甲泼尼龙琥珀酸钠治疗儿童重症支原体肺炎的效果及对炎症因子的影响

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Abstract Objective To investigate the effect of Methylprednisolone Sodium Succinate in the treatment of children with severe mycoplasma pneumonia and its effect on inflammatory factors. Methods A total of 100 children with severe mycoplasma pneumonia in Baoding Children’s Hospital of Heibei Province from October 2018 to September 2020 were selected as research objects，and they were divided into control group（conventional symptomatic treatment）and observation group（Methylprednisolone Sodium Succinate combined with conventional symptomatic treatment）, with 50 cases in each group according to the random number table method. The clinical total effective rate, improvement time of symptoms and signs (fever, cough and pulmonary ronal sound), the levels of serum proinflammatory factors (interleukin-1β [IL-1β], IL-6, and tumor necrosis factor-α [TNF-α]) and anti-inflammatory factors (IL-4 and γ interferon [IFN-γ]) before treatment, three and five days after treatment were compared between two groups. Results The clinical total effective rate of observation group were higher than those of control group， and the differences were statistically significant (P ＜ 0.05). The improvement time of symptoms and signs between two groups were statistically significant (P < 0.05). After three and five days of treatment, the levels of IL-1β, IL-6, TNF-α, IL-4, and IFN-γ in observation group were lower than those in control group, and the differences were statistically significant (P < 0.05). Conclusion Methylprednisolone Sodium Succinate combined with conventional symptomatic treatment has a good curative effect on children with severe mycoplasma pneumonia, and can effectively control the expression level of inflammatory factors in children, so the application value is relatively high.

Key words： Methylprednisolone Sodium Succinate Conventional symptomatic treatment Children with severe mycoplasma pneumonia Clinical effect Inflammatory factors

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	LIU Xiaomeng1 ZHANG Yanbei2 YU Haiming1 ZHANG He1 SUN Yuanyuan2

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LIU Xiaomeng1 ZHANG Yanbei2 YU Haiming1 ZHANG He1 SUN Yuanyuan2. Effect of Methylprednisolone Sodium Succinate in the treatment of children with severe mycoplasma pneumonia and its effect on inflammatory factors#br#[J]. 中国医药导报, 2021, 18(29): 98-101.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I29/98

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