumn and winter” is an important health maintenance rule of traditional Chinese medicine. Since Inner Canon of Yellow Emperor was written, there have been many representative theories. In modern times, due to the multi-dimensional and multi-angle development, its theories are complicated, so it is inevitable to misunderstand and misread, the disadvantages of misuse are also present. Starting from the original meaning, this paper explores the connotation of “nourishing” “yin and yang”, and finds out that “nourishing” contains the meaning of “follow to nourish”, that is following the change of the four nature of drugs, the nature of yin and yang to nourish. “Yin and yang” refers to the root, and also refers to “the response of the four nature of drugs”, which contains the way of “following the principle of obedience and adversity” and “preventive treatment of disease”. It is helpful to understand, explain and apply correctly by distinguishing “normal person” nourishment and “morbid” maintenance.
		2021 Vol. 18 (29): 150-153 [Abstract] ( 53 ) HTML (1 KB) PDF (781 KB) ( 118 )

	154	Effect of ICF-based targeted nursing on postoperative rehabilitation of breast cancer patients#br#
		JI Qiuchen1,2 LIN Zheng1,2▲ WANG Lili1
		Objective To explore the application effect of targeted nursing based on International Classification of Function, Disability and Health (ICF) in postoperative rehabilitation nursing of breast cancer patients. Methods A total of 112 patients who underwent modified radical breast cancer surgery in the First Affiliated Hospital of Nanjing Medical University from August 2019 to January 2020 were selected as the research objects. The patients were divided into observation group and control group by random number table method, with 56 cases in each group. Constant-Murley shoulder function scores were compared between the two groups at one week and 1, 3 months after surgery. The functional assessment of cancer therapy-breast (FACT-B) score of breast cancer patients at one week and three months after surgery was compared between the two groups. Results The overall analysis showed that there were statistically significant differences in the comparison between the two groups of total shoulder function, time point comparison and interaction (P ＜ 0.05). Two further comparison, compare within the group, two groups of shoulder joint function score higher than at 1, 3 months after one week, and the total functional scores of shoulder joint in both groups were higher at three months after surgery than 1 month after surgery (P ＜ 0.05); Comparison between groups: the total score of shoulder joint function in observation group was higher than that in control group one and three months after operation (P ＜ 0.05). Three months after operation, the dimensions and total scores of quality of life in the observation group were higher than those in the control group one week after operation, and the observation group was higher than the control group (P ＜ 0.05). Conclusion Targeted nursing measures based on ICF can promote the recovery of upper limb function and improve the quality of life of breast cancer patients.
		2021 Vol. 18 (29): 154-157,169 [Abstract] ( 30 ) HTML (1 KB) PDF (643 KB) ( 144 )

	158	Application of family integrated care model in continuing care of elderly patients with brittle fracture of hip#br#
		GAO Luoluo1 LI Wenjuan2 YIN Kai3
		Objective To explore the application effect of family integrated care mode in the continuing care of elderly patients with brittle fracture of hip. Methods A total of 98 elderly patients with brittle fracture of hip were selected from the Department of Orthopaedics of Taixing People’s Hospital of Jiangsu Province from January to December 2018. The group was divided into observation group and control group by random number table method, with 49 cases in each group. The control group received routine continuing care services, and the observation group was given family integrated care on the basis of routine continuing care. Self-efficacy, osteoporosis knowledge, Harris hip function score and secondary fracture were compared between the two groups after receiving different nursing modes. Results Overall analysis showed that there were significant differences in osteoporosis self-efficacy score and osteoporosis knowledge score between groups, time point comparison and interaction between the two groups (P ＜ 0.05). Further pair comparison showed that the difference between the observation group and this group before and three months after intervention was statistically significant (P ＜ 0.05), after three and six months of intervention, there were statistically significant differences in self-efficacy level and knowledge score of osteoporosis between the two groups at each time point (P ＜ 0.05). There were statistically significant differences between the control group and this group before and three months after intervention (P ＜ 0.05). After three and six months of intervention, there were statistically significant differences in Harris score and secondary fracture occurrence between the two groups (P ＜ 0.05). Harris score of observation group was higher than that of control group at different time points (P ＜ 0.05), and there was no statistical significance in the occurrence of secondary fractures between the two groups (P ＞ 0.05). Conclusion The family participation nursing model can improve the self-efficacy level of elderly patients with brittle fracture of hip, enrich the knowledge of osteoporosis, promote the recovery of joint function, and is beneficial to the rehabilitation of patients.
		2021 Vol. 18 (29): 158-161,181 [Abstract] ( 40 ) HTML (1 KB) PDF (641 KB) ( 87 )

