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| Immune-related predicted genes of prognosis in non-small cell lung cancer |
| LIU Shu ZHANG Xin XU Shun |
| Department of Thoracic Surgery, the First Hospital of China Medical University, Liaoning Province, Shenyang 110001, China |
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Abstract Objective To study immune-related predicted genes of prognosis in non-small cell lung cancer (NSCLC). Methods After the data were obtained from the cancer genome atlas, standardized processing was carried out, and immune-related differentially expressed genes were screened out. Cox regression analysis was conducted to establish the best risk model, and gene expression omnibus data were used for external verification. Results A total of 336 genes were identified as immune-related differentially expressed genes of NSCLC, and a prognostic risk model of NSCLC with an area under the curve of 0.703 composed of seven genes was obtained by Cox regression analysis. After evaluation and validation, this model can predict prognostic risk of NSCLC, and all seven genes constructed in the model affect prognosis. Conclusion In this study, a prognostic model based on immune-related differentially expressed genes was constructed to provide a new strategy for the prognostic study of NSCLC.
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