	162	Clinical value of medication training centered on Precede-Proceed model in patients with schizophrenia#br#
		YU Xiaoding1 ZHENG Chunmei2
		Objective To analyze the clinical value of medication training centered on Precede-Proceed model in patients with schizophrenia. Methods A total of 82 schizophrenic patients admitted to the 7th People’s Hospital of Shaoxing, Zhejiang Province from January 2019 to June 2020 were selected, they wore divided into two groups by coin toss, 41 cases in control group were treated with routine medication intervention, 41 cases in observation group based on the control group with Precede-Proceed Model as the core of medication training, the patient was assessed for taking medication. Results After intervention, the scores of anxiety and depression, lack of vitality, activation, abnormal thinking and hostile suspicion on the summary psychiatric rating scale of the two groups were lower than those before intervention, and the scores of the observation group were lower than those of the control group, with statistical significance (P ＜ 0.05). After intervention, self-knowledge and treatment attitude questionnaire score and total positive factor score of two groups were higher than those of before intervention, total negative factor score was lower than before interention, and the self-knowledge and treatment attitude questionnaire score and total positive factor score of observation group were higher than the control group, the total negative factor score was lower than the control group, the differences were statistically significant (P ＜ 0.05). The medication compliance of observation group was higher than control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The medication training with Precede-Proceed model as the core can improve the medication compliance of patients with schizophrenia.
		2021 Vol. 18 (29): 162-165 [Abstract] ( 36 ) HTML (1 KB) PDF (591 KB) ( 9 )

	166	Application of zero defect nursing mode guided by prospective theory in emergency treatment of severe craniocerebral injury#br#
		ZHANG Weijuan1 REN Shengnan2▲
		Objective To explore the application of prospective theory guided zero defect nursing mode in emergency treatment of severe craniocerebral injury. Methods A total of 129 patients with severe craniocerebral injury admitted to the First Affiliated Hospital of Air Force Military Medical University from March 2019 to March 2021 were randomly divided into group A, B and C, with 43 cases in each group. After emergency admission, group A received routine emergency nursing, group B received routine emergency nursing + zero defect nursing mode, and group C received routine emergency nursing + prospective theory guided zero defect nursing mode. The emergency room treatment time and emergency treatment success rate of the three groups were compared. Glasgow coma scale (GCS) were compared between the three groups at admission and transfer out of the emergency room. The mortality and complications of the three groups during emergency treatment were compared. Results The time of emergency room treatment in group C were shorter than those in group A and group B, and group B was shorter than group A (P ＜ 0.05); the success rate of emergency treatment in group C was higher than that in group A (P ＜ 0.017). The GCS scores of the three groups were higher when they were transferred out of the emergency room than when they were admitted to the hospital, and group C were higher those in group A and group B, and group B was higher than group A (P ＜ 0.05). The mortality and complication rate of group C were significantly lower than those of group A (P ＜ 0.017). Conclusion The application of the prospective theory guided zero defect nursing mode in severe brain injury patients can significantly shorten the emergency treatment time, reduce the occurrence of complications, and has the value of popularization and application.
		2021 Vol. 18 (29): 166-169 [Abstract] ( 87 ) HTML (1 KB) PDF (593 KB) ( 30 )

	170	Effect of cognitive behavioral intervention based on the humanism perspective on the compliance behavior of children with asthma and the psychological state of their parents#br#
		SONG Qingmei1 SONG Qingli2 ZHANG Xiaojuan1 XIE Kaili1 ZHU Yaqiong1 LIANG Juan1▲
		Objective To explore the impact of cognitive behavioral intervention based on the humanism perspective on the compliance behavior of children with asthma and the psychological state of their parents, and to provide theoretical references for clinical practice. Methods Ninety children with asthma admitted to Xijing Hospital of the First Affiliated Hospital of Air Forth Medical University, from January 2018 to December 2020 were selected as the research objects. They were divided into control group and observation group by random number table method, with 45 cases in each group. The control group adopted conventional nursing intervention, while on the basis of the control group, the observation group adoped cognitive behavioral intervention based on humanism psychological. The compliance behaviors, parents’ awareness rate of asthma health knowledge, self-rating anxiety scale (SAS) scores, and self-rating depression scale (SDS) scores were compared between the two groups. Results The observation group adhered to the doctor’s prescribed medication, avoided contact with allergens, paid attention to keeping warm, physical exercise, and scientific diet compliance behavior rates were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The awareness rate of parents’ health knowledge in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). After the intervention, the SAS and SDS scores of the two groups were lower than before the intervention, while the observation group was lower than the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Cognitive behavior intervention based in the humanism perspective can improve the compliance behavior of children with asthma, enhance parents’ cognition of asthma health knowledge, and regulate parents’ mental state. It is worthy of clinical widespread promotion and application.
		2021 Vol. 18 (29): 170-173 [Abstract] ( 119 ) HTML (1 KB) PDF (591 KB) ( 46 )

	174	Application of rehabilitation nursing based on motivational behavior transformation in postoperative rehabilitation of patients with limb fractures#br#
		GAO Yi ZHANG Shaohua JIA Yan▲
		Objective To explore the application effect of rehabilitation nursing based on motivational behavior transformation in postoperative rehabilitation of patients with limb fractures. Methods From May 2018 to June 2020, a total of 80 patients in the Department of Orthopedics of Jiangsu Provincial People’s Hospital for postoperative rehabilitation care of limb fractures were selected for the study. According to the random number table method, they were divided into control group (40 cases) and study group (40 cases). The control group adopted conventional nursing intervention, and the study group adopted rehabilitation nursing intervention based on motivational behavior transformation. The swelling time, hospitalization time, pain score at 72 hours after surgery, nursing effectiveness, complications, and nursing satisfaction were compared between the two groups. Results The swelling time and hospitalization time of the study group were shorter than those of the control group, while the pain score at 72 hours after the operation was lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). The total effective rate of nursing care in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The total nursing satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Rehabilitation nursing based on motivational behavior transformation is applied to postoperative rehabilitation patients of limb fracture patients, which can reduce the pain of patients after surgery and improve the effect of reducing swelling. It is worthy of promotion.
		2021 Vol. 18 (29): 174-177 [Abstract] ( 74 ) HTML (1 KB) PDF (586 KB) ( 117 )

	178	Clinical application of clinical nursing pathways based on the concept of zero defect in the perioperative period of orthopedics and traumatology patients#br#
		SHAN Yaping
		Objective To explore the clinical application of clinical nursing pathways based on the concept of zero defect in the perioperative period of orthopedics and traumatology patients. Methods According to the order of admission, a total of 80 cases of orthopedics and traumatology patients admitted to the People’s Hospital of Bozhou from August to December 2020 were divided into observation group (40 cases) and control group (40 cases). The control group carried out routine nursing intervention during the perioperative period, and the observation group carried out the clinical nursing path based on the zero defect concept on the basis of the above, and the clinical nursing results in the perioperative period of the two groups were compared. Results The operation time and hospitalization time of the observation group were shorter than those of the control group, intraoperative blood loss and hospitalization expenses were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of nursing defects in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The total incidence of adverse nursing events in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The nursing satisfaction scores of the observation group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The implementation of the zero defect clinical nursing pathway during the perioperative period of orthopedics and traumatology patients can help nurses to cooperate with doctors to better complete the operation, reduce the occurrence of nursing defects and nursing adverse events, and significantly improve the satisfaction of trauma patients with nursing care.
		2021 Vol. 18 (29): 178-181 [Abstract] ( 112 ) HTML (1 KB) PDF (589 KB) ( 74 )

	182	Hypertension with hypokalemia: a case report#br#
		LUO Ruixiang1,2 WU Yang2 ZHANG Chen3
		For hypertension with hypokalemia, primary aldosteronism is given priority clinically. This article reports a case of hypertension with hypokalemia rather than primary aldosteronism to remind clinicians not to fall into the “trap”. The patient was admitted to the hospital for “intermittent dizziness and fatigue for three months”. After admission, he was found to be low in blood potassium. Losartan potassium and Hydrochlorothiazide Tablets were discontinued, and Felodipine Sustained-release Tablets combined with Potassium Chloride Sustained-release Tablets were found to have blood pressure significantly elevated and persistently low serum potassium, primary aldosteronism was initially considered, and Spironolactone was added on this basis, and eventually the patient’s blood pressure and serum potassium returned to normal. A retrospective medical history revealed that the patient had taken Compound Glycyrrhizin, and adverse reactions such as hypokalemia and pseudoaldosteronism might occur when the drug was used simultaneously with Thiazide Diuretics. This article aims to remind clinicians of the importance of detailed medical history, especially medication history, and should have a sound clinical thinking and diagnosis and treatment model, and at the same time improve the understanding of primary aldosteronism.
		2021 Vol. 18 (29): 182-184,188 [Abstract] ( 169 ) HTML (1 KB) PDF (530 KB) ( 105 )

	185	A case of septic shock caused by misdiagnosis of unknown neck abscess#br#
		PANG Yan LI Peijie
		Neck abscesses are mostly caused by odontogenic and pharyngeal infections, usually accompanied by primary infection symptoms. It is easy to be misdiagnosed when there are no typical symptoms and no clear boundary between them and surrounding tissues. This article introduces a case admitted to Lanzhou University Second Hospital on June 7, 2020. The patient, male, 30 years old, presented painful neck mass as the initial symptom and was misdiagnosed as “suppurative thyroiditis”. The initial anti-infection effect was poor, but after admission, the patient was diagnosed as neck abscess caused by odontogenic infection through further imaging and etiological examination, which was improved by anti-infection combined with surgical drainage. The symptoms of this case were not typical, and the low incidence of suppurative thyroiditis and its etiology were not taken into account, and oral periodontal diseases were ignored, leading to misdiagnosis. In order to reduce misdiagnosis, this article differentiates neck abscess from suppurative thyroiditis. In the future, it is necessary to guard against periodontal pathogens when encountering neck abscess of unknown cause, and provide ideas for the diagnosis and treatment of unknown neck abscess.
		2021 Vol. 18 (29): 185-188 [Abstract] ( 42 ) HTML (1 KB) PDF (607 KB) ( 83 )

	189	Bibliometric analysis of research on the competence model of health field in China from 2010 to 2019#br#
		ZHANG Yue1 GAO Shen1 YIN Chenghong3 YUE Wentao1
		Objective To provide evidence for further researches through explore the current situation and problems of research on the competence model of health field in China. Methods The core journal literatures published in Wanfang Data, CNKI, and VIP Chinese journals from January 2010 to December 2019 were comprehensively searched with keywords such as competency model and construction, and the publication year, region, research object, model construction method, and statistical method of the literatures were sorted out and analyzed. Results A total of 64 eligible papers were included, which came from 19 Provinces, Autonomous regions and Municipalities directly under the central government, economic level higher area studies more. Most of the studies were on nursing staff (27 articles, 42.2%). Researchers mostly used the grouping method to construct models (54 articles, 84.4%), and they were more inclined to factor analysis (18 articles, 28.1%) to analyze models. Conclusion There are obvious regional differences in competency model in the field of health care in China. The more nursing staff research is related to the transformation of medical model. There are some problems in these study, such as low sample size, lack of reliability and validity analysis, etc., which suggest that the research quality of competency model of health field in China needs to be improved.
		2021 Vol. 18 (29): 189-192,196 [Abstract] ( 95 ) HTML (1 KB) PDF (596 KB) ( 84 )

	193	Research on the equity of medical resource allocation in Beijing during the 13th Five-Year Plan period#br#
		XU Lei
		Objective To study the equity of medical resource allocation in Beijing during the 13th Five-Year Plan period (2016-2019). Methods Sixteen municipal districts in Beijing were divided according to the urban spatial structure. Based on the number of permanent residents, the distribution of available beds and health personnel resources in 2016 and 2019 was analyzed. Lorentz curve and Gini coefficient were used to calculate the equity of resource allocation, and theil index was used to analyze the main factors of difference and change trend. Results The Gini coefficient of available beds in Beijing was 0.273 in 2016 and 0.288 in 2019. The Gini coefficient of health workers was 0.263 in 2016 and 0.295 in 2019. Theil index of actual beds was 0.091 in 2016 and 0.154 in 2019, respectively. The contribution rate of difference within the group decreased from 62.54% to 33.81%. Theil index of health personnel was 0.067 in 2016 and 0.07 in 2019, respectively, and the contribution rate of difference within the group decreased from 29.96% to 21.86%. Conclusion During the 13th Five-Year Plan period, the allocation of medical resources in Beijing is relatively fair, but the trend of disparity is expanding. The differences of actual beds and health personnel distribution mainly come from different regions, and the differences between regions are still increasing. Compared with actual beds, regional differences have a greater impact on the distribution of health personnel.
		2021 Vol. 18 (29): 193-196 [Abstract] ( 123 ) HTML (1 KB) PDF (695 KB) ( 103 )

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